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1. 发明申请

US20130084651A1 TEST INSTRUMENT FOR MEASURING ANALYTE IN SAMPLE, AND METHOD FOR MEASURING ANALYTE USING SAME 审中-公开
标题翻译：用于测量样品中分析物的测试仪器和使用其测量分析仪的方法
公开(公告)号：US20130084651A1
公开(公告)日：2013-04-04
申请号：US13639582
申请日：2011-04-04
申请人： Ryo Kojima , Kenta Noda , Yoshiro Sato , Natsuki Sato , Kaduho Ashizawa
发明人： Ryo Kojima , Kenta Noda , Yoshiro Sato , Natsuki Sato , Kaduho Ashizawa
IPC分类号： G01N33/53
摘要： Disclosed is a test instrument for measuring an analyte in a liquid sample by a noble metal colloid aggregation measurement method. The test instrument involves a reaction chamber in which at least the liquid sample is to be reacted with a reagent, wherein the reagent is adhered on at least a part of a surface constituting the reaction chamber in a dried state, and the reagent enables the measurement of the analyte by a noble metal colloid aggregation measurement method. The test instrument additionally involves a supply section for supplying the liquid sample and a flow path for delivering the liquid sample that has been supplied to the supply section to the reaction chamber, wherein the liquid sample that has been supplied to the supply section is delivered to the reaction chamber through the flow path to cause the liquid sample to be brought into contact with the reagent that has been adhered in a dried state, thereby producing a difference in pressure between the supply section and the reaction chamber for the purpose of dispersing the reagent in the liquid sample. When the test instrument is used, the measurement based on an absorbance at a visible region can be achieved, the analyte can be measured accurately within a short time, and the measurement suitable for a POCT field can be achieved.
摘要翻译：公开了一种用于通过贵金属胶体聚集测量方法测量液体样品中的分析物的测试仪器。测试仪器包括反应室，其中至少液体样品将与试剂反应，其中试剂在干燥状态下粘附在构成反应室的表面的至少一部分上，并且该试剂能够进行测量的分析物通过贵金属胶体聚集测量方法。测试仪器还包括用于供应液体样品的供应部分和用于将已经供应到供应部分的液体样品输送到反应室的流路，其中已经供应到供应部分的液体样品被递送到反应室通过流路使液体样品与干燥状态下已经粘附的试剂接触，从而产生供给部和反应室之间的压力差，以分散试剂在液体样品中。当使用测试仪器时，可以实现基于可见光区域的吸光度的测量，可以在短时间内精确测量分析物，并且可以实现适合于POCT场的测量。

2. 发明授权

US10670586B2 Test instrument for measuring analyte in sample by an aggregation assay using a metal colloid and using a reagent attached in a dry state in a reaction chamber, and method for measuring analyte using same 审中-公开
公开(公告)号：US10670586B2
公开(公告)日：2020-06-02
申请号：US13639582
申请日：2011-04-04
申请人： Ryo Kojima , Kenta Noda , Yoshiro Sato , Natsuki Sato , Kaduho Ashizawa
发明人： Ryo Kojima , Kenta Noda , Yoshiro Sato , Natsuki Sato , Kaduho Ashizawa
IPC分类号： G01N33/53 , G01N33/553 , G01N33/543 , B01L3/00
摘要： Disclosed is a test instrument for measuring an analyte in a liquid sample by a noble metal colloid aggregation measurement method. The test instrument involves a reaction chamber in which at least the liquid sample is to be reacted with a reagent, wherein the reagent is adhered on at least a part of a surface constituting the reaction chamber in a dried state, and the reagent enables the measurement of the analyte by a noble metal colloid aggregation measurement method. The test instrument additionally involves a supply section for supplying the liquid sample and a flow path for delivering the liquid sample that has been supplied to the supply section to the reaction chamber, wherein the liquid sample that has been supplied to the supply section is delivered to the reaction chamber through the flow path to cause the liquid sample to be brought into contact with the reagent that has been adhered in a dried state, thereby producing a difference in pressure between the supply section and the reaction chamber for the purpose of dispersing the reagent in the liquid sample. When the test instrument is used, the measurement based on an absorbance at a visible region can be achieved, the analyte can be measured accurately within a short time, and the measurement suitable for a POCT field can be achieved.

