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1. 发明申请

WO2009080226A3 HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS 审中-公开
标题翻译：作为P2Y12拮抗剂的杂环吡唑类羧酰胺
公开(公告)号：WO2009080226A3
公开(公告)日：2009-08-27
申请号：PCT/EP2008010572
申请日：2008-12-12
申请人： SANOFIS AVENTIS , NAZARE MARC , ZECH GERNOT , JUST MELITTA , WEISS TILO , HESSLER GERHARD , KOHLMANN MARKUS
发明人： NAZARE MARC , ZECH GERNOT , JUST MELITTA , WEISS TILO , HESSLER GERHARD , KOHLMANN MARKUS
IPC分类号： C07D403/14 , A61K31/496 , A61P7/02
CPC分类号： C07D403/14
摘要： The present invention relates to compounds of the formula (I), wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式（I）化合物，其中R1; R2; Z者除外; 一个; B; D组; Q; 焦耳; V; G和M具有权利要求中所示的含义。式I的化合物是有价值的药理活性化合物。它们对血小板表现出强烈的抗凝集作用，因此表现出抗血栓形成的作用，用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血小板ADP受体P2Y12的可逆拮抗剂，并且通常可用于其中存在血小板ADP受体P2Y12的不期望的活化或用于治疗或预防血小板ADP受体P2Y12的抑制的条件。本发明还涉及式（I）化合物的制备方法，其用途，特别是药物中的活性成分，以及包含它们的药物制剂。

2. 发明申请

WO2009080227A2 PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS 审中-公开
标题翻译：作为P2Y12拮抗剂的吡唑酰胺衍生物
公开(公告)号：WO2009080227A2
公开(公告)日：2009-07-02
申请号：PCT/EP2008010573
申请日：2008-12-12
申请人： SANOFI AVENTIS , NAZARE MARC , ZECH GERNOT , GOERLITZER JOCHEN , JUST MELITTA , WEISS TILO , HESSLER GERHARD , CZECHTIZKY WERNGARD , RUF SVEN
发明人： NAZARE MARC , ZECH GERNOT , GOERLITZER JOCHEN , JUST MELITTA , WEISS TILO , HESSLER GERHARD , CZECHTIZKY WERNGARD , RUF SVEN
IPC分类号： C07D403/12 , A61K31/496 , A61P7/02
CPC分类号： C07D403/12
摘要： The present invention relates to compounds of the Formula (I), wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the Formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式（I）的化合物，其中R1; R2; Z者除外; 一个; B; D组; Q; 焦耳; V; G和M具有权利要求中所示的含义。式I的化合物是有价值的药理活性化合物。它们对血小板表现出强烈的抗凝集作用，因此表现出抗血栓形成的作用，用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血小板ADP受体P2Y12的可逆拮抗剂，并且通常可用于其中存在血小板ADP受体P2Y12的不期望的活化或用于治疗或预防血小板ADP受体P2Y12的抑制的条件。本发明还涉及式（I）化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

3. 发明申请

WO0248700A3 METHOD FOR CLASSIFYING CHEMICAL SUBSTANCES ACCORDING TO OLFACTORY CHARACTERISTICS 审中-公开
标题翻译：程序对化学品分类闻的特点
公开(公告)号：WO0248700A3
公开(公告)日：2003-09-25
申请号：PCT/EP0114242
申请日：2001-12-05
申请人： HENKEL KGAA , WEISS TILO , VOLLMERHAUS DIRK , HILSMANN JUERGEN , PENNINGER JOSEF , SCHAPER ULF-ARMIN , LAHN WOLFGANG
发明人： WEISS TILO , VOLLMERHAUS DIRK , HILSMANN JUERGEN , PENNINGER JOSEF , SCHAPER ULF-ARMIN , LAHN WOLFGANG
IPC分类号： G01N33/00
CPC分类号： G01N33/0001 , G01N33/0031
摘要： Disclosed is a method for automatic qualitative classification of chemical substances and substance mixtures according to olfactory characteristics. The inventive method comprises the following steps: a) measurement of human sensory predetermined reference samples by means of a sensor system comprising at least two sensors; b) creation of at least one measuring value for the respective sample(s)(n); c) formation of one or several olfactory characteristics on the basis of the measuring values determined for the reference samples; d) measurement of a sample of a substance or substance mixture by means of the above-mentioned sensor system, whereby at least one measuring value of the sensor system associated with the substance/substance mixture is obtained; e) determination of the olfactory characteristics of the substance/substance mixture by the relative position of the associated measuring value(s) in or in relation to one of the clusters defined in step (c). The inventive method can be used for production control of chemical processes according to olfactory characteristics, whereby samples of the substance mixture are collected during at least one point of said process, said samples are measured by means of said classification method and the measuring values thus obtained are used to control the amount of at least one used raw material, additive or auxiliary agent by means of a suitable control circuit.
摘要翻译：它是由气味公开的特征在于用于自动的，化学物质和物质混合物的定性分类，其包括以下步骤的方法：1）humansensorisch预定的参考样本的测量通过一个传感器系统，包括至少两个传感器的装置; B）用于相应的（n）的参考样品（一个或多个）产生至少一个测量值; c）形成一个或基于所确定的参照样品的测量值更气味特性簇; D）借助于测量物质或物质混合物的一个样品，所述的传感器系统，至少一个与所述传感器系统的测量值的物质/相关联的获得; E）在步骤（c）中所定义簇通过在或向相应的测量值（一个或多个）的/相对位置物质/物质混合物的气味特性的测定。本发明的方法可以通过一个合适的控制电路的装置被用于化学过程气味特性的生产控制，其特征在于至少一个主体，以在过程中除去，该材料混合物的样品中，样品通过的分类方法来测量，并且将由此获得的测量值，用于控制至少使用量的原料，添加剂或辅助剂使用。

4. 发明申请

WO03007810A2 METHOD FOR THE DETERMINATION OF DERMAL ADHESIVE TAPE STRIPPINGS 审中-公开
标题翻译：一种衍生粘合剂研磨剂的研究方法
公开(公告)号：WO03007810A2
公开(公告)日：2003-01-30
申请号：PCT/EP0207284
申请日：2002-07-02
申请人： HENKEL KGAA , WEISS TILO , PITTERMANN WOLFGANG , HEISE HERBERT MICHAEL , KUEPPER LUKAS
发明人： WEISS TILO , PITTERMANN WOLFGANG , HEISE HERBERT MICHAEL , KUEPPER LUKAS
IPC分类号： G01N21/3563 , G01N21/552 , A61B5/00
CPC分类号： G01N21/552 , G01N21/3563
摘要： The invention relates to a method for the determination of dermal adhesive tape strippings, characterised in that the amount of stratum corneum in an adhesive tape stripping is determined spectroscopically by means of attenuated total reflection (ATR).
摘要翻译：用于研究皮肤粘合剂破裂的方法，其特征在于通过衰减全反射（ATR）在光谱学上测定粘合剂撕裂中角质层的量。

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