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1. 发明申请

WO2012101509A3 IMMUNOLOGICAL COMPOSITIONS COMPRISING HIV GP41 POLYPEPTIDE DERIVATIVES 审中-公开
标题翻译：包含HIV GP41多肽衍生物的免疫组合物
公开(公告)号：WO2012101509A3
公开(公告)日：2012-12-13
申请号：PCT/IB2012000118
申请日：2012-01-26
申请人： SANOFI PASTEUR SA , PX THERAPEUTICS , POLYMUN SCIENT IMMUNBIO FORSCH , UNIV GRANADA , CONEJERO-LARA FRANCISCO , LUQUE IRENE , MATEO PEDRO LUIS , WAGNER ANDREAS , CLAUDE RAPHAELLE , ROGER MARIE-GAELLE , MOUZ NICOLAS , MARTIN CHRISTOPHE
发明人： CONEJERO-LARA FRANCISCO , LUQUE IRENE , MATEO PEDRO LUIS , WAGNER ANDREAS , CLAUDE RAPHAELLE , ROGER MARIE-GAELLE , MOUZ NICOLAS , MARTIN CHRISTOPHE
IPC分类号： C07K14/005 , A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/55555 , A61K2039/55572 , C07K14/08 , C07K14/15 , C07K14/155 , C07K14/16 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16271
摘要： The disclosure relates to immunological compositions for vaccinating human beings against infection by the Human Immunodeficiency Virus (HIV).
摘要翻译：本公开涉及针对人类免疫缺陷病毒（HIV）感染人类的免疫组合物。

2. 发明专利

CA2583332C LIPOSOMAL COMPOSITION COMPRISING AN ACTIVE INGREDIENT FOR RELAXING SMOOTH MUSCLE PRODUCTION AND THERAPEUTICALLY USE OF SAID COMPOSITION 未知
公开(公告)号：CA2583332C
公开(公告)日：2013-10-01
申请号：CA2583332
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

3. 发明专利

DK1802277T3 Liposomal sammensætning indeholdende en aktiv bestanddel til relaksation af glat muskulatur og terapeutisk anvendelse af sammensætningen 未知
公开(公告)号：DK1802277T3
公开(公告)日：2010-05-17
申请号：DK05802312
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127

4. 发明专利

PT1802277E COMPOSIÇÃO LIPOSSOMAL CONTENDO UM INGREDIENTE ACTIVO PARA RELAXAR A MUSCULATURA LISA, PRODUÇÃO DESTA COMPOSIÇÃO E A SUA APLICAÇÃO TERAPÊUTICA 未知
公开(公告)号：PT1802277E
公开(公告)日：2010-04-01
申请号：PT05802312
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： KATINGER HERMANN , VORAUER-UHL KAROLA , WAGNER ANDREAS
IPC分类号： A61K9/127

5. 发明专利

NZ554183A Liposomal composition comprising an active ingredient for relaxing smooth muscle production and therapeutically use of said composition 未知
公开(公告)号：NZ554183A
公开(公告)日：2009-04-30
申请号：NZ55418305
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127
摘要： Disclosed is a pharmaceutical composition comprising an active ingredient included in liposomes, characterized in that the liposomes have, in their interior, an aqueous medium having a pH in the range of 2.5-5.5 and contain therein at least one protonated active ingredient which has a direct or indirect relaxing effect on the smooth muscles and an aqueous medium having a neutral or alkaline pH is present outside the liposomes, with the result that an H+ gradient is present between the inside and outside of the liposomes.

