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1. 发明申请

WO2006091729A3 REVASCULARIZATION OF ISCHEMIC RETINAL TISSUE AND SCREENING METHOD THEREFOR 审中-公开
标题翻译：异位视网膜组织的重新形成及其筛选方法
公开(公告)号：WO2006091729A3
公开(公告)日：2007-03-01
申请号：PCT/US2006006402
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST , FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： A01N37/18 , A61K38/00 , G01N33/567
CPC分类号： A61K49/0008 , A61K38/53 , C12Y601/01002 , G01N33/5088 , G01N2333/515 , G01N2800/164
摘要： The present invention provides a treatment method for promoting beneficial physiological revascularization of ischemic retinal tissue. The method comprises administering to a mammal suffering from a retinal vascular ischemia a therapeutically effective amount of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS), thereby simultaneously inhibiting pathological neovascularization while promoting beneficial physiological revascularization of damaged areas of the retina. In a preferred embodiment, the angiostatic fragment of TrpRS is T2-TrpRS or T2-TrpRS-GD. Preferably, the mammal is a human patient suffering from retinal ischemia. A screening method for identifying and evaluating therapeutic agents for treating retinal neovascular diseases is also disclosed.
摘要翻译：本发明提供了促进缺血性视网膜组织的有益生理血运重建的治疗方法。该方法包括向患有视网膜血管缺血的哺乳动物施用治疗有效量的色氨酰-tRNA合成酶（TrpRS）的血管生成抑制片段，从而同时抑制病理性新血管形成，同时促进视网膜损伤区域的有益生理血运重建。在优选的实施方案中，TrpRS的血管抑制性片段是T2-TrpRS或T2-TrpRS-GD。优选地，哺乳动物是患有视网膜缺血的人类患者。还公开了用于鉴定和评价用于治疗视网膜新生血管疾病的治疗剂的筛选方法。

2. 发明申请

WO2006091895A3 METHOD FOR THE TREATMENT OF RETINOPATHY OF PREMATURITY AND RELATED RETINOPATHIC DISEASES 审中-公开
标题翻译：治疗前列腺疾病及相关再发性疾病的方法
公开(公告)号：WO2006091895A3
公开(公告)日：2008-09-12
申请号：PCT/US2006006744
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST , FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N15/00 , A01N63/00 , A01N65/00 , C12N5/0789
CPC分类号： A61K48/00 , A61K31/137 , A61K2035/124 , C12N5/0647 , C12N2510/00 , C12N2510/02
摘要： The present invention provides a method for treating retinopathy of prematurity (ROP) and related retinopathic diseases. The method comprises administering to the retina of a mammal suffering from, or at risk of developing, retinopathy of prematurity or a related retinopathic disease an amount of cells from a vasculotrophic lineage negative hematopoietic stem cell population, effective to promote beneficial physiological revascularization of damaged areas of the retina and to ameliorate damage to the retina caused by the disease. Preferably, the mammal is a human patient. In one preferred embodiment, the lineage negative hematopoietic stem cell population is a lineage negative hematopoietic stem cell population comprising hematopoietic stem cells and endothelial progenitor cells (i.e., Lin- HSC). In another preferred embodiment, the lineage negative hematopoietic stem cell population is an isolated myeloid-like bone marrow (MLBM) cell population in which the majority of the cells are lineage negative and express CD44 antigen and CD11b antigen. As an alternative, for treatment of newborn infants, a lineage negative hematopoietic stem cell population can be isolated from umbilical cord vein blood.
摘要翻译：本发明提供了治疗早产儿视网膜病变（ROP）和相关视网膜病变的方法。该方法包括向患有或具有发展为早产儿视网膜病变或相关视网膜病变的哺乳动物的视网膜施用来自血管营养谱系的造血干细胞群体的一定数量的细胞，其有效促进损伤区域的有益生理血运重建的视网膜，并改善由该疾病引起的视网膜损伤。优选地，哺乳动物是人类患者。在一个优选的实施方案中，谱系负造血干细胞群是包含造血干细胞和内皮祖细胞（即Lin-HSC）的谱系负造血干细胞群。在另一个优选的实施方案中，谱系负造血干细胞群是分离的骨髓样骨髓（MLBM）细胞群，其中大多数细胞是谱系阴性的并且表达CD44抗原和CD11b抗原。作为替代方案，对于新生儿的治疗，可以从脐带静脉血中分离谱系阴性造血干细胞群。

3. 发明公开

EP1853244A4 METHOD FOR THE TREATMENT OF RETINOPATHY OF PREMATURITY AND RELATED RETINOPATHIC DISEASES 有权
标题翻译：方法ROP的治疗和相关网站的皮肤疾病
公开(公告)号：EP1853244A4
公开(公告)日：2010-06-23
申请号：EP06736134
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N15/00 , A01N63/00 , A01N65/00 , C12N5/0789
CPC分类号： A61K48/00 , A61K31/137 , A61K2035/124 , C12N5/0647 , C12N2510/00 , C12N2510/02
摘要： The present invention provides the use of cells from a vasculotrophic lineage negative hematopoietic stem cell population for the preparation of a pharmaceutical composition for treating a mammal suffering from or at risk of developing retinopathy of prematurity or a related retinopathic disease wherein the cells are transfected with a therapeutically useful gene encoding for an angiostatic fragment of Trp-RS and wherein the pharmaceutical composition is for administering to the retina of the mammal an amount of cells from a vasculotrophic lineage negative hematopoietic stem cell population effective to promote beneficial physiological revascularization of damaged areas of the retina and to ameliorate damage to the retina caused by the disease.

