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1. 发明申请

WO2010117932A1 INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT 审中-公开
标题翻译：吲哚衍生物和抗病毒治疗方法
公开(公告)号：WO2010117932A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029923
申请日：2010-04-05
申请人： SCHERING CORPORATION , PTC THERAPEUTICS, INC , MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , HUANG, Song, Xiao , KAKARLA, Ramesh , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , LIU, Ronggang , LIU, Yalei , MORRILL, Christie , PAGET, Steven, D. , SMITH, Sean, W. , TAKASUGI, James , TURPOFF, Anthony, A. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
发明人： MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , HUANG, Song, Xiao , KAKARLA, Ramesh , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , LIU, Ronggang , LIU, Yalei , MORRILL, Christie , PAGET, Steven, D. , SMITH, Sean, W. , TAKASUGI, James , TURPOFF, Anthony, A. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61P31/12 , A61K31/4439 , A61K31/444 , A61K31/4436 , A61K31/443 , A61K31/4433 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译：本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。

2. 发明申请

WO2006019831A1 METHODS FOR TREATING HEPATITIS C 审中-公开
标题翻译：治疗乙型肝炎的方法C
公开(公告)号：WO2006019831A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/024881
申请日：2005-07-14
申请人： PTC THERAPEUTICS, INC. , HWANG, Peter Seongwoo , TAKASUGI, James , REN, Hongyu , WILDE, Richard Gerald , TURPOFF, Anthony , AREFOLOV, Alexander , KARP, Gary Mitchell , CHEN, Guangming , CAMPBELL, Jeffrey Allen
发明人： HWANG, Peter Seongwoo , TAKASUGI, James , REN, Hongyu , WILDE, Richard Gerald , TURPOFF, Anthony , AREFOLOV, Alexander , KARP, Gary Mitchell , CHEN, Guangming , CAMPBELL, Jeffrey Allen
IPC分类号： A61K31/404 , A61P31/14
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译：根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。

3. 发明申请

WO2006044682A1 COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：WO2006044682A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/037052
申请日：2005-10-13
申请人： PTC THERAPEUTICS, INC. , CAMPBELL, Jeffrey A. , KAHN, Atiyya , TAKASUGI, James , WELCH, Ellen
发明人： CAMPBELL, Jeffrey A. , KAHN, Atiyya , TAKASUGI, James , WELCH, Ellen
IPC分类号： C07D271/06 , C07D413/12 , A61K31/4245 , A61P35/00 , A61P25/28
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

4. 发明申请

WO2015134711A1 PHARMACEUTICAL COMPOSITIONS AND SALTS OF A 1,2,4-OXADIAZOLE BENZOIC ACID 审中-公开
标题翻译： 1,2,4-氧代噻唑酸的药物组合物和盐
公开(公告)号：WO2015134711A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/018889
申请日：2015-03-05
申请人： PTC THERAPEUTICS, INC.
发明人： DALI, Mandar, V. , TAKASUGI, James , WEETALL, Marla, L. , WELCH, Ellen
IPC分类号： A01N43/82
CPC分类号： C07D271/06 , A61K9/0048 , A61K31/4245
摘要： Provided herein are pharmaceutical compositions, which comprise a 1,2,4-oxadiazole benzoic acid or a pharmaceutically acceptable salt thereof. Further provided herein are certain pharmaceutically acceptable salts of a 1,2,4-oxadiazole benzoic acid and methods for making the same. Further provided herein are methods of treating or preventing a disease associated with a nonsense mutation or a premature stop codon, comprising administering such pharmaceutical compositions or pharmaceutically acceptable salts to a patient having a disease associated with a nonsense mutation or a premature stop codon.
摘要翻译：本文提供了包含1,2,4-恶二唑苯甲酸或其药学上可接受的盐的药物组合物。本文还提供了1,2,4-恶二唑苯甲酸的某些药学上可接受的盐及其制备方法。本文还提供了治疗或预防与无义突变或早产终止密码子相关的疾病的方法，包括向具有与无义突变相关的疾病或早产终止密码子的患者施用此类药物组合物或药学上可接受的盐。

