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1. 发明申请

WO2007089102A1 COMPOSITION FOR TREATING DEVELOPMENTAL AND/OR CHRONIC LUNG DISEASES COMPRISING CELLS SEPARATED OR PROLIFERATED FROM UMBILICAL CORD BLOOD 审中-公开
标题翻译：用于治疗包含从脐带血分离或增殖的细胞的发育和/或慢性肺损伤的组合物
公开(公告)号：WO2007089102A1
公开(公告)日：2007-08-09
申请号：PCT/KR2007/000535
申请日：2007-01-31
申请人： SAMSUNGN LIFE PUBLIC WELFARE FOUNDATION , MEDIPOST CO., LTD. , CHANG, Yun Sil , PARK, Won Soon , YANG, Yoon-Sun
发明人： CHANG, Yun Sil , PARK, Won Soon , YANG, Yoon-Sun
IPC分类号： A61K35/14 , C12N5/06
CPC分类号： C12N5/0665 , A61K2035/124
摘要： The present invention provides a composition for treating developmental and/or chronic lung diseases comprising cells separated or proliferated from umbilical cord blood as an active ingredient. The composition of the present invention can be very effectively used for the treatment of developmental and/or chronic diseases by intratracheal administration.
摘要翻译：本发明提供了用于治疗发育和/或慢性肺疾病的组合物，其包含从脐带血分离或增殖的细胞作为活性成分。本发明的组合物可以非常有效地用于通过气管内给药治疗发育和/或慢性疾病。

2. 发明申请

WO2007089063A1 A COMPOSITION COMPRISING SEPARATED OR PROLIFERATED CELLS FROM UMBILICAL CORD BLOOD FOR TREATING DEVELOPMENTAL AND/OR CHRONIC LUNG DISEASE 审中-公开
标题翻译：包含来自脐带血的分离或增殖细胞用于治疗发展和/或慢性肺疾病的组合物
公开(公告)号：WO2007089063A1
公开(公告)日：2007-08-09
申请号：PCT/KR2006/003009
申请日：2006-07-31
申请人： SAMSUNGN LIFE PUBLIC WELFARE FOUNDATION , MEDIPOST CO. LTD. , CHANG, Yun Sil , PARK, Won Soon , YANG, Yoon-Sun
发明人： CHANG, Yun Sil , PARK, Won Soon , YANG, Yoon-Sun
IPC分类号： A61K35/14
CPC分类号： A61K35/28 , A61K35/16 , A61K35/51 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a composition for treating developmental and/or chronic lung diseases comprising cells separated or proliferated from umbilical cord blood, more specifically a composition for treating developmental and/or chronic lung diseases by intratracheal administration comprising cells separated or proliferated from umbilical cord blood. The inventive composition is advantageous in that the cells contained therein have excellent potential for proliferation and differentiation, and the extraction and separation of the origin tissues and selection of a tissue donor are very easy. Accordingly, it can be effectively used for the treatment of developmental and/or chronic diseases via intratracheal administration.
摘要翻译：本发明涉及用于治疗发育和/或慢性肺疾病的组合物，其包含从脐带血分离或增殖的细胞，更具体地说，涉及通过气管内给药治疗发育和/或慢性肺部疾病的组合物，包括从脐带分离或增殖的细胞血液。本发明的组合物的优点在于其中含有的细胞具有优异的增殖和分化潜能，并且起始组织的提取和分离以及组织供体的选择非常容易。因此，可以有效地用于通过气管内给药治疗发育和/或慢性疾病。

