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1. 发明申请

WO2010107493A2 MODIFICATION OF CXCR4 USING ENGINEERED ZINC FINGER PROTEINS 审中-公开
标题翻译：用工程化锌指蛋白修饰CXCR4
公开(公告)号：WO2010107493A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/000807
申请日：2010-03-18
申请人： SANGAMO BIOSCIENCES, INC. , HOLMES, Michael C. , MILLER, Jeffrey C. , WANG, Jianbin
发明人： HOLMES, Michael C. , MILLER, Jeffrey C. , WANG, Jianbin
IPC分类号： A61K48/00
CPC分类号： A61K35/17 , A61K48/00 , C07K14/70596 , C07K14/7158 , C07K2319/81
摘要： Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.
摘要翻译：本文公开了用于调节CXCR4基因活性的方法和组合物，例如使用锌指转录因子（ZF-TF）或锌指核酸酶（ZFN），其包含锌手指蛋白和切割结构域或切割半结构域。还提供了编码ZF-TF或ZFN的多核苷酸，包含编码ZF-TF或ZFN的多核苷酸的载体和包含编码ZF-TF或ZFN的多核苷酸和/或包含ZF-TF或ZFN的细胞的细胞。

2. 发明申请

WO2012012667A3 METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS 审中-公开
公开(公告)号：WO2012012667A3
公开(公告)日：2012-01-26
申请号：PCT/US2011/044902
申请日：2011-07-21
申请人： SANGAMO BIOSCIENCES, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
发明人： COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
IPC分类号： C07K14/00
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.

3. 发明申请

WO2011097036A1 ENGINEERED CLEAVAGE HALF-DOMAINS 审中-公开
标题翻译：工程清除半球面
公开(公告)号：WO2011097036A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/000221
申请日：2011-02-07
申请人： SANGAMO BIOSCIENCES, INC. , DOYON, Yannick , MILLER, Jeffrey C.
发明人： DOYON, Yannick , MILLER, Jeffrey C.
IPC分类号： C07K14/195
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
摘要翻译：本文公开了工程化裂解半结构域; 包含这些工程化裂解半结构域的融合多肽; 编码工程化切割半结构域和融合蛋白的多核苷酸; 和包含所述多核苷酸和/或融合蛋白的细胞。还描述了使用这些多肽和多核苷酸的方法，例如用于基因组序列的靶向切割。

4. 发明申请

WO2011049627A1 ENGINEERED ZINC FINGER PROTEINS TARGETING PLANT GENES INVOLVED IN FATTY ACID BIOSYNTHESIS 审中-公开
标题翻译：工程化锌指纹蛋白质涉及脂肪酸生物合成中涉及的植物基因
公开(公告)号：WO2011049627A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/002817
申请日：2010-10-22
申请人： DOW AGROSCIENCES LLC , SANGAMO BIOSCIENCES, INC. , DEKELVER, Russell , GUPTA, Manju , MILLER, Jeffrey C. , NOVAK, Stephen , PETOLINO, Joseph F.
发明人： DEKELVER, Russell , GUPTA, Manju , MILLER, Jeffrey C. , NOVAK, Stephen , PETOLINO, Joseph F.
IPC分类号： C12N15/82 , C12N5/04 , A01H5/00
CPC分类号： C12N15/8218 , C07K14/415 , C12N9/22 , C12N15/8216 , C12N15/8247 , C12Y203/01041 , C12Y301/00
摘要： The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided.
摘要翻译：本公开涉及靶向参与脂肪酸生物合成的植物中的基因的工程化锌指蛋白。还提供了使用这种锌指蛋白调节基因表达，基因失活和靶向基因修饰的方法。

5. 发明申请

WO2007139898A2 ENGINEERED CLEAVAGE HALF-DOMAINS 审中-公开
标题翻译：工程清除半球面
公开(公告)号：WO2007139898A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012411
申请日：2007-05-23
申请人： SANGAMO BIOSCIENCES, INC. , MILLER, Jeffrey C.
发明人： MILLER, Jeffrey C.
IPC分类号： C12N9/22 , C12N15/55 , C12N15/62
CPC分类号： C12N9/22
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
摘要翻译：本文公开了工程化裂解半结构域; 包含这些工程化裂解半结构域的融合多肽; 编码工程化切割半结构域和融合蛋白的多核苷酸; 和包含所述多核苷酸和/或融合蛋白的细胞。还描述了使用这些多肽和多核苷酸的方法，例如用于基因组序列的靶向切割。

