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1. 发明申请

WO03053966A8 1-ALKYL-1-AZONIABICYCLO [2.2.2] OCTANE CARBAMATE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 1-烷基-1-亚氮杂环戊二烯[2.2.2]月桂酸衍生物及其作为收敛剂拮抗剂的用途
公开(公告)号：WO03053966A8
公开(公告)日：2004-06-24
申请号：PCT/EP0214470
申请日：2002-12-18
申请人： S A L V A T LAB SA , CATENA RUIZ JUAN LORENZO , FARRERONS GALLEMI CARLES , FERNANDEZ SERRAT ANNA , MIQUEL BONO IGNACIO JOSE , BALSA LOPEZ DOLORS , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , FERNANDEZ GARCIA ANDRES
发明人： CATENA RUIZ JUAN LORENZO , FARRERONS GALLEMI CARLES , FERNANDEZ SERRAT ANNA , MIQUEL BONO IGNACIO JOSE , BALSA LOPEZ DOLORS , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , FERNANDEZ GARCIA ANDRES
IPC分类号： A61K31/439 , A61K31/444 , A61K31/506 , A61K45/00 , A61K45/06 , A61P1/00 , A61P7/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/10 , A61P27/02 , A61P43/00 , C07D453/02 , C07D453/06 , A61K31/435
CPC分类号： A61K45/06 , C07D453/02
摘要： Carbamate of general formula (I), wherein R1, R2 and R3 are H, OH, NO2, SH, CN, F, Cl, Br, I, COOH, CONH2, (C1-C4)-alkoxycarbonyl, (C1C4)-alkylsulfanyl, (C1-C4)-alkylsulfinyl, (C1C4)-alkylsulfonyl, (C1-C4)-alkoxyl optionally substituted with one or several F, and (C1-C4)-alkyl optionally substituted with one or several F or OH; R4 is cycloalkyl, phenyl, heteroaryl or a bicyclic ring system; R5 is cycloalkyl, (C5-C10)-alkyl, a substituted (C1-C10)-alkyl; and X is a physiologically acceptable anion. Carbamate (I) is selective M3 receptor antagonists versus M2 receptor and may be used for the treatment of urinary incontinence (particularly, the one caused by overactive bladder), irritable bowel syndrome, and respiratory disorders (particulary, chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema, and rhinitis), as well as in ophthalmic interventions.
摘要翻译：通式（I）的氨基甲酸酯，其中R 1，R 2和R 3是H，OH，NO 2，SH，CN，F，Cl，Br，I，COOH，CONH 2，（C 1 -C 4） - 烷氧基羰基，（C 1 -C 4），（C 1 -C 4） - 烷基亚磺酰基，（C 1 -C 4） - 烷基磺酰基，任选被一个或几个F取代的（C 1 -C 4） - 烷氧基和任选被一个或几个F或OH取代的（C 1 -C 4） - 烷基; R4是环烷基，苯基，杂芳基或双环系统; R5是环烷基，（C5-C10） - 烷基，取代的（C1-C10） - 烷基; 而X - 是生理上可接受的阴离子。氨基甲酸酯（I）是选择性M3受体拮抗剂对M2受体，可用于治疗尿失禁（特别是由膀胱过度活动引起的），肠易激综合征和呼吸系统疾病（特别是慢性阻塞性肺病，慢性支气管炎，哮喘，肺气肿和鼻炎）以及眼科干预。