3. 发明申请

US20120282638A1 METHOD FOR IMMUNOASSAY OF AUTOANTIBODY AGAINST KU86, KIT FOR USE IN SAME, AND METHOD FOR DETERMINATION OF PRIMARY HEPATOCELLULAR CARCINOMA USING SAME 审中-公开
标题翻译：用于免疫KU86的自身抗体的方法，用于其的试剂盒，以及使用该方法测定原发性肝细胞癌的方法
公开(公告)号：US20120282638A1
公开(公告)日：2012-11-08
申请号：US13521084
申请日：2011-01-18
申请人： Ryo Kojima , Kenta Noda , Masanori Seimiya , Kazuyuki Sogawa , Fumio Nomura
发明人： Ryo Kojima , Kenta Noda , Masanori Seimiya , Kazuyuki Sogawa , Fumio Nomura
IPC分类号： G01N33/574 , C07K16/18 , C07K14/46
CPC分类号： G01N33/6854 , G01N33/564 , G01N33/57438 , G01N33/57484 , G01N2333/47 , G01N2333/90
摘要： An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma.
摘要翻译：可以通过使样品中包含的自身抗体与Ku86抗原（其用作试剂）反应以产生自身抗体和Ku86抗原的免疫复合物并使用标记的抗人免疫球蛋白测量免疫复合物来测量针对Ku86的自身抗体抗体。自身抗体的测定能够确定原发性肝细胞癌。

4. 发明申请

US20120276562A1 5.9 kDa PEPTIDE IMMUNOASSAY METHOD 有权
标题翻译： 5.9 kDa肽免疫测定法
公开(公告)号：US20120276562A1
公开(公告)日：2012-11-01
申请号：US13502198
申请日：2010-10-13
申请人： Wataru Kikuchi , Momoe Sato , Kenta Noda , Iwao Kiyokawa , Toshihide Miura , Ryo Kojima , Fumio Nomura , Kazuyuki Sogawa
发明人： Wataru Kikuchi , Momoe Sato , Kenta Noda , Iwao Kiyokawa , Toshihide Miura , Ryo Kojima , Fumio Nomura , Kazuyuki Sogawa
IPC分类号： G01N33/566 , C07K16/00 , G01N21/47 , G01N33/545 , G01N21/78
CPC分类号： G01N33/6893 , C07K16/36 , C07K2317/34 , G01N33/5308 , G01N2333/75 , G01N2800/08
摘要： Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the α-E chain and α chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing antibodies that recognize the N terminal of said peptide marker and antibodies that recognize the C terminal of said peptide marker into contact with said peptide marker, forming immune complexes of said peptide marker and the two antibodies, and immunoassaying the obtained immune complexes.
摘要翻译：公开了一种免疫测定方法，其中可以在含有污染肽的生物样品中特异性地测定由于人纤维蛋白原的α-E链和α链的降解而产生的并用作诊断肝脏疾病的肽标志物的5.9kDa肽通过将识别所述肽标记的N末端的抗体和识别所述肽标记的C末端的抗体与所述肽标记接触，形成所述肽标记和两种抗体的免疫复合物，并免疫测定所获得的免疫复合物。

5. 发明申请

US20120094321A1 METHOD AND KIT FOR MEASUREMENT OF DEHYDROGENASE OR SUBSTRATE FOR THE DEHYDROGENASE 审中-公开
标题翻译：用于测定脱氢酶或底物脱乙酰壳多糖的方法和试剂盒
公开(公告)号：US20120094321A1
公开(公告)日：2012-04-19
申请号：US13379712
申请日：2010-06-21
申请人： Kenta Noda , Yashiro Sato , Ryo Kojima
发明人： Kenta Noda , Yashiro Sato , Ryo Kojima
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , C12Q1/54 , C12Q1/58
摘要： Disclosed is a method for measuring a dehydrogenase or a substrate for the dehydrogenase contained in a sample, wherein both thio-NAD or thio-NADP and NAD or NADP are used as coenzymes. The method enables the measurement on the basis of absorbance values obtained in a visible region, and also enables the accurate measurement of a dehydrogenase or a substrate for the dehydrogenase which is contained in a sample at a high concentration.
摘要翻译：公开了用于测量样品中所含的脱氢酶的脱氢酶或底物的方法，其中硫代NAD或硫代NADP和NAD或NADP都用作辅酶。该方法能够基于在可见区域获得的吸光度值进行测量，并且还能够以高浓度精确测量样品中所含的脱氢酶的脱氢酶或底物。