6. 发明申请

WO2005084190A2 METHODS AND COMPOSTIONS FOR TARGETED CLEAVAGE AND RECOMBINATION 审中-公开
标题翻译：用于目标清除和重构的方法和组合
公开(公告)号：WO2005084190A2
公开(公告)日：2005-09-15
申请号：PCT/US2005/003245
申请日：2005-02-03
申请人： SANGAMO BIOSCIENCES, INC. , MILLER, Jeffrey C. , ZHANG, Lei
发明人： MILLER, Jeffrey C. , ZHANG, Lei
IPC分类号： C07K14/435 , C07K14/47 , C07K14/715 , C12N9/14 , C12N9/22 , C12N15/62 , C12P19/34 , C12Q1/68
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs, to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting (and thereby binding) of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白，以及编码它们的多核苷酸。包含切割半结构域的融合蛋白成对使用，以重构功能性切割结构域。在这些融合蛋白中，锌指结构域可以是切割半结构域的N末端，或者切割半结构域可以是锌指结构域的N末端。具有这些不同极性的融合核酸内切酶的可得性允许锌指核酸内切酶与DNA靶的相对链或DNA靶的相同链靶向（从而结合），从而增加可靶向的可能序列的数目，被融合蛋白切割。

7. 发明申请

WO2009100373A1 TREATMENT OF CHRONIC PAIN WITH ZINC FINGER PROTEINS 审中-公开
标题翻译：用锌指纹蛋白治疗慢性疼痛
公开(公告)号：WO2009100373A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033453
申请日：2009-02-06
申请人： SANGAMO BIOSCIENCES, INC. , TAN, Siyuan , ZHANG, Steve H. , MILLER, Jeffrey C. , GREGORY, Philip D.
发明人： TAN, Siyuan , ZHANG, Steve H. , MILLER, Jeffrey C. , GREGORY, Philip D.
IPC分类号： C07H21/04 , C12N15/09
CPC分类号： C07K14/4702
摘要： A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating chronic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having chronic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing chronic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., Nav1.8) can be repressed.
摘要翻译：提供各种锌指蛋白（ZFP）和利用这些蛋白质的方法用于治疗慢性疼痛。描述了结合到具有慢性疼痛的受试者异常表达的基因中的靶位点的ZFP。此外，还提供了结合受体经历慢性疼痛的受试者的正常水平表达的基因中的目标位点的ZFP，其表达导致疼痛感知降低的调节。例如，可以抑制在疼痛患者的背根神经节（DRG）中过度表达的基因（例如，Nav1.8）。

8. 发明申请

WO2016118726A3 METHODS AND COMPOSITIONS FOR IDENTIFICATION OF HIGHLY SPECIFIC NUCLEASES 审中-公开
标题翻译：用于鉴定高度特异性核酸的方法和组合物
公开(公告)号：WO2016118726A3
公开(公告)日：2016-07-28
申请号：PCT/US2016/014283
申请日：2016-01-21
申请人： SANGAMO BIOSCIENCES, INC. , THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： MILLER, Jeffrey C. , NOYES, Marcus B.
IPC分类号： A61K35/12 , A61K48/00 , C07K14/805 , C12N15/09
摘要： Disclosed herein are methods and compositions for identification of specific DNA binding domains for constructing highly specific nucleases, which allows for pristine genome editing.
摘要翻译：本文公开了鉴定用于构建高度特异性核酸酶的特定DNA结合结构域的方法和组合物，其允许原始基因组编辑。

9. 发明申请

WO2015188065A1 METHODS AND COMPOSITIONS FOR NUCLEASE DESIGN 审中-公开
标题翻译：核素设计的方法和组合
公开(公告)号：WO2015188065A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034410
申请日：2015-06-05
申请人： SANGAMO BIOSCIENCES, INC. , DOYON, Yannick
发明人： DOYON, Yannick , MILLER, Jeffrey C.
IPC分类号： C12P21/04 , C12P19/34 , C07K14/00 , C07H21/04
CPC分类号： C12N15/01 , C07K2319/00 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N15/63 , C12Y301/00
摘要： Methods and compositions for genetic alteration of cells are provided.
摘要翻译：提供了细胞遗传改变的方法和组合物。

10. 发明申请

WO2014036219A2 METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION 审中-公开
标题翻译：治疗遗传病症的方法和组合物
公开(公告)号：WO2014036219A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/057214
申请日：2013-08-29
申请人： SANGAMO BIOSCIENCES, INC.
发明人： COST, Gregory J. , GREGORY, Philip D. , GUSCHIN, Dmitry , HOLMES, Michael C. , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor , ZHANG, Lei
IPC分类号： C12N15/52 , C12N9/22
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Methods and compositions for a genetic disease are provided.
摘要翻译：提供了遗传疾病的方法和组合物。

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