2. 发明申请

WO2006010775A8 TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS 审中-公开
标题翻译：酪氨酸衍生物作为PPAR-GAMMA调节剂
公开(公告)号：WO2006010775A8
公开(公告)日：2006-06-15
申请号：PCT/EP2005053728
申请日：2005-07-29
申请人： S A L V A T LAB SA , SERRA COMAS CARMEN , FERNANDEZ SERRAT ANNA , BALSA LOPEZ DOLORS , MASIP MASIP ISABEL , CATENA RUIZ JUAN LORENZO , HIDALGO RODRIGUEZ JOSE , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , FERNANDEZ GARCIA ANDRES
发明人： SERRA COMAS CARMEN , FERNANDEZ SERRAT ANNA , BALSA LOPEZ DOLORS , MASIP MASIP ISABEL , CATENA RUIZ JUAN LORENZO , HIDALGO RODRIGUEZ JOSE , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , FERNANDEZ GARCIA ANDRES
IPC分类号： C07C233/88 , A61K31/198 , A61K31/341 , A61K31/4406 , A61K31/47 , A61P3/04 , A61P3/10 , C07C229/36 , C07C233/20 , C07C233/69 , C07D213/56 , C07D215/14 , C07D307/54
CPC分类号： C07D213/81 , C07C229/36 , C07C233/20 , C07C233/24 , C07C233/60 , C07C233/69 , C07C233/88 , C07C2601/02 , C07C2601/04 , C07D213/56 , C07D213/82 , C07D215/48 , C07D217/26 , C07D241/24 , C07D241/44 , C07D307/52 , C07D307/54 , C07D307/68 , C07D333/20 , C07D333/24 , C07D333/38
摘要： Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents -(CH 2 ) s -N(COR 3 )-A-J-T or -(CH 2 ) S -N(R 4 )-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPAR? modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
摘要翻译：通式I的化合物及其盐和溶剂化物，其中R1代表2-苯甲酰基苯基; R 2表示 - （CH 2 CH 2）n -N（COR 3） - ， - 或 - （CH 2 2） _{取值 -N（R _{4 ） - BJT; 和s，R3，R4，A，B，J和T具有说明书中公开的含义。这些化合物是PPAR？因此，可用于治疗或预防由这些受体介导的疾病或疾病。}}

3. 发明申请

WO2004004682A3 STABLE OILY SUSPENSION OF MICROGRANULES 审中-公开
标题翻译：微生物稳定的油悬浮物
公开(公告)号：WO2004004682A3
公开(公告)日：2004-10-28
申请号：PCT/EP0306927
申请日：2003-06-30
申请人： S A L V A T LAB SA , ARTALEJO ORTEGA BEATRIZ , BATLLORI CALBO JAVIER , FERNANDEZ GARCIA ANDRES , JULVE RUBIO JORDI
发明人： ARTALEJO ORTEGA BEATRIZ , BATLLORI CALBO JAVIER , FERNANDEZ GARCIA ANDRES , JULVE RUBIO JORDI
IPC分类号： A61K9/00 , A61K9/50 , A61K31/4439 , A61K9/10 , A61K31/4184 , A61K47/10 , A61K47/44
CPC分类号： A61K9/0095 , A61K9/5078 , A61K31/4439
摘要： Pharmaceutical formulation obtainable subjecting conventional microgranules to an external seal-coating layer that avoids the penetration of liquid vehicle, and selecting a hydrophobic liquid vehicle with a viscosity high enough not to wet the microgranules. The seal-coating layer may be obtained by coating the microgranules with an aqueous suspension comprising film formers and plasticizers. The liquid vehicle is comprised of oily solvents, and viscosity agents. The formulation is presented in single dose sachets ready-to-use. This formulation enables the liquid oral administration of antiulcerous microgranules of benzimidazoles (omeprazole, lansoprazole, pantoprazole, rabeprazole), with several advantages comparing to commercially available extemporaneous suspensions. The new formulation of lansoprazole microgranules has a similar bioavailability and slightly higher stability than conventional hard gelatin capsules.
摘要翻译：药物制剂可通过将常规微粒剂施加到避免液体载体渗透的外部密封包衣层上，并选择粘度足够高以不润湿微粒剂的疏水性液体载剂。密封包衣层可以通过用包含成膜剂和增塑剂的含水悬浮液包衣微粒剂来获得。液体载体由油性溶剂和粘度剂组成。该制剂以即用型单剂量小袋包装。该制剂能够液体口服给药苯并咪唑（奥美拉唑，兰索拉唑，泮托拉唑，雷贝拉唑）的抗微生物微粒剂，与市售即用悬浮液相比具有几个优点。兰索拉唑微粒的新制剂具有与常规硬明胶胶囊相似的生物利用度和稍高的稳定性。

