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1. 发明授权

US08926982B2 Reagents and methods for detecting influenza virus proteins 有权
标题翻译：用于检测流感病毒蛋白质的试剂和方法
公开(公告)号：US08926982B2
公开(公告)日：2015-01-06
申请号：US13322459
申请日：2010-05-28
申请人： Xuguang Li , Runtao He , Gary Van Domselaar
发明人： Xuguang Li , Runtao He , Gary Van Domselaar
IPC分类号： A61K39/145 , C07K16/10 , G01N33/569 , G01N33/573 , C12N9/24 , A61K39/00
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/505 , A61K2039/55566 , A61K2039/6081 , C07K16/1018 , C07K16/40 , C07K2317/34 , C12N9/2402 , C12N2760/16134 , C12Y302/01018 , G01N33/573 , G01N2333/924 , G01N2333/9506
摘要： Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate mono-specific and monoclonal antibodies. The two antibodies, one targeting the N-terminus of the type A neuraminidase and the other sequence close to enzymatic active site, were capable of binding to all 9 subtypes of neuraminidase while demonstrating remarkable specificity against the viral neuraminidase sequences since no cross-reactivity against allantoic proteins was observed. Quantitative analyses of NA using slot blot suggest that the antibodies can be used for NA antigen quantitation in vaccines. These represent the first time the antibody-based immunoassay can be used for NA quantitative determination.
摘要翻译：通过大规模序列分析鉴定了来自甲型流感A型神经氨酸酶的两种普遍保守的序列，然后化学修饰并与载体蛋白缀合以产生单特异性和单克隆抗体。靶向A型神经氨酸酶的N末端的两种抗体和接近酶活性位点的其他序列能够结合所有9种亚型的神经氨酸酶，同时显示出对病毒神经氨酸酶序列的显着特异性，因为没有交叉反应观察尿囊蛋白。使用狭缝印迹的NA的定量分析表明抗体可用于疫苗中的NA抗原定量。这些代表了首次基于抗体的免疫测定可用于NA定量测定。

2. 发明授权

US08753623B2 Influenza vaccine 有权
标题翻译：流感疫苗
公开(公告)号：US08753623B2
公开(公告)日：2014-06-17
申请号：US13266801
申请日：2010-04-29
申请人： Runtao He , Xuguang Li , Gary Van Domselaar
发明人： Runtao He , Xuguang Li , Gary Van Domselaar
IPC分类号： A61K39/145 , G01K7/08 , C12Q1/70 , C07K16/10 , C07K17/06 , G01N33/569
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/505 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C07K16/1018 , C07K2317/76 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234
摘要： The present invention discloses isolated peptides encoding an antigen or fragments thereof from the N-terminus of hemagglutinin protein of influenza, methods for isolating such antigens and specific uses thereof. The peptide can be used as a vaccine to generate an antibody response that neutralizes influenza infectivity against a variety of influenza strains.
摘要翻译：本发明公开了从流感的血凝素蛋白N末端编码抗原或其片段的分离的肽，分离这些抗原的方法及其具体用途。肽可以用作疫苗以产生中和针对各种流感病毒株的流感感染性的抗体应答。

3. 发明申请

US20120141519A1 REAGENTS AND METHODS FOR DETECTING INFLUENZA VIRUS PROTEINS 审中-公开
标题翻译：用于检测流感病毒蛋白的试剂和方法
公开(公告)号：US20120141519A1
公开(公告)日：2012-06-07
申请号：US13322459
申请日：2010-05-28
申请人： Xuguang Li , Runtao He , Gary Van Domselaar
发明人： Xuguang Li , Runtao He , Gary Van Domselaar
IPC分类号： A61K39/145 , C07K16/10 , C07K1/00 , A61P31/16 , C12P21/08 , G01N33/573 , C12N9/96 , A61P37/04
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/505 , A61K2039/55566 , A61K2039/6081 , C07K16/1018 , C07K16/40 , C07K2317/34 , C12N9/2402 , C12N2760/16134 , C12Y302/01018 , G01N33/573 , G01N2333/924 , G01N2333/9506
摘要： Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate mono-specific and monoclonal antibodies. The two antibodies, one targeting the N-terminus of the type A neuraminidase and the other sequence close to enzymatic active site, were capable of binding to all 9 subtypes of neuraminidase while demonstrating remarkable specificity against the viral neuraminidase sequences since no cross-reactivity against allantoic proteins was observed. Quantitative analyses of NA using slot blot suggest that the antibodies can be used for NA antigen quantitation in vaccines. These represent the first time the antibody-based immunoassay can be used for NA quantitative determination.
摘要翻译：通过大规模序列分析鉴定了来自甲型流感A型神经氨酸酶的两种普遍保守的序列，然后化学修饰并与载体蛋白缀合以产生单特异性和单克隆抗体。靶向A型神经氨酸酶的N末端的两种抗体和接近酶活性位点的其他序列能够结合所有9种亚型的神经氨酸酶，同时显示出对病毒神经氨酸酶序列的显着特异性，因为没有交叉反应观察尿囊蛋白。使用狭缝印迹的NA的定量分析表明抗体可用于疫苗中的NA抗原定量。这些代表了首次基于抗体的免疫测定可用于NA定量测定。

