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1. 发明专利

DE60204967T2 未知
公开(公告)号：DE60204967T2
公开(公告)日：2006-05-18
申请号：DE60204967
申请日：2002-07-26
申请人： SAN RAFFAELE CENTRO FOND , GLYCORES 2000 SRL
发明人： ZOPPETTI GIORGIO , ORESTE ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

2. 发明专利

ES2246406T3 USO DE POLISACARIDOS SOBRESULFATADOS COMO INHIBIDORES DEL HIV. 未知
公开(公告)号：ES2246406T3
公开(公告)日：2006-02-16
申请号：ES02749173
申请日：2002-07-26
申请人： SAN RAFFAELE CENTRO FOND , GLYCORES 2000 SRL
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： Uso de un polisacárido de K5 N, O-sobresulfatado que tiene un grado de sulfatación, que se expresa como relación sulfato/carboxilo, mayor que 3, 2, para la preparación de composiciones farmacéuticas para combatir infecciones por HIV.

3. 发明申请

WO2005058976A3 LOW MOLECULAR POLYSACCHARIDES HAVING ANTITHROMBOTIC ACTIVITY 审中-公开
标题翻译：具有抗血栓活性的低分子多糖
公开(公告)号：WO2005058976A3
公开(公告)日：2005-08-04
申请号：PCT/IB2004004128
申请日：2004-12-15
申请人： GLYCORES 2000 SRL , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K31/726 , A61K31/727 , A61K31/737 , C08B37/00 , C08B37/10
CPC分类号： C08B37/0063
摘要： depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMWepiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate obtained by nitrous depolymerization of a K5-N-sulfate. A process consists of submitting the starting depolymerized-LMW-epiK5-N-sulfate to four steps: an O-oversulfation, a partial 0-desulfation, a 6-0-sulfation and a N-sulfation. The depolymerizedLMWepiK5-N,O-sulfates present a di- or trisulfated 2,5-anhydromannitol unit at the reducing end of the majority of its chains, have a content of iduronic acid of 40-60%, a sulfation degree of from 2.3 to 2.9 and a mean molecular weight of from about 1,500 to about 12,000. They exhibit a good antithrombotic activity with a low pro-hemorrhagic risk.
摘要翻译：解聚的LMWepiK5-N，O-硫酸盐，可从通过epiK5-N-硫酸盐的亚硝解聚制备的LMWepiK5-N-硫酸盐或通过K5的亚硝解聚得到的LMW-K5-N-硫酸盐的C5差向异构体 -N-硫酸盐。一个过程包括将起始解聚的LMW-epiK5-N-硫酸盐提交到四个步骤：O-过硫酸盐，部分O-脱硫，6-0-硫酸化和N-硫酸化。解聚的MWepiK5-N，O-硫酸盐在其大部分链的还原末端呈现二硫酸化或三硫酸化的2,5-脱水甘露糖醇单元，其具有40-60％的艾杜糖醛酸含量，硫酸化度为2.3至 2.9，平均分子量为约1,500至约12,000。它们具有良好的抗血栓形成活性，具有低的出血性风险。

4. 发明专利

ITMI20011633D0 未知
公开(公告)号：ITMI20011633D0
公开(公告)日：2001-07-27
申请号：ITMI20011633
申请日：2001-07-27
申请人： SAN RAFFAELE CENTRO FOND , ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

5. 发明专利

CA2454945A1 USE OF OVERSULFATED POLYSACCHARIDES AS INHIBITORS OF HIV 未知
公开(公告)号：CA2454945A1
公开(公告)日：2003-02-13
申请号：CA2454945
申请日：2002-07-26
申请人： SAN RAFFAELE CENTRO FOND , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： VICENZI ELISA , POLI GUIDO , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical composition s for treating the infection and the consequent HIV/AIDS disease.

6. 发明专利

DE60204967D1 未知
公开(公告)号：DE60204967D1
公开(公告)日：2005-08-11
申请号：DE60204967
申请日：2002-07-26
申请人： PASQUA ORESTE , ZOPPETTI GIORGIO , SAN RAFFAELE CENTRO FOND
发明人： ZOPPETTI GIORGIO , ORESTE ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

7. 发明专利

AT299027T 未知
公开(公告)号：AT299027T
公开(公告)日：2005-07-15
申请号：AT02749173
申请日：2002-07-26
申请人： SAN RAFFAELE CENTRO FOND , ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

8. 发明专利

ITMI20011633A1 未知
公开(公告)号：ITMI20011633A1
公开(公告)日：2003-01-27
申请号：ITMI20011633
申请日：2001-07-27
申请人： SAN RAFFAELE CENTRO FOND , ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

9. 发明专利

CA2489862C EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE WITH A VERY HIGH DEGREE OF SULFATION 未知
公开(公告)号：CA2489862C
公开(公告)日：2012-03-27
申请号：CA2489862
申请日：2003-06-17
申请人： GLYCORES 2000 SRL
发明人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K8/60 , C08B37/00 , A61K8/72 , A61K8/73 , A61K31/726 , A61K31/727 , A61K31/737 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P17/06 , A61P17/16 , A61P19/02 , A61P27/02 , A61P27/06 , A61P31/12 , A61P35/00 , A61P35/04 , A61P39/06 , A61P43/00 , C07H1/00 , C08B37/08 , C08B37/10
摘要： A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.

10. 发明专利

PT1694714E NOVOS POLISSACÁRIDOS COM PEQUENA MASSA MOLECULAR POSSUINDO ACTIVIDADE ANTI -TROMBÓTICA 未知
公开(公告)号：PT1694714E
公开(公告)日：2008-05-09
申请号：PT04806349
申请日：2004-12-15
申请人： GLYCORES 2000 SRL
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
IPC分类号： C08B37/10 , A61K31/726 , A61K31/727 , A61K31/737 , C08B37/00

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