5. 发明公开

EP3113619A1 PHARMACEUTICAL COMPOSITIONS AND SALTS OF A 1,2,4-OXADIAZOLE BENZOIC ACID 审中-公开
标题翻译：化学药剂ZUSAMMENSETZUNGEN UND SALZE EINER 1,2,4-OXADIAZOLBENZOESÄURE
公开(公告)号：EP3113619A1
公开(公告)日：2017-01-11
申请号：EP15757755.2
申请日：2015-03-05
申请人： PTC Therapeutics, Inc.
发明人： DALI, Mandar, V. , TAKASUGI, James , WEETALL, Marla, L. , WELCH, Ellen
IPC分类号： A01N43/82
CPC分类号： C07D271/06 , A61K9/0048 , A61K31/4245
摘要： Provided herein are pharmaceutical compositions, which comprise a 1,2,4-oxadiazole benzoic acid or a pharmaceutically acceptable salt thereof. Further provided herein are certain pharmaceutically acceptable salts of a 1,2,4-oxadiazole benzoic acid and methods for making the same. Further provided herein are methods of treating or preventing a disease associated with a nonsense mutation or a premature stop codon, comprising administering such pharmaceutical compositions or pharmaceutically acceptable salts to a patient having a disease associated with a nonsense mutation or a premature stop codon.
摘要翻译：本文提供了包含1,2,4-恶二唑苯甲酸或其药学上可接受的盐的药物组合物。本文还提供了1,2,4-恶二唑苯甲酸的某些药学上可接受的盐及其制备方法。本文还提供了治疗或预防与无义突变或早产终止密码子相关的疾病的方法，包括向具有与无义突变相关的疾病或早产终止密码子的患者施用此类药物组合物或药学上可接受的盐。

6. 发明公开

EP1799659A1 COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE 审中-公开
标题翻译：化合物为USE废话抑制和方法
公开(公告)号：EP1799659A1
公开(公告)日：2007-06-27
申请号：EP05807667.0
申请日：2005-10-13
申请人： PTC Therapeutics, Inc.
发明人： CAMPBELL, Jeffrey A. , KAHN, Atiyya , TAKASUGI, James , WELCH, Ellen
IPC分类号： C07D271/06 , C07D413/12 , A61K31/4245 , A61P35/00 , A61P25/28
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

7. 发明公开

EP2417122A1 INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT 审中-公开
标题翻译：用于抗病毒治疗吲哚衍生物和程序
公开(公告)号：EP2417122A1
公开(公告)日：2012-02-15
申请号：EP10714125.1
申请日：2010-04-05
申请人： PTC Therapeutics, Inc.
发明人： MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , HUANG, Song, Xiao , KAKARLA, Ramesh , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , LIU, Ronggang , LIU, Yalei , MORRILL, Christie , PAGET, Steven, D. , SMITH, Sean, W. , TAKASUGI, James , TURPOFF, Anthony, A. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61P31/12 , A61K31/4439 , A61K31/444 , A61K31/4436 , A61K31/443 , A61K31/4433 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

