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1. 发明专利

AT61227T 未知
公开(公告)号：AT61227T
公开(公告)日：1991-03-15
申请号：AT86308738
申请日：1986-11-10
申请人： SANKYO CO
发明人： KANEKO ISAO SANKYO BIO-SCIENCE , SHINAGAWA-KU
IPC分类号： A61K35/16 , A61K35/14 , A61K38/00 , A61K38/17 , A61K38/48 , A61P29/00 , A61P37/00 , A61K37/02
摘要： The administration of Factor I and/or Factor H to a mammal has been found to alleviate or prevent such autoimmune diseases as systemic lupus erythematosus, rheumatoid arthritis and glomerulonephritis. The active ingredients may be administered as a pharmaceutical composition in admixture with suitable carriers, diluents or adjuvants, such as saline, phosphate-buffered saline or Ringer's solution. They are preferably adminstered in unit dosage form.

2. 发明专利

AT39357T 未知
公开(公告)号：AT39357T
公开(公告)日：1989-01-15
申请号：AT84307436
申请日：1984-10-29
申请人： SANKYO CO
发明人： KANEKO MASAKATSU SANKYO CHEMIC , SHINAGAWA-KU , KIMURA MISAKO SANKYO CHEMICAL , MUROFUSHI YOSHINOBU SANKYO CHE , YAMAZAKI MITSUO SANKYO BIOLOGI , IWATA NOBUYOSHI SANKYO BIOLOGI , NAKAGAWA FUMIO SANKYO FERMENTA
IPC分类号： C07H19/16 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P5/12 , A61P7/02 , A61P25/28 , A61P35/00 , A61P43/00 , C07D307/77 , C07D405/06 , C07D473/00 , C07D473/30 , C07D493/04 , C07H19/02
摘要： Griseolic acid derivatives of formula (I):wherein A represents:have enzyme-inhibitory activity, especially against cAMP PDE and cGMP PDE. When formulated as compositions with appropriate carriers or diluents, they may be used for the treatment of a variety of organic disorders and show toxicities less than griseolic acid itself.

3. 发明专利

AT329915T 未知
公开(公告)号：AT329915T
公开(公告)日：2006-07-15
申请号：AT02732180
申请日：2002-01-22
申请人： SANKYO CO
发明人： KIMURA TOMIO , OHKAWA NOBUYUKI , NAKAO AKIRA , NAGASAKI TAKAYOSHI , SHINAGAWA-KU , YAMAZAKI TAKANORI
IPC分类号： A61K31/4985 , A61P29/00 , C07D471/04 , C07D487/04 , C07D491/20
摘要： Compounds of formula (I): [wherein: A is a pyrrole ring; R is an optionally substituted aryl or heteroaryl group; R is an optionally substituted nitrogen-containing heteroaryl group; and R is formulae (IIa), (IIb) or (IIc), wherein m is 1 or 2, one of D and E is nitrogen and the other is >C(R )- (wherein R is hydrogen, a Substituent PROPORTIONAL or a Substituent beta ), B is a nitrogen-containing 4- to 7-membered heterocyclic ring, and R is from 1 to 3 substituents from Substituent group PROPORTIONAL , substituent group beta and Substituent group gamma ; PROVIDED THAT R and R are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R is bonded; Substituent group PROPORTIONAL consists of hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio and halogeno alkythio groups and groups of formula NR R (wherein R and R are hydrogen, alkyl, alkenyl, alkynyl, aralkyl and alkylsulfonyl, or R and R , taken together with the nitrogen atom to which they are attached, form a heterocyclyl); Substituent group beta consists of optionally substituted alkyl, alkenyl and alkynyl groups, and aralkyl and cycloalkyl groups; Substituents group gamma consists of oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsufinyl, alkylsulfonyl, optionally substituted aryl, optionally substituted aryloxy, alkylidenyl and aralkylidenyl groups] have excellent activity against the production of inflammatory cytokines.

4. 发明专利

AT131054T 未知
公开(公告)号：AT131054T
公开(公告)日：1995-12-15
申请号：AT90306960
申请日：1990-06-26
申请人： SANKYO CO
发明人： IWATA NOBUYOSHI C O SANKYO COM , SHINAGAWA-KU , YOSHIMI KENJI C O SANKYO COMPA , NAGANO MITSUO C O SANKYO COMPA
IPC分类号： A61K9/48 , A61K31/41 , A61K31/42 , A61K31/535 , A61K38/01
摘要： Isoxazolin-3-one derivatives of a kind generally known from the literature are of use as antidepressants.

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