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1. 发明授权

US08900603B2 Local delivery of drugs from self assembled coatings 有权
标题翻译：从自组装涂料当地输送药物
公开(公告)号：US08900603B2
公开(公告)日：2014-12-02
申请号：US13516913
申请日：2010-12-20
申请人： Roseita Esfand , J. Paul Santerre , Sylvia Tjahyadi , Bernadette Ilagan
发明人： Roseita Esfand , J. Paul Santerre , Sylvia Tjahyadi , Bernadette Ilagan
IPC分类号： A61K47/34 , A61K31/337 , A61K31/436 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , C08G65/00 , C08L71/02
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61K47/34 , A61K47/59 , A61K47/60 , A61K47/6957 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61M25/10 , A61M2025/1045 , A61M2025/105 , C08G65/007 , C08L71/02 , C08L2203/02 , C08L27/12
摘要： The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.
摘要翻译：本发明涉及寡氟化涂料及其在拖曳递送中的用途。低聚氟化涂料是包含式（XVII）的组合物。这些涂层用于将生物活性剂递送到哺乳动物组织中的组织表面的方法。该方法通过使表面与包含低聚氟化低聚物和生物活性剂的涂层接触而发生，其中涂层驻留在组织表面上并释放生物活性剂到组织表面。

2. 发明申请

US20130142834A1 LOCAL DELIVERY OF DRUGS FROM SELF ASSEMBLED COATINGS 有权
标题翻译：从自组装涂料当地输送药物
公开(公告)号：US20130142834A1
公开(公告)日：2013-06-06
申请号：US13516913
申请日：2010-12-20
申请人： Roseita Esfand , J. Paul Santerre , Sylvia Tjahyadi , Bernadette Ilagan
发明人： Roseita Esfand , J. Paul Santerre , Sylvia Tjahyadi , Bernadette Ilagan
IPC分类号： A61K47/34
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61K47/34 , A61K47/59 , A61K47/60 , A61K47/6957 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61M25/10 , A61M2025/1045 , A61M2025/105 , C08G65/007 , C08L71/02 , C08L2203/02 , C08L27/12
摘要： The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.
摘要翻译：本发明涉及寡氟化涂料及其在拖曳递送中的用途。低聚氟化涂料是包含式（XVII）的组合物。这些涂层用于将生物活性剂递送到哺乳动物组织中的组织表面的方法。该方法通过使表面与包含低聚氟化低聚物和生物活性剂的涂层接触而发生，其中涂层驻留在组织表面上并释放生物活性剂到组织表面。

3. 发明申请

US20110104228A1 SELF-ELIMINATING COATINGS 审中-公开
标题翻译：自消除涂料
公开(公告)号：US20110104228A1
公开(公告)日：2011-05-05
申请号：US12738397
申请日：2008-10-17
申请人： Roseita Esfand , J. Paul Santerre , Mark J. Ernsting , Vivian Z. Wang , Sylvia Tjahyadi
发明人： Roseita Esfand , J. Paul Santerre , Mark J. Ernsting , Vivian Z. Wang , Sylvia Tjahyadi
IPC分类号： A61F2/00 , A61K38/00 , A61K31/70 , A61K31/4353 , A61K39/395 , A61K31/7052 , A61P9/00 , A61L33/06 , A61K9/32
CPC分类号： A61L27/34 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： The invention features the use of a matrix consisting of low molecular weight components for use as a self-eliminating coating for implantable medical devices. The matrix coatings can be used to enhance biocompatibility and to control the local delivery of biologically active agents.
摘要翻译：本发明的特征在于使用由低分子量组分组成的基质，用作可植入医疗装置的自消除涂层。基质涂层可用于增强生物相容性并控制生物活性剂的局部递送。

