专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004050830A2 METHODS FOR COVALENTLY ATTACHING PROTEINS TO SUBSTRATES 审中-公开
标题翻译：将蛋白质与蛋白质共同连接的方法
公开(公告)号：WO2004050830A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/026174
申请日：2003-08-20
申请人： SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO , DOLAN, Patricia , LOPEZ, Gabriel , METZENBERG, Robert , WU, Yang , NELSON, Mary Anne
发明人： DOLAN, Patricia , LOPEZ, Gabriel , METZENBERG, Robert , WU, Yang , NELSON, Mary Anne
IPC分类号： C12N
CPC分类号： G01N33/54353 , B01J19/0046 , B01J2219/005 , B01J2219/00533 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , C40B40/10 , Y10T436/2575
摘要： The present invention provides a microarray comprising: a substrate comprising a diazotized substrate; and at least one polypeptide covalently bound to the diazotized substrate. The present invention also provides methods for making such a microarray.
摘要翻译：本发明提供了一种微阵列，其包括：包含重氮化基底的基底; 和与重氮化底物共价结合的至少一种多肽。本发明还提供了制备这种微阵列的方法。

2. 发明申请

WO2003037491A3 MICROFLUIDIC MICROMIXER 审中-公开
公开(公告)号：WO2003037491A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/034244
申请日：2002-10-25
申请人： SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO , SKLAR, Larry , BURANDA, Tione , EDWARDS, Bruce , GALLEGOS, Carlos , JACKSON, W., Coyt , KUCKUCK, Frederick , LOPEZ, Gabriel , MAMMOLI, Andrea
发明人： SKLAR, Larry , BURANDA, Tione , EDWARDS, Bruce , GALLEGOS, Carlos , JACKSON, W., Coyt , KUCKUCK, Frederick , LOPEZ, Gabriel , MAMMOLI, Andrea
IPC分类号： G01N1/14
摘要： A mixing apparatus (100) is provided comprising: first driving means for driving a plurality of reagent samples from a plurality of respective source wells (110) into a first fluid flow stream; second driving means for introducing a separation gas between each of the plurality of reagent samples (112) in the first fluid flow stream; means for driving a second fluid flow stream comprising a plurality of particles (124); a junction device comprising: a first inlet port (128) for receiving the first fluid flow stream; a second inlet port (120) for receiving a second fluid flow stream; a reaction zone for forcing mixing between the first fluid flow stream and the second fluid flow stream to thereby form a reaction product stream; and an outlet port (134) for allowing the reaction product stream to exit the junction device.

3. 发明申请

WO2003037491A2 MICROFLUIDIC MICROMIXER 审中-公开
标题翻译：微流控MICROMIXER
公开(公告)号：WO2003037491A2
公开(公告)日：2003-05-08
申请号：PCT/US2002/034244
申请日：2002-10-25
申请人： SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO , SKLAR, Larry , BURANDA, Tione , EDWARDS, Bruce , GALLEGOS, Carlos , JACKSON, W., Coyt , KUCKUCK, Frederick , LOPEZ, Gabriel , MAMMOLI, Andrea
发明人： SKLAR, Larry , BURANDA, Tione , EDWARDS, Bruce , GALLEGOS, Carlos , JACKSON, W., Coyt , KUCKUCK, Frederick , LOPEZ, Gabriel , MAMMOLI, Andrea
IPC分类号： B01F
CPC分类号： G01N35/085 , B01F13/0071 , B01L3/0293 , B01L3/5085 , G01N15/1404 , G01N15/1484 , G01N35/0099 , G01N35/08 , G01N35/1011 , G01N2015/1413 , G01N2015/149 , G01N2035/00514 , G01N2035/00544
摘要： A mixing apparatus is provided comprising: first driving means for driving a plurality of reagent samples from a plurality of respective source wells into a first fluid flow stream; second driving means for introducing a separation gas between each of the plurality of reagent sample in the first fluid flow stream; means for driving a second fluid flow stream comprising a plurality of particles; a junction device comprising: a first inlet port for receiving the first fluid flow stream; a second inlet port for receiving the second fluid flow stream; a reaction zone for forcing mixing between the first fluid flow stream and the second fluid flow stream to thereby form a reaction product stream; and an outlet port for allowing the reaction product stream to exit the junction device; a reaction zone where the plurality of reagent samples and the plurality of particles mix to form a plurality of reaction products, the reaction zone communicating with the outlet port; reaction product driving means for driving the reaction product stream through the reaction zone; and means for selectively analyzing the reaction product stream for the reaction products. A method for mixing materials is also provided comprising: driving a first fluid flow stream comprising a plurality of reagent samples separated by gas bubbles through a second inlet port of a junction device; driving a second fluid flow stream comprising particles through a first inlet port of the junction device; mixing the first fluid stream and the second fluid stream in a reaction zone in the junction device to form a reaction product stream; and driving the reaction product stream through an outlet port of the junction device.
摘要翻译：提供了一种混合设备，包括：第一驱动装置，用于将多个试剂样品从多个相应的源阱驱动到第一流体流中; 第二驱动装置，用于在所述第一流体流中的所述多个试剂样品中的每一个之间引入分离气体; 用于驱动包括多个颗粒的第二流体流动流的装置; 连接装置，包括：用于接收第一流体流动的第一入口; 用于接收第二流体流的第二入口; 用于迫使所述第一流体流和所述第二流体流之间的混合从而形成反应产物流的反应区; 以及用于允许反应产物流离开接合装置的出口; 反应区，其中所述多个试剂样品和所述多个颗粒混合以形成多个反应产物，所述反应区与所述出口连通; 用于驱动反应产物流通过反应区的反应产物驱动装置; 以及用于选择性分析反应产物的反应产物流的装置。还提供了一种用于混合材料的方法，包括：驱动包含通过气泡隔开的多个试剂样品的第一流体流，通过连接装置的第二入口; 通过所述连接装置的第一入口驱动包含颗粒的第二流体流; 将所述第一流体流和所述第二流体流在所述连接装置中的反应区中混合以形成反应产物流; 并且通过连接装置的出口驱动反应产物流。

