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    • 1. 发明授权
    • Process for producing an optically active .gamma.-hydroxy-L-glutamic acid
    • 用于制备光学活性的γ-羟基-L-谷氨酸的方法
    • US5643769A
    • 1997-07-01
    • US501177
    • 1995-07-11
    • Ryoichi KatsumataShinichi Hashimoto
    • Ryoichi KatsumataShinichi Hashimoto
    • C12P13/04C12P13/14C12P41/00
    • C12P13/04
    • An object of the present invention is to provide a process for producing an optically active .gamma.-hydroxy-L-glutamic acid advantageously on an industrial scale. The present invention provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst I, an amino group donor, pyruvic acid and glyoxylic acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active .gamma.-hydroxy-L-glutamic acid therefrom, said biocatalyst I having activity of forming the optically active .gamma.-hydroxy-L-glutamic acid from pyruvic acid and glyoxylic acid in the presence of an amino group donor. The present invention also provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst II, an amino group donor and optically active 4-hydroxy-2-ketoglutaric acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active 4-hydroxy-2-ketoglutaric acid therefrom, said biocatalyst II having activity of converting an optically active 4-hydroxy-2-ketoglutaric acid into the optically active .gamma.-hydroxy-L-glutamic acid in the presence of an amino group donor.
    • 本发明的目的是提供一种有利于工业规模生产光学活性的γ-羟基-L-谷氨酸的方法。 本发明提供了一种光学活性γ-羟基-L-谷氨酸的制备方法,其包括使生物催化剂I,氨基供体,丙酮酸和乙醛酸在水性介质中共存,形成光学活性的γ-羟基 -L-谷氨酸,并从其中收集形成的光学活性的γ-羟基-L-谷氨酸,所述生物催化剂I具有从丙酮酸和乙醛酸形成光学活性的γ-羟基-L-谷氨酸的活性 在氨基供体的存在下。 本发明还提供了一种制备光学活性的γ-羟基-L-谷氨酸的方法,其包括允许生物催化剂II,氨基供体和光学活性的4-羟基-2-酮戊二酸共存于水性介质中以形成 在水性介质中的光学活性的γ-羟基-L-谷氨酸,并从其中收集形成的光学活性的4-羟基-2-酮戊二酸,所述生物催化剂II具有将光学活性的4-羟基-2-酮戊二酸 在氨基供体存在下转化为光学活性的γ-羟基-L-谷氨酸。
    • 5. 发明授权
    • Ultrasound diagnostic apparatus and image processing method
    • 超声诊断仪及图像处理方法
    • US09050020B2
    • 2015-06-09
    • US13684722
    • 2012-11-26
    • Yasuhiko AbeShinichi Hashimoto
    • Yasuhiko AbeShinichi Hashimoto
    • A61B8/06A61B8/00A61B8/08
    • A61B8/06A61B8/0883A61B8/461A61B8/463A61B8/488A61B8/5207A61B8/5223A61B8/5284
    • An ultrasound diagnostic apparatus according to an embodiment includes a detector, a determination unit, a retention controller, and a display controller. The detector is configured to detect a peak flow velocity of blood flow velocities acquired from Doppler waveforms collected in a time-serial manner or a peak value of average flow velocities of the blood flow velocities as a representative flow velocity for each predefined period. The determination unit is configured to determine a maximum value in a predefined polarity of a plurality of representative flow velocities. The retention controller is configured to control a memory unit to retain maximum waveform information that is Doppler waveform information of Doppler waveforms collected for a period in which the maximum value was detected. The display controller is configured to control a display unit to display the maximum waveform information with Doppler waveform information having been collected by a present time point.
    • 根据实施例的超声波诊断装置包括检测器,确定单元,保持控制器和显示控制器。 检测器被配置为检测以时间序列方式收集的多普勒波形获取的血流速度的峰值流速或作为每个预定周期的代表性流速的血流速度的平均流速的峰值。 确定单元被配置为以多个代表性流速的预定极性来确定最大值。 保持控制器被配置为控制存储器单元以保留最大波形信息,其是在检测到最大值的时段中收集的多普勒波形的多普勒波形信息。 显示控制器被配置为控制显示单元以当前时间点收集的多普勒波形信息显示最大波形信息。