3. 发明申请

WO2009028870A2 COMPOSITION FOR THE DIAGNOSIS, PREVENTION OR TREATMENT OF DISEASES RELATED TO CELLS EXPRESSING IL-8 OR GRO-ALPHA, COMPRISING UCB-MSCS 审中-公开
标题翻译：用于诊断，预防或治疗与表达UC-8或GRO-ALPHA的细胞相关的疾病的组合物，包含UCB-MSCS
公开(公告)号：WO2009028870A2
公开(公告)日：2009-03-05
申请号：PCT/KR2008/005026
申请日：2008-08-27
申请人： MEDIPOST CO., LTD. , CHANG, Jong Wook , KIM, Dal-Soo , YANG, Yoon-Sun , OH, Won Il
发明人： CHANG, Jong Wook , KIM, Dal-Soo , YANG, Yoon-Sun , OH, Won Il
IPC分类号： A61K35/44
CPC分类号： A61K49/08 , A61K35/44 , A61K48/00 , A61K49/0002 , A61K49/0017
摘要： Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-α and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-α, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.
摘要翻译：提供了将治疗基因，制造者基因或其混合物中的一种转移到表达白细胞介素-8（IL-8）或GRO-α的细胞中并诱导从脐带分离的间充质干细胞向性的基因治疗组合物血液和/或从所述间充质干细胞（UCB-MSC）扩增的间充质干细胞，其中细胞处理组合物包括UCB-MSC。提供了通过使用UCB-MSC来治疗与表达IL-8或GRO-a的细胞相关的疾病，即基因治疗中的脑肿瘤的组合物。提供了用于诊断脑肿瘤，预防脑肿瘤，治疗脑肿瘤或通过使用UCB-MSC监测脑肿瘤治疗进展的组合物或试剂盒。

4. 发明申请

WO2003015802A1 COMPOSITION FOR TREATMENT OF ARTICULAR CARTILAGE DAMAGE 审中-公开
标题翻译：用于治疗大便器质量损伤的组合物
公开(公告)号：WO2003015802A1
公开(公告)日：2003-02-27
申请号：PCT/KR2002/001552
申请日：2002-08-14
申请人： MEDIPOST, CO., LTD. , HA, Chul-Won , YANG, Yoon-Sun , YANG, Sung-Eun
发明人： HA, Chul-Won , YANG, Yoon-Sun , YANG, Sung-Eun
IPC分类号： A61K35/14
CPC分类号： A61K35/28 , A61K35/51 , Y02A50/411
摘要： The present invention is related to a composition for the treatment of articular cartilage damage or loss or defect. The composition for the treatment of articular cartilage injury of the present invention is characterized by that it is composed of cellular components separated, proliferated, and/or differentiated from the umbilical cord blood and their media, or of the above cellular components, their media, and biocompatible polymers. Compared to the conventional cells used for the treatment of articular cartilage damage, cellular components of the composition of the present invention have very superior ability of proliferation and differentiation and more easy to be collected and acquired. And the polymers of the composition of the present invention have one or more characteristics among the biocompatibility, biodegradation property and possible ability to serve to enhance nutrition of cells and possible ability to enhance formation of intercellular substrate as well as the mechanical strength and flexibility to the degree which is proper for cellular transplantation and generation of cartilage tissues.
摘要翻译：本发明涉及用于治疗关节软骨损伤或损失或缺陷的组合物。用于治疗本发明的关节软骨损伤的组合物的特征在于，其由与脐带血及其培养基或上述细胞组分，其培养基分离，增殖和/或分化的细胞成分组成，和生物相容性聚合物。与用于治疗关节软骨损伤的常规细胞相比，本发明组合物的细胞成分具有非常优异的增殖和分化能力，更容易收集和获得。并且本发明组合物的聚合物在生物相容性，生物降解性质和用于增强细胞营养的可能能力以及可能的增强细胞间底物形成能力以及机械强度和柔韧性方面具有一个或多个特征适用于细胞移植和产生软骨组织的程度。

5. 发明申请

WO2012105813A3 USE OF ICAM-1 FOR PREVENTION OR TREATMENT OF NEUROLOGICAL DISEASES 审中-公开
公开(公告)号：WO2012105813A3
公开(公告)日：2012-08-09
申请号：PCT/KR2012/000788
申请日：2012-02-01
申请人： MEDIPOST CO., LTD. , YANG, Yoon-Sun , OH, Won Il , CHANG, Jong Wook , KIM, Ji Hyun
发明人： YANG, Yoon-Sun , OH, Won Il , CHANG, Jong Wook , KIM, Ji Hyun
IPC分类号： A61K38/16 , A61K38/17 , A61K48/00 , A61P25/00
摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (A¥, a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer¡s disease.

