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1. 发明授权

US08067384B2 Chimera (double) decoy 有权
标题翻译：嵌合（双）诱饵
公开(公告)号：US08067384B2
公开(公告)日：2011-11-29
申请号：US11662777
申请日：2005-10-20
申请人： Ryuichi Morishita , Toshio Ogihara , Motokuni Aoki , Takashi Miyake
发明人： Ryuichi Morishita , Toshio Ogihara , Motokuni Aoki , Takashi Miyake
IPC分类号： C12N15/11 , C12N15/113 , C12N15/115
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/13 , C12N2310/3519
摘要： The present invention provides a prophylactic, ameliorative or therapeutic medicament for vascular restenosis, ischemic disease, allergic disease, inflammatory disease, autoimmune disease, or cancer metastasis, invasion (cancer metastasis/invasion) or cachexia based on the inhibitory action on a plural of transcriptional regulatory factor. A chimera (double) decoy of the present invention has plural transcriptional regulatory factor binding sequences in a single molecule thereof. Thus, it is able to inhibit the activity of plural transcriptional regulatory factors with a single molecule. For example, stenosis of an anastomosed site of an artificial blood vessel is caused by thickening of the vascular intima, and this is mainly caused by activation of cell proliferation by an inflammatory reaction occurring at the anastomosed site. Thus, thickening of vessel walls can be inhibited by simultaneously inhibiting two transcriptional regulatory factors involved in inflammation and cell proliferation by using the chimera decoy of the present invention.
摘要翻译：本发明提供了一种用于血管再狭窄，缺血性疾病，过敏性疾病，炎性疾病，自身免疫性疾病或癌症转移，侵袭（癌症转移/侵袭）或恶病质的预防，改善或治疗药物，其基于对多种转录的抑制作用监管因素。本发明的嵌合体（双）诱饵在其单个分子中具有多个转录调节因子结合序列。因此，能够用单个分子抑制多个转录调节因子的活性。例如，人造血管的吻合部位的狭窄是由血管内膜的增厚引起的，这主要是由在吻合部位发生的炎性反应的细胞增殖的激活引起的。因此，通过使用本发明的嵌合体诱饵同时抑制涉及炎症和细胞增殖的两种转录调节因子，可以抑制血管壁的增厚。

2. 发明申请

US20070259826A1 Chimeric (Double) Decoy 有权
标题翻译：嵌合（双）诱饵
公开(公告)号：US20070259826A1
公开(公告)日：2007-11-08
申请号：US11662777
申请日：2005-10-20
申请人： Ryuichi Morishita , Toshio Ogihara , Motokuni Aoki , Takashi Miyake
发明人： Ryuichi Morishita , Toshio Ogihara , Motokuni Aoki , Takashi Miyake
IPC分类号： A61K31/713 , A61K31/70 , A61K31/7105 , A61P17/06 , A61P35/04 , A61P41/00 , C07H21/02 , C07H21/04 , A61P9/10 , A61P37/08 , A61P29/00 , A61P17/00 , A61K31/711
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/13 , C12N2310/3519
摘要： The present invention provides a prophylactic, ameliorative or therapeutic medicament for vascular restenosis, ischemic disease, allergic disease, inflammatory disease, autoimmune disease, or cancer metastasis, invasion (cancer metastasis/invasion) or cachexia based on the inhibitory action on a plural of transcriptional regulatory factor. A chimera (double) decoy of the present invention has plural transcriptional regulatory factor binding sequences in a single molecule thereof. Thus, it is able to inhibit the activity of plural transcriptional regulatory factors with a single molecule. For example, stenosis of an anastomosed site of an artificial blood vessel is caused by thickening of the vascular intima, and this is mainly caused by activation of cell proliferation by an inflammatory reaction occurring at the anastomosed site. Thus, thickening of vessel walls can be inhibited by simultaneously inhibiting two transcriptional regulatory factors involved in inflammation and cell proliferation by using the chimera decoy of the present invention.
摘要翻译：本发明提供了一种用于血管再狭窄，缺血性疾病，过敏性疾病，炎性疾病，自身免疫性疾病或癌症转移，侵袭（癌症转移/侵袭）或恶病质的预防，改善或治疗药物，其基于对多种转录的抑制作用监管因素。本发明的嵌合体（双）诱饵在其单个分子中具有多个转录调节因子结合序列。因此，能够用单个分子抑制多个转录调节因子的活性。例如，人造血管的吻合部位的狭窄是由血管内膜的增厚引起的，这主要是由在吻合部位发生的炎性反应的细胞增殖的激活引起的。因此，通过使用本发明的嵌合体诱饵同时抑制涉及炎症和细胞增殖的两种转录调节因子，可以抑制血管壁的增厚。

