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1. 发明申请

WO1986001828A1 CYCLIC DOUBLE-STRANDED DNA, PROCESS FOR ITS PREPARATION, MICROORGANISM CONTAINING SAID CYCLIC DOUBLE-STRANDED DNA, AND PROCESS FOR PREPARING PROTEIN CONTAINING ANTIGEN DETERMINANT SITE OF POLIOVIRUS CAPSIDE PROTEIN VP1 USING THE SAME 审中-公开
标题翻译：环状双链DNA，其制备方法，含有循环双链DNA的微生物及其制备含有抗生素决定簇的蛋白质的蛋白质VP1的方法
公开(公告)号：WO1986001828A1
公开(公告)日：1986-03-27
申请号：PCT/JP1985000518
申请日：1985-09-18
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS CO., LTD. , HODOGAYA CHEMICAL CO., LTD. , NIPPON SODA CO., LTD. , NISSAN CHEMICAL INDUSTRIES, LTD. , TOYO SODA MANUFACTURING CO., LTD. , NUMAO, Naganori , TAKAHARA, Yoshiyuki , KATO, Seishi
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS CO., LTD. , HODOGAYA CHEMICAL CO., LTD. , NIPPON SODA CO., LTD. , NISSAN CHEMICAL INDUSTRIES, LTD. , TOYO SODA MANUFACTURING CO., LTD.
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C07K2319/40 , C12N9/0069 , C12N15/73 , C12N2770/32622 , C12N2770/32634 , C12Y113/11002 , Y02A50/466
摘要： A process for preparing a protein having an antigen determinant site of capside protein VPI utilizing cyclic double-stranded DNA containing high expression promotor/operator, SD sequence under its control, and a DNA portion which codes an antigen determinant site of capside protein VPI of attenuated poliovirus strain. This invention enables to produce the protein in a large amount as a blended or not-blended protein.

2. 发明申请

WO1997044377A1 MELAMINE POLYMETAPHOSPHATE AND PROCESS FOR ITS PRODUCTION 审中-公开
标题翻译：聚甲基丙烯酸甲酯及其生产工艺
公开(公告)号：WO1997044377A1
公开(公告)日：1997-11-27
申请号：PCT/JP1997001712
申请日：1997-05-21
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , SUZUKI, Keitaro , SHISHIDO, Kouji , SHINDO, Masuo
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C08G79/02
CPC分类号： C08K5/34928 , C08G79/02 , C08K5/529
摘要： A melamine polymetaphosphate having a solubility of from 0.01 to 0.10 g/100 ml in water at 25 DEG C, a pH of from 2.5 to 4.5 in the form of a 10 wt.% aqueous slurry at 25 DEG C and a melamine content of from 1.0 to 1.1 mol per mol of phosphorus atom. A process for producing such a melamine polymetaphosphate, which comprises the following steps (a) and (b): (a) a step of mixing melamine, urea and an aqueous orthophosphoric acid solution containing at least 40 wt.% of orthophosphoric acid, in such a ratio that melamine is from 1.0 to 1.5 mol per mol of orthophosphoric acid and urea is from 0.1 to 1.5 mol per mol of orthophosphoric acid, at a temperature of from 0 to 140 DEG C, to form a reaction mixture, and stirring the reaction mixture at a temperature of from 0 to 140 DEG C, while removing water, to obtain a powdery product of a double salt of orthophosphoric acid with melamine and urea; and (b) a step of calcining the powdery product obtained in step (a) at a temperature of from 240 to 340 DEG C for from 0.1 to 30 hours, while preventing agglomeration, to obtain a melamine polymetaphosphate.
摘要翻译：在25℃下在水中溶解度为0.01至0.10g / 100ml，pH为2.5至4.5，在25℃下为10重量％含水浆料形式的三聚氰胺聚偏磷酸钠，三聚氰胺含量为每摩尔磷原子为1.0-1.1摩尔。一种制备这种三聚氰胺聚偏磷酸盐的方法，其包括以下步骤（a）和（b）：（a）将含有至少40重量％正磷酸的三聚氰胺，尿素和正磷酸水溶液混合在三聚氰胺的摩尔比为每摩尔正磷酸为1.0〜1.5摩尔，尿素为0.1〜1.5摩尔/升正磷酸，温度为0〜140℃，形成反应混合物，搅拌反应混合物在0-140℃的温度下，同时除去水，得到正磷酸的双重盐与三聚氰胺和尿素的粉末状产物; 和（b）在240〜340℃的温度下煅烧步骤（a）中得到的粉末状产物0.1〜30小时，同时防止团聚，得到三聚氰胺聚偏磷酸酯的工序。