4. 发明申请

US20120070455A1 INFLUENZA VACCINE 有权
标题翻译：流感疫苗
公开(公告)号：US20120070455A1
公开(公告)日：2012-03-22
申请号：US13266801
申请日：2010-04-29
申请人： Runtao He , Xuguang Li , Gary Van Domselaar
发明人： Runtao He , Xuguang Li , Gary Van Domselaar
IPC分类号： A61K39/145 , A61K39/385 , A61P31/16 , C07K7/08
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/505 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C07K16/1018 , C07K2317/76 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234
摘要： The present invention discloses isolated peptides encoding an antigen or fragments thereof from the N-terminus of hemagglutinin protein of influenza, methods for isolating such antigens and specific uses thereof. The peptide can be used as a vaccine to generate an antibody response that neutralizes influenza infectivtty against a variety of influenza strains.
摘要翻译：本发明公开了从流感的血凝素蛋白N末端编码抗原或其片段的分离的肽，分离这些抗原的方法及其具体用途。该肽可用作疫苗以产生针对各种流感毒株中和流感感染的抗体应答。

5. 发明申请

US20080225448A1 Ground fault circuit interrupter 失效
标题翻译：接地故障电路断路器
公开(公告)号：US20080225448A1
公开(公告)日：2008-09-18
申请号：US11901759
申请日：2007-09-18
申请人： Xuguang Li , Xiaobing Dong , Yi Yin
发明人： Xuguang Li , Xiaobing Dong , Yi Yin
IPC分类号： H02H3/04
CPC分类号： H02H11/002
摘要： A method of preventing an overload current from a power supply to a load through a ground fault circuit interrupter includes the steps of: obtaining an interrupted fault current from a hot wire to a ground wire via a first zero-phase current inductor and a fault current from a neutral wire to the ground wire via a second zero-phase current inductor; amplifying a signal of the fault current by an Op-Amp; and determining the fault current by a programmable control module, wherein when the fault current is larger than a preset threshold, the programmable control module sends a control signal to a control switch such that the control switch electrifies a second coil of a trip breaker to drive an armature at an unlocked position, so as to separate a movable terminal with a fixed terminal for electrically disconnecting the load with the power supply.
摘要翻译：通过接地故障电路断续器防止来自电源到负载的过载电流的方法包括以下步骤：经由第一零相电流电感器和故障电流从热线到接地线获得中断的故障电流通过第二个零相电流电感从中性线到地线; 通过Op-Amp放大故障电流的信号; 以及通过可编程控制模块确定所述故障电流，其中当所述故障电流大于预设阈值时，所述可编程控制模块向控制开关发送控制信号，使得所述控制开关使跳闸断路器的第二线圈通电以驱动电枢处于解锁位置，以便将可移动端子与固定端子分开，以使电源与电源电断开。

