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1. 发明专利

AU2018209391A1 Anti-TGF-beta antibodies and their use 未知
公开(公告)号：AU2018209391A1
公开(公告)日：2019-09-05
申请号：AU2018209391
申请日：2018-01-19
申请人： SANOFI SA
发明人： SHAPIRO GARY , BROWER KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , QIU HUAWEI , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： The invention provides an improved pan-TGF-β antibody for treatment of conditions that are mediated by TGF-β, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.

2. 发明专利

CA3050845A1 ANTI-TGF-BETA ANTIBODIES AND THEIR USE 未知
公开(公告)号：CA3050845A1
公开(公告)日：2018-07-26
申请号：CA3050845
申请日：2018-01-19
申请人： SANOFI SA
发明人： SHAPIRO GARY , BROWEN KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , QIU HUAWEI , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： The invention provides an improved pan-TGF-ß antibody for treatment of conditions that are mediated by TGF-ß, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.

3. 发明专利

CR20190375A ANTICUERPOS ANTI-TGF-BETA Y SU USO 未知
公开(公告)号：CR20190375A
公开(公告)日：2019-12-17
申请号：CR20190375
申请日：2018-01-19
申请人： SANOFI SA
发明人： KODURI RAO , FINN PATRICK , LIU FENG , MALKOVA NATALIA , QIU HUAWEI , THEILHABER JOACHIM , BROWEN KEVIN , WINTER CHRISTOPHER , GREGORY RICHARD C , MANKOO PARMINDER , POLLARD JACK R , SHAPIRO GARY , YU MARCELLA
IPC分类号： C07K16/30 , A61P35/00 , C07K16/22 , C07K16/28
摘要： La invención proporciona un anticuerpo pan-TGF-ß mejorado para el tratamiento de afecciones que están mediadas por TGF-ß, incluyendo enfermedades autoinmunitarias, afecciones fibróticas, y cánceres. También se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.The invention provides an improved pan-TGF-ß antibody for treatment of conditions that are mediated by TGF-ß, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.

4. 发明专利

CL2019002011A1 Anticuerpos anti-tgf-beta y su uso. 未知
公开(公告)号：CL2019002011A1
公开(公告)日：2019-11-22
申请号：CL2019002011
申请日：2019-07-18
申请人： SANOFI SA
发明人： QIU HUAWEI , SHAPIRO GARY , BROWEN KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： A61P35/00 , C07K16/22 , C07K16/28
摘要： LA INVENCIÓN PROPORCIONA UN ANTICUERPO PAN-TGF-Β MEJORADO PARA EL TRATAMIENTO DE AFECCIONES QUE ESTÁN MEDIADAS POR TGF- Β, INCLUYENDO ENFERMEDADES AUTOINMUNITARIAS, AFECCIONES FIBRÓTICAS, Y CÁNCERES. TAMBIÉN SE PROPORCIONAN USOS Y USOS DEL ANTICUERPO JUNTO CON OTROS AGENTES INMUNOMODULADORES TALES COMO UN ANTICUERPO ANTI-PD-1.

5. 发明专利

PE20200734A1 ANTICUERPOS ANTI-TGF-BETA Y SU USO 未知
公开(公告)号：PE20200734A1
公开(公告)日：2020-07-23
申请号：PE2019001465
申请日：2018-01-19
申请人： SANOFI SA
发明人： SHAPIRO GARY , BROWEN KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , QIU HUAWEI , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： Un anticuerpo monoclonal aislado que se une especificamente a TGF-beta1, TGF-beta2 y TGF-beta3 humanos que comprende las regiones determinantes de la complementariedad (CDR)1-3 de la cadena pesada en la SEQ ID NO:1 y las CDR1-3 de la cadena ligera en la SEQ ID NO:2, en la que el anticuerpo comprende una region constante de IgG4 humana que tiene una prolina en la posicion 228 (numeracion EU), util en el tratamiento de afecciones que estan mediadas por TGF-beta, incluyendo enfermedades autoinmunitarias, afecciones fibroticas y canceres. Tambien se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.

6. 发明专利

MA47311A ANTICORPS ANTI-TGF-BÊTA ET LEUR UTILISATION 未知
公开(公告)号：MA47311A
公开(公告)日：2019-11-27
申请号：MA47311
申请日：2018-01-19
申请人： SANOFI SA
发明人： BROWER KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , QIU HUAWEI , SHAPIRO GARY , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： A61P35/00 , C07K16/22 , C07K16/28

7. 发明专利

CO2019008946A2 Anticuerpos anti-tgf-beta y su uso 未知
公开(公告)号：CO2019008946A2
公开(公告)日：2019-09-30
申请号：CO2019008946
申请日：2019-08-16
申请人： SANOFI SA
发明人： QIU HUAWEI , SHAPIRO GARY , BROWER KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： La invención proporciona un anticuerpo pan-TGF-β mejorado para el tratamiento de afecciones que están mediadas por TGF-β, incluyendo enfermedades autoinmunitarias, afecciones fibróticas, y cánceres. También se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.

