专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100143391A1 HAPTEN COMPOUNDS AND COMPOSITIONS AND USES THEREOF 有权
标题翻译：吸收化合物及其组合物及其用途
公开(公告)号：US20100143391A1
公开(公告)日：2010-06-10
申请号：US12596765
申请日：2008-04-18
申请人： S. Michael Owens , Melinda Gunnell , F. Ivy Carroll
发明人： S. Michael Owens , Melinda Gunnell , F. Ivy Carroll
IPC分类号： A61K39/00 , C07C211/00 , C07C229/00 , C07C237/00
CPC分类号： C07K16/44 , A61K39/385 , C07C217/60 , C07C229/34 , C07C323/12 , C07C323/29 , C07K2317/56 , C07K2319/40
摘要： The invention generally relates to hapten compounds comprising either (+)methamphetamine or (+)amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+)methamphetamine, (+)amphetamine, or (+)MDMA.
摘要翻译：本发明一般涉及包含与接头缀合的（+）甲基苯丙胺或（+）安非他明的半抗原化合物。一般来说，本发明的半抗原化合物可用于引发对（+）甲基苯丙胺，（+）苯丙胺或（+）MDMA中的一种或多种的免疫应答。

2. 发明授权

US07858756B2 Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds 有权
标题翻译：选择性识别甲基苯丙胺和甲基苯丙胺类化合物的单克隆抗体
公开(公告)号：US07858756B2
公开(公告)日：2010-12-28
申请号：US11763948
申请日：2007-06-15
申请人： S. Michael Owens , Melinda Gunnell , Yingni Chi , F. Ivy Carroll , Ralph Henry , Eric Peterson
发明人： S. Michael Owens , Melinda Gunnell , Yingni Chi , F. Ivy Carroll , Ralph Henry , Eric Peterson
IPC分类号： C07K16/00 , A61K39/395 , G01N33/53
CPC分类号： C07K16/44 , C07K2317/56 , C07K2317/92
摘要： The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do not recognize (−) methamphetamine, (−) amphetamine, or (−) MDMA.
摘要翻译：本发明一般涉及识别至少一种由（+）甲基苯丙胺，（+）安非他明和（+）3,4-亚甲二氧基甲基安非他明（（+）MDMA）组成的组的单克隆抗体。一般而言，单克隆抗体不识别（ - ）甲基苯丙胺，（ - ）安非他明或（ - ）MDMA。

3. 发明申请

US20080125579A1 MONOCLONAL ANTIBODIES THAT SELECTIVELY RECOGNIZE METHAMPHETAMINE AND METHAMPHETAMINE LIKE COMPOUNDS 有权
标题翻译：选择性地识别甲基丁胺和甲基喹胺类化合物的单克隆抗体
公开(公告)号：US20080125579A1
公开(公告)日：2008-05-29
申请号：US11763948
申请日：2007-06-15
申请人： S. Michael Owens , Melinda Gunnell , Yingni Chi , F. Ivy Carroll , Ralph Henry , Eric Peterson
发明人： S. Michael Owens , Melinda Gunnell , Yingni Chi , F. Ivy Carroll , Ralph Henry , Eric Peterson
IPC分类号： C07K16/18
CPC分类号： C07K16/44 , C07K2317/56 , C07K2317/92
摘要： The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do not recognize (−) methamphetamine, (−) amphetamine, or (−) MDMA.
摘要翻译：本发明一般涉及识别至少一种由（+）甲基苯丙胺，（+）安非他明和（+）3,4-亚甲二氧基甲基安非他明（（+）MDMA）组成的组的单克隆抗体。一般而言，单克隆抗体不识别（ - ）甲基苯丙胺，（ - ）安非他明或（ - ）MDMA。

4. 发明授权

US08853146B2 Hapten compounds and compositions and uses thereof 有权
标题翻译：加成化合物及其组合物和用途
公开(公告)号：US08853146B2
公开(公告)日：2014-10-07
申请号：US12596765
申请日：2008-04-18
申请人： S. Michael Owens , Melinda Gunnell , F. Ivy Carroll
发明人： S. Michael Owens , Melinda Gunnell , F. Ivy Carroll
IPC分类号： A61K38/38 , C07C323/29 , C07K16/44 , A61K39/385 , C07C217/60 , C07C229/34 , C07C323/12
CPC分类号： C07K16/44 , A61K39/385 , C07C217/60 , C07C229/34 , C07C323/12 , C07C323/29 , C07K2317/56 , C07K2319/40
摘要： The invention generally relates to hapten compounds comprising either (+)methamphetamine or (+)amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+)methamphetamine, (+)amphetamine, or (+)MDMA.
摘要翻译：本发明一般涉及包含与接头缀合的（+）甲基苯丙胺或（+）安非他明的半抗原化合物。一般来说，本发明的半抗原化合物可用于引发对（+）甲基苯丙胺，（+）苯丙胺或（+）MDMA中的一种或多种的免疫应答。

