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1. 发明申请

WO2012146673A1 DISPENSE INTERFACE WITH LOCKOUT ELEMENT 审中-公开
标题翻译：具有锁定元件的接口
公开(公告)号：WO2012146673A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057685
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
发明人： EGGERT, Ilona , DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
IPC分类号： A61M5/34 , A61M5/50
CPC分类号： A61M5/34 , A61M5/19 , A61M5/31535 , A61M5/50 , A61M5/504
摘要： The invention relates to a dispense interface (6605,6805,7005) for use with a drug delivery device with an inner body (6607,6807,7007) and with a lockout element (6600,6800,7000), wherein the lockout element (6600,6800,7000) is coupled to the inner body (6607,6807,7007), wherein the lockout element (6600,6800,7000) is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface (6605,6805,7005) is attachable to the drug delivery device, wherein in the locked condition the dispense interface (6605,6805,7005) is not-attachable to the drug delivery device and wherein the lockout element (6600,6800,7000) is configured to move from the receptive condition to the locked condition when said dispense interface (6605,6805,7005) is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface (6605,6805,7005) and with a drug delivery device, wherein the dispense interface (6605,6805,7005) is removably attached to the drug delivery device.
摘要翻译：本发明涉及一种用于具有内部主体（6607,6807,7007）和具有锁定元件（6600,6800,7000）的药物输送装置的分配接口（6605,6805,7005），其中锁定元件 6600,6800,7000）联接到所述内部主体（6607,6807,7007），其中所述锁定元件（6600,6800,7000）可从接受状态移动到锁定状态，其中在接受状态下，所述分配接口（6605,6805,7005）可附接到药物输送装置，其中在锁定状态下，分配界面（6605,6805,7005）不可附接到药物输送装置，并且其中锁定元件（6600,6800,7000 ）配置成当所述分配接口（6605,6805,7005）附接到所述药物递送装置并从所述药物递送装置分离时，从所述接受状态移动到所述锁定状态。本发明解决了在已经与药物递送装置一起使用之后降低分配界面的再利用风险的技术问题。本发明还涉及具有分配界面（6605,6805,7005）和药物递送装置的装置，其中分配界面（6605,6805,7005）可移除地附接到药物递送装置。

2. 发明申请

WO2012059458A1 MEDICATED MODULE FOR ADMINISTERING FIXED DOSE 审中-公开
标题翻译：用于管理固定剂量的药物模块
公开(公告)号：WO2012059458A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069107
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , MOORE, David
发明人： DAVIES, James, Alexander , MOORE, David
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32
CPC分类号： A61M5/283 , A61M5/2033 , A61M5/2066 , A61M5/2425 , A61M5/2448 , A61M5/2466 , A61M5/31596 , A61M5/326 , A61M5/3294 , A61M2005/1787 , A61M2005/247 , A61M2005/31516 , A61M2005/3247 , A61M2005/3267
摘要： A medicated module (260) attachable to a drug delivery device. The medicated module comprises a housing configured for attachment to a drug delivery device. The drug delivery device comprises a first medicament. A movable reservoir (250) is contained within the housing. A pre-determined volume of a second medicament is contained within the reservoir. An injection needle (230) is configured within the housing and the needle arrangement is arranged in fluid communication with the movable reservoir. A spring (210) can drive a piston (270) of the movable reservoir (250) to dispense the drugs.
摘要翻译：可附接到药物输送装置的药物模块（260）。药物模块包括构造成附接到药物递送装置的壳体。药物递送装置包括第一药物。可动容器（250）容纳在壳体内。第二药物的预定体积被包含在储存器内。注射针（230）构造在壳体内，并且针装置布置成与可移动储存器流体连通。弹簧（210）可以驱动可移动储存器（250）的活塞（270）以分配药物。

