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1. 发明专利

JP2009280577A Method for producing quaternary salt of piperidyl mandelate 审中-公开
标题翻译：制备管状四季铵盐的方法
公开(公告)号：JP2009280577A
公开(公告)日：2009-12-03
申请号：JP2009106522
申请日：2009-04-24
申请人： Saltigo Gmbh , サルティゴ・ゲーエムベーハー
发明人： JOB ANDREAS , BASKAKOV DENYS , KRAHWINKEL RALF , HIERONYMI ANTJE
IPC分类号： C07D211/46 , A01N43/40 , A01P3/00 , A61K8/46 , A61Q5/00 , A61Q13/00 , A61Q19/00
CPC分类号： C07D211/46
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a quaternary salt of piperidyl mandelate. SOLUTION: The method for producing a compound of formula (I) (wherein R 1 , R 2 , and R 3 are each independently hydrogen, an alkyl group or an aryl group) comprises reacting a compound of formula (II) (wherein R 1 , and R 2 are the same as defined above) with an alkylating agent of formula (III): R 3 X (wherein X is a halogen and R 3 is the same as defined above). COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种制备哌啶基扁桃酸酯的季盐的方法。解决方案：制备式（I）化合物（其中R SB 1，R SB 2，R SB 2和R SB 3）的方法各自独立地是氢，烷基或芳基）包括使式（II）化合物（其中R SB 1，R SB和R SB 2与上述定义相同）与式式（III）的烷基化剂：R SB 3 X（其中X是卤素，R SB 3与上述定义相同）。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009256351A Method of brominating alkylthiophene 审中-公开
标题翻译：阿尔茨海默病的方法
公开(公告)号：JP2009256351A
公开(公告)日：2009-11-05
申请号：JP2009096169
申请日：2009-04-10
申请人： Saltigo Gmbh , サルティゴ・ゲーエムベーハー
发明人： HIERONYMI ANTJE , MARTIN ANDREAS , WITOLD BRODA
IPC分类号： C07D333/28 , H01L51/05 , H01L51/30 , H01L51/40 , H01L51/42
CPC分类号： C07D333/28 , Y02E10/549 , Y02P70/521
摘要： PROBLEM TO BE SOLVED: To provide a method of brominating an alkylthiophene. SOLUTION: The method of brominating an alkylthiophene comprises a step of bringing an alkylthiophene represented by general formula (I), in which R represents a 1-12C linear or branched alkyl group, into contact with a stoichiometric amount of HBr and H 2 O 2 optionally in the presence of a solvent. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供溴化烷基噻吩的方法。解决方案：溴化烷基噻吩的方法包括使由通式（I）表示的烷基噻吩（其中R表示1-12C直链或支链烷基）与化学计量的HBr和H接触的步骤任选在溶剂存在下进行。版权所有（C）2010，JPO＆INPIT

3. 发明专利

PL2426116T3 Sposób wytwarzania (S)-3-N-metyloamino-1-(2-tienylo)-1-propanolu 未知
公开(公告)号：PL2426116T3
公开(公告)日：2013-11-29
申请号：PL10174550
申请日：2010-08-30
申请人： SALTIGO GMBH
发明人： KREIS MICHAEL , HIERONYMI ANTJE , GIFFELS GUIDO , KREBS OLIVER
IPC分类号： C07D333/20

4. 发明专利

DK2426116T3 Fremgangsmåde til fremstilling af (S)-3-N-methylamino-1-(2-thienyl)-1-propanol 未知
公开(公告)号：DK2426116T3
公开(公告)日：2013-09-08
申请号：DK10174550
申请日：2010-08-30
申请人： SALTIGO GMBH
发明人： KREIS MICHAEL , HIERONYMI ANTJE , GIFFELS GUIDO , KREBS OLIVER
IPC分类号： C07D333/20

5. 发明专利

ES2425379T3 Procedimiento para la preparación de (S)-3-N-metilamino-1-(2-tienil)-1-propanol 未知
公开(公告)号：ES2425379T3
公开(公告)日：2013-10-15
申请号：ES10174550
申请日：2010-08-30
申请人： SALTIGO GMBH
发明人： KREIS MICHAEL , HIERONYMI ANTJE , GIFFELS GUIDO , KREBS OLIVER
IPC分类号： C07D333/20
摘要： Procedimiento para la preparación de (S)-3-N-metilamino-1-(2-tienil)-1-propanol y sales del mismo, caracterizado por que se hacer reaccionar clorhidrato o metanosulfato de 3-N-metilamino-1-(2-tienil)-1-propanona en presencia de dímero p-Cimoldiclororutenio y S,S-N-p-toluenosulfonil-1,2-difeniletilendiamina en presencia de al menos una amina y en presencia de ácido fórmico y/o formiatos o mezclas de los mismos.

