专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CZ2003151A3 Serine protease NS3 peptide inhibitors and pharmaceutical preparation 未知
公开(公告)号：CZ2003151A3
公开(公告)日：2003-05-14
申请号：CZ2003151
申请日：2001-07-19
申请人： SCHERING CORP , CORVAS INTERNATIONAL
发明人： MCCORMICK JINPING L , WANG HAIYAN , PIKE RUSSELL E , BOGEN STEPHANE L , CHAN TIN YAU , LIU YI-TSUNG , ZHU ZHAONING , NJOROGE F GEORGE , ARASAPPAN ASHOK , PAREKH TEJAL N , GANGULY ASHIT K , CHEN KEVIN X , VENKATRAMAN SRIKANTH , VACCARO HENRY A , PINTO PATRICK A , SANTHANAM BAMA , WU WANLI , HENDRATA SISKA , HUANG YUHUA , KEMP SCOTT JEFFREY , LEVY ODILE ESTHER , LIM-WILBY MARGUERITA , TAMURA SUSAN Y , SAKSENA ANIL K , GIRIJAVALLABHAN VIYYOOR MOOPIL , LOVEY RAYMOND G , JAO EDWIN E , BENNETT FRANK
IPC分类号： A61K45/00 , A61K31/7056 , A61K38/00 , A61K38/08 , A61K38/21 , A61P31/14 , A61P43/00 , C07K5/02 , C07K5/08 , C07K5/087 , C07K7/02 , C07K5/10 , A61K38/07 , A61K38/06 , A61P31/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

3. 发明专利

HU0303358A2 NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU0303358A2
公开(公告)日：2004-01-28
申请号：HU0303358
申请日：2001-07-19
申请人： CORVAS INTERNATIONAL , SCHERING CORP
发明人： ARASAPPAN ASHOK , BENNETT FRANK , BOGEN STEPHANE L , CHAN TIN-YAU , CHEN KEVIN X , GANGULY ASHIT K , GIRIJAVALLABHAN VIYYOOR MOOPIL , JAO EDWIN E , KEMP SCOTT JEFFREY , LEVY ODILE ESTHER , LIM-WILBY MARGUERITA , LIU YI-TSUNG , LOVEY RAYMOND G , MCCORMICK JINPING L , NJOROGE F GEORGE , PAREKH TEJAL N , PIKE RUSSELL E , PINTO PATRICK A , SAKSENA ANIL K , SANTHANAM BAMA , TAMURA SUSAN Y , VACCARO HENRY A , VENKATRAMAN SRIKANTH , WANG HAIYAN , ZHU ZHAONING
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

5. 发明专利

CZ2003195A3 Peptide inhibitors of serine protease NS3 and pharmaceutical preparation containing thereof 未知
公开(公告)号：CZ2003195A3
公开(公告)日：2003-04-16
申请号：CZ2003195
申请日：2001-07-19
申请人： SCHERING CORP , CORVAS INTERNATIONAL
发明人： SAKSENA ANIL K , GIRIJAVALLBHAN VIYYOOR MOOPIL , BOGEN STEPHANE L , LOVEY RAYMOND G , JAO EDWIN E , BENNETT FRANK , MC CORMICK JINPING L , WANG HAIYAN , PIKE RUSSELL E , LIU YI-TSUNG , CHAN TIN-YAU , ZHU ZHAONING , ARASAPPAN ASHOK , CHEN KEVIN X , VENKATRAMAN SRIKANTH , PAREKH TEJAL , PINTO PATRICK A , SANTHANAM BAMA , NJOROGE F GEORGE , GANGULY ASHIT K , VACCARO HENRY A , KEMP SCOTT JEFFREY , LEVY ODILE ESTHER , LIM-WILBY MARGUERITA , TAMURA SUSAN Y
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06 , C07K7/00 , C07K5/10 , A61K38/08 , A61K38/07
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

6. 发明授权

US3920629A Desevernitrose everninomicins and method for their manufacture 失效
标题翻译：脱乙酰壳多糖及其制备方法
公开(公告)号：US3920629A
公开(公告)日：1975-11-18
申请号：US51083774
申请日：1974-09-30
申请人： SCHERING CORP
发明人： GANGULY ASHIT K , SARRE OLGA , SZMULEWICZ SOL
IPC分类号： C07H19/01 , C07C15/00
CPC分类号： C07H19/01 , Y10S514/937
摘要： Everninomicin derivatives having a nitroso function (e.g. everninomicins B, C and D) upon treatment with a trisubstituted, trivalent phosphorus reagent (e.g. triphenyl phosphine or triethyl phosphite) are converted to novel desevernitrose everninomicin derivatives. Described are desevernitrose everninomicins B, C and D and pharmaceutically acceptable salts thereof which possess antibacterial activity.
摘要翻译：用三取代的三价磷试剂（例如三苯基膦或亚磷酸三乙酯）处理时，具有亚硝基功能的欧文尼米星衍生物（例如，伊维菌素B，C和D）被转化为新的脱乙酰壳多糖衍生物。描述了具有抗菌活性的脱乙酰壳多糖蛋白B，C和D及其药学上可接受的盐。