4. 发明申请

US20110091508A1 OLIGOFLUORINATED CROSS-LINKED POLYMERS AND USES THEREOF 审中-公开
标题翻译：低聚合交联聚合物及其用途
公开(公告)号：US20110091508A1
公开(公告)日：2011-04-21
申请号：US12681757
申请日：2008-10-02
申请人： Roseita Esfand , J. Paul Santerre , Mark J. Ernsting , H. Hung Pham , Vivian Z. Wang , Meilin Yang
发明人： Roseita Esfand , J. Paul Santerre , Mark J. Ernsting , H. Hung Pham , Vivian Z. Wang , Meilin Yang
IPC分类号： A61K9/00 , C07C21/18 , C07D303/08 , C07D203/06 , C07D403/02 , C07D403/14 , C07D263/08 , C07K2/00 , C07H99/00 , C07K16/00 , C08G63/88 , C08G77/32 , A61K38/02 , A61K31/70 , A61K31/436 , A61K39/395 , A61K31/7088 , A61P3/02 , A61P35/00 , A61P37/02 , A61P23/00 , A61P29/00 , A61P7/02 , A61P9/00 , A61P31/12 , A61P25/00 , B05D3/02
CPC分类号： A61L31/10 , A61L31/04 , C08G18/10 , C08G18/2885 , C08G18/4854 , C08G18/672 , C08G18/771 , C08G63/06 , C08G63/912 , C08J5/18 , C08J2367/04 , C08J2367/07 , C08J2371/02 , C09D167/04 , C09D167/07 , C09D175/16
摘要： The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.
摘要翻译：本发明具有低聚氟化交联聚合物及其用于制造制品和涂层表面的用途。

5. 发明授权

US08445016B2 Grafted polymers and uses thereof 有权
标题翻译：接枝聚合物及其用途
公开(公告)号：US08445016B2
公开(公告)日：2013-05-21
申请号：US12226162
申请日：2007-04-13
申请人： J. Paul Santerre , Roseita Esfand , Meilin Yang
发明人： J. Paul Santerre , Roseita Esfand , Meilin Yang
IPC分类号： A61K9/14
CPC分类号： A61L27/54 , A61L27/38 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C08F251/00 , C08F283/00
摘要： The invention features grafted polymer systems for use in medical devices and/or for the delivery of active agents. The grafted polymers include at least one transport moiety, a linear backbone segment, and a pendant segment.
摘要翻译：本发明的特征在于用于医疗装置和/或用于递送活性剂的接枝聚合物体系。接枝聚合物包括至少一个转运部分，线性骨架部分和侧链部分。

6. 发明授权

US08574604B2 Methods and compositions for the delivery of biologically active agents 有权
标题翻译：用于递送生物活性剂的方法和组合物
公开(公告)号：US08574604B2
公开(公告)日：2013-11-05
申请号：US11404290
申请日：2006-04-14
申请人： Roseita Esfand , Paul J. Santerre , Meilin Yang
发明人： Roseita Esfand , Paul J. Santerre , Meilin Yang
IPC分类号： A01N25/00
CPC分类号： A61L27/54 , A61K9/7007 , A61K47/30 , A61L27/14 , A61L31/041 , A61L31/16 , A61L2300/80 , C08G18/2885 , C08G18/4854 , C08G18/771
摘要： The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
摘要翻译：本发明的特征在于与生物活性剂非共价复合的聚合物。聚合物复合物包括共价连接至至少一个络合部分的至少一个屏蔽部分，其与至少一种生物活性剂络合。

7. 发明申请

US20060039891A1 Antineoplastic-dendritic polymer drug delivery system 审中-公开
标题翻译：抗肿瘤树突状聚合物药物递送系统
公开(公告)号：US20060039891A1
公开(公告)日：2006-02-23
申请号：US10493354
申请日：2001-10-29
申请人： Navid Malik , Ruth Duncan , Donald Tomalia , Roseita Esfand
发明人： Navid Malik , Ruth Duncan , Donald Tomalia , Roseita Esfand
IPC分类号： A61K31/765
CPC分类号： A61K31/765
摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.
摘要翻译：制备用于将抗肿瘤药物携带到恶性肿瘤中的有用的药物递送系统的抗肿瘤树突状聚合物缀合物。使用离子电荷分流机制将抗肿瘤剂包封在树突状聚合物内，由此，抗肿瘤剂与树突状聚合物表面上的阴离子官能团相互作用，允许抗肿瘤剂被树状聚合物吸收，通过与树枝状聚合物内部的官能团。抗肿瘤性树突状聚合物缀合物可以以有效抑制恶性肿瘤生长的量静脉内，口服，亲本，皮下，动脉内或局部给予具有恶性肿瘤的动物。抗肿瘤树突状聚合物缀合物具有药效高，药物携带能力强，水溶性好，储存稳定性好，毒性降低。