6. 发明专利

EA011391B1 ЛИПОСОМНАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АКТИВНОЕ ВЕЩЕСТВО ДЛЯ РЕЛАКСАЦИИ ГЛАДКОЙ МУСКУЛАТУРЫ, ПОЛУЧЕНИЕ ЭТОЙ КОМПОЗИЦИИ И ЕЕ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ 未知
公开(公告)号：EA011391B1
公开(公告)日：2009-02-27
申请号：EA200700892
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127 , A61P15/00
摘要： Изобретениеотноситсяк фармацевтическойкомпозициинаосновезаключенногов липосомыактивноговеществадлятопическогонанесения, причемэтилипосомыимеютводнуюсредув ихвнутреннемпространствеи содержатв нейпоменьшеймереодноактивноевещество, котороепрямоилиопосредованнооказываетрелаксирующеедействиенагладкуюмускулатуруи выбранопредпочтительноизгруппыпростагландинов, аденилатциклазцАМФ, АМФ, АТФ, NO-синтетаз, моноксидаазота (NO), NO-соединений, нитратов, гуанилатциклаз, цГМФ, ГМФ, ГТФи фосфодиэстераз. Изобретениеотноситсядополнительнок способуполученияэтойкомпозиции, необязательнов стерильнойформе, атакжек применениюзагруженныхактивнымвеществомлипосомв различныхгаленовыхпрепаратахдлянаружногопримененияв областиполовыхорганов, дляпрофилактикиполовыхнарушенийу мужчини женщини/илидляповышенияощущенияполовоговлечения.

7. 发明专利

EA010404B1 СВЕРХЗАГРУЗКА ЛИПОСОМ ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ 未知
公开(公告)号：EA010404B1
公开(公告)日：2008-08-29
申请号：EA200602172
申请日：2005-05-24
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： KATINGER HERMANN , WAGNER ANDREAS , VORAUER-UHL KAROLA , KUNERT RENATE , STROBACH STEFANIE
IPC分类号： A61K9/127 , A61K38/18 , A61P7/06
摘要： Настоящееизобретениеотноситсяк липосомамдлядоставкилекарственныхвеществ, причемлипосомасодержитмолекулыпоменьшеймереодногожелаемоголекарственноговещества, распределенногов воднойфазевнутрилипосомы, атакжелипосомадополнительносодержитмолекулытогожеилидругоголекарственноговещества, присоединенногок однойилик обеимсторонамлипосомноймембраны. Болееконкретно, изобретениеотноситсяк липосомам, вкоторыхпоменьшеймеречастьмолекултребуемоголекарственноговеществасодержитфункциональнуюгруппу, котораяподвергаетсявзаимодействиюс функциональнойгруппой, присутствующейпоменьшеймерев однойлипиднойфракции, игделекарственноевеществоковалентносвязанос мембраннымилипидамихимическойсвязью, напримерсложноэфирнойсвязьюмеждугидроксильнойгруппоймолекулылипидаи кислотнымостаткомлекарственноговещества. Впредпочтительномвариантеосуществлениятребуемоелекарственноевеществопредставляетсобойгликопротеин, такойкакэритропоэтин. Изобретениедополнительноотноситсяк способуполучениявышеупомянутыхлипосоми кфармацевтическимкомпозициям, которыеихсодержат.

8. 发明专利

CA2583332A1 LIPOSOMAL COMPOSITION COMPRISING AN ACTIVE INGREDIENT FOR RELAXING SMOOTH MUSCLE PRODUCTION AND THERAPEUTICALLY USE OF SAID COMPOSITION 未知
公开(公告)号：CA2583332A1
公开(公告)日：2006-04-27
申请号：CA2583332
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , KATINGER HERMANN , VORAUER-UHL KAROLA
IPC分类号： A61K9/127
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

9. 发明专利

DE502005008880D1 未知
公开(公告)号：DE502005008880D1
公开(公告)日：2010-03-04
申请号：DE502005008880
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

10. 发明专利

AT454884T 未知
公开(公告)号：AT454884T
公开(公告)日：2010-01-15
申请号：AT05802312
申请日：2005-10-14
申请人： POLYMUN SCIENT IMMUNBIO FORSCH
发明人： WAGNER ANDREAS , VORAUER-UHL KAROLA , KATINGER HERMANN
IPC分类号： A61K9/127
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

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