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1. 发明申请

WO2021197267A1 METHOD AND DEVICE FOR NEURO-STIMULATION 审中-公开
公开(公告)号：WO2021197267A1
公开(公告)日：2021-10-07
申请号：PCT/CN2021/083598
申请日：2021-03-29
申请人： SCENERAY CO., LTD.
发明人： ZHU, Weiran , CHEN, Lei , NING, Yihua
IPC分类号： A61N1/36 , A61N1/025 , A61N1/0531 , A61N1/0534 , A61N1/36089 , A61N1/36096 , A61N1/36139 , G06N20/00 , G16H20/30 , G16H20/70
摘要： Provided are a method and device for neuro-stimulation. The method for neuro-stimulation includes: detecting a physiological activity signal of each brain region in at least one brain region of a patient through an implantable electrode device; comparing the detected physiological activity signal of the each brain region with a preset detection condition to determine whether the detected physiological activity signal of the each brain region belongs to an abnormal physiological activity signal; and controlling whether to apply an electrical stimulation signal to the at least one brain region through the implantable electrode device based on a determination result of the physiological activity signal of the each brain region.

2. 发明公开

EP4400158A1 METHOD AND SYSTEM FOR RECOMMENDING STIMULATION ELECTRODE COMBINATION 审中-公开
公开(公告)号：EP4400158A1
公开(公告)日：2024-07-17
申请号：EP21956456.4
申请日：2021-09-14
申请人： Sceneray Co., Ltd
发明人： LIU, Bin , ZHU, Weiran
IPC分类号： A61N1/36 , A61B5/383
摘要： Provided are a method and system for recommending a stimulation electrode combination. The method includes the following steps: Potentials of a plurality of electrodes are received in the process of treatment delivery; a difference between potentials of any two electrodes is calculated based on the potentials of the plurality of electrodes to obtain a voltage between any two electrodes; a feature signal corresponding to an electrode combination formed by any two electrodes is acquired based on the voltage between any two electrodes within a preset time range; and a recommended stimulation electrode combination is determined from all electrode combinations based on a feature signal corresponding to each electrode combination. The manner of simultaneous stimulation and collection can accurately reflect the real-time state of a patient when receiving electrical stimulation, improving the accuracy of the stimulation electrode combination. The arrangement of acquiring the feature signal according to the voltage between any two electrodes and determining the recommended stimulation electrode combination can reduce the workload of a doctor, improve the working efficiency of the doctor, and further improve the accuracy of the doctor in selecting a stimulation electrode combination.

3. 发明公开

EP4126200A1 METHOD AND DEVICE FOR NEURO-STIMULATION 审中-实审转让
公开(公告)号：EP4126200A1
公开(公告)日：2023-02-08
申请号：EP21779666.3
申请日：2021-03-29
申请人： Suzhou Sceneray Co., Ltd.
发明人： ZHU, Weiran , CHEN, Lei , NING, Yihua
IPC分类号： A61N1/36

4. 发明公开

EP4311364A1 METHOD FOR TRANSMITTING BRAIN ELECTRICAL SIGNAL, AND DEVICE 审中-实审
公开(公告)号：EP4311364A1
公开(公告)日：2024-01-24
申请号：EP22770566.2
申请日：2022-03-16
申请人： Sceneray Co., Ltd.
发明人： CHEN, Lei , ZHU, Weiran , CHEN, Jinghua , CHANG, Yueyan
IPC分类号： H04W76/10
摘要： Provided are a method for transmitting a brain electrical signal, and a device. The method for transmitting a brain electrical signal is applied to a brain electrical signal acquisition device associated with a patient and includes the following: establishing a two-way communication with a charging device; receiving a charging instruction sent by the charging device, and interacting with the charging device according to the charging instruction to perform charging; and in a case where the brain electrical signal acquisition device is charging, receiving a brain electrical related data fetch instruction sent by the charging device, and transmitting brain electrical related data of the patient acquired by the brain electrical signal acquisition device to the charging device according to the brain electrical related data fetch instruction.