3. 发明申请

US20110022027A1 DRUG-ELUTING CATHETER AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：药液导管及其制造方法
公开(公告)号：US20110022027A1
公开(公告)日：2011-01-27
申请号：US12921443
申请日：2009-03-12
申请人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
发明人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
IPC分类号： A61L29/16 , A61M25/10 , B05D5/00
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/258 , A61L2300/624 , A61L2400/12 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： Biocompatible nanoparticles 1 which entrap a bioactive substance and whose surface is positive-charge-modified are electrically adhered to a balloon portion 9 of a catheter main body 5 through a negatively charged resin layer 11, and thus a nanoparticle layer 12 is formed. After the catheter main body 5 is indwell in vivo, the nanoparticles 1 are gradually eluted from the nanoparticle layer 12 and are effectively delivered to cells.
摘要翻译：将生物活性物质捕获并将其表面进行正电荷改性的生物相容性纳米粒子1通过带负电的树脂层11电连接到导管主体5的球囊部9，形成纳米粒子层12。在导管主体5体内静置之后，纳米颗粒1从纳米颗粒层12逐渐洗脱并被有效地递送至细胞。

4. 发明申请

US20090069678A1 Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus 审中-公开
标题翻译：超声波药物输送和医学诊断成像仪的方法和装置
公开(公告)号：US20090069678A1
公开(公告)日：2009-03-12
申请号：US12087407
申请日：2007-01-05
申请人： Yoshiaki Taniyama , Ryuichi Morishita , Takashi Miyake , Katsuhiko Fujimoto
发明人： Yoshiaki Taniyama , Ryuichi Morishita , Takashi Miyake , Katsuhiko Fujimoto
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61M37/0092 , A61B5/413 , A61B5/4839 , A61B6/508 , A61B8/00
摘要： According to the present invention, there are provided an ultrasonic drug delivery method and an ultrasonic drug delivery apparatus each capable of performing more localized and efficient drug-delivery with the aid of ultrasonic irradiation under static pressure, which increases the effect of drug delivery to deep tissue parts in treatment by ultrasonic irradiation to a living body for delivery of drugs such as nucleic acids (such as DNA, RNA, decoys, and RNAi), proteins and pharmaceutical compounds, and there is also provided a medical diagnostic imaging apparatus.
摘要翻译：根据本发明，提供了一种超声药物输送方法和超声药物输送装置，其能够在静压下借助超声波照射进行更局部有效的药物输送，这增加了药物输送到深度的作用通过超声波照射到用于输送诸如核酸（例如DNA，RNA，诱饵和RNAi）的药物的生物体的组织部件，蛋白质和药物化合物，并且还提供了医疗诊断成像装置。

5. 发明授权

US09186439B2 Drug-eluting catheter and method of manufacturing the same 有权
标题翻译：药物洗脱导管及其制造方法
公开(公告)号：US09186439B2
公开(公告)日：2015-11-17
申请号：US12921443
申请日：2009-03-12
申请人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
发明人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
IPC分类号： A61L29/16 , A61M25/10 , B05D5/00 , A61L29/08 , A61M25/00
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/258 , A61L2300/624 , A61L2400/12 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： Biocompatible nanoparticles 1 which entrap a bioactive substance and whose surface is positive-charge-modified are electrically adhered to a balloon portion 9 of a catheter main body 5 through a negatively charged resin layer 11, and thus a nanoparticle layer 12 is formed. After the catheter main body 5 is indwell in vivo, the nanoparticles 1 are gradually eluted from the nanoparticle layer 12 and are effectively delivered to cells.
摘要翻译：将生物活性物质捕获并将其表面进行正电荷改性的生物相容性纳米粒子1通过带负电的树脂层11电连接到导管主体5的球囊部9，形成纳米粒子层12。在导管主体5在体内静置之后，纳米颗粒1从纳米颗粒层12逐渐洗脱并被有效地递送至细胞。

