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1. 发明申请

US20100269573A1 LOSSLESS DROPLET TRANSFER OF DROPLET-BASED MICROFLUIDIC ANALYSIS 有权
标题翻译：基于DROPLET的微流控分析的无害DROPLET转移
公开(公告)号：US20100269573A1
公开(公告)日：2010-10-28
申请号：US12430490
申请日：2009-04-27
申请人： Ryan T. Kelly , Keqi Tang , Jason S. Page , Richard D. Smith
发明人： Ryan T. Kelly , Keqi Tang , Jason S. Page , Richard D. Smith
IPC分类号： G01N30/84 , H01J49/00
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0816 , B01L2400/0421 , G01N27/44743 , G01N30/7266 , H01J49/00
摘要： A transfer structure for droplet-based microfluidic analysis is characterized by a first conduit containing a first stream having at least one immiscible droplet of aqueous material and a second conduit containing a second stream comprising an aqueous fluid. The interface between the first conduit and the second conduit can define a plurality of apertures, wherein the apertures are sized to prevent exchange of the first and second streams between conduits while allowing lossless transfer of droplets from the first conduit to the second conduit through contact between the first and second streams.
摘要翻译：用于基于液滴的微流体分析的转移结构的特征在于包含具有至少一种不混溶的水性材料的液滴的第一流的第一导管和含有含水流体的第二流的第二导管。第一导管和第二导管之间的界面可以限定多个孔，其中孔的尺寸设定成防止第一和第二流在导管之间的交换，同时允许液滴从第一导管到第二导管的无损转移，第一和第二个流。

2. 发明申请

US20090057551A1 LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS 有权
标题翻译：低压电沉积离子系统和有效传输离子的方法
公开(公告)号：US20090057551A1
公开(公告)日：2009-03-05
申请号：US11848884
申请日：2007-08-31
申请人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
发明人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
IPC分类号： H01J49/04 , B05B5/025
CPC分类号： H01J49/165 , H01J49/066
摘要： A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel “interfaceless” electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.
摘要翻译：公开了一种系统和方法，其提供在具有低有效离子损耗的耦合级之间的离子的完全传输。进一步描述了一种新颖的“无接触”电喷雾离子化系统，其在减压下操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦并将离子传输到质量分析器中的电动离子漏斗中。

3. 发明授权

US07671344B2 Low pressure electrospray ionization system and process for effective transmission of ions 有权
标题翻译：低压电喷雾离子化系统和有效传输离子的方法
公开(公告)号：US07671344B2
公开(公告)日：2010-03-02
申请号：US11848884
申请日：2007-08-31
申请人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
发明人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
IPC分类号： H01J27/00
CPC分类号： H01J49/165 , H01J49/066
摘要： A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel “interfaceless” electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.
摘要翻译：公开了一种系统和方法，其提供在具有低有效离子损耗的耦合级之间的离子的完全传输。进一步描述了一种新颖的“无接触”电喷雾离子化系统，其在减压下操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦并将离子传输到质量分析器中的电动离子漏斗中。

4. 发明申请

US20090242755A1 LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS 有权
标题翻译：低压电沉积离子系统和有效传输离子的方法
公开(公告)号：US20090242755A1
公开(公告)日：2009-10-01
申请号：US12468645
申请日：2009-05-19
申请人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
发明人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/0431 , H01J49/066
摘要： Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An “interfaceless” electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.
摘要翻译：提供耦合级之间离子完全传输的系统和方法，具有低有效离子损耗。进一步描述了一种“无接口”电喷雾离子化系统，其以减压的方式操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦和离子传输到质量分析器中的电动离子漏斗中。此外，保持在不同压力的室可以为电喷雾发射器和离子导向器提供更优化的操作条件。

5. 发明授权

US07491341B2 Method of making tapered capillary tips with constant inner diameters 有权
标题翻译：制造具有恒定内径的锥形毛细管尖端的方法
公开(公告)号：US07491341B2
公开(公告)日：2009-02-17
申请号：US11394840
申请日：2006-03-31
申请人： Ryan T. Kelly , Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Ryan T. Kelly , Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： C03C25/68 , B44C1/22
CPC分类号： H01J49/167
摘要： Methods of forming electrospray ionization emitter tips are disclosed herein. In one embodiment, an end portion of a capillary tube can be immersed into an etchant, wherein the etchant forms a concave meniscus on the outer surface of the capillary. Variable etching rates in the meniscus can cause an external taper to form. While etching the outer surface of the capillary wall, a fluid can be flowed through the interior of the capillary tube. Etching continues until the immersed portion of the capillary tube is completely etched away.
摘要翻译：本文公开了形成电喷雾电离发射器尖端的方法。在一个实施例中，毛细管的端部可以浸入蚀刻剂中，其中蚀刻剂在毛细管的外表面上形成凹弯月面。弯液面中的可变蚀刻速率可能导致形成外部锥度。在蚀刻毛细管壁的外表面时，流体可以流过毛细管的内部。继续蚀刻直到毛细管的浸入部分被完全蚀刻掉。

6. 发明申请

US20090108194A1 METHOD AND APPARATUS FOR SELECTIVE FILTERING OF IONS 有权
标题翻译：选择性过滤离子的方法和装置
公开(公告)号：US20090108194A1
公开(公告)日：2009-04-30
申请号：US11251529
申请日：2005-09-30
申请人： Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： B01D59/44
CPC分类号： H01J49/066 , G01N27/622
摘要： An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution.
摘要翻译：公开了一种可调节的低质量 - 电荷（m / z）滤波器，其使用电喷雾电离来阻挡与不想要的低m / z物质相关的离子进入质谱仪并且为下游离子累积步骤贡献其空间电荷。低质量过滤器通过使用来自电动离子漏斗的电导限制端子电极的可调势势垒来制造，其阻止具有较高离子迁移率的物质被传输。滤波器提供从大约50到大约500的m / z值的低质量滤波的线性电压调节。也可以执行m / z 500以上的质量过滤; 然而，更高的m / z物种减弱。通过对白蛋白胰蛋白酶消化物的液相色谱 - 质谱分析来评估质量过滤器，并且导致阻断低质量“背景”离子的能力，其占离子源的总离子电流的40-70％峰洗脱。

7. 发明授权

US07514676B1 Method and apparatus for selective filtering of ions 有权
标题翻译：选择性过滤离子的方法和装置
公开(公告)号：US07514676B1
公开(公告)日：2009-04-07
申请号：US11251529
申请日：2005-09-30
申请人： Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/066 , G01N27/622
摘要： An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution.
摘要翻译：公开了一种可调节的低质量 - 电荷（m / z）滤波器，其使用电喷雾电离来阻挡与不想要的低m / z物质相关的离子进入质谱仪并且为下游离子累积步骤贡献其空间电荷。低质量过滤器通过使用来自电动离子漏斗的电导限制端子电极的可调势势垒来制造，其阻止具有较高离子迁移率的物质被传输。滤波器提供从大约50到大约500的m / z值的低质量滤波的线性电压调节。也可以执行m / z 500以上的质量过滤; 然而，更高的m / z物种减弱。通过对白蛋白胰蛋白酶消化物的液相色谱 - 质谱分析来评估质量过滤器，并且导致阻断低质量“背景”离子的能力，其占离子源的总离子电流的40-70％峰洗脱。

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