4. 发明申请

WO2004110983A8 NEW BENZAMIDES AS PPARϒ MODULATORS 审中-公开
标题翻译：新的苯甲酸酯作为PPARY调制剂
公开(公告)号：WO2004110983A8
公开(公告)日：2005-08-11
申请号：PCT/EP2004006330
申请日：2004-06-11
申请人： S A L V A T LAB SA , FERNANDEZ SERRAT ANNA , SERRA COMAS CARME , BALSA LOPEZ DOLORS , LLEBARIA SOLDEVILA AMADEU , FARRERONS GALLEMI CARLES , MIQUEL BONO IGNACIO JOSE , CATENA RUIZ JUAN LORENZO , LAGUNAS ARNAL CARMEN , CORDOMI MONTOYA ARNAU , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , MARRERO GONZALEZ PEDRO , HARO BAUTISTA DIEGO , FERNANDEZ GARCIA ANDRES
发明人： FERNANDEZ SERRAT ANNA , SERRA COMAS CARME , BALSA LOPEZ DOLORS , LLEBARIA SOLDEVILA AMADEU , FARRERONS GALLEMI CARLES , MIQUEL BONO IGNACIO JOSE , CATENA RUIZ JUAN LORENZO , LAGUNAS ARNAL CARMEN , CORDOMI MONTOYA ARNAU , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , MARRERO GONZALEZ PEDRO , HARO BAUTISTA DIEGO , FERNANDEZ GARCIA ANDRES
IPC分类号： A61P5/00 , C07C235/52 , C07D209/18 , C07D213/30 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/26 , C07D223/16 , C07D233/54 , C07D241/44 , C07D277/64 , C07D333/16 , A61K31/166 , A61K31/381 , A61K31/404 , A61K31/435 , A61K31/498 , C07D209/04 , C07D213/02 , C07D241/40 , C07D333/08
CPC分类号： C07D213/30 , C07C235/52 , C07D209/18 , C07D215/20 , C07D215/227 , C07D215/26 , C07D223/16 , C07D233/54 , C07D241/44 , C07D277/64 , C07D333/16
摘要： Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.
摘要翻译：一般结构（I）的化合物，其中中间苯环可以在间位或对位取代; -A是任选取代的羟基，烷氧基，羟胺，烷氧基胺或胺基; -W是从几种可能性中选择的N-和C-连接的双基; -Z是选自几种可能性的碳根。这些化合物是PPARγ和PPARγ/PPARδ调节剂，因此可用于预防性和/或治疗性治疗由这些重症患者介导的病症或疾病。