8. 发明授权

US08877062B2 Antithrombogenic hollow fiber membranes and filters 有权
标题翻译：抗血栓形成中空纤维膜和过滤器
公开(公告)号：US08877062B2
公开(公告)日：2014-11-04
申请号：US12834730
申请日：2010-07-12
申请人： Sanjoy Mullick , Weilun Chang , Hanje Chen , Mark Steedman , Roseita Esfand
发明人： Sanjoy Mullick , Weilun Chang , Hanje Chen , Mark Steedman , Roseita Esfand
IPC分类号： A61M1/16 , A61M1/34 , B01D61/20 , B01D61/28 , B01D71/06 , B01D71/26 , B01D71/44 , B01D71/68 , B01D71/76 , B01D63/02 , A61M1/36 , B01D67/00 , B01D69/02 , B01D69/08 , B29C47/00 , B29L23/00 , B29L31/00
CPC分类号： A61M1/3673 , A61L33/062 , A61M1/3672 , A61M2202/0413 , B01D63/022 , B01D63/023 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2323/30 , B01D2323/36 , B29C47/00 , B29C47/0014 , B29C47/0026 , B29L2023/00 , B29L2031/731
摘要： The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
摘要翻译：本发明涉及体外血液回路及其组分（例如，中空纤维膜，灌封束和血液管），包括0.005％至10％（w / w）的表面改性大分子。体外血液回路具有抗血栓形成的表面，可用于血液透析，血液透析，血液透析滤过，血液浓缩，血氧合和相关用途。

9. 发明授权

US07005124B2 Dendritic-antineoplastic drug delivery system 失效
公开(公告)号：US07005124B2
公开(公告)日：2006-02-28
申请号：US10016733
申请日：2001-10-29
申请人： Navid Malik , Ruth Duncan , Donald A. Tomalia , Roseita Esfand
发明人： Navid Malik , Ruth Duncan , Donald A. Tomalia , Roseita Esfand
IPC分类号： A61K47/48 , A61K33/24 , A61K31/80
CPC分类号： B82Y5/00 , A61K47/6949 , C08G69/00 , C08G69/02 , C08G83/003 , Y10S424/16
摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to an antineoplastic agent capable of interacting with the functional groups, and contacting the dendritic polymer with the antineoplastic agent. The preferred platin-based analogues of the antineoplastic agents conjugated to the dendritic polymer may be administered intravenously, orally, parentally, subcutaneously, intramuscularly, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.

10. 发明申请

US20110009799A1 ANTITHROMBOGENIC HOLLOW FIBER MEMBRANES AND FILTERS 有权
标题翻译：抗生素中空纤维膜和过滤器
公开(公告)号：US20110009799A1
公开(公告)日：2011-01-13
申请号：US12834730
申请日：2010-07-12
申请人： Sanjoy Mullick , Weilun Chang , Hanje Chen , Mark Steedman , Roseita Esfand
发明人： Sanjoy Mullick , Weilun Chang , Hanje Chen , Mark Steedman , Roseita Esfand
IPC分类号： A61M1/14 , B01D69/02 , B01D69/08 , B01D63/04 , B01D61/24 , B01D61/28 , B29C47/14 , B01J41/00
CPC分类号： A61M1/3673 , A61L33/062 , A61M1/3672 , A61M2202/0413 , B01D63/022 , B01D63/023 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2323/30 , B01D2323/36 , B29C47/00 , B29C47/0014 , B29C47/0026 , B29L2023/00 , B29L2031/731
摘要： The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
摘要翻译：本发明涉及体外血液回路及其组分（例如，中空纤维膜，灌封束和血液管），包括0.005％至10％（w / w）的表面改性大分子。体外血液回路具有抗血栓形成的表面，可用于血液透析，血液透析，血液透析滤过，血液浓缩，血氧合和相关用途。

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