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1. 发明授权

US07034033B2 Substituted quinazolinone compounds 失效
公开(公告)号：US07034033B2
公开(公告)日：2006-04-25
申请号：US10444495
申请日：2003-05-23
申请人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号： C07D239/90 , A61K31/517 , A61P3/04 , A61P3/10
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.

2. 发明授权

US07858641B2 Substituted dihydroisoquinolinone compounds 失效
标题翻译：取代的二氢异喹啉酮化合物
公开(公告)号：US07858641B2
公开(公告)日：2010-12-28
申请号：US11248040
申请日：2005-10-11
申请人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号： A61K31/47
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基的二氢异喹啉基。该化合物可用于治疗MC4-R介导的疾病。化合物具有其中在此定义变量的值的结构ID。

3. 发明授权

US07858631B2 Substituted pyrido [2,3-d] pyrimidinone compounds 失效
标题翻译：取代的吡啶并[2,3-d]嘧啶酮化合物
公开(公告)号：US07858631B2
公开(公告)日：2010-12-28
申请号：US10515434
申请日：2003-05-23
申请人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号： A61K31/519
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

4. 发明授权

US07625909B2 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US07625909B2
公开(公告)日：2009-12-01
申请号：US10850967
申请日：2004-05-21
申请人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
发明人： Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
IPC分类号： A61K31/517 , A61K31/519 , A61P5/50 , C07D239/88 , C07D239/95 , C07D471/04 , C07D487/04
CPC分类号： C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种小分子，含胍分子。当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

5. 发明申请

US20100105654A1 SUBSTITUTED QUINAZOLINONE COMPOUNDS 审中-公开
标题翻译：替代喹唑啉酮化合物
公开(公告)号：US20100105654A1
公开(公告)日：2010-04-29
申请号：US12605174
申请日：2009-10-23
申请人： Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
发明人： Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
IPC分类号： A61K31/517 , C07D403/12 , C07D239/86 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/5377 , A61P3/04 , A61P3/10
CPC分类号： C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种小分子，含胍分子。当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。化合物具有结构VA，VB，VIIA和VIIB，其中变量的值在本文中定义。

6. 发明申请

US20060030573A1 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US20060030573A1
公开(公告)日：2006-02-09
申请号：US11248040
申请日：2005-10-11
申请人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号： A61K31/519 , A61K31/517 , C07D239/88 , C07D403/02 , C07D487/02
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有结构IA，IB或IC，其中变量的值在本文中定义。

7. 发明申请

US20050059662A1 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US20050059662A1
公开(公告)日：2005-03-17
申请号：US10850967
申请日：2004-05-21
申请人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher Conlee , Brian Thompson , Judith Kuntz , David Musso , Kevin Barvian , Stephen Thomson , William Swain , Kien Du , Brian Chauder , Jason Speake , Michael Bishop
发明人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher Conlee , Brian Thompson , Judith Kuntz , David Musso , Kevin Barvian , Stephen Thomson , William Swain , Kien Du , Brian Chauder , Jason Speake , Michael Bishop
IPC分类号： A61K31/517 , A61K31/519 , A61K31/525 , A61K31/53 , A61P3/04 , A61P3/10 , C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D475/02 , C07D487/02 , C07D487/04
CPC分类号： C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种小分子，含胍分子。当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

8. 发明申请

US20060235019A1 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US20060235019A1
公开(公告)日：2006-10-19
申请号：US10515434
申请日：2003-05-23
申请人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
发明人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
IPC分类号： A61K31/53 , A61K31/525 , A61K31/519 , C07D487/02 , C07D475/02
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

9. 发明授权

US06716840B2 Guanidino compounds 失效
标题翻译：胍基化合物
公开(公告)号：US06716840B2
公开(公告)日：2004-04-06
申请号：US10118730
申请日：2002-04-08
申请人： Daniel Chu , Rustum S. Boyce , David Duhl , Bryan H. Chang
发明人： Daniel Chu , Rustum S. Boyce , David Duhl , Bryan H. Chang
IPC分类号： A61K315375
CPC分类号： C07D209/46 , C07D209/48 , C07D217/24 , C07D235/08 , C07D235/10
摘要： Compounds having the general structure I are provided: X and Y are independently selected from the group consisting of CH2, N, NR9, C═O, C═S, S═O, SO2, S, O, (CR6R7)n, C(═O)—(CR6R7)n, and C(═S)—(CR6R7)n, where n is 1, 2, or 3. W is selected from the group consisting of and L is selected from the group consisting of N, O, S, S═O, SO2, C(O), NC(O), NC(S), OC(O), OC(S), C(NR10), C(NOR10), and a covalent bond. Z1, Z2, and Z3 are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (“MC-4r”) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.
摘要翻译：提供具有通式结构I的化合物：X和Y独立地选自CH 2，N，NR 9，C = O，C = S，S = O，SO 2，S，O，（R 6 R 7）n，C（= O） - （CR 6 R 7）n和C（= S） - （CR 6 R 7）n，其中n为1 W选自N，O，S，S = O，SO 2，C（O），NC（O），NC（S），OC （O），OC（S），C（NR 10），C（NOR 10））和共价键。 Z 1，Z 2和Z 3独立地选自取代的碳和氮。式I化合物是黑皮质素-4受体（“MC-4r”）的激动剂，因此可能具有控制人类MC-4r作用相关疾病如肥胖和II型糖尿病的有用性质。

10. 发明授权

US06995269B2 Guanidinobenzamides 失效
标题翻译：胍基苯甲酰胺
公开(公告)号：US06995269B2
公开(公告)日：2006-02-07
申请号：US10379397
申请日：2003-03-04
申请人： Paul A. Renhowe , Daniel Chu , Rustum S. Boyce , David Duhl
发明人： Paul A. Renhowe , Daniel Chu , Rustum S. Boyce , David Duhl
IPC分类号： C07D211/72 , C07D295/20 , A61K31/44
CPC分类号： C07D233/64 , C07B2200/07 , C07B2200/09 , C07C279/18 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/16 , C07D215/12 , C07D241/08 , C07D241/42 , C07D295/215 , C07D307/24 , C07D309/14 , C07D333/20 , C07D487/04 , C07D487/08
摘要： Compounds of formula IIA and IIB are novel guanidine compounds where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.
摘要翻译：式IIA和IIB的化合物是新的胍化合物，化学式id =“CHEM-US-00001”num =“000

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