6. 发明申请

US20100248393A1 METHOD FOR DETERMINATION OF ANTIGEN AND ANTIBODY AGAINST THE ANTIGEN, AND DETERMINATION REAGENT FOR USE IN THE METHOD 审中-公开
标题翻译：用于确定抗原的抗原和抗体的方法和用于该方法的测定试剂
公开(公告)号：US20100248393A1
公开(公告)日：2010-09-30
申请号：US12438035
申请日：2007-09-06
申请人： Ryo Kojima , Satoshi Inoue , Satoshi Arai , Katsuhiro Katayama , Kenta Noda
发明人： Ryo Kojima , Satoshi Inoue , Satoshi Arai , Katsuhiro Katayama , Kenta Noda
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/54313
摘要： For determining an antigen or an antibody against the antigen in a sample, a determination reagent is used which comprises an antibody capable of causing an antigen-antibody reaction with the antigen contained in the sample and an antigen capable of causing an antigen-antibody reaction with both of the antibody contained in the sample and the antibody contained in the reagent. Either one of the antigen and the antibody in the reagent is supported on a microparticle. The sample is mixed with the reagent. The antigen or the antibody in the sample can be determined based on the degree of increase or decrease in agglutination caused by the antigen-antibody reaction. It becomes possible to determine both of an antigen and an antibody against the antigen in a sample accurately using one and the same reagent.
摘要翻译：为了确定样品中抗原或抗体的抗体，使用的测定试剂包含能够引起与样品中所含的抗原的抗原 - 抗体反应的抗体和能够引起抗原抗体反应的抗原样品中包含的抗体和试剂中包含的抗体。试剂中的任一种抗原和抗体都负载在微粒上。样品与试剂混合。样品中的抗原或抗体可以基于由抗原 - 抗体反应引起的凝集的增加或减少程度来确定。可以使用同一试剂精确地确定样品中的抗原和针对抗原的抗体两者。

7. 发明申请

US20060008915A1 Reagent for determination of calcium and determination method 有权
公开(公告)号：US20060008915A1
公开(公告)日：2006-01-12
申请号：US11169749
申请日：2005-06-30
申请人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
发明人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
IPC分类号： G01N33/20
CPC分类号： G01N33/84 , G01N31/22
摘要： A method for determination of calcium in a sample derived from a living body, by the reaction of calcium in the sample with Chlorophosphonazo-III or a compound analogous thereto in the presence of vanadate ions, followed by determination of calcium in the sample on the basis of an optical change caused by the reaction product, is excellent in various respects as follows: it is free from the problem of absorption of carbonic acid gas caused by a high pH; it is free from the problem of use of a toxic reagent containing arsenic; it makes it possible to subject a large number of samples to determination in a short time because it can be applied to an autoanalyzer; and it permits determination in a wide range because of low sample blank values.

8. 发明授权

US09017959B2 5.9 kDa peptide immunoassay method 有权
标题翻译： 5.9 kDa肽免疫测定法
公开(公告)号：US09017959B2
公开(公告)日：2015-04-28
申请号：US13502198
申请日：2010-10-13
申请人： Wataru Kikuchi , Momoe Sato , Kenta Noda , Iwao Kiyokawa , Toshihide Miura , Ryo Kojima , Fumio Nomura , Kazuyuki Sogawa
发明人： Wataru Kikuchi , Momoe Sato , Kenta Noda , Iwao Kiyokawa , Toshihide Miura , Ryo Kojima , Fumio Nomura , Kazuyuki Sogawa
IPC分类号： G01N33/53 , G01N33/543 , G01N33/68 , C07K16/36
CPC分类号： G01N33/6893 , C07K16/36 , C07K2317/34 , G01N33/5308 , G01N2333/75 , G01N2800/08
摘要： Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the α-E chain and α chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing antibodies that recognize the N terminal of said peptide marker and antibodies that recognize the C terminal of said peptide marker into contact with said peptide marker, forming immune complexes of said peptide marker and the two antibodies, and immunoassaying the obtained immune complexes.
摘要翻译：公开了一种免疫测定方法，其中可以在含有污染肽的生物样品中特异性地测定由于人纤维蛋白原的α-E链和α链的降解而产生的并用作诊断肝脏疾病的肽标志物的5.9kDa肽通过将识别所述肽标记的N末端的抗体和识别所述肽标记的C末端的抗体与所述肽标记接触，形成所述肽标记和两种抗体的免疫复合物，并免疫测定所获得的免疫复合物。