3. 发明申请

WO1997034610A1 PROCESS FOR PRODUCING EFONIDIPINE HYDROCHLORIDE PREPARATIONS 审中-公开
标题翻译：生产氟尼泊替氯化氢制剂的方法
公开(公告)号：WO1997034610A1
公开(公告)日：1997-09-25
申请号：PCT/JP1997000842
申请日：1997-03-17
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , ZERIA PHARMACEUTICAL CO., LTD. , MIYAMOTO, Misao , ODA, Toshihisa , BUNRIN, Toyohiko , OKABE, Toshio , NISHIYAMA, Tetsuyuki
发明人： NISSAN CHEMICAL INDUSTRIES, LTD. , ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/675
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K31/66 , A61K31/675
摘要： The present invention can form an amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability which can be formed by subjecting a mixture containing efonidipine hydrochloride of formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140 DEG C or mechanochemical treatment at from 0 to 140 DEG C, and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vapor-containing gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140 DEG C and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required.
摘要翻译：本发明可以形成具有高肠吸收能力的盐酸依替地平盐酸盐的无定形固体分散体，其可以通过使式（I）的依地尼地平盐酸盐，乙酸琥珀酸羟丙基甲基纤维素和任选的热稳定剂的混合物进行热处理步骤A 85〜140℃，0〜140℃下进行机械化学处理，然后进行浸渍处理至含水溶液的工序B，用含水溶液进行浸渍处理或与含有水蒸汽的气体进行接触处理 ; 或用100〜140℃的热蒸汽和高压处理上述混合物。此外，在上述步骤A中，将混合物进行高频加热，使得可以在不使用步骤B的情况下得到具有高肠吸收能力的盐酸依替地平的固体分散体。该方法在生产中是非常有利的不需要使用有机溶剂。

4. 发明申请

WO1997031908A1 THIFLUZAMIDE WITH ENHANCED POTENCY 审中-公开
标题翻译：具有增强光泽度的噻菌胺
公开(公告)号：WO1997031908A1
公开(公告)日：1997-09-04
申请号：PCT/JP1997000613
申请日：1997-02-28
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , ROHM AND HAAS COMPANY , HAYAKAWA, Norihito , BABA, Masatoshi , SUWA, Norihiro , YAMAGISHI, Kazuhiro
发明人： NISSAN CHEMICAL INDUSTRIES, LTD. , ROHM AND HAAS COMPANY
IPC分类号： C07D277/56
CPC分类号： C07D277/56 , A01N43/78
摘要： Thifluzamide with its crystal form dislocated, a process for producing the same, and a pesticidal composition containing the same as the active ingredient. The thifluzamide has an increased rate of dissolution into water and the composition has an enhanced potency.
摘要翻译：其晶体形式脱落的噻吗喃酰胺，其制造方法和含有该活性成分的杀虫剂组合物。 thifluzamide具有增加的水溶解速率，并且组合物具有增强的效力。

5. 发明申请

WO1997023627A1 RICE NADH-DEPENDENT REDUCTASE, GENE THEREFOR, AND USE THEREOF 审中-公开
标题翻译：赖氨酸依赖性还原酶，其基因及其用途
公开(公告)号：WO1997023627A1
公开(公告)日：1997-07-03
申请号：PCT/JP1995002641
申请日：1995-12-22
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , UCHIMIYA, Hirofumi , FUSHIMI, Takaomi , KUDOU, Ume , TAGAWA, Michito
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C12N15/53
CPC分类号： C12N9/0036 , C12N9/0004 , C12N15/8282
摘要： A gene for rice NADH-dependent reductase or a modification thereof; a rice NADH-dependent reductase or an analogue thereof; a DNA or expression vector containing the gene or modification thereof and capable of expressing in microorganisms or plant cells; and a plant transformed by the expression vector or seeds thereof. By cultivating the transformed plant, it is possible to protect the plant from damages caused by disease bacteria.
摘要翻译：水稻NADH依赖性还原酶的基因或其修饰; 水稻NADH依赖性还原酶或其类似物; 含有该基因或其修饰并能够在微生物或植物细胞中表达的DNA或表达载体; 和由表达载体或其种子转化的植物。通过培育转化植物，可以保护植物免受疾病细菌的损害。

