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JP2013240323A Nucleic acid construct and method for producing nanoparticle using the same 有权
标题翻译：核酸结构及使用其制备纳米颗粒的方法
公开(公告)号：JP2013240323A
公开(公告)日：2013-12-05
申请号：JP2013098967
申请日：2013-05-09
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： PARK NO KYOUNG
IPC分类号： C12N15/09 , B82Y30/00 , B82Y40/00
CPC分类号： C07H23/00 , B82Y5/00 , C07H21/00
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid construct and a method for producing a nanoparticle using the same.SOLUTION: A nanoparticle comprises a metal ion or a metal precursor and a nucleic acid construct. The nucleic acid construct comprises two or more single-stranded nucleic acids, and the two or more single-stranded nucleic acids comprise ten or more nucleotides and two or more adjacent fragments, respectively. Each of the fragments is complementary to the mutually different fragments and the fragment is hybridized with the substantially complementary fragment, respectively. In the nanoparticle, the nucleic acid construct comprises a plurality of double-stranded fragments and the metal or the metal precursor is linked to a phosphate main chain of the nucleic acid construct or a base of the nucleic acid construct.
摘要翻译：要解决的问题：提供核酸构建体和使用其的纳米颗粒的制备方法。溶液：纳米颗粒包含金属离子或金属前体和核酸构建体。核酸构建体包含两个或多个单链核酸，并且两个或更多个单链核酸分别包含十个或更多个核苷酸和两个或更多个相邻片段。每个片段与相互不同的片段互补，并且片段分别与基本上互补的片段杂交。在纳米颗粒中，核酸构建体包含多个双链片段，并且金属或金属前体连接到核酸构建体的磷酸主链或核酸构建体的碱基。

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