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1. 发明申请

US20070082370A1 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
标题翻译：血浆或血清分离膜和包括血浆或血清分离膜的过滤装置
公开(公告)号：US20070082370A1
公开(公告)日：2007-04-12
申请号：US11635239
申请日：2006-12-07
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： G01N33/567 , C12M3/00
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.
摘要翻译：能够省略离心分离的血浆或血清分离膜不会因红细胞破坏引起溶血，并能实现血液或血清从血液中的轻松快速分离; 以及包括血浆或血清分离膜的过滤装置。特别地，血浆或血清分离膜是用于从血液中分离血浆或血清并具有30％或更低的空隙率的膜; 以及过滤器装置，其包括能够获得比等离子体更快速移动的过滤器构件，以及与过滤构件的后侧串联连接的血浆或血清分离膜。

2. 发明授权

US07744820B2 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
标题翻译：血浆或血清分离膜和包括血浆或血清分离膜的过滤装置
公开(公告)号：US07744820B2
公开(公告)日：2010-06-29
申请号：US11635239
申请日：2006-12-07
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： B01L11/00 , G01N15/06 , C12M1/36 , C12M1/34 , G01N1/00 , G01N1/18 , B01D33/00 , B01D63/00
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.
摘要翻译：能够省略离心分离的血浆或血清分离膜不会因红细胞破坏引起溶血，并能实现血液或血清从血液中的轻松快速分离; 以及包括血浆或血清分离膜的过滤装置。特别地，血浆或血清分离膜是用于从血液中分离血浆或血清并具有30％或更低的空隙率的膜; 以及过滤器装置，其包括能够获得比等离子体更快速移动的过滤器构件，以及与过滤构件的后侧串联连接的血浆或血清分离膜。

3. 发明申请

US20060171915A1 Blood coagulation promoter and blood collection tube 有权
标题翻译：血液凝固促进剂和采血管
公开(公告)号：US20060171915A1
公开(公告)日：2006-08-03
申请号：US10548541
申请日：2004-04-21
申请人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
发明人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
IPC分类号： A61K38/48 , A61K31/765 , A61K31/785
CPC分类号： C08L71/02 , A61B5/15003 , A61B5/150755 , A61B5/154 , B01L3/5082 , C08L2666/04
摘要： The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.
摘要翻译：本发明提供能够发挥优异的凝血促进能力和优异的血块分离能力的凝血促进剂; 以及容纳血液凝固促进剂的采血管。本发明提供一种凝血促进剂，其包含难溶于水的聚氧化烯衍生物; 部分皂化聚乙烯醇; 选自吸附性无机物质和能够水解Arg和任意氨基酸之间的键的水解物中的至少一种物质存在于肽链中Lys和任意氨基酸残基之间的和/或之间的键; 聚乙烯吡咯烷酮优选水溶性硅油，以及血液收集管，其中所述血液凝固促进剂容纳在具有底部的管状容器中。

4. 发明授权

US08586323B2 Blood coagulation promoter and blood collection tube comprising a polyoxyalkylene glycerin derivative 有权
标题翻译：含有聚氧化烯甘油衍生物的凝血促进剂和采血管
公开(公告)号：US08586323B2
公开(公告)日：2013-11-19
申请号：US10548541
申请日：2004-04-21
申请人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
发明人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
IPC分类号： C12Q1/56 , G01N33/86
CPC分类号： C08L71/02 , A61B5/15003 , A61B5/150755 , A61B5/154 , B01L3/5082 , C08L2666/04
摘要： The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter.The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.
摘要翻译：本发明提供能够发挥优异的凝血促进能力和优异的血块分离能力的凝血促进剂; 以及容纳血液凝固促进剂的采血管。本发明提供一种凝血促进剂，其包含难溶于水的聚氧化烯衍生物; 部分皂化聚乙烯醇; 选自吸附性无机物质和能够水解Arg和任意氨基酸之间的键的水解物中的至少一种物质存在于肽链中Lys和任意氨基酸残基之间的和/或之间的键; 聚乙烯吡咯烷酮优选水溶性硅油，以及血液收集管，其中所述血液凝固促进剂容纳在具有底部的管状容器中。

5. 发明授权

US08795957B2 Blood collection container 有权
标题翻译：采血容器
公开(公告)号：US08795957B2
公开(公告)日：2014-08-05
申请号：US13033120
申请日：2011-02-23
申请人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
发明人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
IPC分类号： A01N1/02
CPC分类号： A61B5/150755 , A61B5/15003 , A61B5/150351 , A61B5/154 , B01L3/5082 , B01L2300/163
摘要： The present invention provides a blood collection container capable of allowing blood to coagulate in a short time and preventing blood from coagulating with bubbles contained therein and thus preventing formation of bubbly clots when used to collect blood therein. A blood collection container 1 stores a blood coagulation promoting agent 4 for promoting blood coagulation and an antifoaming agent 5, which is a polyoxyalkylene or a derivative thereof. The amount of the antifoaming agent 5 is 2.0×10−3 to 0.2 mg per mL of blood to be collected in the blood collection container 1.
摘要翻译：本发明提供一种采血容器，其能够使血液在短时间内凝结，并且防止血液凝结，其中含有气泡，从而防止在用于在其中收集血液时形成气泡凝块。采集容器1存储促凝血用促凝剂4和作为聚氧化烯或其衍生物的消泡剂5。消肿剂5的量在采血容器1中收集的每毫升血液量为2.0×10-3〜0.2mg。

6. 发明授权

US07993847B2 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
公开(公告)号：US07993847B2
公开(公告)日：2011-08-09
申请号：US11635240
申请日：2006-12-07
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： G01N1/00 , G01N33/53
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.