7. 发明授权

US3915956A Reduction products of everninomicins and methods for their manufacture 失效
标题翻译： everninomicins的还原产物及其制备方法
公开(公告)号：US3915956A
公开(公告)日：1975-10-28
申请号：US41154873
申请日：1973-10-31
申请人： SCHERING CORP
发明人： GANGULY ASHIT K , SARRE OLGA
IPC分类号： C07H19/01 , C07G3/00
CPC分类号： C07H19/01 , Y10S514/937
摘要： Everninomicin antibiotics having a nitro function, e.g. everninomicin B, everninomicin C, and everninomicin D, upon treatment with aluminum amalgam in aqueous alkanol are converted to a mixture of at least two reduction products having antibacterial activity, said reduction products being an everninomicin having a nitroso function and an everninomicin having a hydroxylamino function. The nitrosoeverninomicins are also prepared by treating the corresponding hydroxylaminoeverninomicin with an oxidizing reagent selected from the group consisting of aerial oxidation in alkaline solution, and an alkali metal hypobromite in an aprotic solvent. The everninomicin reduction products and salts thereof are described as well as nitrone derivatives of the hydroxylaminoeverninomicins and salts thereof, all of which possess antibacterial activity. A preferred compound is hydroxylaminoeverninomicin D, particularly the sodium salt thereof.
摘要翻译：具有硝基功能的Everninomicin抗生素，例如 everninomicin B，everninomicin C和everninomicin D在铝链烷醇水溶液处理后，转化为具有抗菌活性的至少两种还原产物的混合物，所述还原产物是具有亚硝基功能的乙酰氨基葡蛋白酶和具有羟基氨基官能团的依托米酮。还可以通过用选自碱性溶液中的空气氧化的氧化剂和非质子溶剂中的碱金属次溴酸盐处理相应的羟基氨基炔诺酮来制备亚硝基诺霉素。还描述了依维生素A还原产物及其盐以及羟基氨基炔诺酮及其盐的硝酮衍生物，它们都具有抗菌活性。优选的化合物是D-氨基甘氨酸，尤其是其钠盐。

8. 发明授权

US3896220A Method of treating fungal infections with azido compounds 失效
标题翻译：用叠氮化合物治疗真菌感染的方法
公开(公告)号：US3896220A
公开(公告)日：1975-07-22
申请号：US46205574
申请日：1974-04-18
申请人： SCHERING CORP
发明人： SHAPIRO ELLIOT L , GANGULY ASHIT K
IPC分类号： C07D307/94 , A61K27/00
CPC分类号： C07D307/94
摘要： Disclosed herein are novel azido compounds, useful as antifungal agents.
摘要翻译：本文公开了可用作抗真菌剂的新型叠氮化合物。

9. 发明授权

US3880839A Process for the preparation of rifamycin 5 and analogs thereof from the halomicins 失效
标题翻译：制备利福霉素5及其类似物的方法
公开(公告)号：US3880839A
公开(公告)日：1975-04-29
申请号：US42719573
申请日：1973-12-21
申请人： SCHERING CORP
发明人： GANGULY ASHIT K , SZMULEWICZ SOL , SARRE OLGA Z
IPC分类号： C07D498/08 , C07D99/02 , C07D99/04
CPC分类号： C07D498/08
摘要： Halomicin A, B and D may be converted to rifamycin S which may then be converted to rifampin by methods known in the art. Similarly, Halomicin C may be converted to an analog of rifamycin S which by analogy may be converted to a rifampin analog. The compounds so produced have antibacterial activity.
摘要翻译： Halomicin A，B和D可以转化为利福霉素S，然后可以通过本领域已知的方法将其转化成利福平。类似地，Halomicin C可以转化为利福霉素S的类似物，其类似物可以转化为利福平类似物。如此制备的化合物具有抗菌活性。

10. 发明申请

WO0023455A9 RIBAVIRIN-INTERFERON ALFA COMBINATION THERAPY FOR ERADICATING DETECTABLE HCV-RNA IN PATIENTS HAVING CHRONIC HEPATITIS C INFECTION 审中-公开
标题翻译： RIBAVIRIN-INTERFERON ALFA联合治疗可检测HCV RNA的患者有慢性乙型肝炎感染
公开(公告)号：WO0023455A9
公开(公告)日：2000-08-24
申请号：PCT/US9921450
申请日：1999-10-14
申请人： SCHERING CORP , GANGULY ASHIT K , MCCORMICK JINPING , LOVEY RAYMOND G , BENNETT FRANK , SAKSENA ANIL K , GIRIJAVALLABHAN VIYYOOR M
发明人： GANGULY ASHIT K , MCCORMICK JINPING , LOVEY RAYMOND G , BENNETT FRANK , SAKSENA ANIL K , GIRIJAVALLABHAN VIYYOOR M
IPC分类号： C07H19/056 , A61K31/70
CPC分类号： C07H19/056 , Y10S514/894
摘要： Ribavirin derivatives represented by formula (I) wherein at least one of R , R or R is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as their use to treat patients having susceptible viral infections, alone and in combination with a therapeutically effective amount of interferon-alpha are disclosed.
摘要翻译：由式（I）表示的利巴韦林衍生物，其中R 2，R 3或R 5中的至少一个是直链或支链聚环氧烷聚合物缀合物，以及含有它们的药物组合物及其用于治疗公开了具有易感病毒感染的患者，单独和与治疗有效量的干扰素-α组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式