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1. 发明申请

US20090292327A1 IMPLANTABLE MEDICAL DEVICE WITH ANTI-INFECTION AGENT 有权
标题翻译：具有抗感染剂的可植入医疗器械
公开(公告)号：US20090292327A1
公开(公告)日：2009-11-26
申请号：US12536258
申请日：2009-08-05
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device comprises an anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：可植入医疗装置包括抗感染剂。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

2. 发明授权

US07596408B2 Implantable medical device with anti-infection agent 失效
标题翻译：具有抗感染剂的植入式医疗器械
公开(公告)号：US07596408B2
公开(公告)日：2009-09-29
申请号：US10837319
申请日：2004-04-30
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device with anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：具有抗感染剂的可植入医疗器械。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

3. 发明授权

US07242982B2 Overmold for a modular implantable medical device 有权
标题翻译：用于模块化可植入医疗设备的包覆模型
公开(公告)号：US07242982B2
公开(公告)日：2007-07-10
申请号：US10730873
申请日：2003-12-09
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device permits implantable medical devices to have a smaller profile in order to better fit into locations within the human body. A modular implantable medical device separates various functional components of the implantable medical device into a set of interconnected modules. This distributed architecture of a modular implantable medical device may permit the device footprint to be distributed over a larger area while making the profile smaller, and may permit the overall shape of the implantable medical device to better match the body location into which it is to be implanted. An overmold integrates the modules of a modular implantable medical device into a single structure. In some embodiments the overmold is flexible and provides a biocompatible interface from the component modules and the patient, while restraining potentially harmful intermodule motion.
摘要翻译：模块化可植入医疗装置允许植入式医疗装置具有更小的外形，以便更好地适应人体内的位置。模块化可植入医疗装置将可植入医疗装置的各种功能部件分离成一组互连的模块。模块化可植入医疗设备的这种分布式架构可以允许设备占地面积分布在更大的区域上，同时使轮廓更小，并且可以允许可植入医疗设备的整体形状更好地匹配要被植入的医疗设备的身体位置植入。包覆模具将模块化可植入医疗设备的模块集成到单个结构中。在一些实施方案中，包覆成型是柔性的并且提供来自组件模块和患者的生物相容性界面，同时限制潜在有害的模块间运动。

4. 发明授权

US09162072B2 Implantable medical device with lubricious material 有权
标题翻译：具有光滑材料的植入式医疗器械
公开(公告)号：US09162072B2
公开(公告)日：2015-10-20
申请号：US11526514
申请日：2006-09-25
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/375 , A61N1/36 , A61N1/05
CPC分类号： A61N1/375 , A61B2560/0443 , A61N1/0526 , A61N1/3605
摘要： An implantable medical device with lubricious material permits implantable medical devices to have a reduced friction between the device and at least a portion of the surrounding tissue. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the tissue. The lubricious material may be provided on or impregnated in the housing or the member. In some embodiments, the device is configured for implantation in the head of a human body. In other embodiments, the device is configured for implantation between the cranium and the scalp. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled together to provide a smaller profile.
摘要翻译：具有润滑材料的可植入医疗装置允许植入式医疗装置在装置与周围组织的至少一部分之间具有减小的摩擦。可植入医疗装置可以具有壳体，或者可以具有壳体和用于在装置和组织之间提供平滑界面的构件。润滑材料可以设置在或浸渍在壳体或构件中。在一些实施例中，该装置被配置用于植入人体的头部。在其他实施例中，该装置被配置用于在颅骨和头皮之间植入。在一些实施例中，设备包括单个模块，而在其他实施例中，多个模块耦合在一起以提供较小的轮廓。

5. 发明授权

US08086313B2 Implantable medical device with anti-infection agent 有权
标题翻译：具有抗感染剂的植入式医疗器械
公开(公告)号：US08086313B2
公开(公告)日：2011-12-27
申请号：US12536258
申请日：2009-08-05
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device comprises an anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：可植入医疗装置包括抗感染剂。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

6. 发明授权

US08457744B2 Low-profile implantable medical device 有权
标题翻译：低调植入式医疗器械
公开(公告)号：US08457744B2
公开(公告)日：2013-06-04
申请号：US10730877
申请日：2003-12-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Paulette C. Olson , Robert M. Skime
发明人： Darren A. Janzig , Carl D. Wahlstrand , Paulette C. Olson , Robert M. Skime
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： Components of an implantable medical device are arranged to facilitate a low-profile housing. A circuit board within the housing carries integrated circuits and discrete components. In some embodiments, the integrated circuits and discrete components are located on first and second opposing surfaces of the circuit board, respectively. In some embodiments, the implantable medical device is implanted on a cranium of a patient and the housing is concave such that it substantially conforms to the cranium. In such embodiments, the integrated circuits and/or discrete components can be arranged on the circuit board according to height to better conform to the concavity of the housing. In some embodiments, the implantable medical device includes a telemetry coil that is positioned within the housing such that it occupies space that cannot be practically occupied by the circuit board.
摘要翻译：可植入医疗装置的部件被布置成便于小型外壳。外壳内的电路板承载集成电路和分立元件。在一些实施例中，集成电路和分立元件分别位于电路板的第一和第二相对表面上。在一些实施例中，将可植入医疗装置植入患者的颅骨上，并且所述外壳是凹形的，使得其基本上符合颅骨。在这样的实施例中，集成电路和/或分立组件可以根据高度布置在电路板上，以更好地符合壳体的凹面。在一些实施例中，可植入医疗装置包括位于壳体内的遥测线圈，使其占据不能被电路板实际占据的空间。

