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1. 发明专利

CA681930A PROCESS FOR PRODUCING L-GLUTAMIC ACID 未知
公开(公告)号：CA681930A
公开(公告)日：1964-03-10
申请号：CA681930D
申请人： SANRAKU SHUZO KABUSHIKI KAISHA , AJINOMOTO KK
发明人： OHARA MASAMI , KAWAMOTO AKIO , SHIIO TSUYOSHI , MOTOZAKI SHINICHI , KINOSHITA KAZUMOTO , TSUCHIYA TAKUJI , TSUNODA TOSHINAO

2. 发明专利

CA658581A PROCESS FOR PREPARING L-GLUTAMIC ACID 未知
公开(公告)号：CA658581A
公开(公告)日：1963-02-26
申请号：CA658581D
申请人： SANRAKU SHUZO KABUSHIKI KAISHA , AJINOMOTO KK
发明人： SHIIO TSUYOSHI , KINOSHITA KAZUMOTO , TSUCHIYA TAKUJI , TSUNODA TOSHINAO , MOTOZAKI SHINICHI

3. 发明授权

US3625825A Method of producing nucleosides by fermentation 失效
标题翻译：通过发酵生产核苷酸的方法
公开(公告)号：US3625825A
公开(公告)日：1971-12-07
申请号：US3625825D
申请日：1969-01-03
申请人： AJINOMOTO KK
发明人： SHIBAI HIROSHI , YAMANOI AKIO , SHIRO TERUO , HAMA AKIRA , KINOSHITA KAZUMOTO
IPC分类号： C12P19/40 , C12D13/06
CPC分类号： C12P19/40 , Y10S435/839
摘要： All strains of Bacillus subtilis which produce inosine or guanosine by fermentation give higher yields of these nucleosides when the culture medium contains potassium, magnesium, or calcium ions in much higher concentrations than were commonly employed heretofore.

4. 发明专利

DE1061790B 未知
公开(公告)号：DE1061790B
公开(公告)日：1959-07-23
申请号：DEA0028716
申请日：1958-01-20
申请人： AJINOMOTO KK
发明人： OGAWA TETSUO , TSUNODA TOSHINAO , AOKI RYOHEI , KINOSHITA KAZUMOTO , OKUMURA SHINJI , KONDO YASUHIRO
IPC分类号： C12P13/14

5. 发明专利

GB1143048A Improvements in the production of guanosine 未知
公开(公告)号：GB1143048A
公开(公告)日：1969-02-19
申请号：GB2896767
申请日：1967-06-22
申请人： AJINOMOTO KK
发明人： SHIBAI HIROSHIRO , NAITO YUJIRO , HIROSE YOSHIO , KINOSHITA KAZUMOTO , SHIRO TERUO
IPC分类号： C12P19/40
摘要： 1,143,048. Production of guanosine. AJINOMOTO CO. Inc. 22 June, 1967 [27 June, 1966], No. 28967/67. Heading C2C. In a process for producing guanosine by the fermentation of an aqueous culture medium inoculated with a strain of bacteria of the genus Bacillus capable of producing guanosine, the improvement comprising maintaining in each decilitre of the culture medium at least 650 mg. potassium ions, and/or at least 230 mg. magnesium ions and/or, in such a process performed in the presence of ammonia, at least 370 mg. calcium ions. The potassium ions are preferably present in an amount of 650-1100 mg/dl, the magnesium ions in an amount of 230-700 mg/dl, and the calcium ions in an amount of 370 to 1500 mg/dl, and the ions may be introduced into the culture in the form of salts. The strain of bacteria employed may be of the species Bacillus subtilis, specific micro-organisms described being Bacillus subtilis ATCC 19221 or ATCC 19222.

6. 发明专利

GB1104355A Fermentation process for the production of inosine 未知
公开(公告)号：GB1104355A
公开(公告)日：1968-02-28
申请号：GB2633366
申请日：1966-06-13
申请人： AJINOMOTO KK
发明人： SHIBAI HIROSHIRO , HAMA AKIRA , YAMANOI AKIO , SHIRO TERUO , KINOSHITA KAZUMOTO
IPC分类号： C12P19/40
摘要： Inosine is prepared by fermentation of an aqueous culture medium with a strain of bacteria of the genus Bacillus which is capable of producing inosine and employing in the culture medium potassium ions in an amount of at least 500 mg/dl. and/or magnesium ions in an amount of at least 400 mg/dl. The invention also includes a process for preparing inosine in the presence of gaseous or aqueous ammonia, and including in the culture medium calcium ions in an amount of more than 1 g/l. The potassium and magnesium ions may be added in the form of their salts, and calcium ions may be provided by, e.g. calcium chloride. Specified strains of Bacilli are Bacillus Subtilis strains.