6. 发明专利

ES2391598T3 Procedimiento para la preparación de tiofenos sustituidos con alquilo 未知
公开(公告)号：ES2391598T3
公开(公告)日：2012-11-28
申请号：ES08760040
申请日：2008-05-27
申请人： SALTIGO GMBH
发明人： HIERONYMI ANTJE , RODEFELD LARS
IPC分类号： C07D333/08
摘要： Procedimiento para la preparación de tiofenos sustituidos de fórmula general (I)en la queX es azufreyR4 es alquilo C1-C20,R1, R2, R3 son hidrógeno, halógeno, alquilo C1-C20, arilo C5-C6 o heteroarilo, mediante la reacción deA) un compuesto heteroaromático halogenado de fórmula general (II)en la queX tiene el significado especificado para la fórmula (I) yR6 es bromo, yodo o cloro yR1, R2 y R3 tienen el significado especificado para la fórmula (I),con un reactivo de Grignard de fórmula general (III)R4MgHal (III)en la queR4 tiene el significado especificado para la fórmula (I) yHal es bromo, yodo o cloro oB) reacción del compuesto heteroaromático halogenado de fórmula (II) con magnesio dando inicialmente uncompuesto de Grignard de fórmula general (IIIa)

7. 发明专利

DE102008018485A1 未知
公开(公告)号：DE102008018485A1
公开(公告)日：2009-10-15
申请号：DE102008018485
申请日：2008-04-11
申请人： SALTIGO GMBH
发明人： HIERONYMI ANTJE , MARTIN ANDREAS , BRODA WILFRIED
IPC分类号： C07D333/28
摘要： Bromination of an alkylthiophene compound (I) comprises contacting (I) with stoichiometric amount of hydrogen bromide (HBr) and hydrogen peroxide, optionally in the presence of a solvent. Bromination of an alkylthiophene compound of formula (I) comprises contacting (I) with stoichiometric amount of hydrogen bromide (HBr) and hydrogen peroxide, optionally in the presence of a solvent. R : 1-12C alkyl. [Image].

8. 发明专利

DE102008020746A1 未知
公开(公告)号：DE102008020746A1
公开(公告)日：2009-10-29
申请号：DE102008020746
申请日：2008-04-25
申请人： SALTIGO GMBH
发明人： JOB ANDREAS , BASKAKOV DENYS , KRAHWINKEL RALF , HIERONYMI ANTJE
IPC分类号： C07D211/46
摘要： Preparing piperidinium compound (I), comprises reacting piperidine compound (II) with an alkylating agent (III) optionally in the presence of a solvent. Preparing piperidinium compound of formula (I), comprises reacting piperidine compound of formula (II) with an alkylating agent of formula (R 3>-X) (III) optionally in the presence of a solvent. R 1>H, alkyl or aryl group, preferably cyclopentyl; R 2>R 1>, preferably CH 3; R 3>R 1>, preferably CH 3; and X : halo, preferably Br. [Image].

9. 发明专利

DE102007026763A1 未知
公开(公告)号：DE102007026763A1
公开(公告)日：2009-01-15
申请号：DE102007026763
申请日：2007-06-09
申请人： SALTIGO GMBH
发明人： HIERONYMI ANTJE , RODEFELD LARS
IPC分类号： C07D333/08 , C07D333/28
摘要： A process is described for the preparation of substituted heteroaromatics of the general formula (I) where X is oxygen, sulphur or NR5 where R5 is hydrogen, C1-C20-alkyl or C5-C6-aryl and R4 is C1-C20-alkyl, C5-C6-aryl or heteroaryl, R1, R2, R3 is hydrogen, halogen, C1-C20-alkyl, C5-C6-aryl or heteroaryl, by reaction A) of a halogenated heteroaromatic of the general formula (II) where X has the meaning given for formula (I) and R6 is bromine, iodine or chlorine and R1, R2 and R3 have the meaning given for formula (I), with a Grignard reagent of the general formula (III) R4MgHal (III) where R4 has the meaning given for formula (I) and Hal is bromine, iodine or chlorine or B) reaction of the halogenated heteroaromatics of the formula (II) with magnesium firstly to give a Grignard compound of the general formula (IIIa) where Hal is bromine, iodine or chlorine and X and R1, R2 and R3 have the meaning given for formula (I), and further reaction with a halogenated compound of the general formula (IV) R4Hal (IV) where R4 has the meaning given for formula (I) and Hal is bromine, iodine or chlorine, where the reactions A) or B) are in each case carried out in the presence of an Ni or Pd catalyst, characterized in that the process is carried out in the presence of cycloalkyl alkyl ether as solvent and optionally a further solvent. Likewise described is the use of cycloalkyl alkyl ethers, in particular cyclopentyl methyl ether, in the Kumada reaction for the preparation of substituted heteroaromatics, in particular substituted thiophenes.

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