5. 发明公开

EP4309609A1 SYSTEM FOR PRE-OPERATIVELY SCREENING NERVE STIMULATOR IMPLANTATION POSITION IN SKULL 审中-实审
公开(公告)号：EP4309609A1
公开(公告)日：2024-01-24
申请号：EP22770567.0
申请日：2022-03-16
申请人： Sceneray Co., Ltd.
发明人： CHEN, Lei , ZHU, Weiran
IPC分类号： A61B34/20
摘要： Provided is a system for pre-operatively screening an implantation position of a nerve stimulator in a skull. The system includes an acquisition module, a reconstruction module, an adaptation calculation module, and an implantation position determination module. The acquisition module is configured to acquire image data of a skull of a patient and a 3D appearance model of the nerve stimulator. The reconstruction module is configured to reconstruct a 3D structure of the skull of the patient according to the image data. The adaptation calculation module is configured to use the 3D appearance model of the nerve stimulator and the 3D structure of the skull of the patient to calculate an adaptation coefficient of a region of interest in which the nerve stimulator is to be implanted in the skull. The implantation position determination module is configured to determine, according to the adaptation coefficient, an optimal position at which the nerve stimulator is to be implanted in the skull.

6. 发明公开

EP4043067A1 VOLTAGE REGULATOR MODULE AND IMPLANTABLE NERVE STIMULATION SYSTEM 无效转让
公开(公告)号：EP4043067A1
公开(公告)日：2022-08-17
申请号：EP19950638.7
申请日：2019-11-28
申请人： Suzhou Sceneray Co., Ltd.
发明人： LIU, Bin , CHEN, Jinghua , ZHU, Weiran
IPC分类号： A61N1/36
摘要： Provided are a voltage regulating module (100) and an implantable nerve stimulation system. The voltage regulating module (100) includes a fine regulating charge pump (10) and a voltage-multiplying charge pump (20). The first output voltage of the fine regulating charge pump (10) is Vi = m ∗ V 0 , a second output voltage of the voltage-multiplying charge pump (20) is V 2 = n ∗ V 0 , and a total output voltage of the voltage regulating module (100) is V = Vi + V 2 . V 0 is an input voltage, a value of m ranges from 0 to 1, and n is an integer greater than or equal to 1. The system uses a combination of the fine regulating charge pump (10) and the voltage-multiplying charge pump (20) to output a large-scale finely-regulatable total output voltage V, so that the actual output voltage V is close to a required stimulation amplitude as much as possible, thereby greatly reducing power consumption.

7. 发明公开

EP4389195A1 SYSTEM FOR ELECTRICAL ACTIVITY SENSING 审中-公开
公开(公告)号：EP4389195A1
公开(公告)日：2024-06-26
申请号：EP21956455.6
申请日：2021-09-14
申请人： SceneRay Co., Ltd.
发明人： LIU, Bin , ZHU, Weiran , CHEN, Jinghua
IPC分类号： A61N1/36
摘要： Provided is a system (40) including multiple electrodes, a treatment delivery circuit (10), a sensing circuit (20) and a controller (30). The multiple electrodes are capable of being positioned within a brain of a patient to deliver a treatment to the patient or sense an electrical activity. The treatment delivery circuit (10) is operably coupled to the multiple electrodes to deliver the treatment to the patient. The sensing circuit (20) is operably coupled to the multiple electrodes to sense the electrical activity. The controller (30) includes a processing circuit system operably coupled to the treatment delivery circuit (10) and the sensing circuit (20). The controller (30) is configured to: control, through the treatment delivery circuit (10), one or more electrodes among the multiple electrodes to deliver the treatment to the patient; sense, through the sensing circuit (20), potentials of the multiple electrodes in a process of delivering the treatment; and calculate, based on the potentials of the multiple electrodes, a difference value between potentials of any two electrodes among the multiple electrodes to obtain a voltage between the any two electrodes. The system (40) can collect the electrical signal of the deep brain of the patient in a case where the patient receives the stimulus.

