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1. 发明授权

US4162314A 7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivatives 失效
标题翻译： 7 {8 2（取代苯基）2-（氨基）乙酰氨基{9头孢菌素衍生物
公开(公告)号：US4162314A
公开(公告)日：1979-07-24
申请号：US806241
申请日：1977-06-13
申请人： Rudolf Gottschlich , Rolf Gericke , Horst Juraszyk , Jurgen Seubert , Wighard Strehlow , Helmut Wahlig , Rolf Bergmann , Elvira Dingeldein
发明人： Rudolf Gottschlich , Rolf Gericke , Horst Juraszyk , Jurgen Seubert , Wighard Strehlow , Helmut Wahlig , Rolf Bergmann , Elvira Dingeldein
IPC分类号： A61K20060101 , A61K31/165 , A61K31/395 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07B20060101 , C07D499/48 , C07D499/64 , C07D499/68 , C07D501/20 , C07D501/22 , C07D501/32 , C07D501/36 , C07D501/60
CPC分类号： C07D501/20 , C07D499/68
摘要： Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.
摘要翻译：新型β-内酰胺抗生素是下式的化合物：其中R是至多6个碳原子的烷基，或当A是氧时，R是氢; A是氧或-OCO-; Z是氢，乙酰氧基或S-Het; Het是1,2,3-三唑-5-基，1-甲基四唑-5-基，1,3,4-噻二唑-2-基或2-甲基-1,3,4-噻二唑-5-基; 且n为0至8的整数; 或易裂解的酯或其生理上可接受的盐。

2. 发明授权

US4937257A Flavanone derivatives 失效
标题翻译：黄酮衍生物
公开(公告)号：US4937257A
公开(公告)日：1990-06-26
申请号：US770327
申请日：1985-08-28
申请人： Rolf Gericke , Helmut Wahlig , Elvira Dingeldein
发明人： Rolf Gericke , Helmut Wahlig , Elvira Dingeldein
IPC分类号： C07D311/32 , A61K31/35 , A61K31/352 , A61K31/655 , A61K31/665 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , A61P37/08 , C07D311/30 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/22
CPC分类号： C07H15/207 , C07D311/30 , C07F9/65522 , C07H15/22
摘要： New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.
摘要翻译：式I的新的黄烷酮衍生物其中Ar 1和Ar 2各自是未取代或被OH，烷基，烷氧基，酰氨基，卤素，COO烷基和/或NO 2单取代或三取代的苯基和/或被亚甲二氧基取代的苯基，并且烷基，烷氧基和酰基各自具有1-7个C原子，但如果基团Ar 1和Ar 2中的至少一个是取代的苯基，则HO基团仅在6位，并且其磷酸酯和这些化合物的盐显示抗过敏作用。 N-磷酸酯与氨基糖苷类抗生素的盐非常稳定，具有有利的释放动力学。

3. 发明授权

US08003121B1 Modular implant system containing active substances and method for the production thereof 有权
标题翻译：含有活性物质的模块化植入体系及其生产方法
公开(公告)号：US08003121B1
公开(公告)日：2011-08-23
申请号：US10343363
申请日：2000-08-01
申请人： Elvira Dingeldein , Helmut Wahlig , Jörg Bauer , Edgar Wüst , Christoph Sattig
发明人： Elvira Dingeldein , Helmut Wahlig , Jörg Bauer , Edgar Wüst , Christoph Sattig
IPC分类号： A61L24/00 , A61L24/06
CPC分类号： A61L24/0015 , A61L24/06 , A61L2300/406 , A61L2300/416 , A61L2300/44 , C08L33/06
摘要： System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives.Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.
摘要翻译：包含活性剂的植入物组分的系统，其中每个组分旨在作为用粉末状或精细粒化的原料和/或活性剂和添加剂生产的植入材料的添加剂。每种组分是粉状或细粒化的，并且包括至少一种粉末状或细粒状的活性剂或添加剂，其用量高于所需应用浓度。组分本身由用于植入材料以及活性剂或添加剂的粉末状或精细制粒的起始材料制成。活性剂可以是化学治疗剂，例如抗生素，而添加剂可以是改变起始物质的物理性质的X射线对比材料和/或添加剂，例如其弹性或粘度。