5. 发明申请

WO2004110983A2 NEW BENZAMIDES AS PPRTϒ MODULATORS 审中-公开
标题翻译：新的苯甲酸酯作为PPRTY调制剂
公开(公告)号：WO2004110983A2
公开(公告)日：2004-12-23
申请号：PCT/EP2004006330
申请日：2004-06-11
申请人： S A L V A T LAB SA , FERNANDEZ SERRAT ANNA , SERRA COMAS CARME , BALSA LOPEZ DOLORS , LLEBARIA SOLDEVILA AMADEU , FARRERONS GALLEMI CARLES , MIQUEL BONO IGNACIO JOSE , CATENA RUIZ JUAN LORENZO , LAGUNAS ARNAL CARMEN , CORDOMI MONTOYA ARNAU , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , MARRERO GONZALEZ PEDRO , HARO BAUTISTA DIEGO , FERNANDEZ GARCIA ANDRES
发明人： FERNANDEZ SERRAT ANNA , SERRA COMAS CARME , BALSA LOPEZ DOLORS , LLEBARIA SOLDEVILA AMADEU , FARRERONS GALLEMI CARLES , MIQUEL BONO IGNACIO JOSE , CATENA RUIZ JUAN LORENZO , LAGUNAS ARNAL CARMEN , CORDOMI MONTOYA ARNAU , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , MARRERO GONZALEZ PEDRO , HARO BAUTISTA DIEGO , FERNANDEZ GARCIA ANDRES
IPC分类号： A61P5/00 , C07C235/52 , C07D209/18 , C07D213/30 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/26 , C07D223/16 , C07D233/54 , C07D241/44 , C07D277/64 , C07D333/16 , C07C235/00
CPC分类号： C07D213/30 , C07C235/52 , C07D209/18 , C07D215/20 , C07D215/227 , C07D215/26 , C07D223/16 , C07D233/54 , C07D241/44 , C07D277/64 , C07D333/16
摘要： Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.
摘要翻译：一般结构（I）的化合物，其中中间苯环可以在间位或对位取代; -A是任选取代的羟基，烷氧基，羟胺，烷氧基胺或胺基; -W是从几种可能性中选择的N-和C-连接的双基; -Z是选自几种可能性的碳根。这些化合物是PPARγ和PPARγ/PPARδ调节剂，因此可用于预防性和/或治疗性治疗由这些重症患者介导的病症或疾病。

7. 发明专利

GEP20084477B NEW BENZAMIDES AS PPARγ MODULATORS 未知
公开(公告)号：GEP20084477B
公开(公告)日：2008-09-10
申请号：GEAP2004009172
申请日：2004-06-11
申请人： S A L V A T LAB SA
发明人： CATENA RUIZ JUAN LORENZO , FARRERONS GALLEMI CARLES , MIQUEL BONO IGNACIO JOSE , BALSA LOPEZ DOLORS , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , FERNANDEZ SERRAT ANNA , SERRA COMAS CARMEN , LLEBARIA SOLDEVILA AMADEU , CORDOMI MONTOYA ARNAU , MARRERO GONZALEZ PEDRO , HARO BAUTISTA DIEGO , FERNANDEZ GARCIA ANDRES
IPC分类号： C07C235/52 , A61K31/166 , A61K31/381 , A61K31/404 , A61K31/435 , A61K31/498 , A61P5/00 , C07D209/04 , C07D209/18 , C07D213/02 , C07D213/30 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/26 , C07D223/16 , C07D233/54 , C07D241/40 , C07D241/44 , C07D277/64 , C07D333/08 , C07D333/16
摘要： Compounds of formula I wherein Z, W and A are provided in the claims; said compounds are PPARγ and PPARγ/ PPARγ mo¬dulators and therefore, are useful for the prophylactic and/or curative treatment of a condi¬ti¬on or a disease mediated by these receptors inclu¬ding cardiovascular disease associated with a meta¬bolic effect for the prophylactic and/or curative treatment of inflammation or an inflammatory process, cancer and other diseases.

8. 发明专利

EA009038B1 ЗАМЕЩЕННЫЕ ИМИДАЗОПИРИМИДИНЫ ДЛЯ ПРЕДУПРЕЖДЕНИЯ И ЛЕЧЕНИЯ РАКА 未知
公开(公告)号：EA009038B1
公开(公告)日：2007-10-26
申请号：EA200600330
申请日：2004-07-29
申请人： S A L V A T LAB SA
发明人： CATENA RUIZ JUAN LORENZO , FARRERONS GALLEMI CARLES , FERNANDEZ SERRAT ANNA , SERRA COMAS CARMEN , BALSA LOPEZ DOLORS , LAGUNAS ARNAL CARMEN , SALCEDO ROSA CAROLINA , FERNANDEZ GARCIA ANDRES
IPC分类号： C07D487/04 , A61K31/505 , A61P35/00 , C07D235/00 , C07D239/00
摘要： Соединенияобщейформулы (I), гдеА1-А5 иВ1-В5 означают, средипрочих, Н, алкил, алкоксил, галоген, карбоксильныепроизводныеилипроизводныесеры; и P1-P3 означают, средипрочих, Н, галоген, алкилилиалкоксил. Вышеупомянутыесоединенияможноприменятьдляхимиопрофилактикии лечениякакпредраковыхпоражений, таки рака.