6. 发明申请

WO1997023209A1 THERAPEUTIC AGENT FOR CARDIAC FAILURE 审中-公开
标题翻译：治疗失败的治疗剂
公开(公告)号：WO1997023209A1
公开(公告)日：1997-07-03
申请号：PCT/JP1996003761
申请日：1996-12-24
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , TANIKAWA, Keizo , OHRAI, Kazuhiko , SATO, Masayuki , YAMASHITA, Toru
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： A61K31/35
CPC分类号： C07D311/68 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/55
摘要： A therapeutic agent for cardiac failure comprising as the active ingredient either a benzopyran derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R and R each independently represent hydrogen, halogeno, nitro, cyano, amino, C1-6 alkylcarbonylamino, etc.; R and R each independently represents hydrogen, C1-6 alkyl, or phenyl, or R and R are bonded together to form C3-6 cycloalkyl in cooperation with the carbon atom bonded thereto; R represents hydroxy, C1-6 alkoxy, or C1-6 alkylcarbonyloxy, or R is bonded to R to form a bond; R represents hydrogen, or R is bonded to R to form a bond; and R and R each independently represent hydrogen or C1-6 alkyl, or R and R are bonded together to form pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidyl, piperazinyl, etc. in cooperation with the nitrogen atom bonded thereto, or R and R are bonded together to form, in cooperation with the nitrogen atom bonded thereto, pyrrole ring optionally substituted with R (where R has the same meaning as R ).
摘要翻译：一种用于心力衰竭的治疗剂，其包含作为活性成分的通式（I）表示的苯并吡喃衍生物或其药理学上可接受的盐，其中R 1和R 2各自独立地表示氢，卤素，硝基，氰基，氨基，C 1-6烷基羰基氨基等; R 3和R 4各自独立地表示氢，C 1-6烷基或苯基，或者R 3和R 4与键合的碳原子一起形成C 3-6环烷基; R 5表示羟基，C 1-6烷氧基或C 1-6烷基羰基氧基，或R 5与R 6结合形成键; R 6表示氢，或R 6与R 5键合形成键; R 7和R 8各自独立地表示氢或C 1-6烷基，或者R 7和R 8结合在一起形成吡咯烷基，咪唑烷基，吡唑烷基，哌啶基，哌嗪基等，与与其键合的氮原子或R 7和R 8键合在一起，以与其键合的氮原子一起形成任选被R 9取代的吡咯环（其中R 9具有相同的含义作为R 1）。