3. 发明申请

WO2012146675A1 DISPENSE INTERFACE WITH LOCKOUT ELEMENT 审中-公开
标题翻译：具有锁定元件的接口
公开(公告)号：WO2012146675A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057689
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
发明人： DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
IPC分类号： A61M5/34 , A61M5/50 , A61M5/00
CPC分类号： A61M5/50 , A61M5/2448 , A61M5/284 , A61M5/34 , A61M2205/273
摘要： The invention relates to a dispense interface for use with a drug delivery device with an inner body (5807) and with a lockout element (5800), wherein the lockout element (5800) is coupled to the inner body (5807), wherein the lockout element (5800) is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface (5805) is attachable to the drug delivery device (5815), wherein in the locked condition the dispense interface (5805) is not-attachable to the drug delivery device (5815) and wherein the lockout element (5800) is configured to move from the receptive condition to the locked condition when said dispense interface (5805) is attached to and detached from said drug delivery device (5815). The invention solves the technical problem of reducing the risk of reuse of a dispense interface (5805), after it has already been used with a drug delivery device (5815). The invention furthermore relates to an apparatus with a dispense interface (5805) according to the invention and with a drug delivery device (5815), wherein the dispense interface (5805) is removably attached to the drug delivery device (5815).
摘要翻译：本发明涉及一种用于与具有内体（5807）和锁定元件（5800）的药物输送装置一起使用的分配界面，其中锁定元件（5800）联接到内体（5807），其中锁定元件（5800）可以从接收状态移动到锁定状态，其中在接受状态下，分配界面（5805）可附接到药物输送装置（5815），其中在锁定状态下，分配界面（5805）不是（5815），并且其中所述锁定元件（5800）构造成当所述分配界面（5805）附接到所述药物输送装置（5815）并从所述药物输送装置（5815）分离）时从所述接受状态移动到所述锁定状态，。本发明解决了在已经与药物输送装置（5815）一起使用之后降低分配界面（5805）的再利用风险的技术问题。本发明还涉及具有根据本发明的分配界面（5805）和药物递送装置（5815）的装置，其中分配界面（5805）可移除地附接到药物递送装置（5815）。

4. 发明申请

WO2012059453A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2012059453A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069098
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel, Thomas , SANDERS, David , DRAPER, Paul, Richard
发明人： DAVIES, James, Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel, Thomas , SANDERS, David , DRAPER, Paul, Richard
IPC分类号： A61M5/24 , A61M5/32
CPC分类号： A61M5/31545 , A61M5/2066 , A61M5/2425 , A61M5/2448 , A61M5/31525 , A61M5/31533 , A61M5/3291 , A61M5/3294 , A61M5/5086 , A61M2005/1787 , A61M2005/3247 , A61M2205/581 , A61M2205/582
摘要： A system for delivering a user-settable dose of a first medicament and a non-user settable dose of a second medicament through a single dose setter and single dispense interface. The drug delivery system includes a drug delivery device (100) and a medicated module (104). The drug delivery device comprises single dose setter operably connected to a primary reservoir containing the first medicament. The medicated module comprises (i) a collapsible feature holding the second medicament and (ii) the single dispense interface having an output needle. Further, the drug delivery device and medicated module are each configured such that the single dose setter is mechanically linked to the collapsible feature after attachment of the medicated module to the drug delivery device.
摘要翻译：一种用于通过单个剂量设定器和单个分配界面递送用户可设置剂量的第一药物和第二药物的非用户可设置剂量的系统。药物递送系统包括药物递送装置（100）和药物模块（104）。药物递送装置包括可操作地连接到包含第一药物的主储器的单剂量定量器。药物模块包括（i）保持第二药剂的可收缩特征和（ii）具有输出针的单个分配界面。此外，药物递送装置和药物模块各自被配置为使得在将药物模块附接到药物递送装置之后，单次剂量设定器机械连接到可收缩特征。

5. 发明申请

WO2011095486A1 MEDICATED MODULE WITH LOCKABLE NEEDLE GUARD 审中-公开
标题翻译：具有可锁定针头保护的药物模块
公开(公告)号：WO2011095486A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051405
申请日：2011-02-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BOYD, Malcolm, Stanley , DAVIES, James, Alexander , DE SAUSMAREZ LINTELL, Daniel, Thomas
发明人： BOYD, Malcolm, Stanley , DAVIES, James, Alexander , DE SAUSMAREZ LINTELL, Daniel, Thomas
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/284 , A61M5/2448 , A61M5/2466 , A61M5/288 , A61M5/3146 , A61M5/31525 , A61M5/3155 , A61M5/326 , A61M5/3294 , A61M5/347 , A61M2005/1787 , A61M2005/3132 , A61M2005/3247 , A61M2005/3267 , A61M2205/583
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device (7) containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a single hollow needle (3). The medicated module (4) is configured so that it will first deliver both the primary and secondary medicaments and then, if needed, a dose(s) of additional primary medicament. The module (4) also contains a needle guard (22) that locks the first dose delivery, but can be manually overridden by a user to perform a second or subsequent injection of primary medicament.
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的药物模块（4），其中包含主要药物的主要递送装置（7）接受含有单剂量次级药物的药物模块（4）药物通过单个空心针（3）递送。药物组合体（4）被配置成首先递送主要和次要药物，然后如果需要，递送另外的初级药物的剂量。模块（4）还包含锁定第一剂量递送的针护罩（22），但是可以由用户手动覆盖以执行第二次或随后的初级药物的注射。

