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1. 发明授权

US07316925B2 Codon optimized synthetic plasmids 有权
标题翻译：密码子优化的合成质粒
公开(公告)号：US07316925B2
公开(公告)日：2008-01-08
申请号：US10619939
申请日：2003-07-15
申请人： Ruxandra Draghia-Akli , Ronald V. Abruzzese , Douglas R. Kern
发明人： Ruxandra Draghia-Akli , Ronald V. Abruzzese , Douglas R. Kern
IPC分类号： C12N15/85 , C07H21/04 , A61K48/00
CPC分类号： C12N15/67 , A61K48/00 , C07K14/60 , C12N15/85 , C12N2830/008 , C12N2830/15 , C12N2840/20 , C12N2840/203
摘要： One aspect of the current invention is an optimized synthetic mammalian expression plasmid (e.g. pAV0201). This new plasmid comprise a therapeutic element, and a replication element. The therapeutic element of the new plasmid comprises a eukaryotic promoter; a 5′ untranslated region (“UTR”); a codon-optimized-eukaryotic therapeutic gene sequence; and a poly adenylation signal. The therapeutic elements of this plasmid are operatively linked and located in a first operatively-linked arrangement. Additionally, the optimized synthetic mammalian expression plasmid comprises replication elements, wherein the replication elements are operatively linked and located in a second operatively-linked arrangement. The replication elements comprise a selectable marker gene promoter, a ribosomal binding site, and an origin of replication. The first-operatively-linked arrangement and the second-operatively-linked arrangement comprise a circular structure of the codon optimized synthetic mammalian expression plasmid.
摘要翻译：本发明的一个方面是优化的合成哺乳动物表达质粒（例如pAV0201）。该新质粒包含治疗元件和复制元件。新质粒的治疗元件包含真核启动子; 5'非翻译区（“UTR”）; 密码子优化的真核治疗基因序列; 和聚腺苷酸化信号。该质粒的治疗元件可操作地连接并位于第一可操作连接的布置中。此外，优化的合成哺乳动物表达质粒包含复制元件，其中复制元件可操作地连接并位于第二可操作连接的布置中。复制元件包括选择性标记基因启动子，核糖体结合位点和复制起点。第一操作连接的排列和第二操作连接的排列包括密码子优化的合成哺乳动物表达质粒的圆形结构。

2. 发明申请

US20080194511A1 CODON OPTIMIZED SYNTHETIC PLASMIDS 审中-公开
标题翻译： CODON优化合成PLASMIDS
公开(公告)号：US20080194511A1
公开(公告)日：2008-08-14
申请号：US11941876
申请日：2007-11-16
申请人： Ruxandra Draghia-Akli , Ronald V. Abruzzese , Douglas R. Kern
发明人： Ruxandra Draghia-Akli , Ronald V. Abruzzese , Douglas R. Kern
IPC分类号： A61K31/711
CPC分类号： C12N15/67 , A61K48/00 , C07K14/60 , C12N15/85 , C12N2830/008 , C12N2830/15 , C12N2840/20 , C12N2840/203
摘要： One aspect of the current invention is an optimized synthetic mammalian expression plasmid (e.g. pAV0201). This new plasmid comprise a therapeutic element, and a replication element. The therapeutic element of the new plasmid comprises a eukaryotic promoter; a 5′ untranslated region (“UTR”); a codon-optimized-eukaryotic therapeutic gene sequence; and a poly adenylation signal. The therapeutic elements of this plasmid are operatively linked and located in a first operatively-linked arrangement. Additionally, the optimized synthetic mammalian expression plasmid comprises replication elements, wherein the replication elements are operatively linked and located in a second operatively-linked arrangement. The replication elements comprise a selectable marker gene promoter, a ribosomal binding site, and an origin of replication. The first-operatively-linked arrangement and the second-operatively-linked arrangement comprise a circular structure of the codon optimized synthetic mammalian expression plasmid.
摘要翻译：本发明的一个方面是优化的合成哺乳动物表达质粒（例如pAV0201）。该新质粒包含治疗元件和复制元件。新质粒的治疗元件包含真核启动子; 5'非翻译区（“UTR”）; 密码子优化的真核治疗基因序列; 和聚腺苷酸化信号。该质粒的治疗元件可操作地连接并位于第一可操作连接的布置中。此外，优化的合成哺乳动物表达质粒包含复制元件，其中复制元件可操作地连接并位于第二可操作连接的布置中。复制元件包括选择性标记基因启动子，核糖体结合位点和复制起点。第一操作连接的排列和第二操作连接的排列包括密码子优化的合成哺乳动物表达质粒的圆形结构。

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