8. 发明申请

WO2003039255A1 USE OF SUBSTITUTED DIBENZOTHIEPINE DERIVATIVES AS INSECTICIDAL, ACARICIDAL AND NEMATICIDAL AGENTS 审中-公开
标题翻译：用作杀虫剂，杀虫剂和神经毒剂的替代二苯并噻吩衍生物的使用
公开(公告)号：WO2003039255A1
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012228
申请日：2002-11-02
申请人： BASF AKTIENGESELLSCHAFT , CHIARELLO, Ronald, H. , WOOD, Wakefield, William , CULTBERTSON, Deborah , SMITH, Daniel, W. , SPERRY, Robin, C. , SCHMIDT, Thomas , STEINER, Gerd , KORDES, Markus , VON DEYN, Wolfgang , GÖTZ, Norbert , HOFMANN, Michael , BARNES, Keith , TAKASUGI, James , TREACY, Michael, F. , OLOUMI-SADEGHI, Hassan , DIEHL, Robert
发明人： CHIARELLO, Ronald, H. , WOOD, Wakefield, William , CULTBERTSON, Deborah , SMITH, Daniel, W. , SPERRY, Robin, C. , SCHMIDT, Thomas , STEINER, Gerd , KORDES, Markus , VON DEYN, Wolfgang , GÖTZ, Norbert , HOFMANN, Michael , BARNES, Keith , TAKASUGI, James , TREACY, Michael, F. , OLOUMI-SADEGHI, Hassan , DIEHL, Robert
IPC分类号： A01N43/22
CPC分类号： C07D337/14 , A01N43/22 , A01N43/42 , A01N43/46 , A01N43/60 , A01N43/62 , A01N43/84 , A01N45/02 , A01N47/36 , C07D295/033 , C07D295/073 , C07D313/14
摘要： A composition comprising a) compounds of formula (I):, wherein A-B denotes C-C or C=C; x is S, O, SO, SO 2 , NR a , or CR b R c ; R 1 , R 2 are H, halogen, OH, SH, NH 2 , CN, NO 2 , alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenyl, alkenyloxy, alkenylamino, alkenylthio, alkynyl, alkynyloxy, alkynylamino, alkynylthio, alkylsulfonyl, alkylsulfoxyl, alkenylsulfonyl, alkynylsulfoxyl, formyl, alkylcarbonyl, hydroxycarbonyl,alkoxycarbonyl, carbonyloxy, alkylcarbonyloxy, phenyloxy, C(O)NR d R e , (S0 2 )nNR d R e , or C(=NOR f )-Γ p -R f' , a mono- or bicyclic 5- to 10-membered aromatic ringsystem, a 5- to 10-membered heteroaromatic ring system, or cycloalkyl, each optionally substituted, which is unfused or fused to the aromatic group to which it is bonded and which, when unfused, is bonded directly or through an O, S, alkyl, or alkoxy linkage; R 3 , R 4 are each independently H, alkyl, haloalkyl, alkylamine, alkoxy, cycloalkyl, wherein the carbon atoms in these aliphatic groups may be substituted, or R 3 and R 4 together with the nitrogen atom to which they are attached form a saturated or partially saturated mono-or bicyclic 5- to 10-membered ringsystem or a 5-membered hetaryl, wherein the rings are optionally substituted and are bonded directly or via an O, S, or alkyl linkage, and cycloalkenyl, wherein the carbon atoms in these aliphatic groups can be substituted, and wherein the group NR 3 R 4 can be present as [N + -O-]R 3 R 4 (aminoxide) if R 3 and R 4 are bonded through a single bond to the nitrogen atom; and R a , R b , R c , R d , R e , R f' , R f , Γ, and p are as defined in the description; m is 0, 1 ,2 ,3, or 4; n is 0, 1, 2, 3, or 4; or the enantiomers or diastereomers, salts or esters thereof, and b) an agronomically acceptable carrier, methods for protecting crops from attack by insects, arachnids and nematodes by contacting the crop or the target species with a pesticidally effective amount of the compound of formula (I), compounds of formula I, and a process for their preparation.
摘要翻译：包含式I化合物的组合物，其中AB表示C C或C = C x为S，O，SO，SO 2，NR a或CR b R c R 1，R 2为H，卤素，OH，SH，NH 2，CN，NO 2，烷基氨基，烷基氨基，二烷基氨基，烷硫基，烯基，烯氧基，烯基氨基，烯基硫基，炔基，炔氧基，炔基氨基，炔基硫代，烷基磺酰基，烷基亚砜基，链烯基磺酰基，炔基磺酰基，甲酰基，烷基羰基，羟基羰基，烷氧基羰基，羰基氧基，烷基羰氧基，苯氧基，CONRdRe， S02nNRdRe或C = NORf-GAMMAp-Rf'，单环或双环5至10元芳族环系统，5至10元杂芳族环系统或环烷基，各自任选取代，其未融合或稠合至其键合的芳族基团，当未被取代时，其直接键合或通过O，S，烷基或烷氧基键R 3键合，R 4各自独立地为H，烷基，卤代烷基，烷基胺，烷氧基，环烷基，其中碳这些脂族基团中的原子可以被取代，或者R3和R4 与其连接的氮原子一起形成饱和或部分饱和的单环或双环5-至10-元环系或5元杂芳基，其中所述环任选被取代并直接键合或经由O，S 或烷基键，和环烯基，其中这些脂族基团中的碳原子可以被取代，并且其中如果R3和R4通过单键与氮键合，则基团NR 3 R 4可以[N + -O-] R 3 R 4氨基氧化物存在原子和R a，R b，R c，R d，R f，R f'，R f，GAMMA和p如说明书中所定义，m为0,1,2,3或4，n为0,1,2,3或 4或其对映异构体或非对映异构体，其盐或酯，以及b农艺学上可接受的载体，通过使作物或目标物种与农药有效量的式I化合物接触来保护作物免受昆虫，蜘蛛和线虫袭击的方法，式I化合物及其制备方法。

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