7. 发明申请

WO1997013757A1 PYRAZOLONE DERIVATIVES 审中-公开
标题翻译：吡唑啉酮衍生物
公开(公告)号：WO1997013757A1
公开(公告)日：1997-04-17
申请号：PCT/JP1996002944
申请日：1996-10-11
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , TANIKAWA, Keizo , MATSUMOTO, Takashi , NAKAMURA, Masumi , ASADA, Yasunori , SHUDO, Norimasa
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D231/22
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04
摘要： Pyrazolone derivatives represented by general formula (I) or salts thereof which have antiplatelet aggregation effects and thus are useful as a preventive or remedy for various thrombotic diseases. In said formula (I) X and X represents (a), wherein A represents cyano, cyano(C1-4 alkyl), amino, amino-(C1-4 alkyl), amidino, guanidino, etc.; and R and R independently represents each hydrogen, halogeno, C1-6 alkyl, etc.; another of X and X represents C1-6 alkyl, C3-6 alkenyl, aryl(C1-4 alkyl) or aryl; one of Y and Y represents (b), wherein Q represents oxygen or sulfur; Z represents oxygen, -NR - or -CHR -; Z represents cyclic C3-7 alkylene, C1-3 alkylene, -CH2CO-, -CH2CH2CO-, etc.; Z represents oxygen, sulfur, sulfinyl, sulfonyl, etc.; Z represents C1-3 alkylene, etc.; and Z represents carboxyl, etc.; and another of Y and Y represents D-E-, wherein E represents a bond, C1-4 alkylene, phenylene, etc.; and D represents hydrogen, C1-6 alkyl, etc.
摘要翻译：具有抗血小板聚集效应的由通式（I）表示的吡唑啉酮衍生物或其盐，因此可用作各种血栓形成疾病的预防或治疗。在所述式（I）中，X 1和X 2代表（a），其中A表示氰基，氰基（C 1-4烷基），氨基，氨基 - （C 1-4烷基），脒基，胍基等 ; R 1和R 2各自独立地表示氢，卤代C 1-6烷基等; X 1和X 2中的另一个表示C 1-6烷基，C 3-6烯基，芳基（C 1-4烷基）或芳基; Y 1和Y 2中的一个表示（b），其中Q表示氧或硫; Z 1表示氧，-NR 7 - 或-CHR 7 - ; Z 2表示环状C 3-7亚烷基，C 1-3亚烷基，-CH 2 CO-，-CH 2 CH 2 CO-等; Z 3表示氧，硫，亚磺酰基，磺酰基等; Z 4表示C 1-3亚烷基等。 Z 5表示羧基等。 Y 1和Y 2中的另一个表示D-E-，其中E表示键，C 1-4亚烷基，亚苯基等; D表示氢，C 1-6烷基等。

8. 发明申请

WO1996028250A1 TITANIUM CATALYST, ORGANOTITANIUM REACTION REAGENT, PROCESSES FOR PRODUCING THESE, AND METHOD OF REACTION USING THESE 审中-公开
标题翻译：钛催化剂，有机反应试剂，生产这些试剂的方法和使用这些反应的反应方法
公开(公告)号：WO1996028250A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000578
申请日：1996-03-08
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , SATO, Fumie
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： B01J31/22
CPC分类号： C07F7/083 , B01J31/0211 , B01J31/0212 , B01J31/0252 , B01J31/122 , B01J2231/32 , B01J2231/324 , B01J2231/341 , C07B37/02 , C07B41/02 , C07B43/04 , C07B2200/07 , C07C29/00 , C07C29/38 , C07C45/49 , C07C45/54 , C07C49/24 , C07C49/753 , C07C49/835 , C07C209/60 , C07C209/66 , C07C209/68 , C07C213/02 , C07C2601/02 , C07C2601/06 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/26 , C07C2603/06 , C07D207/20 , C07D307/28 , C07D307/58 , C07D309/32 , C07C211/40 , C07C211/42 , C07C215/24 , C07C215/30 , C07C33/02 , C07C33/025 , C07C33/042 , C07C33/16 , C07C33/28 , C07C33/30 , C07C33/36 , C07C33/38 , C07C33/483 , C07C33/486 , C07C35/04 , C07C35/06 , C07C35/27 , C07C35/36 , C07C35/37
摘要： A titanium catalyst for use in the reaction between unsaturated carbon-to-carbon bonds and a compound having an electrophilic functional group or an electrophilic agent, which catalyst comprises a titanium compound represented by the general formula (1): TiX X X X (wherein X , X , X and X represent each independently halogeno, C1-C20 alkoxy, aralkyloxy, aryloxy or -NRxRy (wherein Rx and Ry represent each independently C1-C20 alkyl or aralkyl), or alternatively any of X , X , X and X may form a ring together with the other of them) and 1.5-2.5 times by mole as much Grignard reagent represented by the general formula (2): R MgX (wherein R represents C2-C10 alkyl having a hydrogen atom at the beta -position; and X represents halogeno).
摘要翻译：用于不饱和碳 - 碳键之间的反应的钛催化剂和具有亲电子官能团或亲电子剂的化合物，该催化剂包含由通式（1）表示的钛化合物：TiX 1 X 2 X 3 X 4（其中X 1，X 2，X 3和X 4各自独立地表示卤代，C 1 -C 20烷氧基，芳烷氧基，芳氧基或-NR x R y（其中R x 和R 3各自独立地表示C1-C20烷基或芳烷基），或者X 1，X 2，X 3和X 4中的任一个可以与它们中的另一个一起形成环） 2.5倍摩尔的由通式（2）表示的格利雅试剂：R 1 MgX 5（其中R 1表示在β-位具有氢原子的C2-C10烷基; X <5 >表示卤代）。