4. 发明申请

WO2011044580A2 MATERIALS INCORPORATING ANTIMICROBIAL POLYMERS 审中-公开
标题翻译：掺入抗微生物聚合物的材料
公开(公告)号：WO2011044580A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/052332
申请日：2010-10-12
申请人： STC. UNM , WHITTEN, David , ISTA, Linnea , CORBITT, Thomas , OGAWA, Motokatsu , SCHANZE, Kirk , LOPEZ, Gabriel , NAGARAJAN, Ramanathan
发明人： WHITTEN, David , ISTA, Linnea , CORBITT, Thomas , OGAWA, Motokatsu , SCHANZE, Kirk , LOPEZ, Gabriel , NAGARAJAN, Ramanathan
IPC分类号： D06M14/02 , D06M15/37 , D06M13/165 , D06M11/32 , D06M14/04
CPC分类号： A01N43/90 , D06M13/513 , D06M14/02 , D06M14/04 , D06M14/06 , D06M14/08 , D06M15/227 , D06M16/00 , D06M23/005 , D06M2400/01 , Y10T442/20 , Y10T442/2525 , A01N25/10 , A01N25/34
摘要： The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.
摘要翻译：本公开描述了软表面的制造和使用，例如承载表面接枝抗微生物聚合物的织物。

5. 发明申请

WO2009137129A3 RAPID DETECTION OF ANTI-CHROMATIN AUTOANTIBODIES IN HUMAN SERUM USING A PORTABLE ELECTROCHEMICAL BIOSENSOR 审中-公开
公开(公告)号：WO2009137129A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/033943
申请日：2009-02-12
申请人： STC.UNM , RUBIN, Robert , SITDIKOV, Ravil , ATANASSOV, Plamen , LOPEZ, Gabriel , KONSTANTINOV, Konstantin
发明人： RUBIN, Robert , SITDIKOV, Ravil , ATANASSOV, Plamen , LOPEZ, Gabriel , KONSTANTINOV, Konstantin
IPC分类号： G01N33/53 , G01N27/26 , G01N33/561
摘要： A rapid electrochemical flow-through sensor and method for detecting the presence of autoantibodies in a fluid sample such as blood is shown and described. The sensor may take either a single- or multi-plexed form. The sensor comprises a fluid inlet, a reaction region comprising immobilized autoantigens and an electrode assembly, and a fluid outlet.

