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1. 发明专利

CA2420184A1 CONOTOXINS HAVING ACETYLCHOLIN RECEPTOR BINDING PROPERTIES 未知
公开(公告)号：CA2420184A1
公开(公告)日：1995-01-12
申请号：CA2420184
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： RIVIER JEAN E F , DYKERT JOHN , ABOGADIE FE , HOPKINS CHRIS E , CRUZ LOURDES J , OLIVERA BALDOMERO M , TORRES JOSEP L
IPC分类号： A61K38/10 , A61K38/17 , A61P25/00 , C07K7/08 , C07K14/435 , G01N33/566
摘要： A substantially pure conotoxin which is highly selective for a specific human receptor, which conotoxin is selected from the group consisting of: Glu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro- Tyr-Ile-Leu (SEQ ID NO:13) wherein Glu in the 1-position is pGlu and the C-terminus is amidated; Gly-Glu-Xaa-Xaa-Va1-Ala-Lys-Met-Ala-Ala-Xaa-Leu-Ala- Arg-Xaa-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr- Pro (SEQ ID NO:12) wherein Xaa is Gla; Ser-Thr-Ser-Cys-Met-Glu-Ala-Gly-Ser-Tyr-Cys-Gly-Ser- Thr-Thr-Arg-Ile-Cys-Cys-Gly-Tyr-Cys-Ala-Tyr-Phe-Gly- Lys-Lys-Cys-Ile-Asp-Tyr-Pro-Ser-Asn (SEQ ID NO:11); Cys-Lys-Thr-Tyr-Ser-Lys-Tyr-Cys-Xaa-Ala-Asp-Ser-Xaa- Cys-Cys-Thr-Xaa-Gln-Cys-Val-Arg-Ser-Tyr-Cys-Thr-Leu- Phe (SEQ ID NO:10) wherein Xaa is Gla and the C-terminus is amidated; His-Xaa-Xaa-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr- Xaa-Gly-Cys-Ser- Ser-Ala-Ser-Cys-Cys-Gln (SEQ ID NO:9) wherein Xaa is 4Hyp; Gly-Cys-Cys-Ser-His-Pro-Ala-Cys-Ser-Gly-Lys-Tyr-Gln- Xaa-Tyr-Cys-Arg- Xaa- Ser (SEQ ID NO:8) wherein Xaa is Gla and the C-terminus is amidated; and Gly-Xaa-Ser-Phe-Cys-Lys-Ala-Asp-Glu-Lys-Xaa-Cys-Glu- Tyr-His-Ala-Asp-Cys-Cys-Asn-Cys-Cys-Leu-Ser-Gly-Ile- Cys-Ala-Xaa-Ser-Thr-Asn-Trp-Ile-Leu-Pro-Gly-Cys-Ser- Thr-Ser-Ser-Phe-Phe-Lys-Ile (SEQ ID NO:7) wherein Xaa is 4Hyp. These conotoxins may be used to prepare medicaments for the treatment of neuromuscular disorders. Some may be used for rapid reversible immobilisation of muscles or for diagnosing myasthenia gravis or Lambert-Eaton myasthenic syndrome.