7. 发明授权

US07529586B2 Concavity of an implantable medical device 有权
标题翻译：可植入医疗器械的凹陷
公开(公告)号：US07529586B2
公开(公告)日：2009-05-05
申请号：US10731867
申请日：2003-12-09
申请人： Carl D. Wahlstrand , Darren A. Janzig , Ruchika Singhal , Robert M. Skime , Erik R. Scott , James E. Randall
发明人： Carl D. Wahlstrand , Darren A. Janzig , Ruchika Singhal , Robert M. Skime , Erik R. Scott , James E. Randall
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： At least one surface of an implantable medical device is concave along at least one axis such that it substantially conforms to a surface within a patient, such as the cranium, when it is implanted on that surface. In some embodiments, the surface of the implantable medical device substantially conforms to an arc with a radius that is between 4.5 and 9.5 centimeters, and is preferably approximately equal to 7 centimeters. In some embodiments, the implantable medical device comprises a plurality of interconnected modules, and an overmold that at least partially encapsulates each of the modules. In such embodiments, at least one surface of the overmold is concave along at least one axis. Further, each of the modules of such an implantable medical device may comprise a housing, and at least one surface of at least one of the housings may be concave along at least one axis.
摘要翻译：可植入医疗装置的至少一个表面沿着至少一个轴线是凹形的，使得当植入在该表面上时，其基本上符合患者（例如颅骨）内的表面。在一些实施例中，可植入医疗装置的表面基本上符合半径在4.5和9.5厘米之间的弧度，并且优选地大约等于7厘米。在一些实施例中，可植入医疗装置包括多个互连的模块，以及至少部分地封装每个模块的包覆模制。在这样的实施例中，包覆模制体的至少一个表面沿着至少一个轴线是凹形的。此外，这种可植入医疗装置的每个模块可以包括壳体，并且至少一个壳体的至少一个表面沿着至少一个轴线可以是凹形的。

8. 发明授权

US07848817B2 Coupling module of a modular implantable medical device 有权
标题翻译：模块化可植入医疗器械的耦合模块
公开(公告)号：US07848817B2
公开(公告)日：2010-12-07
申请号：US10731699
申请日：2003-12-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
发明人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
摘要翻译：在具有各个模块的可植入医疗装置中，耦合模块将模块彼此连接。联接模块支持模块的电气和/或机械耦合。联接模块可呈现各种形状或构型。联接模块的各种实施例可以提供模块相对于彼此的不同移动自由度。

9. 发明授权

US07392089B2 Reducing relative intermodule motion in a modular implantable medical device 失效
标题翻译：在模块化可植入医疗设备中减少相对模块间运动
公开(公告)号：US07392089B2
公开(公告)日：2008-06-24
申请号：US10731881
申请日：2003-12-09
申请人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
发明人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device includes a plurality of modules that are at least partially encapsulated by an overmold. The modules may be connected by coupling modules, which may be flexible to provide for one or more degrees of relative intermodular motion. The overmold may also be flexible. In order to reduce relative intermodule motion to acceptable direction and/or ranges, the overmold may include one or more motion reduction elements.
摘要翻译：模块化可植入医疗装置包括至少部分地由包覆成型包封的多个模块。模块可以通过耦合模块连接，耦合模块可以是柔性的，以提供一个或多个相对的模块间运动程度。包覆成型也可以是柔性的。为了将相对模块间运动减小到可接受的方向和/或范围，包覆模具可以包括一个或多个运动减少元件。

10. 发明授权

US08666497B2 Coupling module of a modular implantable medical device 有权
标题翻译：模块化可植入医疗器械的耦合模块
公开(公告)号：US08666497B2
公开(公告)日：2014-03-04
申请号：US12942806
申请日：2010-11-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
发明人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
IPC分类号： A61N1/372
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
摘要翻译：在具有各个模块的可植入医疗装置中，耦合模块将模块彼此连接。联接模块支持模块的电气和/或机械耦合。联接模块可呈现各种形状或构型。联接模块的各种实施例可以提供模块相对于彼此的不同移动自由度。

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