6. 发明申请

WO2010139671A1 MEDICATED MODULE WITH USER SELECTION 审中-公开
标题翻译：具有用户选择的药物模块
公开(公告)号：WO2010139671A1
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057579
申请日：2010-06-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel, Thomas , BOYD, Malcolm, Stanley , REKAYA, Naceur , BILTON, Simon, Lewis , CROSS, John, David
发明人： DAVIES, James, Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel, Thomas , BOYD, Malcolm, Stanley , REKAYA, Naceur , BILTON, Simon, Lewis , CROSS, John, David
IPC分类号： A61M5/28 , A61M5/32
CPC分类号： A61M5/2448 , A61M5/204 , A61M5/284 , A61M5/288 , A61M5/31525 , A61M5/3213 , A61M5/326 , A61M5/3294 , A61M5/3297 , A61M5/347 , A61M2005/1787 , A61M2005/3142 , A61M2005/3247 , A61M2005/3267
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments are delivered through a single hollow needle (5). The medicated module (4) is user selectable so that it will deliver both the primary (1) and secondary medicaments (2), or only the primary medicament (1). The module (4) also contains a guard (42) that locks after dose delivery.
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的药物组件（4），其中包含主要药物的主要递送装置接受含有单剂量次级药物（2）的药物组件（4），并且其中两者药物通过单个中空针（5）递送。药物模块（4）是用户可选择的，使得其将递送初级（1）和次级药物（2）或仅递送初级药物（1）。模块（4）还包含在剂量递送之后锁定的护罩（42）。

7. 发明申请

WO2011095489A1 PUSH ROD ACTIVATED MEDICATED MODULE 审中-公开
标题翻译：推杆激活药物模块
公开(公告)号：WO2011095489A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051410
申请日：2011-02-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , WALLACE, Andrew, Gordon , BOYD, Malcolm, Stanley , SANDERS, David
发明人： DAVIES, James, Alexander , WALLACE, Andrew, Gordon , BOYD, Malcolm, Stanley , SANDERS, David
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/3245 , A61M5/2448 , A61M5/2466 , A61M5/284 , A61M5/288 , A61M5/3146 , A61M5/31525 , A61M5/3155 , A61M5/326 , A61M5/3294 , A61M5/3297 , A61M5/347 , A61M5/5086 , A61M2005/1787 , A61M2005/3247 , A61M2005/3267 , A61M2205/583
摘要： A medicated module (200)for an injection system to co-deliver at least two medicaments is disclosed. The drug delivery device (100)includes a push rod (400) operably connected to a dose dial button (113).The medicated module (200) includes a housing (202)having a connector configured for attachment to the drug delivery device (100), and the housing (202) is configured to receive a portion of the push rod (400) when the medicated module (200)is attached to the drug delivery device (100). The medicated module (200) further includes a reservoir (302) in the housing (202) comprising a single dose of a medicament(300)and a needle guard (216) operably connected to the housing (202) and configured to move in an axial direction (218) during application to an injection site. Still further, the medicated module (200) includes a sleeve (220) in the housing (202) configured to move axially in the housing (202) and a locking collar (223) in the housing (202) configured to move axially and rotationally in the housing (202).
摘要翻译：公开了一种用于共注射至少两种药物的注射系统的药物组合物（200）。药物输送装置（100）包括可操作地连接到剂量拨号按钮（113）的推杆（400）。药物模块（200）包括具有连接器的壳体（202），该连接器被配置为附接到药物输送装置），并且当所述药物模块（200）附接到所述药物输送装置（100）时，所述壳体（202）构造成接收所述推杆（400）的一部分。所述药物模块（200）还包括在所述壳体（202）中的储存器（302），其包括单个剂量的药物（300）和可操作地连接到所述壳体（202）并且被配置为在在施加到注射部位期间的轴向方向（218）。另外，所述药物组件（200）包括壳体（202）中的套筒（220），所述套筒构造成在所述壳体（202）中轴向移动，并且所述壳体（202）中的锁定套环（223）被构造成轴向和旋转地移动在壳体（202）中。