9. 发明专利

AT370129T 未知
公开(公告)号：AT370129T
公开(公告)日：2007-09-15
申请号：AT02748888
申请日：2002-07-17
申请人： S A L V A T LAB SA
发明人： FARRERONS GALLEMI CARLES , LAGUNAS ARNAL CARMEN , FERNANDEZ SERRAT ANNA , CATENA RUIZ JUAN LORENZO , MIQUEL BONO IGNACIO JOSE , BALSA LOPEZ DOLORS , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , FERNANDEZ GARCIA ANDRES
IPC分类号： C07D261/08 , C07D261/14 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/496 , A61P31/00 , A61P35/00 , C07D413/12 , C07D413/14 , C07D417/14
摘要： 3-(heterocyclyl-substituted aryl)-5-substituted-isoxazole derivatives (I) are new. 3-(heterocyclyl-substituted aryl)-5-substituted-isoxazole derivatives of formula (I), their stereoisomers or mixtures, different polymorphs or mixtures, N-oxides, solvates and salts are new. [Image] X : O, S, NH, OCO, NHCO, NHCOO, NHCS, NHCONH or NHCSNH; R 4>H, 1-3C alkyl (optionally substituted by 1-3 F, Cl or Br) or Het 1>; R 1>, R 3>H or F; Het 1>C-bound 5-membered ring having 1-4 N, O or S atoms and optionally substituted by NH 2, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylamino, 1-4C alkoxycarbonyl, 1-4C alkylcarbonyl, amido, CN, NO 2, F, Cl or Br, or a 6-membered ring with 1-3 N, and optionally substituted by 1-3 F, Cl or Br; R 2>pyrrolidin-1-yl, 2-oxopyrrolidin-1-yl, 1,3,4-triazol-1-yl, tetrazol-1-yl, or pyrrol-1-yl or 1,2,4-triazol-1-yl (both 3-substituted by R 6>), or pyrazol-1-yl, imidazol-1-yl, 1,2,5-triazol-1-yl, 1,2,3-triazol-1-yl or tetrazol-1-yl (all 4-substituted by R 6>), or a group of formula (i)-(vi); Q : O, S(O) xor NR 5>; x : 0-2; R 5>-(CH 2) nCOR 7>, SO 2R 7>or a group of formula (vii)-(xii); Q 1>O or S; R 1>6>-R 1>8>COR 9>, COOR 9>, CN, NO 2or C=NR 1>0>; R 7>1-4C alkyl, 1-3C alkenyl (sic), -(CH 2) p-R' 2>, -(CH 2) m-Y-(CH 2) q-R 8>or Het 2>; n, p, q, m : 0-8; Y : O, S or NH; R' 2>R 2>excluding (ii); R 8>H, 1-3C alkyl, vinyl, allyl, ethynyl, propargyl, phenyl or an optionally fused aromatic system comprising one or more 5-6 membered rings, optionally including 1-3 O, S or N and optionally substituted by 1-3 T; T, R 1>3>-R 1>5>1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, NHCOR 9>, NHCOOR 9>, COR 9>, COOR 9>, CN, NO 2, CH=NR 1>0>, F, Cl or Br; R 9>H, 1-3C alkyl or NR 1>1>R 1>2>; R 1>1>, R 1>2>H or 1-3C alkyl; R 1>0>H, 1-3C alkyl, phenyl, benzyl, OH or 1-3C alkoxy; Het 2>a group of formula (xiii)-(xix); R 6>H, F, Cl, Br, CF 3, CN, NO 2, carbamoyl, hydroxymethyl, 1-3C alkyl, 1-3C alkoxy, 1-3C alkoxycarbonyl, 1-3C alkylcarbonyl, 1-3C alkoxy, benzyloxy-1-3C alkoxy, CONR 1>9>R 2>0>, NR 1>9>R 2>0>, 1-3C alkylamino, 1-3C alkyl-CH=NOR 2>1>, CH=NOR 21>, CH=CR 22>R 2>3>, (CH 2) sNHR 1>9>, or CH=NR 1>9>; R 1>9>, R 2>0>H, 1-3C alkyl, COR 2>4>or optionally fused aromatic system comprising one or more 5-6 membered rings, optionally including 1-3 O, S or N and optionally substituted by 1-3 T; R 2>1>H or 1-3C alkyl; R 2>2>, R 2>3>H, CN, NO 2, CONR 1>9>R 2>0>or hydroxymethyl; R 2>4>H, 1-3C alkyl or alkoxy or Het 2>; and s : 0-4. [Image] [Image] [Image] ACTIVITY : Antibacterial; Cytostatic. In tests to determine antibacterial activity, 3-[3-fluoro-4-(hydroxyacetyl)piperazin-1-yl-phenyl]-5-(isoxazol-3-yl-aminomethyl) isoxazole displayed MIC values of 4, 2 and 8 Microg/ml against Streptococcus faecalisBCM-010, Staphylococcus aureusBCM-012 and Moraxella catarrhalisBCM-015, respectively. MECHANISM OF ACTION : None given.