6. 发明授权

US09389687B2 Tactile sensation providing apparatus and control method for tactile sensation providing apparatus 有权
标题翻译：触觉感觉提供装置及其触感提供装置的控制方法
公开(公告)号：US09389687B2
公开(公告)日：2016-07-12
申请号：US13812397
申请日：2011-07-05
申请人： Kenji Kono , Takashi Miyake , Takayuki Shinozaki , Megumi Kuwabara , Jun Takeda
发明人： Kenji Kono , Takashi Miyake , Takayuki Shinozaki , Megumi Kuwabara , Jun Takeda
IPC分类号： G06F3/041 , G06F3/01
CPC分类号： G06F3/016 , G06F2203/014 , G06F2203/04105
摘要： A tactile sensation is provided without exchanging a signal indicating a pressing load between a dual chip. A tactile sensation providing apparatus includes a touch sensor, a load detection unit for detecting a pressing load on the sensor, a tactile sensation providing unit for vibrating a face of the sensor, a tactile sensation provision control unit for controlling drive of the providing unit, and a main control unit for controlling an operation of the provision control unit based on an output of the sensor. The main control unit determines whether a predetermined area of the touch face is touched based on the output of the sensor and, when the area is touched, transmits a tactile sensation control instruction to the provision control unit. The provision control unit, upon receiving the instruction from the main control unit, controls drive of the providing unit based on the instruction and the pressing load.
摘要翻译：提供触觉，而不交换指示双芯片之间的按压负载的信号。触觉感觉提供装置包括触摸传感器，用于检测传感器上的按压负载的负载检测单元，用于使传感器的面振动的触感提供单元，用于控制提供单元的驱动的触感提供控制单元，以及主控制单元，用于基于传感器的输出来控制提供控制单元的操作。主控制单元基于传感器的输出来确定触摸面的预定区域是否被触摸，并且当触摸该区域时，将触觉控制指令发送到提供控制单元。提供控制单元在接收到来自主控制单元的指令后，根据该指令和按压负载来控制提供单元的驱动。

7. 发明授权

US09329712B2 Electronic device having changeable touch receiving region 有权
标题翻译：具有可变触摸接收区域的电子设备
公开(公告)号：US09329712B2
公开(公告)日：2016-05-03
申请号：US13982242
申请日：2012-01-27
申请人： Takashi Miyake
发明人： Takashi Miyake
IPC分类号： G06F3/01 , G06F3/041 , G06F3/0488
CPC分类号： G06F3/041 , G06F3/016 , G06F3/0414 , G06F3/0416 , G06F3/0488
摘要： An electronic device (1) prevents unintended operations when a contact position shifts, by having a display unit (20) that displays an object, a contact detection unit (10) that detects contact by a contacting body, a pressure detection unit (30) that detects pressure on the detection unit (10), and a control unit (60) that performs processing associated with the object displayed on the display unit (20) in accordance with a contact position of the contacting body in a region of the detection unit (10) corresponding to an receiving region of the object and with data based on pressure on the detection unit (10) acquired from the pressure detection unit (30), such that when the contact position of the contacting body changes as the data based on pressure increases, the control unit (60) changes the receiving region of the object in a direction of change of the contact position.
摘要翻译：电子设备（1）通过具有显示对象的显示单元（20），检测接触体的接触的接触检测单元（10），压力检测单元（30），防止接触位置偏移时的意外操作，该检测单元检测所述检测单元（10）上的压力;以及控制单元（60），其根据所述接触体在所述检测单元的区域中的接触位置执行与所述显示单元（20）上显示的对象相关联的处理（10）对应于物体的接收区域，并且基于从压力检测单元（30）获取的对检测单元（10）的压力的数据，使得当接触体的接触位置作为基于压力增加时，控制单元（60）根据接触位置的变化方向改变物体的接收区域。