6. 发明申请

WO2008143731A3 SURFACE GRAFTED CONJUGATED POLYMERS 审中-公开
公开(公告)号：WO2008143731A3
公开(公告)日：2008-11-27
申请号：PCT/US2008/002756
申请日：2008-02-29
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , WHITTEN, David, G. , CHEMBURU, Sireesha , CORBITT, Thomas , ISTA, Linnea , LOPEZ, Gabriel , SCHANZE, Kirk, S. , OGAWA, Motokatsu
发明人： WHITTEN, David, G. , CHEMBURU, Sireesha , CORBITT, Thomas , ISTA, Linnea , LOPEZ, Gabriel , SCHANZE, Kirk, S. , OGAWA, Motokatsu
IPC分类号： C07K17/08 , C12Q1/68 , G01N33/533
摘要： A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involve the inclusion of the surface is modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.

7. 发明申请

WO2009097174A3 ELECTROCHEMICAL BIOSENSOR 审中-公开
公开(公告)号：WO2009097174A3
公开(公告)日：2009-08-06
申请号：PCT/US2009/030304
申请日：2009-01-07
申请人： STC.UNM , SITDIKOV, Ravil , IVNITSKIV, Dmitri , LOPEZ, Gabriel , RAMIREZ, Brianna , ATANASSOV, Plamen
发明人： SITDIKOV, Ravil , IVNITSKIV, Dmitri , LOPEZ, Gabriel , RAMIREZ, Brianna , ATANASSOV, Plamen
IPC分类号： G01N27/327 , G01N33/48 , G01N27/28 , G01N33/487 , G01N27/416
摘要： A simple, fast, selective and highly sensitive electrochemical method assay and disposable device for detection of viruses, bacteria, proteins, DNA, and/or organic/inorganic compounds. The sensor has a multi-layered construction, with each successive layer performing a different function. The design further allows for the packing of numerous microscopic electrode transducers onto the small footprint of a biochip device, allowing for a high-density array of sensors.

8. 发明申请

WO2010132474A2 STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS 审中-公开
标题翻译：稳定的弹性体负反射粒子及其在声辐射场中的应用
公开(公告)号：WO2010132474A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034415
申请日：2010-05-11
申请人： STC.UNM , LOPEZ, Gabriel , KADUCHAK, Gregory
发明人： LOPEZ, Gabriel , KADUCHAK, Gregory
IPC分类号： A61K9/14 , A61K9/16 , A61K47/30 , A61K49/00
CPC分类号： C08L83/04 , A61K9/0009 , A61K9/1641 , A61K9/1682 , A61K47/34 , A61K49/225 , G01N33/538 , G01N33/54313
摘要： We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.
摘要翻译：我们描述了具有可压缩性和密度的稳定的弹性体负声学对比粒子的合成方法和配方。这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

9. 发明申请

WO2010132471A3 SYNTHESIS OF STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES 审中-公开
公开(公告)号：WO2010132471A3
公开(公告)日：2010-11-18
申请号：PCT/US2010/034411
申请日：2010-05-11
申请人： STC.UNM , LOPEZ, Gabriel , CARROLL, Nick , CUSHING, Kevin , PETSEV, Dimiter, N.
发明人： LOPEZ, Gabriel , CARROLL, Nick , CUSHING, Kevin , PETSEV, Dimiter, N.
IPC分类号： A61K9/14 , A61K9/16 , A61K47/30 , A61K49/00
摘要： We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

10. 发明申请

WO2009158606A9 STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR OLIGO PHENYLENE ETHYNYLENES 审中-公开
公开(公告)号：WO2009158606A9
公开(公告)日：2009-12-30
申请号：PCT/US2009/048838
申请日：2009-06-26
申请人： STC.UNM , WHITTEN, David , TANG, Yanli , ZHOU, Zhijun , ISTA, Linnea , OGAWA, Motokatsu , KELLER, David , ANDREZEJEWSKI, Brett , LOPEZ, Gabriel , SCHANZE, Kirk
发明人： WHITTEN, David , TANG, Yanli , ZHOU, Zhijun , ISTA, Linnea , OGAWA, Motokatsu , KELLER, David , ANDREZEJEWSKI, Brett , LOPEZ, Gabriel , SCHANZE, Kirk
IPC分类号： C07C211/63 , C07C69/76 , A01N33/12 , A01N33/06 , C12M1/00 , C12Q1/00 , G01N27/00
摘要： Novel compounds generally referred to herein as cationic oligomeric phenylene ethynylenes (OPEs), methods of synthesizing OPEs and various uses for the OPEs are described. The compounds can be synthesized in both symmetrical (S-OPE) and non- symmetrical (N-OPE) forms. Suitable uses include sensor and biocidal applications. Reusable structures incorporating the OPEs that are able to capture and release biological species of interest are also described.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式