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1. 发明申请

WO2010040136A2 SELECTION OF HIV VACCINE ANTIGENS BY USE OF INTRAPATIENT SEQUENCE VARIATION TO IDENTIFY MUTATIONS IN THE HIV ENVELOPE GLYCOPROTEIN THAT AFFECT THE BINDING OF BROADLY NEUTRALIZING ANTIBODIES 审中-公开
公开(公告)号：WO2010040136A2
公开(公告)日：2010-04-08
申请号：PCT/US2009059583
申请日：2009-10-05
申请人： UNIV CALIFORNIA , BERMAN PHILLIP W , O'ROURKE SARA , SCOTT WILLIAM
发明人： BERMAN PHILLIP W , O'ROURKE SARA , SCOTT WILLIAM
IPC分类号： C12Q1/68 , A61K39/21 , C07K14/155 , G01N33/68
CPC分类号： C12Q1/703 , A61K39/00 , C07K14/005 , C12N2740/16122 , G01N33/56988 , G01N2500/00
摘要： Selection of HIV vaccine antigens by use of intrapatient sequence variation to identify mutations in the HIV envelope glycoprotein that affect the binding of broadly neutralizing antibodies and polypeptides identified by these methods.

2. 发明申请

WO2009091550A8 SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS 审中-公开
标题翻译： SULFONE取代的2,3-二羟基喹喔啉[1,2-C]喹唑啉衍生物有助于治疗高血压疾病和疾病与血管发生
公开(公告)号：WO2009091550A8
公开(公告)日：2010-08-26
申请号：PCT/US2009000228
申请日：2009-01-13
申请人： BAYER SCHERING PHARMA AG , HENTEMANN MARTIN F , SCOTT WILLIAM , WOOD JILL , JOHNSON JEFFREY , REDMAN ANIKO , BULLION ANN-MARIE , GUERNON LEATTE
发明人： HENTEMANN MARTIN F , SCOTT WILLIAM , WOOD JILL , JOHNSON JEFFREY , REDMAN ANIKO , BULLION ANN-MARIE , GUERNON LEATTE
IPC分类号： A61K38/16
CPC分类号： A61K45/06 , A61K31/519 , A61K31/541 , A61K2300/00 , C07D487/04
摘要： This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新的砜2I3-二氢咪唑并[11l-c]喹唑啉化合物，含有这些化合物的药物组合物以及这些化合物或组合物用于磷脂酰肌醇-3-激酶（PI3K）的用途，其用于抑制和治疗与磷脂酰肌醇-3- 激酶（PI3K）活性，特别是治疗高增殖和/或血管发生介导的病症，作为唯一的药剂或与其它活性成分组合。

3. 发明申请

WO2009091550A2 SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS 审中-公开
标题翻译： SULFONE取代的2,3-二羟基喹喔啉[1,2-C]喹唑啉衍生物有助于治疗高血压疾病和疾病与血管发生
公开(公告)号：WO2009091550A2
公开(公告)日：2009-07-23
申请号：PCT/US2009000228
申请日：2009-01-13
申请人： BAYER HEALTHCARE LLC , HENTEMAN MARTIN F , SCOTT WILLIAM , WOOD JILL , JOHNSON JEFFREY , REDMAN ANIKO , BULLION ANN-MARIE , GUERNON LEATTE
发明人： HENTEMAN MARTIN F , SCOTT WILLIAM , WOOD JILL , JOHNSON JEFFREY , REDMAN ANIKO , BULLION ANN-MARIE , GUERNON LEATTE
IPC分类号： A61K38/16
CPC分类号： A61K45/06 , A61K31/519 , A61K31/541 , A61K2300/00 , C07D487/04
摘要： This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新的砜2I3-二氢咪唑并[11l-c]喹唑啉化合物，含有这些化合物的药物组合物以及这些化合物或组合物用于磷脂酰肌醇-3-激酶（PI3K）的用途，其用于抑制和治疗与磷脂酰肌醇-3- 激酶（PI3K）活性，特别是治疗高增殖和/或血管发生介导的病症，作为唯一的药剂或与其它活性成分组合。

4. 发明专利

CA211462A AUTO JACK 未知
公开(公告)号：CA211462A
公开(公告)日：1921-05-10
申请号：CA211462D
申请人： SHAMSKY JACOB , SCOTT WILLIAM , GOLDSMITH JOSEPH BENJAMIN
发明人： SCOTT WILLIAM , SHAMSKY JACOB , GOLDSMITH JOSEPH BENJAMIN

5. 发明专利

GB191518044A Improvements in or relating to Means for Filling Sacks and the like. 未知
公开(公告)号：GB191518044A
公开(公告)日：1916-11-30
申请号：GB191518044D
申请日：1915-12-28
申请人： SCOTT WILLIAM
发明人： SCOTT WILLIAM
IPC分类号： B65B39/06
摘要： 18,044. Scott, W. Dec. 28. Sack-holders.-A hopper having a contractible discharge end that tends to expand during filling is formed in two parts, one c of which is rigidly secured to the feeding table a, the other d being pivoted and longitudinally adjustable in slots p in brackets e. The pivot bolts q are carried by a bar j secured to the hopper section d and formed with extensions k, l, so that the end of the hopper can be enlarged or reduced at will. The upper extension is connected by a cord m to a treadle o. Strips of angle-iron r, s are fixed to the ends of the hopper to assist in holding the sack.

