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1. 发明申请

WO2011159951A2 TARGETING TUMOR ASSOCIATED MACROPHAGES USING BISPHOSPHONATE-LOADED PARTICLES 审中-公开
标题翻译：使用二磷酸酯加载的颗粒靶向肿瘤相关巨噬细胞
公开(公告)号：WO2011159951A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040776
申请日：2011-06-16
申请人： SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE , SMITH, Jeff , SHARMA, Gaurav
发明人： SMITH, Jeff , SHARMA, Gaurav
IPC分类号： A61K31/663
CPC分类号： A61K31/663 , A61K9/5138 , A61K47/62 , A61K47/6937 , B82Y5/00
摘要： Provided herein are compositions including particles that comprise a bisphosphonate compound and a tumor specific targeting peptide or peptidomimetic. Also provided herein are methods of reducing tumor associated macrophages and methods of treating cancer with said compositions.
摘要翻译：本文提供了包含包含双膦酸盐化合物和肿瘤特异性靶向肽或肽模拟物的颗粒的组合物。本文还提供了减少肿瘤相关巨噬细胞的方法和用所述组合物治疗癌症的方法。

2. 发明申请

WO2018207140A1 SAFEPAY PROCESS 审中-公开
公开(公告)号：WO2018207140A1
公开(公告)日：2018-11-15
申请号：PCT/IB2018/053288
申请日：2018-05-11
申请人： SHARMA, Gaurav
发明人： SHARMA, Gaurav
IPC分类号： G06Q20/00
摘要： Described is a Cheque ( aka Check ) Clearing Process and System with ability to process payments of such issued Cheques in real time, Cheques being the e-Cheques or physical Cheques issued by a Bank ( or such financial Institution that may or not be a Regulated Entity ) to an Entity ( including Individuals / Persons ). The said Cheque having been provided to such Entity by such Bank ( s ) and in turn signed as a 'Drawn Note' to said Bank for immediate payment across the counter for cash to Self or Bearer or Payee, mentioned as Beneficiary or crediting some other account of self or Payee. The described process makes redundant, practice of large clearing houses which were created to facilitate rapid settlement of such Negotiable Instruments / Notes, having become more of a bottleneck today, due to massive volumes ( in billions ) of such instruments used annually.

3. 发明申请

WO2019108665A1 AUTOPHAGY MODULATORS FOR USE IN TREATING CANCER 审中-公开
公开(公告)号：WO2019108665A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062866
申请日：2018-11-28
申请人： DEPAMPHILIS, Melvin L. , SHARMA, Gaurav , MARUGAN, Juan Jose , FERRER, Marc , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , ROY, Ajit
发明人： DEPAMPHILIS, Melvin L. , SHARMA, Gaurav , MARUGAN, Juan Jose , FERRER, Marc , ROY, Ajit
IPC分类号： A61K31/506 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/506 , A61K31/53 , A61K31/5377 , A61P35/00
摘要： Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.

4. 发明申请

WO2019073400A1 SAFECASE PROCESS 审中-公开
公开(公告)号：WO2019073400A1
公开(公告)日：2019-04-18
申请号：PCT/IB2018/057842
申请日：2018-10-10
申请人： SHARMA, Gaurav
发明人： SHARMA, Gaurav
IPC分类号： G06Q10/00
摘要： Described is a secure, electronic, submission process providing and enabling applicants to initiate requests to desirous requestors seeking such submissions based on authenticated and trusted identities and / or credentials or which could be authenticated securely through other defined processes. SafeCase is an innovative process for convenience, ease and security in application submissions for anyone and everyone through an electronic interface that has been built innovatively on the strong foundations of Identity Management, giving irrevocable and irrefutable trust on the Identity and / or credentials and / or the purpose that an applicant is applying for or wishes to achieve. SafeCase is an end - to - end secure and transparent interface, wherein the applicant ( i.e. the Candidate ) utilizes his / her Authenticated Credential ( s ) or Identity ( ies ) to submit an application. The applicant remains updated in real time on the status of the submitted application till its final disposal. On the other hand, the Requestor securely receives the said application and gets further updated if and when there is any change to the said submitted identity or credentials thereof

5. 发明申请

WO2018207139A1 ULTRASAFE LOGIN 审中-公开
公开(公告)号：WO2018207139A1
公开(公告)日：2018-11-15
申请号：PCT/IB2018/053286
申请日：2018-05-11
申请人： SHARMA, Gaurav
发明人： SHARMA, Gaurav
IPC分类号： G06F21/31 , G06F3/048 , H04L29/06
摘要： Our Names in physical and real world have transformed into 'username's in virtual digital world. Anything that we need to access in digital world asks us for a 'username', which can be user selected ( like an e-mail address ) or provided to a user ( like an employee ID / Number ). This 'username' has indeed become a SuperName, giving access to restricted areas, based on privileges, links to other services as well. So, to a cybercriminal, if a 'username' is known, more than half the job is done. And once corresponding password is cracked, the whole digital identity lies threadbare. Damages done through transactions of such unauthorized access may get quantified, but dent to privacy is far more damaging.