6. 发明授权

US07005401B2 Method of preparation of non-platinum composite electrocatalyst for cathode of fuel cell 失效
标题翻译：燃料电池阴极非铂复合电催化剂的制备方法
公开(公告)号：US07005401B2
公开(公告)日：2006-02-28
申请号：US10612336
申请日：2003-07-03
申请人： Tianhong Lu , Xuguang Li , Wei Xing
发明人： Tianhong Lu , Xuguang Li , Wei Xing
IPC分类号： H01M4/88 , H01M4/86 , B01J21/18 , B01J31/00
CPC分类号： H01M4/8652 , B01J21/063 , B01J21/18 , B01J23/70 , B01J37/0203 , B01J37/0205 , B01J37/086 , H01M4/9008 , H01M2008/1095
摘要： A method of preparing non-platinum composite electrocatalyst for a fuel cell cathode, comprising: (1) preparing a carbon supporting titanium dioxide; (2) compounding the carbon supporting titanium dioxide with a transition metal macrocyclic compound in an organic solvent to produce a carbon supporting titanium dioxide-transition metal macrocyclic compound comprising 0.1–5 g/L of macrocyclic compound; and (3) thermal treating the resulting compound in step (2) at 100–1000° C. to produce a composite catalyst. The composite catalyst prepared with the method according to the present invention also has the advantages of better resistance to methanol and lower cost over the Pt/C catalyst. The said composite catalyst would have better prospects in application.
摘要翻译：一种制备用于燃料电池阴极的非铂复合电催化剂的方法，包括：（1）制备负载二氧化钛的碳; （2）将碳载体二氧化钛与过渡金属大环化合物在有机溶剂中混合以制备包含0.1-5g / L大环化合物的碳载体二氧化钛 - 过渡金属大环化合物; 和（3）在步骤（2）中在100-1000℃下热处理所得化合物以产生复合催化剂。用本发明方法制备的复合催化剂还具有耐甲醇性好，Pt / C催化剂成本低的优点。所述复合催化剂的应用前景将更好。

7. 发明授权

US07692904B2 Ground fault circuit interrupter 失效
标题翻译：接地故障电路断路器
公开(公告)号：US07692904B2
公开(公告)日：2010-04-06
申请号：US11901759
申请日：2007-09-18
申请人： Xuguang Li , Xiaobing Dong , Yi Yin
发明人： Xuguang Li , Xiaobing Dong , Yi Yin
IPC分类号： H02H3/00
CPC分类号： H02H11/002
摘要： A method of preventing an overload current from a power supply to a load through a ground fault circuit interrupter includes the steps of: obtaining an interrupted fault current from a hot wire to a ground wire via a first zero-phase current inductor and a fault current from a neutral wire to the ground wire via a second zero-phase current inductor; amplifying a signal of the fault current by an Op-Amp; and determining the fault current by a programmable control module, wherein when the fault current is larger than a preset threshold, the programmable control module sends a control signal to a control switch such that the control switch electrifies a second coil of a trip breaker to drive an armature at an unlocked position, so as to separate a movable terminal with a fixed terminal for electrically disconnecting the load with the power supply.
摘要翻译：通过接地故障电路断续器防止来自电源到负载的过载电流的方法包括以下步骤：经由第一零相电流电感器和故障电流从热线到接地线获得中断的故障电流通过第二个零相电流电感从中性线到地线; 通过Op-Amp放大故障电流的信号; 以及通过可编程控制模块确定所述故障电流，其中当所述故障电流大于预设阈值时，所述可编程控制模块向控制开关发送控制信号，使得所述控制开关使跳闸断路器的第二线圈通电以驱动电枢处于解锁位置，以便将可移动端子与固定端子分开，以使电源与电源电断开。

8. 发明申请

US20080161183A1 Carbon-Based Composite Electrocatalysts for Low Temperature Fuel Cells 有权
标题翻译：用于低温燃料电池的碳基复合电催化剂
公开(公告)号：US20080161183A1
公开(公告)日：2008-07-03
申请号：US11930322
申请日：2007-10-31
申请人： Branko N. Popov , Jong-Won Lee , Nalini P. Subramanian , Swaminatha P. Kumaraguru , Hector R. Colon-Mercado , Vijayadurga Nallathambi , Xuguang Li , Gang WU
发明人： Branko N. Popov , Jong-Won Lee , Nalini P. Subramanian , Swaminatha P. Kumaraguru , Hector R. Colon-Mercado , Vijayadurga Nallathambi , Xuguang Li , Gang WU
IPC分类号： H01M4/88
CPC分类号： H01M4/92 , B01J21/18 , B01J37/086 , B01J37/12 , H01M4/9083 , H01M4/926 , H01M2008/1095
摘要： A process for synthesis of a catalyst is provided. The process includes providing a carbon precursor material, oxidizing the carbon precursor material whereby an oxygen functional group is introduced into the carbon precursor material, and adding a nitrogen functional group into the oxidized carbon precursor material.
摘要翻译：提供合成催化剂的方法。该方法包括提供碳前体材料，氧化碳前体材料，由此将氧官能团引入到碳前体材料中，并在氧化碳前体材料中加入氮官能团。