4. 发明授权

US4853225A Process for implanting a medicament depot 失效
标题翻译：植入药剂库的方法
公开(公告)号：US4853225A
公开(公告)日：1989-08-01
申请号：US938200
申请日：1986-12-05
申请人： Helmut Wahlig , Elvira Dingeldein , Johannes Rothe , Wolfgang Stille
发明人： Helmut Wahlig , Elvira Dingeldein , Johannes Rothe , Wolfgang Stille
IPC分类号： A61K45/00 , A61K9/00 , A61K9/22 , A61K31/47 , A61K31/505 , A61K47/02 , A61K47/32 , A61K47/36 , A61K47/42 , A61L24/00
CPC分类号： A61K9/0024 , A61L24/0015 , A61L2300/434
摘要： The invention relates to an implantable medicament depot comprising physiologically acceptable excipients and at least one delayed release active compound which is a chemotherapeutic of the gyrase inhibitor type.The depot can be used for combating infections.
摘要翻译：本发明涉及包含生理上可接受的赋形剂和至少一种缓释活性化合物的可植入药物贮库，所述延迟释放活性化合物是促旋酶抑制剂类型的化学治疗剂。仓库可用于对抗感染。

5. 发明授权

US4617293A Flavonoid phosphate salts of aminoglycoside antibiotics 失效
标题翻译：氨基糖苷类抗生素类黄酮磷酸盐
公开(公告)号：US4617293A
公开(公告)日：1986-10-14
申请号：US613131
申请日：1984-05-23
申请人： Helmut Wahlig , Elvira Dingeldein , Richard Kirchlechner , Dieter Orth , Werner Rogalski
发明人： Helmut Wahlig , Elvira Dingeldein , Richard Kirchlechner , Dieter Orth , Werner Rogalski
IPC分类号： C07H15/20 , C07H17/065 , A61K31/71 , C07H15/22
CPC分类号： C07H17/065 , C07H15/20
摘要： Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect.
摘要翻译：氨基糖苷类抗生素的黄酮类磷酸盐是有用的微溶盐，例如用于达到贮库作用。

6. 发明授权

US06957909B1 Blister pack 有权
标题翻译：吸塑包装
公开(公告)号：US06957909B1
公开(公告)日：2005-10-25
申请号：US09980547
申请日：2000-07-20
申请人： Elvira Dingeldein , Helmut Wahlig , Christoph Sattig , Edgar Wüst
发明人： Elvira Dingeldein , Helmut Wahlig , Christoph Sattig , Edgar Wüst
IPC分类号： A61B19/02 , A61F2/46 , B65D75/36 , B65D75/58 , B65D77/04 , B65D81/32 , B65D71/00 , B01F15/00 , B65D69/00
CPC分类号： B65D77/0446 , A61B50/33 , B65D75/36 , B65D75/366 , B65D75/368 , B65D75/58 , B65D81/32 , B65D2575/365
摘要： Blister packaging unit (10) for at least two components packed in separate individual packages, at least one of which has a pulverulent or granular consistency, which are to be prepared before use with the further packaged component(s) in a mixer or applicator to form a ready-to-use mixture. The individual packages of the components are inserted in correspondingly pre-shaped receptacles (32; 34) in the blister (30) of a suitable film or other material and this blister is closed on the side of the open mouth of the receptacles by a cover (36) of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.The component(s) having the pulverulent or granular consistency is/are packaged in a respective individual blister pack (12; 14; 16) shaped at least approximately complementarily to the associated receptacle (32) in the blister packaging unit, the blister of which has the shape of an elongate trough element (12) of plastic material tapered at at least one end in the manner of a spout, which trough element(s) comprises a separate tear-off cover (16) of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.
摘要翻译：吸塑包装单元（10）用于至少两个组件，其包装在单独的单个包装中，其中至少一个具有粉末或颗粒状稠度，其将在与混合器或涂布器中的另外包装的组分一起使用之前制备，形成即用型混合物。组件的各个包装被插入适当的胶片或其他材料的泡罩（30）中相应的预形状的容器（32; 34）中，并且该泡罩在容器的敞开的嘴的一侧通过盖子（36）的纸板，塑料，金属或一些其他合适的材料，可以以某种其他方式被撕下或打开。具有粉状或颗粒状稠度的组分被包装在与吸塑包装单元中的相关容器（32）至少大致互补成形的相应单独的泡罩包装（12; 14; 16）中，其泡罩具有塑料材料的细长槽元件（12）的形状，其在至少一端以喷嘴的方式逐渐变细，所述槽元件包括纸板，塑料，金属或金属的分开的撕开盖（16）可能以某种其他方式撕下或打开的一些其他合适的材料。

