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2. 发明专利

DE69824576T2 未知
公开(公告)号：DE69824576T2
公开(公告)日：2005-06-30
申请号：DE69824576
申请日：1998-04-17
申请人： SANOFI AVENTIS SA
发明人： BOURRIE BERNARD , CASELLAS PIERRE , MAFFRAND JEAN-PIERRE
IPC分类号： C07D211/70 , A61K31/44 , A61K31/4418 , A61K31/444 , A61K31/445 , A61K31/4525 , A61K31/4545 , A61P21/00 , A61P29/00 , A61P37/06 , C07D401/04 , C07D405/06
摘要： The invention relates to the use of tetrahydropyridine derivatives of the formulain which:R1 is a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group;Y is a nitrogen atom or a CH group;Z' and Z'' are each hydrogen or a (C1-C3)alkyl group, or one is hydrogen and the other is a hydroxyl group, or the two together are an oxo group; andZ is:a phenyl radical;a phenyl radical monosubstituted by a substituent X, X being:(a) a (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C7)carboxyalkyl, (C1-C4)alkoxycarbonyl(C1-C6)alkyl, (C3-C7)carboxyalkoxy or (C1-C4)alkoxycarbonyl(C1-C6)alkoxy group;(b) a group selected from (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C3-C7)cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, it being possible for said group to be substituted by a halogen, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, amino or mono- or di-(C1-C4)alkylamino group; or(c) a group selected from phenyl, phenoxy, phenylamino, N-(C1-C3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkylamino, (C1-C4)acylamino, carboxy, (C1-C4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl group;a phenyl radical disubstituted by a substituent R2, R2 being a halogen or a hydroxy, methyl, ethyl, (C3-C6)alkyl, (C1-C4)alkoxy or trifluoromethyl group, and by a substituent X, X being as defined above;a 1-naphthyl or 2-naphthyl radical; ora 1-naphthyl or 2-naphthyl radical substituted in the 5-, 6-, 7- and/or 8-positions by one or two hydroxy groups, one or two (C1-C4)alkoxy groups or a 6,7-methylenedioxy group;or Z'' is hydrogen and Z and Z' are each independently an unsubstituted or mono-, di- or tri-substituted phenyl group,or a pharmaceutically acceptable salt and solvate thereof, for the preparation of pharmaceutical compositions intended for treating diseases which cause demyelination.

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