6. 发明申请

WO2008066330A1 USE OF A COMPOSITION CONTANING HUMAN UMBILICAL CORD BLOOD-DERIVED MESENCHYMAL STEM CELL FOR INDUCING DIFFERENTIATION AND PROLIFERATION OF NEURAL PRECURSOR CELLS OR NEURAL STEM CELLS TO NEURAL CELLS 审中-公开
标题翻译：用于诱导人神经干细胞衍生的中枢神经干细胞的组合物的用途，用于诱导神经前体细胞或神经干细胞向神经细胞的分化和增殖
公开(公告)号：WO2008066330A1
公开(公告)日：2008-06-05
申请号：PCT/KR2007/006084
申请日：2007-11-29
申请人： MEDIPOST CO., LTD. , OH, Wonil , YANG, Yoon-Sun , CHANG, Jong Wook , CHOI, Soo Jin , KIM, Ju-Yeon
发明人： OH, Wonil , YANG, Yoon-Sun , CHANG, Jong Wook , CHOI, Soo Jin , KIM, Ju-Yeon
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： A61K35/51 , A61K9/0019 , A61K35/28 , A61K35/50 , A61K45/06 , A61K2300/00 , C12N5/0623 , C12N5/0647 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2502/03 , C12N2502/1358
摘要： A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.
摘要翻译：提供了包含脐带血来源的间充质干细胞用于诱导神经前体细胞或神经干细胞向神经细胞的分化和增殖的组合物的用途，所述组合物对于治疗神经损伤疾病是有效的。

7. 发明申请

WO2010056075A2 COMPOSITION COMPRISING MESENCHYMAL STEM CELLS OR CULTURE SOLUTION OF MESENCHYMAL STEM CELLS FOR THE PREVENTION OR TREATMENT OF NEURAL DISEASES 审中-公开
标题翻译：包含间质干细胞的组合物或用于预防或治疗神经疾病的间质干细胞的培养溶液
公开(公告)号：WO2010056075A2
公开(公告)日：2010-05-20
申请号：PCT/KR2009/006712
申请日：2009-11-16
申请人： MEDIPOST CO., LTD , YANG, Yoon-Sun , OH, Won Il , CHANG, Jong Wook , KIM, Ju Yeon
发明人： YANG, Yoon-Sun , OH, Won Il , CHANG, Jong Wook , KIM, Ju Yeon
IPC分类号： A61K35/44 , A61K35/28 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： A61K35/28 , A61K38/2026 , C12N5/0619 , C12N5/0665 , C12N2502/1358 , C12N2502/137
摘要： Provided are a pharmaceutical composition for prevention and treatment of a neural disease including at least one selected from the group consisting of mesenchymal stem cells (MSCs), a culture solution of the MSCs, activin A, PF4, decorin, galectin 3, GDF15, glypican 3, MFRP, ICAM5, IGFBP7, PDGF-AA, SPARCL1, thrombospondin-1, WISP1, progranulin, IL-4, a factor inducing expression thereof, and any combination thereof, and a method therefor.
摘要翻译：本发明提供用于预防和治疗神经疾病的药物组合物，其包含选自间充质干细胞（MSC），MSC的培养液，激活素A，PF4，核心蛋白聚糖，半乳糖凝集素3，GDF15，磷脂酰肌醇蛋白聚糖3，MFRP，ICAM5，IGFBP7，PDGF-AA，SPARCL1，血小板反应蛋白-1，WISP1，颗粒体蛋白前体，IL-4，诱导其表达的因子及其任意组合。