9. 发明申请

WO1996026979A1 HALOGEN-CONTAINING RESIN STABILIZED AGAINST HEAT AND LIGHT 审中-公开
标题翻译：含卤素的树脂耐热和稳定
公开(公告)号：WO1996026979A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000475
申请日：1996-02-29
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , MIYAKE, Satoru , OSAWA, Kenichi , TANAKA, Norio , MIMIURA, Naotaka , SATO, Yoshinori
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C08L27/00
CPC分类号： C08K5/34922
摘要： A halogen-containing resin composition stabilized against heat and light, comprising: (a) 100 parts by weight of a halogen-containing resin; (b) 0.1 to 10 parts by weight of an organic acid (an aliphatic or aromatic carboxylic acid or a phenol) salt of a metal selected among group I-IV metals of the periodic table; (c) 0.01 to 1.0 part by weight of one or two triazine compounds having substituted amino groups and represented by general formula (I), wherein R represents a group selected among C1-18 staight-chain and branched monoalkylamino and dialkylamino groups, C4-8 monocycloalkylamino and dicycloalkylamino groups, a pyrrolidino group, and a piperidino group; and R and R represents a group selected among those exemplified by R and an -NH2 group, provided that R and R may be the same or different; (d) 0.01 to 1.0 part by weight of a phenolic antioxidant; and/or (e) 0.01 to 1.0 part by weight of a hindered amine stabilizer.
摘要翻译：一种耐热和耐光稳定的含卤树脂组合物，包括：（a）100重量份的含卤树脂; （b）0.1-10重量份选自元素周期表Ⅰ-Ⅳ族金属的金属的有机酸（脂族或芳族羧酸或苯酚）盐; （c）0.01至1.0重量份具有取代氨基并由通式（I）表示的一种或两种三嗪化合物，其中R 1表示选自C1-18直链和支链单烷基氨基和二烷基氨基的基团 C4-8单环烷基氨基和二环烷基氨基，吡咯烷子基和哌啶子基; R 2和R 3表示选自由R 1和-NH 2基团例示的基团中的基团，条件是R 2和R 3可以相同或不同; （d）0.01〜1.0重量份的酚类抗氧化剂; 和/或（e）0.01〜1.0重量份的受阻胺稳定剂。

10. 发明申请

WO1996026891A1 SUBSTITUTED CYCLOPENTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：取代环己基衍生物及其制备方法
公开(公告)号：WO1996026891A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000422
申请日：1996-02-23
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , SATO, Fumie
发明人： NISSAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C01B03/00
CPC分类号： C07C69/738 , C07C405/00 , C07C2601/10 , C07F7/1804 , Y02P20/55
摘要： A halogen-containing substituted cyclopentene derivative being useful as a novel intermediate for the preparation of prostaglandins useful as drugs and represented by general formula (I) [wherein R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C7-C19 aralkyl, C6-C12 aryl, C1-C6 alkoxy, C2-C6 alkenyloxy, C1-C6 alkylthio or C2-C6 alkenylthio; X is ( alpha -OZ , beta -H) or ( alpha -H, beta -OZ ); X is ( alpha -OZ , beta -H), ( alpha -H, beta -OZ ) or oxygen; Z and Z are each independently hydrogen or a hydroxyl-protecting group; and W is halogen], and a process for the preparation of the derivative.
摘要翻译：一种含卤素取代的环戊烯衍生物可用作制备用作药物并由通式（I）表示的前列腺素的新型中间体[其中R为氢，C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基， C 3 -C 8环烷基，C 7 -C 19芳烷基，C 6 -C 12芳基，C 1 -C 6烷氧基，C 2 -C 6烯氧基，C 1 -C 6烷硫基或C 2 -C 6烯硫基; X 1是（α-OZ a，β-H）或（α-H，β-OZ a）; X 3是（α-OZ d，β-H），（α-H，β-OZ d）或氧; Z a和Z d各自独立地为氢或羟基保护基; W是卤素]，以及制备衍生物的方法。

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