9. 发明申请

US20120309034A1 METHOD FOR MEASURING IMMUNITY OF COMPLEX OF Ku86 AND AUTOANTIBODY THEREOF, KIT USED THEREFOR, AND METHOD FOR DETERMINING CANCER USING SAME 审中-公开
标题翻译：用于测量Ku86复合物及其自身抗体的方法，其使用的试剂盒及使用其确定癌症的方法
公开(公告)号：US20120309034A1
公开(公告)日：2012-12-06
申请号：US13577530
申请日：2011-02-07
申请人： Ryo Kojima , Kenta Noda , Masanori Seimiya , Kazuyuki Sogawa , Fumio Nomura
发明人： Ryo Kojima , Kenta Noda , Masanori Seimiya , Kazuyuki Sogawa , Fumio Nomura
IPC分类号： G01N21/59 , G01N33/574 , G01N33/566
CPC分类号： G01N33/57484 , G01N33/564 , G01N2333/922
摘要： A reaginic antibody of Ku86 and a substance capable of binding with the autoantibody of Ku86 are acted on a complex of Ku86 and the autoantibody thereof in a subject. Said complex can be measured by measuring the obtained immune complex of the aforementioned complex, reaginic antibody, and substance capable of binding with the autoantibody of Ku86. As a consequence, it is possible to determine whether the cancer is a primary hepatoma, colon cancer, stomach cancer, pancreatic cancer, breast cancer, lung cancer, or an esophageal cancer.
摘要翻译： Ku86的反应性抗体和能够与Ku86的自身抗体结合的物质作用于受试者中Ku86和其自身抗体的复合物。所述复合物可以通过测量获得的上述复合物，反应性抗体和能够与Ku86自身抗体结合的物质的免疫复合物来测量。因此，可以确定癌症是原发性肝癌，结肠癌，胃癌，胰腺癌，乳腺癌，肺癌或食管癌。

10. 发明授权

US07544516B2 Reagent for determination of calcium and determination method 有权
标题翻译：用于测定钙和测定方法的试剂
公开(公告)号：US07544516B2
公开(公告)日：2009-06-09
申请号：US11169749
申请日：2005-06-30
申请人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
发明人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
IPC分类号： G01N30/74
CPC分类号： G01N33/84 , G01N31/22
摘要： A method for determination of calcium in a sample derived from a living body, by the reaction of calcium in the sample with Chlorophosphonazo-III or a compound analogous thereto in the presence of vanadate ions, followed by determination of calcium in the sample on the basis of an optical change caused by the reaction product, is excellent in various respects as follows: it is free from the problem of absorption of carbonic acid gas caused by a high pH; it is free from the problem of use of a toxic reagent containing arsenic; it makes it possible to subject a large number of samples to determination in a short time because it can be applied to an autoanalyzer; and it permits determination in a wide range because of low sample blank values.
摘要翻译：通过在钒酸根离子存在下，将样品中的钙与氯膦腈III或类似化合物的反应，测定来自活体的样品中的钙的方法，然后基于样品中的钙测定由反应产物引起的光学变化，在各个方面优异如下：它没有由高pH引起的碳酸气体吸收的问题; 没有使用含砷的有毒试剂的问题; 它可以在很短的时间内对大量样品进行测定，因为它可以应用于自动分析仪; 并且由于样品空白值较低，可以在宽范围内进行测定。

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