7. 发明授权

US4869906A Tricalcium phosphate for implant materials wherein the pores of the tricalciumphosphate are filled with antibiotic and amino acid 失效
标题翻译：用于植入材料的磷酸三钙，其中磷酸三钙的孔被抗生素和氨基酸填充
公开(公告)号：US4869906A
公开(公告)日：1989-09-26
申请号：US39254
申请日：1987-04-17
申请人： Elvira Dingeldein , Helmut Wahlig , Manfred Wotschokowsky , Gu Moddelmog
发明人： Elvira Dingeldein , Helmut Wahlig , Manfred Wotschokowsky , Gu Moddelmog
IPC分类号： C04B22/16 , A61L24/00 , A61L27/00 , A61L27/54
CPC分类号： A61L24/0015 , A61L27/54 , A61L2300/214 , A61L2300/406 , A61L2300/45 , A61L2430/02
摘要： A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.
摘要翻译：使用抗生素和填料，特别是氨基酸的填料混合物密封孔的可再吸收的多孔磷酸三钙对于用于骨水泥的制备是特别有利的。

8. 发明授权

US4797282A Drug depot containing cytostatics 失效
标题翻译：含有细胞抑制剂的药物库
公开(公告)号：US4797282A
公开(公告)日：1989-01-10
申请号：US853320
申请日：1986-04-18
申请人： Helmut Wahlig , Elvira Dingeldein
发明人： Helmut Wahlig , Elvira Dingeldein
IPC分类号： A61K49/04 , A61K9/00 , A61K9/20 , A61K9/22 , A61K47/32 , A61L24/00 , A61L24/06 , A61F13/00
CPC分类号： A61K9/0024 , A61K9/2013 , A61K9/2027 , A61L24/0015 , A61L24/06 , A61L2300/404 , A61L2300/406 , A61L2300/416
摘要： A drug depot, which can be implanted in the body, for the controlled, delayed release of cytostatics, comprises a synthetic material based on polyacrylates and/or polymethacrylates containing a cytostatic and at least one amino acid. The depot can be used in a particularly advantageous manner for the local control of tumors.
摘要翻译：可以植入体内的用于抑制，延迟释放细胞抑制剂的药物贮库包含基于含有细胞抑制剂和至少一种氨基酸的聚丙烯酸酯和/或聚甲基丙烯酸酯的合成材料。储存库可以以特别有利的方式用于肿瘤的局部控制。

9. 发明授权

US4291013A Medicinally useful, shaped mass of collagen resorbable in the body 失效
标题翻译：医疗上有用的成型质量的胶原蛋白可吸收体内
公开(公告)号：US4291013A
公开(公告)日：1981-09-22
申请号：US82520
申请日：1979-10-09
申请人： Helmut Wahlig , Elvira Dingeldein , Dietrich Braun
发明人： Helmut Wahlig , Elvira Dingeldein , Dietrich Braun
IPC分类号： A61L15/64 , A61K9/22 , A61K38/17 , A61K47/42 , A61L15/32 , A61L17/00 , A61L27/26 , A61L27/46 , A61L27/54 , A61L27/58 , A61F13/00 , A61K9/26 , A61L15/03
CPC分类号： A61L27/58 , A61L15/325 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/54 , A61L2300/406 , Y10S514/801
摘要： A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.
摘要翻译：在体内可再吸收的成形质量包括胶原和生物可再吸收的胶原结合剂，所述粘合剂选自例如C2-16α-羟基链烷酸的聚合物，天然氨基酸的聚合物，水解胶原或水解弹性蛋白。

10. 发明授权

US06689375B1 Resorbable bone implant material and method for producing the same 有权
标题翻译：可再吸收的骨植入材料及其制造方法
公开(公告)号：US06689375B1
公开(公告)日：2004-02-10
申请号：US10129753
申请日：2002-06-05
申请人： Helmut Wahlig , Elvira Dingeldein , Edgar Wüst , Christoph Sattig
发明人： Helmut Wahlig , Elvira Dingeldein , Edgar Wüst , Christoph Sattig
IPC分类号： A61F200
CPC分类号： A61L24/0063 , A61F2/28 , A61F2002/2817 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61L24/0042 , A61L27/425 , A61L27/58 , A61L2430/02
摘要： The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically prepared, precipitated crystalline nanoparticles of high purity, which have a crystal size of 10-20 nm width and 50-60 nm length. The specific absorbing BET surface area of the nanocrystals is preferably 100-150 m2/g.
摘要翻译：植入材料的粉末组分基本上由羟基磷灰石粉末和硫酸钙粉末的混合物组成，其中羟基磷灰石粉末由合成制备的高纯度的沉淀结晶纳米颗粒组成，其具有10-20nm宽的晶体尺寸和 50-60nm长。纳米晶体的比吸收BET表面积优选为100-150m 2 / g。

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