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1. 发明申请

WO2009021740A3 SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS 审中-公开
标题翻译：取代的四氢萘制造方法相同，它们作为药物
公开(公告)号：WO2009021740A3
公开(公告)日：2009-05-14
申请号：PCT/EP2008006700
申请日：2008-08-14
申请人： SANOFIS AVENTIS , SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HAACK TORSTEN , LENNIG PETRA
发明人： SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HAACK TORSTEN , LENNIG PETRA
IPC分类号： C07D307/12 , A61P3/00
CPC分类号： C07D405/12 , A61K31/397 , A61K31/4025 , A61K31/4525 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D307/12
摘要： The invention relates to substituted tetrahydronaphthalenes of formula (I), the physiologically tolerated salts thereof, the use thereof, medicaments containing at least one substituted tetrahydronaphthalene according to the invention and the use of the substituted tetrahydronaphthalenes according to the invention and derivatives thereof as MCH antagonists, wherein in the case that X = O, C(R43)(R43'), B = (C1-C6)alkyI, (C1-C4)alkoxy-(C1-C4)alkyl, hydroxy-(C1-C6)alkyl, a 3- to 10-membered mono-, bi- or spirocyclic non-aromatic ring, which can contain 0 to 3 heteroatoms, selected from the group oxygen, nitrogen and sulfur, wherein the ring system can be additionally substituted with one or several of the following substituents: F, CF3, (C1-C6)alkyI, O-(C1-C8)alkyl, (C1-C4)alkoxy-(C1-C4)alkyI, hydroxy-(C1-C4)alkyl, oxo, CO(R64), hydroxy; wherein in the case that X = C(R43)(R43'), L3 = C(R62)(R63)O, and a 4- to 10-membered mono-, bi- or spirocyclic non-aromatic ring, which contains 1 to 3 heteroatoms, selected from the group oxygen, nitrogen and sulfur, wherein the ring system can be additionally substituted with one or several of the following substituents: F, CF3, (C1-C6)alkyl, (C1-C4)alkyl, (C1-C4)alkoxy-(C1-C4)alkyl, hydroxy-(C1-C4)alkyl, oxo, CO(R64), hydroxy.
摘要翻译：本发明涉及式（I），以及它们的生理学可接受的盐，其制备的取代的四氢萘，含有至少一种本发明的取代的四氢化萘和使用本发明的取代的四氢萘和它们作为MCH拮抗剂的衍生物的药物，和当X = O，C （R43）（R43“），B =（C1-C6）-AlkyI，（C1-C4）烷氧基 - （C1-C4）烷基，羟基（C1-C6）烷基，3-至10- 元单 - ，二环或螺环非芳香环，其可以包括选自氧，氮和硫，其中该环系可以另外被一个或多个下列取代基取代选择0至3个杂原子：F，CF 3，（C1-C6）-AlkyI，O-（C1-C8）烷基，（C1-C4）烷氧基 - （C1-C4）-alkyI，羟基（C1-C4） - 烷基，氧代，CO（R64），羟基; 其中，在X = C（R43）（R43“），L3 = C（R62）（R63）O，和4-至10-元单环，双环或含有1至3个杂原子的螺环非芳族环包括选自氧，氮和硫的，其中该环系可以另外被一个或多个下列取代基取代选自：F，CF 3，（C1-C6）烷基，（C1-C4）烷基，（C 1 -C C4）烷氧基（C1-C4）烷基，羟基（C1-C4） - 烷基，氧代，CO（R64），羟基; 意思。

2. 发明申请

WO2007093365A3 NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：新型氨基醇取代的芳基亚氨基吡啶酮，其制备方法及其作为药物的用途
公开(公告)号：WO2007093365A3
公开(公告)日：2007-10-04
申请号：PCT/EP2007001213
申请日：2007-02-13
申请人： SANOFI AVENTIS , SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , HAACK TORSTEN , LENNIG PETRA
发明人： SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , HAACK TORSTEN , LENNIG PETRA
IPC分类号： C07D519/00
CPC分类号： C07D495/04 , C07D519/00
摘要： The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol- substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
摘要翻译：本发明涉及氨基醇取代的芳基噻吩并嘧啶酮及其衍生物，以及它们的生理学耐受盐和生理学功能衍生物，它们的制备方法，包含至少一种本发明的氨基醇取代的芳基噻吩并嘧啶酮或其衍生物的药物，以及氨基醇 - 取代的本发明的芳基噻吩并嘧啶酮及其衍生物作为MCH拮抗剂。

3. 发明申请

WO2006018280A3 ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT 审中-公开
标题翻译：芳POLYCYCLICHE AMINES，其制造方法相同，它们作为药物
公开(公告)号：WO2006018280A3
公开(公告)日：2006-05-11
申请号：PCT/EP2005008889
申请日：2005-08-16
申请人： SANOFI AVENTIS DEUTSCHLAND , SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , LENNIG PETRA
发明人： SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , LENNIG PETRA
IPC分类号： C07D487/04 , A61K31/407 , A61K31/424 , A61P3/04 , A61P3/10 , C07D487/10 , C07D498/10
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of formula (I), particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.
摘要翻译：本发明涉及式（I）的芳基取代的多环胺，尤其是双环胺，和其生理学耐受的盐和生理学功能衍生物; 其中符号和基团在本说明书中进行说明。

4. 发明申请

WO2006018279A3 ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT 审中-公开
标题翻译：芳基取代的多环胺，其制备方法及其作为药物的用途
公开(公告)号：WO2006018279A3
公开(公告)日：2006-05-11
申请号：PCT/EP2005008888
申请日：2005-08-16
申请人： SANOFI AVENTIS DEUTSCHLAND , SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , LENNIG PETRA
发明人： SCHWINK LOTHAR , STENGELIN SIEGFRIED , GOSSEL MATTHIAS , HESSLER GERHARD , LENNIG PETRA
IPC分类号： C07D471/04 , A61K31/407 , A61K31/437 , A61K31/4375 , A61P3/04 , A61P3/10 , C07D487/04 , C07D487/08
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of formula I, particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.
摘要翻译：本发明涉及式（I）的芳基取代的多环胺，特别是双环胺及其生理学耐受的盐和生理学功能衍生物; 其中符号和部首在说明书中解释。

5. 发明专利

AU2008286316A1 Substituted tetrahydronaphthalenes, process for the preparation thereof and the use thereof as medicaments 未知
公开(公告)号：AU2008286316A1
公开(公告)日：2009-02-19
申请号：AU2008286316
申请日：2008-08-14
申请人： SANOFIS AVENTIS
发明人： SCHWINK LOTHAR , GOSSEL MATTHIAS , STENGELIN SIEGFRIED , HAACK TORSTEN , LENNIG PETRA
IPC分类号： C07D307/12 , A61P3/00

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