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1. 发明授权

US08399630B2 Engineered anti-IL-13 antibodies, compositions, methods and uses 有权
标题翻译：工程化的抗IL-13抗体，组合物，方法和用途
公开(公告)号：US08399630B2
公开(公告)日：2013-03-19
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

2. 发明申请

US20120045438A1 ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES 有权
标题翻译：工程抗IL-13抗体，组合物，方法和用途
公开(公告)号：US20120045438A1
公开(公告)日：2012-02-23
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P11/06 , C12P21/00 , G01N33/566 , A61K39/00 , A61P37/04 , C12N5/10 , C12N1/19 , C12N1/21 , A61P31/00 , A61P9/00 , A61P25/00 , A61P11/00 , A61P1/00 , A61P7/00 , A61P37/02 , A61P35/00 , A61P3/12 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

3. 发明授权

US08323646B2 Engineered anti-IL-13 antibodies, compositions, methods and uses 有权
标题翻译：工程化的抗IL-13抗体，组合物，方法和用途
公开(公告)号：US08323646B2
公开(公告)日：2012-12-04
申请号：US12539630
申请日：2009-08-12
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

4. 发明申请

US20100111959A1 ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES 有权
标题翻译：工程抗IL-13抗体，组合物，方法和用途
公开(公告)号：US20100111959A1
公开(公告)日：2010-05-06
申请号：US12539630
申请日：2009-08-12
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , G01N33/53 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

5. 发明授权

US08071103B2 Pharmaceutical composition comprising a human GLP-1 mimetibody 有权
标题翻译：包含人GLP-1模拟体的药物组合物
公开(公告)号：US08071103B2
公开(公告)日：2011-12-06
申请号：US11779316
申请日：2007-07-18
申请人： Karyn T. O'Neil , Kristen Picha
发明人： Karyn T. O'Neil , Kristen Picha
IPC分类号： A61K39/00 , A61K38/00 , C07K16/00
CPC分类号： C07K14/605 , A01K2227/105 , A01K2267/0362 , C07K2317/52 , C07K2319/30
摘要： The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译：本发明涉及至少一种改进的人GLP-1模拟体或特定部分或变体，包括编码至少一种GLP-1模拟体或特定部分或变体的分离核酸，GLP-1模拟体或特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括治疗组合物，方法和装置。

6. 发明申请

US20090098108A1 USE OF LONG-ACTING GLP-1 RECEPTOR AGONISTS TO IMPROVE INSULIN SENSITIVITY AND LIPID PROFILES 有权
标题翻译：使用长效GLP-1受体激动剂来提高胰岛素敏感性和脂质谱
公开(公告)号：US20090098108A1
公开(公告)日：2009-04-16
申请号：US11962214
申请日：2007-12-21
申请人： Karyn T. O'Neil , Kristen Picha , Vedrana Stojanovic-Susulic
发明人： Karyn T. O'Neil , Kristen Picha , Vedrana Stojanovic-Susulic
IPC分类号： A61K38/00 , A61P3/00 , A61K38/04 , A61K38/16 , A61K31/7088 , A61K39/395 , C12N5/00 , G01N33/53
CPC分类号： A61K38/26 , G01N2800/044
摘要： The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
摘要翻译：本发明提供至少一种新型人GLP-1受体激动剂或特定部分或变体，包括编码至少一种GLP-1受体激动剂或特定部分或变体GLP-1受体激动剂的分离核酸，或特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括使用长效GLP-1受体激动剂来改善肥胖中的胰岛素敏感性或脂质分布以及相关的治疗和/或诊断组合物，方法和装置。

