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1. 发明申请

WO2005041931A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2005041931A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/034359
申请日：2004-10-18
申请人： SCHERING CORPORATION , BERRY, Julianne , SHERWOOD, Jill, K. , CHAUDHRY, Saeed , SEQUEIRA, Joel, A.
发明人： BERRY, Julianne , SHERWOOD, Jill, K. , CHAUDHRY, Saeed , SEQUEIRA, Joel, A.
IPC分类号： A61K9/12
CPC分类号： A61K9/008 , A61K9/12 , A61K9/124 , A61K31/58 , A61K2300/00
摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 µg of non-volatile residue as measured by ultraviolet spectroscopy.
摘要翻译：公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂包含小于约500μg的通过紫外光谱测量的非挥发性残余物。

2. 发明申请

WO2004020289A1 PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS 审中-公开
标题翻译：生产计量剂量吸入剂制剂的方法
公开(公告)号：WO2004020289A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/026512
申请日：2003-08-26
申请人： SCHERING CORPORATION , CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
发明人： CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
IPC分类号： B65B31/00
CPC分类号： B65B3/003 , A61M11/04 , A61M15/0065 , B65B31/003
摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorflourocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.
摘要翻译：公开了将药物（优选无糠酸莫米松）的悬浮液或溶液引入计量剂量吸入器容器中的方法，所述容器具有附着于其上的阀，所述方法包括以下步骤：将无糠酸莫米松，无表面活性剂和无氯氟碳推进剂进入保持在压力下以形成悬浮液或溶液的容器中，使所述悬浮液或溶液从容器循环通过包括填充头的管线，使所述填充头通过所述的所述阀的所述阀门与所述计量吸入器容器连通计量剂量吸入器容器，通过所述计量吸入器容器的所述阀从管线的填充头将一定数量的这种悬浮液或溶液引入容器中，从所述计量吸入器容器中取出所述填充头，并密封所述计量剂量吸入器集装箱，以及由此生产的产品改进计量吸入器中活性成分的粒度分布。

3. 发明申请

WO2007095041A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2007095041A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003316
申请日：2007-02-07
申请人： SCHERING CORPORATION , BERRY, Julianne , CHAUDHRY, Saeed, M. , SEQUEIRA, Joel , KLINE, Lukeysha, Charisse , D'SOUZA, Susan, S.
发明人： BERRY, Julianne , CHAUDHRY, Saeed, M. , SEQUEIRA, Joel , KLINE, Lukeysha, Charisse , D'SOUZA, Susan, S.
IPC分类号： A61K9/00 , A61K31/4245 , A61K47/32 , A61K47/38 , A61K47/44
CPC分类号： A61K9/0043 , A61K9/0073
摘要： An aspect of the present invention provides for a medicament suitable for administration as a nasal inhalant including an aqueous carrier and suspended therein particulate pleconaril, the aqueous carrier including a thixotropic composition including microcrystalline cellulose and a polymer selected from an alkali metal carboxyalkylcellulose, a polyvinylpyrrolidone polymer, and mixtures thereof.
摘要翻译：本发明的一个方面提供了一种药物，其适用于作为包含水性载体的鼻吸入剂并且悬浮在其中的颗粒pleconaril的鼻吸入剂，所述水性载体包括触变组合物，其包含微晶纤维素和选自碱金属羧烷基纤维素，聚乙烯吡咯烷酮聚合物，及其混合物。

4. 发明申请

WO2007095043A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2007095043A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003335
申请日：2007-02-07
申请人： SCHERING CORPORATION , BERRY, Julianne , CHAUDHRY, Saeed, M. , SEQUEIRA, Joel , KLINE, Lukeysha, Charisse , D'SOUZA, Susan, S.
发明人： BERRY, Julianne , CHAUDHRY, Saeed, M. , SEQUEIRA, Joel , KLINE, Lukeysha, Charisse , D'SOUZA, Susan, S.
IPC分类号： A61K9/12 , A61K9/72 , A61K47/14 , A61K31/4245 , A61P31/14 , A61P11/00
CPC分类号： A61K9/008 , A61K9/0043 , A61K31/4245 , A61K31/573 , A61K31/65 , A61K31/7034 , A61K47/14 , Y02A50/465
摘要： An aspect of the present invention provides for a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent comprising said solution is a pleconaril-dissolving glyceride oil, and the solution is suitable for inhalation administration as an aerosol mist.
摘要翻译：本发明的一个方面提供了一种药物，其包含含有pleconaril或其药学上可接受的盐的溶液，其中至少一种包含所述溶液的溶剂是溶解于胆酸的甘油酯油，并且该溶液适合作为气雾剂的吸入给药。

5. 发明申请

WO2007095039A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2007095039A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003306
申请日：2007-02-07
申请人： SCHERING CORPORATION , CHAUDHRY, Saeed, M. , BERRY, Julianne , SEQUEIRA, Joel
发明人： CHAUDHRY, Saeed, M. , BERRY, Julianne , SEQUEIRA, Joel
CPC分类号： A61K9/008 , A61K31/137 , A61K31/4164 , A61K31/4245 , A61K31/573 , A61K47/34 , Y02A50/465
摘要： An aspect of the present invention provides for a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent including the solution is a pleconaril-dissolving hydrofluorocarbon.
摘要翻译：本发明的一个方面提供了一种药物，其包含含有pleconaril或其药学上可接受的盐的溶液，其中至少一种包括溶液的溶剂是溶解于溶剂的氢氟烃。