8. 发明申请

WO2003070922A1 ISOLATION AND CULTURE-EXPANSION METHODS OF MESENCHYMAL STEM/PROGENITOR CELLS FROM UMBILICAL CORD BLOOD, AND DIFFERENTIATION METHOD OF UMBILICAL CORD BLOOD-DERIVED MESENCHYMAL STEM/PROGENITOR CELLS INTO VARIOUS MESENCHYMAL TISSUES 审中-公开
标题翻译：来自脐带血的骨髓干细胞/祖细胞的分离和培养扩增方法以及脐带血衍生的MESENCHYMAL STEM / PROGENITOR细胞分化为各种组织细胞的分化方法
公开(公告)号：WO2003070922A1
公开(公告)日：2003-08-28
申请号：PCT/KR2003/000339
申请日：2003-02-19
申请人： MEDIPOST CO., LTD. , HA, Chul-Won , YANG, Yoon-Sun , YANG, Sung-Eun
发明人： HA, Chul-Won , YANG, Yoon-Sun , YANG, Sung-Eun
IPC分类号： C12N5/08
CPC分类号： C12N5/0665 , C12N2500/24 , C12N2500/32 , C12N2500/42 , C12N2501/15
摘要： The present invention relates to a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method comprises the steps of: overlaying umbilical cord blood onto Ficoll-Hypaque solution; centrifuging the umbilical cord blood on the Ficoll-Hypaque solution to obtain a mononuclear cell layer; reacting cells obtained by monolayer culture of the mononuclear cells with antibodies to mesenchymal stem/progenitor cell-specific antigens for a predetermined period of incubation time; isolating only cells bound to their corresponding antibodies using a cell sorter; and cultivating the isolated cells, thereby obtaining mesenchymal stem/progenitor cells with high purity and excellent viability. The mesenchymal stem/progenitor cells of the present invention are capable of differentiating into various mesenchymal tissues including chondrocytes and osteoblasts. Thus, the method of cell isolation and cultivation according to the present invention allows mass production of the mesenchymal stem/progenitor cells, and the cells obtained by the present invention are useful in the renewal and treatment of injured mesenchymal tissues.
摘要翻译：本发明涉及从脐带血分离和培养间充质干细胞/祖细胞的方法，还涉及将脐带血来源的间充质干细胞/祖细胞分化为各种间充质组织的方法。该方法包括以下步骤：将脐带血重叠在Ficoll-Hypaque溶液上; 在Ficoll-Hypaque溶液上离心脐带血，获得单核细胞层; 将单核细胞的单层培养获得的细胞与间充质干/祖细胞特异性抗原的抗体反应预定的孵育时间; 使用细胞分选器分离仅与其相应抗体结合的细胞; 并培养分离的细胞，从而获得高纯度和优良活力的间充质干细胞/祖细胞。本发明的间充质干/祖细胞能够分化为包括软骨细胞和成骨细胞在内的各种间充质组织。因此，根据本发明的细胞分离和培养方法允许大量生产间充质干细胞/祖细胞，并且通过本发明获得的细胞可用于损伤的间充质组织的更新和治疗。

9. 发明申请

WO2015034212A1 METHOD FOR CULTURING MESENCHYMAL STEM CELLS ACCORDING TO CELL SIZE 审中-公开
标题翻译：根据细胞大小培养细胞干细胞的方法
公开(公告)号：WO2015034212A1
公开(公告)日：2015-03-12
申请号：PCT/KR2014/008079
申请日：2014-08-29
申请人： MEDIPOST CO., LTD.
发明人： YANG, Yoon-Sun , OH, Won Il , JIN, Hye Jin , KWON, Soon-Jae , KIM, Miyeon
IPC分类号： C12N5/0775 , C12N5/02 , A61K35/12
CPC分类号： C12N5/0665 , A61K35/28 , C12N2500/02 , C12N2500/14 , C12N2500/16
摘要： The present invention relates to a method for culturing mesenchymal stem cells, including isolating mesenchymal stem cells having a size of 8 μm or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition. The method of the present invention can significantly improve the proliferative capacity and differentiation potential of the mesenchymal stem cells.
摘要翻译：本发明涉及培养间充质干细胞的方法，包括分离大小为8μm或更小的间充质干细胞，并在含有钙和镁的培养基中和在低氧条件下培养间充质干细胞。本发明的方法可以显着改善间充质干细胞的增殖能力和分化潜能。

10. 发明申请

WO2007100211A1 SISP-1, A NOVEL P53 TARGET GENE AND USE THEREOF 审中-公开
标题翻译： SISP-1，新型P53靶基因及其用途
公开(公告)号：WO2007100211A1
公开(公告)日：2007-09-07
申请号：PCT/KR2007/001023
申请日：2007-02-28
申请人： CURONIX CO., LTD , YANG, Yoon-Sun
发明人： YANG, Yoon-Sun
IPC分类号： C12N15/12 , C12N15/09 , C07K16/00 , A61K45/00 , A61P35/00
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/47
摘要： The present invention relates to a novel p53 target gene SISP-I (Stress induced Secreted Protein 1) and a SISP-I protein encoded by the gene. The SISP-I protein of the present invention induces apoptosis by interaction with p53. The present invention provides the use of the gene/ protein associated with treating abnormal apoptosis such as tumor.
摘要翻译：本发明涉及一种新的p53靶基因SISP-1（应激诱导的分泌蛋白1）和由该基因编码的SISP-1蛋白。本发明的SISP-1蛋白通过与p53的相互作用诱导凋亡。本发明提供与治疗异常细胞凋亡相关的基因/蛋白质如肿瘤的用途。

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