10. 发明专利

EA006505B1 ПРОИЗВОДНЫЕ КАРБАМАТА 1-АЛКИЛ-1-АЗОНИАБИЦИКЛО[2.2.2]ОКТАНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТАГОНИСТОВ МУСКАРИНОВОГО РЕЦЕПТОРА 未知
公开(公告)号：EA006505B1
公开(公告)日：2005-12-29
申请号：EA200400832
申请日：2002-12-18
申请人： S A L V A T LAB SA
发明人： CATENA RUIZ JUAN LORENZO , FARRERONS GALLEMI CARLES , FERNANDEZ SERRAT ANNA , MIQUEL BONO IGNACIO JOSE , BALSA LOPEZ DOLORS , LAGUNAS ARNAL CARMEN , SALCEDO ROCA CAROLINA , TOLEDO MESA NATIVIDAD , FERNANDEZ GARCIA ANDRES
IPC分类号： A61K31/439 , A61K31/444 , A61K31/506 , A61K45/00 , A61K45/06 , A61P1/00 , A61P7/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/10 , A61P27/02 , A61P43/00 , C07D453/02 , C07D453/06 , A61K31/435
摘要： Карбаматобщейформулы (I), где R1, R2 и R3 означаютН, ОН, NO, SH, CN, F, Cl, Br, I, COOH, CONH, (С-С)-алкоксикарбонил, (C-C)-алкилсульфанил, (C-C)-алкилсульфинил, (С-С)-алкилсульфонил, (С-С)-алкоксил, необязательнозамещенныйоднимилинесколькимиатомами F, и (С-С)-алкил, необязательнозамещенныйоднимилинесколькимиатомами F илиОН; R4 означаетциклоалкил, фенил, гетероарилилибициклическуюкольцевуюсистему; R5 означаетциклоалкил, (C-С)-алкил, замещенный (C-С)-алкил, и Xозначаетфизиологическиприемлемыйанион. Карбаматы (I) являютсяселективнымиантагонистамирецептораМпротиврецептораМимогутбытьиспользованыдлялечениянедержаниямочи (особенно, еслионовызваносверхактивностьюмочевогопузыря), синдромараздраженнойтолстойкишкии респираторныхрасстройств (вчастности, хроническойобструктивнойболезнилегких, хроническогобронхита, астмы, эмфиземыи ринита), атакжеприофтальмическихвмешательствах.

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