4. 发明公开

EP1853113A4 REVASCULARIZATION OF ISCHEMIC RETINAL TISSUE AND SCREENING METHOD THEREFOR 审中-公开
标题翻译：缺血性视网膜组织的血运重建和筛选方法THEREFOR
公开(公告)号：EP1853113A4
公开(公告)日：2011-03-30
申请号：EP06735886
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： A61K38/53 , A61K38/43 , A61P27/02
CPC分类号： A61K49/0008 , A61K38/53 , C12Y601/01002 , G01N33/5088 , G01N2333/515 , G01N2800/164

5. 发明专利

ES2382357T3 Células de tipo mieloide transfectadas para el tratamiento de retinopatía de la prematuridad y enfermedades relacionadas 未知
公开(公告)号：ES2382357T3
公开(公告)日：2012-06-07
申请号：ES07021593
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N5/07 , A61K35/12 , A61K35/14 , A61K48/00 , C12N5/0789
摘要： Utilización de células en la preparación de una composición farmacéutica para el tratamiento de un mamífero que corre el riesgo de desarrollar o padecer una enfermedad retinopática, en particular una retinopatía de la prematuridad, en la que: (a) las células son una población de células de la médula ósea de tipo mieloide, vasculotrópicas, de linaje negativo, aisladas, en la que las células expresan los antígenos CD44 y CD11b; (b) las células han sido transfectadas con un ácido nucleico que codifica para un fragmento angiostático de triptofanil-ARNt sintetasa (Trp-RS); (c) la composición farmacéutica es para la administración de dichas células a la retina del mamífero en una cantidad eficaz para favorecer la revascularización fisiológica de las zonas dañadas de la retina y para mejorar la lesión a la retina provocada por la enfermedad.

6. 发明专利

CA2599172A1 METHOD FOR THE TREATMENT OF RETINOPATHY OF PREMATURITY AND RELATED RETINOPATHIC DISEASES 未知
公开(公告)号：CA2599172A1
公开(公告)日：2006-08-31
申请号：CA2599172
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： BANIN EYAL , FRIEDLANDER MARTIN , AGUILAR EDITH
IPC分类号： A61K31/137 , A61K35/12 , C12N5/0789

7. 发明专利

ES2466649T3 Revascularización de tejido retiniano isquémico 未知
公开(公告)号：ES2466649T3
公开(公告)日：2014-06-10
申请号：ES07021431
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： A61K38/53 , A61P27/02
摘要： Utilización de un fragmento angiostático de triptofanil-ARNt sintetasa (TrpRS) para la preparación de una composición farmacéutica para promover la revascularización fisiológica beneficiosa de tejido retiniano isquémico, en la que la composición farmacéutica está destinada a administrar a un mamífero que sufre isquemia retiniana una cantidad terapéuticamente eficaz de un fragmento angiostático de TrpRS suficiente para inhibir la neovascularización patológica y promover la revascularización fisiológica de las zonas isquémicas de la retina.

8. 发明专利

PL1935976T3 Transfekowane komórki mieloidopodobne do leczenia retinopatii wcześniaków i pokrewnych chorób 未知
公开(公告)号：PL1935976T3
公开(公告)日：2012-07-31
申请号：PL07021593
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N5/07 , A61K35/12 , A61K35/14 , A61K48/00 , C12N5/0789

9. 发明专利

PT1935976E CÉLULAS DO TIPO MIELÓIDE TRANSFECTADAS PARA O TRATAMENTO DE RETINOPATIA DA PREMATURIDADE E DOENÇAS RELACIONADAS 未知
公开(公告)号：PT1935976E
公开(公告)日：2012-05-15
申请号：PT07021593
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N5/07 , A61K35/12 , A61K35/14 , A61K48/00 , C12N5/0789

10. 发明专利

AT545697T 未知
公开(公告)号：AT545697T
公开(公告)日：2012-03-15
申请号：AT07021593
申请日：2006-02-24
申请人： SCRIPPS RESEARCH INST
发明人： FRIEDLANDER MARTIN , BANIN EYAL , AGUILAR EDITH
IPC分类号： C12N5/07 , A61K35/12 , A61K35/14 , A61K48/00 , C12N5/0789

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