8. 发明专利

ECSP19059553A ANTICUERPOS ANTI-TGF-BETA Y SU USO 未知
公开(公告)号：ECSP19059553A
公开(公告)日：2019-08-30
申请号：ECDI201959553
申请日：2019-08-19
申请人： SANOFI SA
发明人： FINN PATRICK , KODURI RAO , MANKOO PARMINDER , MALKOVA NATALIA , GREGORY RICHARD , SHAPIRO GARY , YU MARCELLA , WINTER CHRISTOPHER , BROWEN KEVIN , QIU HUAWEI , THEILHABER JOACHIM , LIU FENG , POLLARD JACK
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： La invención proporciona un anticuerpo pan-TGF-B; mejorado para el tratamiento de afecciones que están mediadas por TGF-B, incluyendo enfermedades autoinmunitarias, afecciones fibróticas, y cánceres. También se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.

9. 发明专利

PH12019501635A1 ANTI-TGF-BETA ANTIBODIES AND THEIR USE 未知
公开(公告)号：PH12019501635A1
公开(公告)日：2019-11-04
申请号：PH12019501635
申请日：2019-07-12
申请人： SANOFI SA
发明人： SHAPIRO GARY , BROWER KEVIN , FINN PATRICK , GREGORY RICHARD C , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK R , QIU HUAWEI , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28
摘要： The invention provides an improved pan-TGF-á antibody for treatment of conditions that are mediated by TGF-á, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.

10. 发明专利

SG11201906660TA ANTI-TGF-BETA ANTIBODIES AND THEIR USE 未知
公开(公告)号：SG11201906660TA
公开(公告)日：2019-08-27
申请号：SG11201906660T
申请日：2018-01-19
申请人： SANOFI SA
发明人： SHAPIRO GARY , BROWEN KEVIN , FINN PATRICK , GREGORY RICHARD , KODURI RAO , LIU FENG , MALKOVA NATALIA , MANKOO PARMINDER , POLLARD JACK , QIU HUAWEI , THEILHABER JOACHIM , WINTER CHRISTOPHER , YU MARCELLA
IPC分类号： A61P35/00 , C07K16/22 , C07K16/28
摘要： PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) omit IIl °nolo ow () International Publication Number WO 2018/134681 Al WIPO I PCT (51) International Patent Classification: C07K 16/22 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/IB2018/000088 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,800 20 January 2017 (20.01.2017) US 1730561.8 20 January 2017 (20.01.2017) EP (71) Applicant: SANOFI [FR/FR]; 54, Rue La Boetie, 75008 Paris (FR). (72) Inventors: SHAPIRO, Gary; 15 Intervale Road, Arling- ton, MA 02474 (US). BROWEN, Kevin; c/o Sanofi, 55 Corporate Drive, Mail Code: 55a-505a, Bridgewater, NJ 08807 (US). FINN, Patrick; 472 Dailey Drive, Franklin, MA 02038 (US). GREGORY, Richard, C.; c/o Sanfi, 55 Corporate Drive, Mail Code: 55a-505a, Bridgewater, NJ 08807 (US). KODURI, Rao; c/o Sanofi, 55 Corpo- rate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). LIU, Feng; 3987 Montefrio Ct., San Diego, CA 92130 (US). MALKOVA, Natalia; c/o Sanofi, 55 Corpo- rate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). MANKOO, Parminder; P.O. Box 8174, Foster City, CA 91101 (US). POLLARD, Jack, R.; c/o Sanofi, 55 Cor- porate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). QIU, Huawei; c/o Sanofi, 55 Corporate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). THEIL- HABER, Joachim; c/o Sanofi, 55 Corporate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). WINTER, Christopher; 169 Bradlee Ave, Swampscott, MA 01907 (US). YU, Marcella; 37129 Spur Way, Fremont, CA 94555 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 1-1 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. I — 00 (54) Title: ANTI-TGF-BETA ANTIBODIES AND THEIR USE 0 (57) : The invention provides an improved pan-TGF-13 antibody for treatment of conditions that are mediated by TGF-13, \" including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction 0 with other immunomodulatory agents such as an anti-PD-1 antibody. (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1

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