7. 发明授权

US06623981B2 Detection of patients at risk for developing integrin antagonist/agonist mediated disease states 有权
标题翻译：检测患有发展为整合素拮抗剂/激动剂介导的疾病状态的患者
公开(公告)号：US06623981B2
公开(公告)日：2003-09-23
申请号：US09237061
申请日：1999-01-26
申请人： Jeffrey T. Billheimer , Dietmar A. Seiffert , Leah A. Breth , Timothy C. Burn , Ira B. Dicker , Henry J. George , Gregory F. Hollis , Jeannine M. Hollis , Jennifer E. Kochie , Karyn T. O'Neil
发明人： Jeffrey T. Billheimer , Dietmar A. Seiffert , Leah A. Breth , Timothy C. Burn , Ira B. Dicker , Henry J. George , Gregory F. Hollis , Jeannine M. Hollis , Jennifer E. Kochie , Karyn T. O'Neil
IPC分类号： G01N33553
CPC分类号： G01N33/6893 , C07K14/70557 , C07K16/2848 , G01N33/566 , G01N33/68 , G01N2333/70546 , G01N2500/00 , Y10S435/968 , Y10S436/811
摘要： This invention relates to the detection of patients at risk for developing integrin antagonist/agonist mediated disease states. This invention relates to assays useful for the detection in a patient bodily fluid sample of drug-dependent antibodies which bind to integrins, or intergrin-associated proteins or complexes thereof in the presence of an integrin antagonist/agonist. This invention also relates to assays useful for the detection in a patient bodily fluid sample of drug-dependent antibodies (DDABS) that bind to integrins, including the platelet glycoprotein IIb/IIIa (GPIIb/IIIa), in the presence of a integrin agonist and/or antagonist. This invention also relates to procedures for identifying integrin antagonists/agonists that are less prone to elicit integrin antagonist/agonist mediated disease states. This invention also relates to procedures which increase the recovery of integrin-directed antibodies in body fluids, resulting in an increased sensitivity and specificity of DDAB detection assays. This invention also relates to procedures for treating blood samples, which dissociate antibodies to GPIIb/IIIa from the platelet surface, thereby increasing the recovery from the platelet supernatant. This invention also relates to the use of different GPIIb/IIIa preparations to identify patients at risk for early-onset thrombocytopenia upon treatment with GPIIb/IIIa antagonist/agonists, thereby increasing the specificity of antibody detection. This invention also relates to the use of DDABs as a positive control and calibration standard for DDAB assays. Such methods, procedures and assays are useful for identifying patients who may be at risk to develop disease states mediated by treatment with integrin antagonists/agonists.
摘要翻译：本发明涉及检测发展为整合素拮抗剂/激动剂介导的疾病状态的风险的患者。本发明涉及可用于在整联蛋白拮抗剂/激动剂存在下结合整联蛋白或整合蛋白相关蛋白或其复合物的药物依赖性抗体的患者体液样品中的检测。本发明还涉及用于在整联蛋白激动剂存在下结合整联蛋白（包括血小板糖蛋白IIb / IIIa（GPIIb / IIIa））的药物依赖性抗体（DDABS）的患者体液样品中检测的测定法， /或拮抗剂。本发明还涉及识别不易引起整联蛋白拮抗剂/激动剂介导的疾病状态的整联蛋白拮抗剂/激动剂的方法。本发明还涉及增加体液中整联蛋白定向抗体的回收率的方法，导致敏感性增加和DDAB检测测定的特异性。本发明还涉及用于治疗血液样品的方法，其从血小板表面解离GPIIb / IIIa的抗体，从而增加血小板上清液的回收。本发明还涉及使用不同的GPIIb / IIIa制剂来鉴定在用GPIIb / IIIa拮抗剂/激动剂治疗时患有早发性血小板减少症的患者，从而增加抗体检测的特异性。本发明还涉及使用DDAB 作为DDAB测定的阳性对照和校准标准。这些方法，程序和测定法可用于鉴定可能患有通过用整联蛋白拮抗剂/激动剂治疗介导的疾病状态的风险的患者。

8. 发明授权

US07833531B2 Method for treating insulin sensitivity by long-acting GLP-1 receptor mimetibody agonists 有权
标题翻译：用长效GLP-1受体模拟体激动剂治疗胰岛素敏感性的方法
公开(公告)号：US07833531B2
公开(公告)日：2010-11-16
申请号：US11962214
申请日：2007-12-21
申请人： Karyn T. O'Neil , Kristen Picha , Vedrana Stojanovic-Susulic
发明人： Karyn T. O'Neil , Kristen Picha , Vedrana Stojanovic-Susulic
IPC分类号： A61K39/00 , A61K38/00 , C07K16/00
CPC分类号： A61K38/26 , G01N2800/044
摘要： The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
摘要翻译：本发明提供至少一种新型人GLP-1受体激动剂或特定部分或变体，包括编码至少一种GLP-1受体激动剂或特定部分或变体GLP-1受体激动剂的分离核酸，或特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括使用长效GLP-1受体激动剂来改善肥胖中的胰岛素敏感性或脂质分布以及相关的治疗和/或诊断组合物，方法和装置。

9. 发明申请

US20090325873A1 HUMAN GLP-1 MIMETIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：人GLP-1物质，组成，方法和用途
公开(公告)号：US20090325873A1
公开(公告)日：2009-12-31
申请号：US12305034
申请日：2007-07-18
申请人： Karyn T. O'Neil , Kristen Picha
发明人： Karyn T. O'Neil , Kristen Picha
IPC分类号： A61K38/17 , C07H21/04 , C07K14/435 , C07K16/00 , C12N15/63 , C12N5/08 , C12Q1/68 , C12P21/02 , A61P9/00 , A61P25/00
CPC分类号： C07K14/605 , A01K2227/105 , A01K2267/0362 , C07K2317/52 , C07K2319/30
摘要： The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译：本发明涉及至少一种改进的人GLP-1模拟体或特定部分或变体，包括编码至少一种GLP-1模拟体或特定部分或变体的分离核酸，GLP-1模拟体或特定部分或变体，载体，宿主细胞，转基因动物或植物，及其制备和使用方法，包括治疗组合物，方法和装置。

10. 发明授权

US07744897B2 Human immunodeficiency virus gp41 mimetibody polypeptides 有权
标题翻译：人类免疫缺陷病毒gp41模拟体多肽
公开(公告)号：US07744897B2
公开(公告)日：2010-06-29
申请号：US11018102
申请日：2004-12-21
申请人： Susan B. Dillon , Alfred Michael Del Vecchio , Chichi Huang , Karyn T. O'Neil , Robert T. Sarisky
发明人： Susan B. Dillon , Alfred Michael Del Vecchio , Chichi Huang , Karyn T. O'Neil , Robert T. Sarisky
IPC分类号： A61K39/00 , A61K30/21 , C12N5/00
CPC分类号： C07K14/005 , C07K16/00 , C07K2317/52 , C07K2317/56 , C07K2319/00 , C07K2319/035 , C07K2319/31 , C07K2319/74 , C12N2740/16122 , C12N2740/16222
摘要： HIV gp41 mimetibody polypeptides and encoding polynucleotides are disclosed. Methods of utilizing the polypeptides to reduce or inhibit HIV fusion with a cell membrane and entry into target cells are also disclosed.
摘要翻译：公开了HIV gp41模拟体多肽和编码多核苷酸。还公开了利用多肽来减少或抑制与细胞膜的HIV融合并进入靶细胞的方法。

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