7. 发明专利

GB1153114A Fermentation processes and apparatus for Carrying Out the same 未知
公开(公告)号：GB1153114A
公开(公告)日：1969-05-21
申请号：GB361268
申请日：1968-01-23
申请人： AJINOMOTO KK
发明人： HIROSE YOSHIO , SONODA HIROSHI , IKEDA SHIGEHO , KINOSHITA KAZUMOTO , YAMASHITA SUNAO , NOGUCHI HIDEO
IPC分类号： C12M1/36
摘要： 1,153,114. Amino acids; nucleosides by regulated fermentation. AJINOMOTO CO. Inc. 23 Jan., 1968 [6 Feb., 1967], No. 3612/68. Heading C2C. [Also in Divisions C6 and C7] A fermentation process involves culturing micro-organisms in a culture medium in a closed system, removing from the closed system carbon dioxide produced during the process, agitating the culture medium and feeding oxygen to the closed system at a desired controlled rate. A measurement of the partial pressure of oxygen in the liquid or gas phases within the system may be used for on-off control of an electrolytic cell providing oxygen, or of an oxygen cylinder. Alternatively, the amount of oxygen produced by an electrolytic cell 21, Fig. 3, operated under constant voltage potential may be regulated by the variation in level of the electrolyte 21 in the region of the electrode 20 produced by changes in the partial pressure of oxygen in the gas phase of the closed fermenter 1. In this embodiment the oxygen analyser 17 and recorder 18 do not participate in the control action. Carbon dioxide produced is removed by continuously circulating the gaseous phase through a solution of sodium or potassium hydroxide in a washing bottle 6. The fermenter itself may be agitated. Examples relate to the production of L- glutamic acid by cultivation of Corynebacterium acetoacidophilum ATCC 13870 on a specified glucose-containing culture medium in which a dissolved oxygen content of 0À05 atm. at 31.5‹ C. was maintained, as by periodic actuation of a 1 1. capacity electrolytic cell connected to a direct current stabilized power source of 5-15 volts; the production of 5-amino-4-imidazolecarboxamide-riboside by cultivation of Bacillus megaterium ATCC 15117 on a specified culture medium containing glucose and ribonucleic acid (dissolved oxygen=0À02 atm. at 34‹ C.); the production of inosine by cultivation of Bacillus subtilis ATCC 13952 on a specified culture medium containing glucose and adenine (dissolved oxygen=0À06 atm. at 31‹ C.); and the production of L-glutamic acid by cultivation of Corynebacterium hydrocarboclastus ATCC 15110 on specified n-alkane containing culture media (dissolved oxygen partial pressure=0À06 atm. or partial pressure of oxygen in the gas phase= 0À6 atm. at 30‹ C.).

8. 发明专利

GB1096974A Fermentation process for the production of 5-amino-4-imidazolecarboxamide ribofuranoside 未知
公开(公告)号：GB1096974A
公开(公告)日：1967-12-29
申请号：GB2563266
申请日：1966-06-08
申请人： AJINOMOTO KK
发明人： SASAKI HIROSHI , AOKI MIKIO , OKADA HIROSHI , KINOSHITA KAZUMOTO , SHIRO TERUO
IPC分类号： C07H19/04 , C12P19/28
摘要： 5 - Amino - 4 - imidazolecarboxamide ribofuranoside is made by culturing a strain of a species of Bacillus capable of producing 5-amino - 4 - imidazolecarboxamide ribofuranoside in a culture medium containing a saturated C3- 9 fatty acid, or a salt thereof. The fatty acid may be added to the medium after culturing has begun, but preferably no longer than 20 hours after commencement. The preferred acid is butyric acid.

9. 发明专利

DE1082599B 未知
公开(公告)号：DE1082599B
公开(公告)日：1960-06-02
申请号：DEA0029086
申请日：1958-03-20
申请人： AJINOMOTO KK
发明人： OGAWA TETSUO , TSUNODA TOSHINAO , AOKI RYOHEI , KINOSHITA KAZUMOTO , OKUMURA SHINJI , KONDO YASUHIRO
IPC分类号： C12P13/14

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