5. 发明授权

US06559159B2 Kappa opioid receptor ligands 失效
公开(公告)号：US06559159B2
公开(公告)日：2003-05-06
申请号：US09774566
申请日：2001-02-01
申请人： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
发明人： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
IPC分类号： A61K3144
CPC分类号： C07D471/08
摘要： Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

6. 发明授权

US06974824B2 Kappa opioid receptor ligands 失效
标题翻译：卡帕阿片受体配体
公开(公告)号：US06974824B2
公开(公告)日：2005-12-13
申请号：US09755021
申请日：2001-01-08
申请人： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
发明人： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
IPC分类号： C07D211/22 , A61K31/445 , A61K31/4725 , A61P25/04 , A61P25/36 , A61P43/00 , C07D401/12 , C07D217/00 , C07D251/00 , C07D401/00 , C07D487/00
CPC分类号： C07D401/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译：提供了卡帕阿片受体拮抗剂，其相对于nor-BNI对κ阿片受体的功能结合测定产生显着改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因结合而改善的疾病状态的用途成瘾

7. 发明授权

US07615567B2 Compounds and methods for promoting smoking cessation 失效
标题翻译：促进戒烟的化合物和方法
公开(公告)号：US07615567B2
公开(公告)日：2009-11-10
申请号：US11272492
申请日：2005-11-14
申请人： F. Ivy Carroll
发明人： F. Ivy Carroll
IPC分类号： A61K31/4439 , A61K51/04
CPC分类号： A61K31/4439 , A61K31/44 , C07D487/22
摘要： Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
摘要翻译：促进戒烟的化合物和方法。这些化合物可用于治疗各种其他病症和疾病状态。

8. 发明授权

US06538010B1 Compounds and methods for promoting smoking cessation 失效
公开(公告)号：US06538010B1
公开(公告)日：2003-03-25
申请号：US09708095
申请日：2000-11-08
申请人： F. Ivy Carroll
发明人： F. Ivy Carroll
IPC分类号： A61K314427
CPC分类号： A61K31/4439 , A61K31/44 , C07D487/22
摘要： Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.

9. 发明授权

US5831095A Synthesis of 5-aminocarbonyl-5H-dibenzo�a,d!cyclohepten-5,10-imine 失效
标题翻译：合成5-氨基羰基-5H-二苯并[a，d]环庚烯-5,10-亚胺
公开(公告)号：US5831095A
公开(公告)日：1998-11-03
申请号：US715480
申请日：1996-09-18
申请人： Javier Gonzalez , F. Ivy Carroll
发明人： Javier Gonzalez , F. Ivy Carroll
IPC分类号： C07D451/02 , C07D221/18
CPC分类号： C07D451/02
摘要： A powerful new anti-convulsant and anti-ischemic pharmaceutical, 5-aminocarbonyl-5H-dibenzo�a,d!cycloheptene-5,10-imine is prepared according to a novel synthesis which converts the starting material, commercially available dibenzosubernone to ADCI without the use of chromatographic purification, hazardous reagents or extreme conditions. The starting material is converted to the corresponding imine through ammonia exposure, and directly converted with acetone cyanohydrin in the presence of sodium cyanide to a 5-amino, 5-cyanocycloheptene intermediate. The intermediate is cyclized using bromine, followed by a reduction of the bromine-carbon bond using sodium cyanoborohydride. The target compound is obtained through selective hydrolysis. An overall yield of 46 percent or better is obtained.
摘要翻译：根据新的合成制备了一种功能强大的新型抗惊厥药和抗缺血药物5-氨基羰基-5H-二苯并[a，d]环庚烯-5,10-亚胺，其将起始原料，可商购的二苯并四氮烯转化为ADCI，使用色谱纯化，危险试剂或极端条件。通过氨暴露将原料转化为相应的亚胺，并在氰化钠存在下用丙酮氰醇直接转化成5-氨基-5-氰基环庚烯中间体。中间体使用溴环化，随后用氰基硼氢化钠还原溴 - 碳键。通过选择性水解获得目标化合物。总产率达到46％以上。

10. 发明授权

US5436369A Alicyclic phospholipase A.sub.2 inhibitors 失效
标题翻译：脂环磷脂酶A2抑制剂
公开(公告)号：US5436369A
公开(公告)日：1995-07-25
申请号：US200798
申请日：1994-02-23
申请人： Joanne J. Bronson , Katharine M. Greene , Muzammil M. Mansuri , Stanley V. D'Andrea , F. Ivy Carroll , Anita Lewin
发明人： Joanne J. Bronson , Katharine M. Greene , Muzammil M. Mansuri , Stanley V. D'Andrea , F. Ivy Carroll , Anita Lewin
IPC分类号： C07C69/612 , A61K31/19 , A61P29/00 , C07C63/66 , C07C67/30 , C07C69/00 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/76 , C07C69/94 , C07C63/64
CPC分类号： C07C63/66 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/76 , C07C69/94 , C07C2103/74
摘要： Certain novel alicyclic compounds are effective phospholipase A.sub.2 (PLA.sub.2) inhibitors.
摘要翻译：某些新型脂环化合物是有效的磷脂酶A2（PLA2）抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式