6. 发明申请

WO2009022991A1 DIE PACKAGE AND METHOD FOR MANUFACTURING THE DIE PACKAGE 审中-公开
标题翻译： DIE包装和制造DIE包装的方法
公开(公告)号：WO2009022991A1
公开(公告)日：2009-02-19
申请号：PCT/SG2008/000297
申请日：2008-08-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KRIPESH, Vaidyanathan , ORATTI KALANDAR, Navas Khan , VEMPATI, Srinivasa Rao , KUMAR, Aditya , HO, Soon Wee , LIM, Yak Long Samuel , SHARMA, Gaurav , LEE, Wen Sheng Vincent
发明人： KRIPESH, Vaidyanathan , ORATTI KALANDAR, Navas Khan , VEMPATI, Srinivasa Rao , KUMAR, Aditya , HO, Soon Wee , LIM, Yak Long Samuel , SHARMA, Gaurav , LEE, Wen Sheng Vincent
IPC分类号： H01L21/48
CPC分类号： H01L25/50 , H01L21/568 , H01L21/6835 , H01L23/3128 , H01L24/24 , H01L24/82 , H01L24/96 , H01L24/97 , H01L25/0652 , H01L25/0657 , H01L25/18 , H01L27/14618 , H01L2221/68318 , H01L2223/6677 , H01L2224/05001 , H01L2224/05024 , H01L2224/05124 , H01L2224/05147 , H01L2224/05548 , H01L2224/12105 , H01L2224/13124 , H01L2224/13147 , H01L2224/24226 , H01L2224/32145 , H01L2224/73253 , H01L2224/73267 , H01L2224/94 , H01L2224/97 , H01L2225/06517 , H01L2225/06562 , H01L2225/06568 , H01L2225/06582 , H01L2225/06589 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01082 , H01L2924/10253 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/15311 , H01L2924/181 , H01L2924/18161 , H01L2924/18162 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/19105 , H01L2924/3025 , H01L2924/3511 , H01L2224/82 , H01L2924/00 , H01L2924/00014 , H01L2224/03
摘要： A die package and a method for manufacturing the die package are provided. The die package includes a second die arranged above a first die, the first die comprising an interconnect region on a surface facing the second die, wherein the second die is arranged laterally next to the interconnect region of the first die; a first package-internal free-standing interconnect structure disposed above the interconnect region of the first die; a second package-internal free-standing interconnect structure disposed above an interconnect region of the second die, the interconnect region of the second die being on a surface of the second die facing away from the first die; and package material formed partially around the first package-internal free-standing interconnect structure and the second package-internal free-standing interconnect structure such that a connecting portion of the first package-internal free-standing interconnect structure and a connecting portion of the second package-internal free-standing interconnect structure remains uncovered to be electrically connected to a package-external interconnect structure.
摘要翻译：提供了一种管芯封装和用于制造管芯封装的方法。所述管芯封装包括布置在第一管芯上方的第二管芯，所述第一管芯包括在面向所述第二管芯的表面上的互连区域，其中所述第二管芯横向布置在所述第一管芯的互连区域旁边; 设置在所述第一管芯的所述互连区域上方的第一封装 - 内部独立互连结构; 设置在所述第二管芯的互连区域上方的第二封装内部独立互连结构，所述第二管芯的互连区域位于所述第二管芯的远离所述第一管芯的表面上; 以及部分地围绕第一包装内部独立互连结构形成的包装材料和第二包装内部独立互连结构，使得第一包装内部独立互连结构的连接部分和第二包装内部独立互连结构的连接部分封装内部独立的互连结构保持未覆盖以电连接到封装 - 外部互连结构。

7. 发明申请

WO2018154405A1 A SAFETY HELMET SYSTEM 审中-公开
公开(公告)号：WO2018154405A1
公开(公告)日：2018-08-30
申请号：PCT/IB2018/050781
申请日：2018-02-08
申请人： SHARMA, Gaurav
发明人： SHARMA, Gaurav
IPC分类号： A42B3/04 , B60K28/04
摘要： A helmet system which is designed to ignite the two-wheeler, once the driver and the pillion rider wear the helmet. The invention is designed for the safety of the driver and the pillion rider, wherein the engine ignited only once the driver and the pillion rider wear the helmet. The area above the meter on the handle of the two-wheeler will serve as the receiver (113) from the helmet of the driver(DH), while receiver attached to the back rest (204) of the two-wheeler(114) will receive signals from pillion rider's helmet(PH). Back-rest receiver (203) gets activated once the weight sensor (202) beneath pillion rider seat senses a predetermined weight. Once the frequency from both the helmets have been detected the driver has to push the start button to start the engine.

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