2. 发明专利

CA2420184C CONOTOXINS 未知
公开(公告)号：CA2420184C
公开(公告)日：2004-09-21
申请号：CA2420184
申请日：1994-06-27
申请人： UNIV UTAH RES FOUND , SALK INST FOR BIOLOGICAL STUDI
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L , ABOGADIE FE
IPC分类号： A61K38/10 , A61K38/17 , A61P25/00 , C07K7/08 , C07K14/435 , G01N33/566
摘要： A substantially pure conotoxin which is highly selective for a specific human receptor, which conotoxin is selected from the group consisting of: Glu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro- Tyr-Ile-Leu (SEQ ID NO:13) wherein Glu in the 1-position is pGlu and the C-terminus is amidated; Gly-Glu-Xaa-Xaa-Va1-Ala-Lys-Met-Ala-Ala-Xaa-Leu-Ala- Arg-Xaa-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr- Pro (SEQ ID NO:12) wherein Xaa is Gla; Ser-Thr-Ser-Cys-Met-Glu-Ala-Gly-Ser-Tyr-Cys-Gly-Ser- Thr-Thr-Arg-Ile-Cys-Cys-Gly-Tyr-Cys-Ala-Tyr-Phe-Gly- Lys-Lys-Cys-Ile-Asp-Tyr-Pro-Ser-Asn (SEQ ID NO:11); Cys-Lys-Thr-Tyr-Ser-Lys-Tyr-Cys-Xaa-Ala-Asp-Ser-Xaa- Cys-Cys-Thr-Xaa-Gln-Cys-Val-Arg-Ser-Tyr-Cys-Thr-Leu- Phe (SEQ ID NO:10) wherein Xaa is Gla and the C-terminus is amidated; His-Xaa-Xaa-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr- Xaa-Gly-Cys-Ser- Ser-Ala-Ser-Cys-Cys-Gln (SEQ ID NO:9) wherein Xaa is 4Hyp; Gly-Cys-Cys-Ser-His-Pro-Ala-Cys-Ser-Gly-Lys-Tyr-Gln- Xaa-Tyr-Cys-Arg- Xaa- Ser (SEQ ID NO:8) wherein Xaa is Gla and the C-terminus is amidated; and Gly-Xaa-Ser-Phe-Cys-Lys-Ala-Asp-Glu-Lys-Xaa-Cys-Glu- Tyr-His-Ala-Asp-Cys-Cys-Asn-Cys-Cys-Leu-Ser-Gly-Ile- Cys-Ala-Xaa-Ser-Thr-Asn-Trp-Ile-Leu-Pro-Gly-Cys-Ser- Thr-Ser-Ser-Phe-Phe-Lys-Ile (SEQ ID NO:7) wherein Xaa is 4Hyp. These conotoxins may be used to prepare medicaments for the treatment of neuromuscular disorders. Some may be used for rapid reversible immobilisation of muscles or for diagnosing myasthenia gravis or Lambert-Eaton myasthenic syndrome.

3. 发明专利

AU699078B2 Conotoxins having acetylcholin receptor binding properties 未知
公开(公告)号：AU699078B2
公开(公告)日：1998-11-19
申请号：AU3519797
申请日：1997-08-21
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERA M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61P21/00 , C07K7/08 , C07K14/435 , C12N15/12 , G01N33/53 , G01N33/577

4. 发明专利

AU678837B2 Conotoxins having acetylcholin receptor binding properties 未知
公开(公告)号：AU678837B2
公开(公告)日：1997-06-12
申请号：AU7115894
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

5. 发明专利

AT286128T 未知
公开(公告)号：AT286128T
公开(公告)日：2005-01-15
申请号：AT03075795
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

6. 发明专利

CA2165566A1 CONOTOXINS HAVING ACETYLCHOLIN RECEPTOR BINDING PROPERTIES 未知
公开(公告)号：CA2165566A1
公开(公告)日：1995-01-12
申请号：CA2165566
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO , RIVIER JEAN E F , CRUZ LOURDES , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , C07K7/08 , A61K38/10 , A61K38/17 , G01N33/566
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissi ons at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular recep tors, such as the acetylcholine receptor, and ion channe ls. The peptides are of such length that they can be made by chemical synthesis. The y also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorpo rated as plant defense genes into plant species of inter est.

7. 发明专利

AT248222T 未知
公开(公告)号：AT248222T
公开(公告)日：2003-09-15
申请号：AT94920316
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

8. 发明专利

AU3519797A Conotoxins having acetylcholin receptor binding properties 未知
公开(公告)号：AU3519797A
公开(公告)日：1997-11-20
申请号：AU3519797
申请日：1997-08-21
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERA M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61P21/00 , C07K7/08 , C07K14/435 , C12N15/12 , G01N33/53 , G01N33/577

9. 发明专利

AU7115894A Conotoxins having acetylcholin receptor binding properties 未知
公开(公告)号：AU7115894A
公开(公告)日：1995-01-24
申请号：AU7115894
申请日：1994-06-27
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

10. 发明专利

DE69433090D1 未知
公开(公告)号：DE69433090D1
公开(公告)日：2003-10-02
申请号：DE69433090
申请日：1994-06-27
申请人： SALK INST FOR BIOLOG STUDIES L , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

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