8. 发明公开

EP4119186A1 NERVE ELECTRICAL STIMULATION SYSTEM 审中-实审转让
公开(公告)号：EP4119186A1
公开(公告)日：2023-01-18
申请号：EP20939168.9
申请日：2020-11-06
申请人： Suzhou Sceneray Co., Ltd.
发明人： ZHU, Weiran , ZHANG, Haitao
IPC分类号： A61N1/36 , H01R43/20
摘要： A neuro electrical stimulation system includes an extension wire (100) and a lead connected to the extension wire (100). A channel (12) is provided in the extension wire (100), the lead is inserted into the channel (12) and is abutted with the extension wire (100), and a fixing assembly (13) configured to restrict the lead to move in the channel (12) is arranged in the channel (12). The neuro electrical stimulation system avoids the step of additional sealing after the lead is abutted with the extension wire (100), and uses a fixing assembly (13) which is simple in structure, easy to manufacture, excellent in sealing performance, low in cost, and time-saving, labor-saving and reliable.

9. 发明公开

EP4046679A1 STIMULATION SOURCE GENERATION CIRCUIT FOR NERVE STIMULATOR 审中-实审转让
公开(公告)号：EP4046679A1
公开(公告)日：2022-08-24
申请号：EP19949164.8
申请日：2019-11-28
申请人： Suzhou Sceneray Co., Ltd.
发明人： LIU, Bin , ZHU, Weiran
IPC分类号： A61N1/36 , H02M3/00
摘要： Provided is a stimulation source generation circuit for a nerve stimulator, including a power module, a boosting module, and an adjustment module. The power module supplies an input voltage. The boosting module is connected to the power module, boosts the input voltage and generates a stimulation source. A charge branch of the boosting module is connected in parallel with two ends of the power module and includes an inductor and a first MOS tube. An input end of the first MOS tube is connected to the other end of the inductor. An output end of the first MOS tube is connected to a negative electrode of the power module. A discharge circuit includes a second MOS tube and an output branch for outputting the stimulation source. An input end of the second MOS tube is connected to one end of the inductor facing away from the power module. An output end of the second MOS tube is connected to one end of the output branch. The adjustment module is connected to the output branch and outputs an operating frequency according to a magnitude of the stimulation source. The adjustment module is further connected to control ends of the first MOS tube and the second MOS tube and adjusts on or off of the first MOS tube and the second MOS tube according to the operating frequency. The first MOS tube and the second MOS tube cannot be turned on at the same time.

10. 发明公开

EP4039323A1 DETECTION CIRCUIT FOR NERVE STIMULATOR 审中-实审
公开(公告)号：EP4039323A1
公开(公告)日：2022-08-10
申请号：EP19948012.0
申请日：2019-11-25
申请人： Sceneray Co., Ltd
发明人： ZHU, Weiran , LI, Caijun
IPC分类号： A61N1/36 , A61N1/372
摘要： Provided is a detection circuit for a nerve stimulator. The nerve stimulator includes a stimulation source (VDDH) and a stimulation branch communicated with the stimulation source (VDDH). A sampling resistor (Rs) is disposed in the stimulation branch. The detection circuit includes an open circuit detection branch and a current detection branch. The open circuit detection branch includes a comparator (U1) and a digital logic branch (DI). A positive input terminal of the comparator (U1) is connected to one end of the sampling resistor (Rs) adjacent to the stimulation source (VDDH), a negative input terminal of the comparator (U1) is connected to one end of the sampling resistor (Rs) facing away from the stimulation source (VDDH), and an output terminal of the comparator (U1) is connected to the digital logic branch (DI). The current detection branch includes an amplifier (U1) and a first switch (S1). A negative input terminal of the amplifier (U1) is connected to the one end of the sampling resistor (Rs) facing away from the stimulation source (VDDH), an output terminal of the amplifier (U1) is connected to a control terminal of the first switch (S1), two connection terminals of the first switch (S1) are connected to a first resistor (R1) and a second resistor (R2), respectively, another end of the first resistor (R1) is connected to the stimulation source (VDDH), another end of the second resistor (R2) is grounded, and a positive input terminal of the amplifier (U1) is connected to one end of the first resistor (R1) adjacent to the first switch (S1).

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