6. 发明专利

GB190806333A Improvements in Machinery for Cutting Up Boiler Flues, Boiler Shells, or the like Cylinders or Tubes. 未知
公开(公告)号：GB190806333A
公开(公告)日：1909-01-14
申请号：GB190806333D
申请日：1908-03-21
申请人： SCOTT WILLIAM
发明人： SCOTT WILLIAM
摘要： 6333. Scott, W. March 21. Shearing.-A machine for cutting boiler shells and flues, tubes, &c. into scrap has reciprocating cutters coacting with stationary cutters, and is provided with foot-operated clutch mechanism. An eccentric-operated slide E carries three cutters F, F, G, the cutter G being shaped to take the curved surface of the work J, Fig. 4 ; these cutters coact with fixed cutters P, P, R on the bed, and the piece cut out passes through a space L. The work is guided through a machine by rollers 15, and to prevent the slot cut out from fouling the frame A of the machine, the cutters are arranged to cut out a dovetail slot, Fig. 7. A stripper H, Fig. 1, prevents the work from rising with the cutters. The shaft C is driven through a foot-operated clutch U ; and when the clutch is disengaged, the shaft is always stopped so that the slide E is at the top of its stroke by providing a friction sleeve 5 on the driving-wheel which turns the shaft until a recess 7 engages a bolt 8 and thus locks the shaft. The cutters F are provided with heels F , which act as stops for feeding the work and also guide the cutters.

7. 发明专利

CA113126A DOOR STOP AND FASTENER 未知
公开(公告)号：CA113126A
公开(公告)日：1908-07-21
申请号：CA113126D
申请日：1908-06-22
申请人： SCOTT WILLIAM
发明人： SCOTT WILLIAM

8. 发明专利

CA89701A BAKER'S OVEN 未知
公开(公告)号：CA89701A
公开(公告)日：1904-10-25
申请号：CA89701D
申请日：1904-09-03
申请人： RICHARD MURDOCK , SCOTT WILLIAM
发明人： RICHARD MURDOCK , SCOTT WILLIAM

9. 发明专利

GB190327547A Improvements in Bakers' Ovens. 未知
公开(公告)号：GB190327547A
公开(公告)日：1904-04-07
申请号：GB190327547D
申请日：1903-12-16
申请人： RICHARD MURDOCH , SCOTT WILLIAM
发明人： RICHARD MURDOCH , SCOTT WILLIAM
摘要： 27,547. Richard, M., and Scott, W. Dec. 16. Oven furnaces.-A baker's oven a is heated by a furnace b at one end and below the floor c, the hot gases passing through a flue d to the back of the oven, then up through a passage e into the interior of the oven, finally escaping by a flue f, the entrance f to which is arranged near the front of the oven and is partly above and partly below the drawplate g. Openings are left on each side of the back k of the oven, and a canopy m, consisting of firebrick slabs supported by the back k and cross-bars m , prevents the bread at the inner end of the plate g from being burned. Lateral flues q at each side of the flue d communicate with longitudinal spaces at each side of the floor c which are open at their tops to the interior of the oven. The flues q may be made of cast-iron plates q secured at each side of the floor c, and are fitted with dampers actuated by rods from the front of the oven. A damper t in the passage e is actuated by a rod passing through a passage u in the floor c to the front of the oven, and a sliding damper o actuated by a rod p allows the size of the upper part of the outlet f to be regulated.

10. 发明专利

GB190105460A Improvements in and relating to Pre-payment Meters for the Supply of Electricity. 未知
公开(公告)号：GB190105460A
公开(公告)日：1902-03-06
申请号：GB190105460D
申请日：1901-03-15
申请人： FINLAYSON JAMES , SCOTT WILLIAM
发明人： FINLAYSON JAMES , SCOTT WILLIAM
摘要： 5460. Finlayson, J. and Scott, W. March 15. Electricity, supplying, in general ; delivery mechanism.-Relates to an electric meter of the type in which the insertion of a coin, token, or the like introduces a quantity of electrolytic fluid between the electrodes so as to give a supply of electricity while decomposition takes place ; or the electrodes may be lowered into the electrolyte on the insertion of a coin. As shown in Fig. 1, a coin or token Z, inserted through a slotted tube A , causes electrolyte to pass from a vessel B to a vessel D, into which the electrodes a, b depend. A plug z allows the coins or tokens to be removed. The coins may be dropped into a float in the vessel B, and a partition may be placed between two electrodes, which pass down into the electrolyte in the vessel D. Actuating-mechanism; coin action; coin tipping or discharging mechanism.-Tokens may be delivered into a shoot leading to the electrolyte by a slide, normally held closed by a projection on it engaging a lever released by a coin dropped on its end. A second projection on the slide discharges the coin from the lever. As shown in Fig. 5, electrolyte is expelled from the vessel B by a plunger I carrying a rack I operated by a spring-withdrawn pawl H held in engagement by a coin Z dropped into a spring-raised tube G. When this tube is depressed, the rack I is operated and the coin discharged through a slot J into a vessel K. In a modification, the rack I is connected to a crosshead carrying rods to which the electrodes are attached.

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