9. 发明授权

US5600318A Seismic data acquisition system 失效
标题翻译：地震数据采集系统
公开(公告)号：US5600318A
公开(公告)日：1997-02-04
申请号：US396128
申请日：1995-02-28
申请人： Xuguang Li
发明人： Xuguang Li
IPC分类号： G01V1/24 , H04B14/04 , G06F15/00
CPC分类号： G01V1/247
摘要： The present invention is a method of processing digitized signal samples generated by a free running analog-to-digital converter and sampled at a first sample rate. The method includes the steps of convolving the digitized signal samples with a single-stage digital filter and generating a series of resampled signal samples having a second sample rate no greater than the first sample rate. The resampled signal samples are synchronized with a predetermined time reference during the step of generating the series of resampled signal samples.The present invention is also an apparatus for recording seismic surveys. The apparatus comprises: a delta-sigma analog-to-digital converter; a means for calculating an average of a plurality of outputs of the delta-sigma converter; a means for subtracting the average from a single output of the converter; and a single-stage digital filter which has the capability of synchronizing digital signal samples from the delta-sigma converter to a predetermined time reference and can resample the digital signal samples to a lower sampling rate than that rate provided by the delta-sigma converter.
摘要翻译：本发明是一种处理由自由运行的模数转换器产生并以第一采样率采样的数字化信号采样的方法。该方法包括以下步骤：将数字化信号样本与单级数字滤波器进行卷积，并产生具有不大于第一采样率的第二采样率的一系列重采样信号样本。在产生一系列重采样信号样本的步骤期间，重新采样的信号样本与预定的时间基准同步。本发明也是用于记录地震勘测的装置。该装置包括：Δ-Σ模数转换器; 用于计算所述Δ-Σ转换器的多个输出的平均值的装置; 用于从转换器的单个输出中减去平均值的装置; 以及具有将来自Δ-Σ转换器的数字信号样本与预定时间基准同步的能力的单级数字滤波器，并且可以将数字信号样本重新采样到比由Δ-Σ转换器提供的速率更低的采样速率。

10. 发明授权

US07629285B2 Carbon-based composite electrocatalysts for low temperature fuel cells 有权
标题翻译：用于低温燃料电池的碳基复合电催化剂
公开(公告)号：US07629285B2
公开(公告)日：2009-12-08
申请号：US11930322
申请日：2007-10-31
申请人： Branko N. Popov , Jog-Won Lee , Nalini P. Subramanian , Swaminatha P. Kumaraguru , Hector R. Colon-Mercado , Vijayadurga Nallathambi , Xuguang Li , Gang Wu
发明人： Branko N. Popov , Jog-Won Lee , Nalini P. Subramanian , Swaminatha P. Kumaraguru , Hector R. Colon-Mercado , Vijayadurga Nallathambi , Xuguang Li , Gang Wu
IPC分类号： B01J31/00 , B01J21/18 , B01J27/06 , B01J23/00 , B01J23/02 , B01J23/06 , B01J23/40 , B01J23/74
CPC分类号： H01M4/92 , B01J21/18 , B01J37/086 , B01J37/12 , H01M4/9083 , H01M4/926 , H01M2008/1095
摘要： A process for synthesis of a catalyst is provided. The process includes providing a carbon precursor material, oxidizing the carbon precursor material whereby an oxygen functional group is introduced into the carbon precursor material, and adding a nitrogen functional group into the oxidized carbon precursor material.
摘要翻译：提供合成催化剂的方法。该方法包括提供碳前体材料，氧化碳前体材料，由此将氧官能团引入到碳前体材料中，并在氧化碳前体材料中加入氮官能团。

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