7. 发明申请

US20100248329A1 BLOOD COAGULATION PROMOTER AND BLOOD COLLECTION TUBE 审中-公开
标题翻译：血液凝血促进剂和血液收集管
公开(公告)号：US20100248329A1
公开(公告)日：2010-09-30
申请号：US12757956
申请日：2010-04-09
申请人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
发明人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
IPC分类号： C12N9/48 , C12M1/00
CPC分类号： A61B5/150755 , A61B5/150015 , B01L3/5082 , C08L29/04 , C08L39/06 , C08L71/02 , C08L2203/02 , C08L2666/04
摘要： The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability, and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.
摘要翻译：本发明提供能够发挥优异的凝血促进能力和优异的血块分离能力的凝血促进剂，以及容纳凝血促进剂的采血管。本发明提供一种凝血促进剂，其包含难溶于水的聚氧化烯衍生物; 部分皂化聚乙烯醇; 选自吸附性无机物质和能够水解Arg和任意氨基酸之间的键的水解物中的至少一种物质存在于肽链中Lys和任意氨基酸残基之间的和/或之间的键; 聚乙烯吡咯烷酮优选水溶性硅油，以及血液收集管，其中所述血液凝固促进剂容纳在具有底部的管状容器中。

8. 发明授权

US09028688B2 Instrument for separating blood and apparatus for separating blood 有权
标题翻译：用于分离血液的仪器和用于分离血液的装置
公开(公告)号：US09028688B2
公开(公告)日：2015-05-12
申请号：US11994055
申请日：2006-06-26
申请人： Ryusuke Okamoto , Katsuya Togawa
发明人： Ryusuke Okamoto , Katsuya Togawa
IPC分类号： B01D29/00 , B01L3/00 , G01N33/49
CPC分类号： B01L3/5635 , B01L2300/0681 , G01N33/491
摘要： Blood separation material which separates blood collected in a blood-sampling container, into blood cells and plasma or serum within a short period of time. An apparatus for separating blood with the blood separation material. An instrument for separating blood having a first hollow needle extending toward one end, a second hollow needle extending toward the other end, a tubular container with an inner space in which the blood flows, and a blood separation material. A container with a first channel for supplying blood into an inner space through which blood flows from the needlepoint of the first hollow needle into the inner space, a second channel for blood to flow out from the inner space toward the needlepoint of the second hollow needle, and a third channel which allows air to flow from the outer space toward the needlepoint of the first hollow needle.
摘要翻译：将在血液取样容器中收集的血液在短时间内分离成血细胞和血浆或血清的血液分离材料。一种用血液分离材料分离血液的装置。一种用于分离具有朝向一端延伸的第一中空针的血液的仪器，朝向另一端延伸的第二空心针，具有血液流过的内部空间的管状容器和血液分离材料。一种具有第一通道的容器，用于将血液供应到内部空间中，血液从第一中空针的针尖流到内部空间，血液从内部空间朝向第二中空针的针尖流出的第二通道以及第三通道，其允许空气从外部空间朝向第一中空针的针尖流动。

9. 发明申请

US20110144536A1 BLOOD COLLECTION CONTAINER 有权
标题翻译：血液收集容器
公开(公告)号：US20110144536A1
公开(公告)日：2011-06-16
申请号：US13033120
申请日：2011-02-23
申请人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
发明人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
IPC分类号： A61B5/15
CPC分类号： A61B5/150755 , A61B5/15003 , A61B5/150351 , A61B5/154 , B01L3/5082 , B01L2300/163
摘要： The present invention provides a blood collection container capable of allowing blood to coagulate in a short time and preventing blood from coagulating with bubbles contained therein and thus preventing formation of bubbly clots when used to collect blood therein. A blood collection container 1 stores a blood coagulation promoting agent 4 for promoting blood coagulation and an antifoaming agent 5, which is a polyoxyalkylene or a derivative thereof. The amount of the antifoaming agent 5 is 2.0×10−3 to 0.2 mg per mL of blood to be collected in the blood collection container 1.
摘要翻译：本发明提供一种采血容器，其能够使血液在短时间内凝结，并且防止血液凝结，其中含有气泡，从而防止在用于在其中收集血液时形成气泡凝块。采集容器1存储促凝血用促凝剂4和作为聚氧化烯或其衍生物的消泡剂5。消肿剂5的量在采血容器1中收集的每毫升血液量为2.0×10-3〜0.2mg。

10. 发明授权

US07927810B2 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
标题翻译：血浆或血清分离膜和包括血浆或血清分离膜的过滤装置
公开(公告)号：US07927810B2
公开(公告)日：2011-04-19
申请号：US10533539
申请日：2003-11-18
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.
摘要翻译：能够省略离心分离的血浆或血清分离膜不会因红细胞破坏引起溶血，并能实现血液或血清从血液中的轻松快速分离; 以及包括血浆或血清分离膜的过滤装置。特别地，血浆或血清分离膜是用于从血液中分离血浆或血清并具有30％或更低的空隙率的膜; 以及过滤器装置，其包括能够获得比等离子体更快速移动的过滤器构件，以及与过滤构件的后侧串联连接的血浆或血清分离膜。

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