6. 发明申请

WO1998008519A1 CHLOROFLUOROCARBON-FREE MOMETASONE FUROATE AEROSOL FORMULATIONS 审中-公开
标题翻译：氯氟隆无呋喃酮酚醛树脂制剂
公开(公告)号：WO1998008519A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014708
申请日：1997-08-26
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , BERRY, Julianne , SEQUEIRA, Joel, A. , CHAUDRY, Imtiaz, A.
IPC分类号： A61K31/58
CPC分类号： A61K9/008 , A61K9/124 , A61K31/58
摘要： The invention relates to suspension aerosol formulations which exhibit stable particle sizes, containing mometasone furoate, about 1 to about 10 weight percent ethanol and 1,1,1,2,3,3,3-Heptafluoropropane as the propellant. A surfactant, such as oleic acid, can also be included. These formulations are suitable for use in metered dose inhalers.
摘要翻译：本发明涉及悬浮气溶胶制剂，其表现出稳定的粒度，含有糠酸莫米他松，约1至约10重量％的乙醇和1,1,1,2,3,3,3-七氟丙烷作为推进剂。还可以包括表面活性剂，例如油酸。这些制剂适用于计量吸入器。

7. 发明授权

EP1542904B1 PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS 有权
标题翻译：用于生产DOSIERINHALATORFORMULIERUNGEN
公开(公告)号：EP1542904B1
公开(公告)日：2008-01-16
申请号：EP03791745.7
申请日：2003-08-26
申请人： Schering Corporation
发明人： CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
IPC分类号： B65B31/00
CPC分类号： B65B3/003 , A61M11/04 , A61M15/0065 , B65B31/003
摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorflourocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.

8. 发明授权

EP0588897B1 NON-CHLOROFLUOROCARBON AEROSOL FORMULATIONS 有权
标题翻译：非氯氟烃气溶胶制剂
公开(公告)号：EP0588897B1
公开(公告)日：1996-02-28
申请号：EP92912490.7
申请日：1992-06-08
申请人： SCHERING CORPORATION
发明人： BERRY, Julianne , SEQUEIRA, Joel, A. , CHAUDRY, Imtiaz, A. , KOPCHA, Michael
IPC分类号： A61K9/72 , C09K3/30
CPC分类号： A61K9/008 , A61K9/124 , A61K31/58 , C09K3/30 , Y10S514/826
摘要： Aerosol formulations substantially free of chlorofluorocarbons for oral and/or nasal administration are described. The formulations comprise 1,1,1,2,3,3,3 heptafluoropropane, a medicament, optionally an excipient and optionally a surfactant. Methods of treatment utilizing the formulations are also described.
摘要翻译：描述了用于口服和/或鼻腔给药的基本上不含氯氟烃的气雾剂制剂。该制剂包含1,1,1,2,3,3,3-七氟丙烷，药物，任选的赋形剂和任选的表面活性剂。还描述了使用该制剂的治疗方法。

9. 发明公开

EP1981545A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：EP1981545A2
公开(公告)日：2008-10-22
申请号：EP07717220.3
申请日：2007-02-07
申请人： Schering Corporation
发明人： CHAUDHRY, Saeed, M. , BERRY, Julianne , SEQUEIRA, Joel
IPC分类号： A61K47/34 , A61K9/00 , A61K31/4245
CPC分类号： A61K9/008 , A61K31/137 , A61K31/4164 , A61K31/4245 , A61K31/573 , A61K47/34 , Y02A50/465
摘要： An aspect of the present invention provides for a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent including the solution is a pleconaril-dissolving hydrofluorocarbon.

10. 发明公开

EP1878664A1 Process for producing metered dose inhaler formulations 有权
标题翻译： Verfahren zur Herstellung von FormulierungenfürInhaliergerätemit abgemessener Dosis
公开(公告)号：EP1878664A1
公开(公告)日：2008-01-16
申请号：EP07119781.8
申请日：2003-08-26
申请人： Schering Corporation
发明人： CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
IPC分类号： B65B31/00
CPC分类号： B65B3/003 , A61M11/04 , A61M15/0065 , B65B31/003
摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorflourocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.
摘要翻译：公开了将药物（优选无糠酸莫米松）的悬浮液或溶液引入计量剂量吸入器容器中的方法，所述容器具有附着于其上的阀，所述方法包括以下步骤：将无糠酸莫米松，无表面活性剂和无氯氟碳推进剂进入保持在压力下以形成悬浮液或溶液的容器中，使所述悬浮液或溶液从容器循环通过包括填充头的管线，使所述填充头通过所述的所述阀的所述阀门与所述计量吸入器容器连通计量剂量吸入器容器，通过所述计量吸入器容器的所述阀从管线的填充头将一定数量的这种悬浮液或溶液引入容器中，从所述计量吸入器容器中取出所述填充头，并密封所述计量剂量吸入器集装箱，以及由此生产的产品改进计量吸入器中活性成分的粒度分布。

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