8. 发明授权

US09170651B2 Tactile sensation providing apparatus and control method for tactile sensation providing apparatus 有权
标题翻译：触觉感觉提供装置及其触感提供装置的控制方法
公开(公告)号：US09170651B2
公开(公告)日：2015-10-27
申请号：US13812382
申请日：2011-07-05
申请人： Kenji Kono , Takashi Miyake , Takayuki Shinozaki , Megumi Kuwabara , Jun Takeda
发明人： Kenji Kono , Takashi Miyake , Takayuki Shinozaki , Megumi Kuwabara , Jun Takeda
IPC分类号： G06F3/0487 , G06F3/01 , G06F3/041
CPC分类号： G06F3/016 , G06F3/041 , G06F3/04886 , G06F2203/04105
摘要： By dual chips exchanging a signal indicating a pressing load detected for providing the tactile sensation, application process based thereon is performed. A tactile sensation providing apparatus includes a touch sensor, a load detection unit for detecting the pressing load on the sensor for providing the sensation, a tactile sensation providing unit for vibrating a surface the sensor, a provision control unit for controlling drive of the providing unit, and a main control unit for controlling an application. The main control unit determines whether a predetermined area of the surface is touched based on an output of the sensor and, when touched, transmits an instruction to the provision control unit. The provision control unit, upon receiving the instruction from the main control unit, detects the pressing load and transmits the detected load to the main control unit. The main control unit, based on the load, performs the application process.
摘要翻译：通过双芯片交换指示检测用于提供触感的按压负载的信号，执行基于其的应用处理。触觉感觉提供装置包括触摸传感器，用于检测用于提供感觉的传感器上的按压负载的负载检测单元，用于使传感器的表面振动的触觉提供单元，用于控制提供单元的驱动的提供控制单元以及用于控制应用的主控制单元。主控制单元基于传感器的输出来确定表面的预定区域是否被触摸，并且当被触摸时，向提供控制单元发送指令。提供控制单元在接收到来自主控制单元的指令时，检测按压负载并将检测到的负载发送到主控制单元。主控单元根据负载进行应用处理。

9. 发明授权

US08878419B2 Piezoelectric device 有权
标题翻译：压电元件
公开(公告)号：US08878419B2
公开(公告)日：2014-11-04
申请号：US13348033
申请日：2012-01-11
申请人： Takashi Miyake
发明人： Takashi Miyake
IPC分类号： H03H9/56 , H03H9/13 , H03H3/04
CPC分类号： H03H9/564 , H03H9/132 , H03H9/566 , H03H2003/0471
摘要： A piezoelectric device includes first and second piezoelectric resonators each including a piezoelectric thin film, an upper electrode provided on one main surface of the piezoelectric thin film, and a lower electrode provided on another main surface of the piezoelectric thin film. In the piezoelectric resonators, portions in which the upper and lower electrodes are superposed on each other with the piezoelectric thin film therebetween define piezoelectric vibrating portions that are acoustically isolated from a substrate. The first and second piezoelectric resonators are connected in series or parallel between an input terminal and an output terminal such that polarization directions of corresponding portions of the piezoelectric thin film are opposite to each other when seen from the input terminal. The first piezoelectric resonator and the second piezoelectric resonator are arranged to have different resonant frequencies of a transverse vibration mode.
摘要翻译：压电装置包括第一和第二压电谐振器，每个压电谐振器包括压电薄膜，设置在压电薄膜的一个主表面上的上电极和设置在压电薄膜的另一个主表面上的下电极。在压电谐振器中，上部和下部电极之间的压电薄膜彼此叠置的部分之间形成与基板隔离的压电振动部分。第一和第二压电谐振器串联或并联连接在输入端子和输出端子之间，使得当从输入端子看时压电薄膜的对应部分的偏振方向彼此相反。第一压电谐振器和第二压电谐振器布置成具有不同的横振模式的谐振频率。

10. 发明授权

US08751717B2 Interrupt control apparatus and interrupt control method 有权
标题翻译：中断控制装置和中断控制方法
公开(公告)号：US08751717B2
公开(公告)日：2014-06-10
申请号：US13474246
申请日：2012-05-17
申请人： Takashi Miyake
发明人： Takashi Miyake
IPC分类号： G06F13/26
CPC分类号： G01C21/3629 , G01C21/3655 , G01C21/3697
摘要： An interrupt control apparatus and interrupt control method reduce situations in which the output of interrupt information is suspended and thus reduce stress caused in a user, without missing the appropriate output timing for interrupt information having a high priority level. A priority level setting unit raises the value of a priority level for an interrupt voice message during a period in which the interrupt voice message is being outputted, and a voice output control unit, when interrupts from two or more overlapping interrupt voice messages occurs, carries out control in accordance with priority levels set for each of the two or more interrupt voice messages so that the interrupt voice message having the higher priority level value is preferentially outputted.
摘要翻译：中断控制装置和中断控制方法减少中断信息的输出暂停的情况，从而减少用户产生的压力，而不会丢失具有高优先级的中断信息的适当的输出定时。优先级设置单元在输出中断语音消息的时段期间提高中断语音消息的优先级的值，并且当发生来自两个或更多个重叠的中断语音消息的中断时，语音输出控制单元携带根据为两个或更多个中断语音消息中的每一个设置的优先级来输出控制，使得优先输出具有较高优先级值的中断话音消息。

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