8. 发明申请

WO2011095483A1 MEDICATED MODULE WITH TIME LOCK 审中-公开
标题翻译：具有时间锁定的药物模块
公开(公告)号：WO2011095483A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051401
申请日：2011-02-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BOYD, Malcolm, Stanley , DAVIES, James, Alexander , WALLACE, Andrew, Gordon
发明人： BOYD, Malcolm, Stanley , DAVIES, James, Alexander , WALLACE, Andrew, Gordon
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/284 , A61M5/2448 , A61M5/3146 , A61M5/31525 , A61M5/3155 , A61M5/326 , A61M5/3294 , A61M5/347 , A61M2005/1787 , A61M2005/3128 , A61M2005/3247 , A61M2005/3267
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device (7) containing a primary medicament accepts a medicated module (4) containing a single dose of a second medicament (2) and where both medicaments are delivered through a single hollow needle (3).The medicated module (4) contains a time lock feature to prevent further use after a predetermined time elapses. The medicated module (4) can also contain a rotary valve (19) operably connected to a retractable needle shield (16) that locks after a predetermined time elapses.
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的药物组合物（4），其中含有主要药物的主要递送装置（7）接受含有单剂量第二药物（2）的药物组合物（4）并且其中两种药物通过单个空心针（3）递送。药物模块（4）包含时间锁定特征，以在经过预定时间后防止进一步使用。药物模块（4）还可以包含可操作地连接到可预定时间过去之后锁定的可缩回的针护罩（16）的旋转阀（19）。

9. 发明申请

WO2010112565A1 DOSE BUTTON FOR A DRUG DELIVERY DEVICE AND METHOD FOR MANUFACTURING A DOSE BUTTON 审中-公开
标题翻译：用于药物递送装置的剂量按钮和用于制造剂量按钮的方法
公开(公告)号：WO2010112565A1
公开(公告)日：2010-10-07
申请号：PCT/EP2010/054352
申请日：2010-03-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HARMS, Michael , RAAB, Steffen , STAUDER, Udo , AVERY, Richard, James, Vincent , LANGLEY, Christopher, Nigel , SENIOR, James, Alexander , DAVIES, James, Alexander
发明人： HARMS, Michael , RAAB, Steffen , STAUDER, Udo , AVERY, Richard, James, Vincent , LANGLEY, Christopher, Nigel , SENIOR, James, Alexander , DAVIES, James, Alexander
IPC分类号： A61M5/00 , A61M5/20
CPC分类号： A61M5/20 , A61M5/003 , A61M37/00 , A61M2205/582 , A61M2205/584 , A61M2205/6036 , A61M2205/6081 , Y10T82/10 , Y10T82/16016 , Y10T409/303752
摘要： The present invention relates to a drug delivery device (6) comprising a dose button (1). Furthermore it relates to a method for manufacturing a dose button (1) by using a cutting-off process. The aim of the present invention is to minimize the risk of using a drug delivery device (6) containing a wrong drug. By means of tactile features, a drug delivery device (6) is distinguishable from another drug delivery device (6) containing another type of drug. This tactile feature is manufactured by using a dose button (1) out of metal which is milled or lathed.
摘要翻译：本发明涉及包含剂量按钮（1）的药物输送装置（6）。此外，本发明涉及一种通过使用切断处理来制造剂量按钮（1）的方法。本发明的目的是最小化使用含有错误药物的药物递送装置（6）的风险。通过触觉特征，药物递送装置（6）可以与另一种类型的药物的另一种药物递送装置（6）区分开来。这种触觉特征是通过使用碾磨或车床的金属的剂量按钮（1）来制造的。

10. 发明申请

WO2014140158A1 Body part and diaphragm materials for medical devices 审中-公开
标题翻译：用于医疗器械的身体部位和隔膜材料
公开(公告)号：WO2014140158A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054932
申请日：2014-03-13
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： MANDERSCHEID, Markus , DAVIES, James, Alexander
IPC分类号： A61M39/24
CPC分类号： A61M5/2448 , A61M5/2066 , A61M39/24 , A61M2005/3128 , A61M2039/2433
摘要： The present invention inter alia relates to an apparatus. The apparatus comprises a body part (2100, 2200, 2300), wherein the body part (2100, 2200, 2300) is made from a cyclic olefin polymer material or a cyclic olefin copolymer material or a mixture therefrom, and a diaphragm valve (2700, 2750) with a diaphragm (2700, 2750), wherein at least a surface portion of the diaphragm (2700, 2750) is made from a diaphragm material, wherein said diaphragm material is a fluoroelastomer material or a perfluoroelastomer material or a mixture therefrom.
摘要翻译：本发明尤其涉及一种装置。该装置包括主体部分（2100,2200,2300），其中主体部分（2100,2200,22300）由环状烯烃聚合物材料或环状烯烃共聚物材料或其混合物制成，并且隔膜阀（2700 ，2750），其具有隔膜（2700,2750），其中所述隔膜（2700,2750）的至少一个表面部分由隔膜材料制成，其中所述隔膜材料是含氟弹性体材料或全氟弹性体材料或其混合物。

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