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1. 发明申请

US20050090891A1 Stent lining 失效
公开(公告)号：US20050090891A1
公开(公告)日：2005-04-28
申请号：US10997088
申请日：2004-11-23
申请人： Ronald Sahatjian , James Barry , Maria Palasis
发明人： Ronald Sahatjian , James Barry , Maria Palasis
IPC分类号： A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L27/00 , A61L29/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61M16/04 , A61M25/00 , A61M29/02 , A61F2/06
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/958 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0011 , A61L33/0023 , A61L33/0029 , A61L33/0047 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61M25/0045 , A61M25/104 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter assembly and methods for delivering a hydrogel-lined stent to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter which has a balloon at least a portion of which is coated with a hydrogel and an expansible stent mounted on the balloon in a contracted condition for passage with the catheter to a site of a body. Expansion of the balloon lodges the stent in the body with hydrogel coated on the inner surfaces of the stent as a lining.

2. 发明申请

US20070197980A1 Biocompatible medical devices 有权
标题翻译：生物相容性医疗器械
公开(公告)号：US20070197980A1
公开(公告)日：2007-08-23
申请号：US11451634
申请日：2006-06-12
申请人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg
发明人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg
IPC分类号： A61M25/00
CPC分类号： A61L29/085 , A61L29/103 , A61L29/106 , A61L31/10
摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.
摘要翻译：描述了用于递送药物活性物质的改进的医疗装置。本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

3. 发明授权

US07344490B2 System for administering a combination of therapies to a body lumen 有权
标题翻译：用于将治疗组合施用于体腔的系统
公开(公告)号：US07344490B2
公开(公告)日：2008-03-18
申请号：US11131001
申请日：2005-05-16
申请人： William J. Shaw , James Barry , Paul J. Goll , Maria Palasis
发明人： William J. Shaw , James Barry , Paul J. Goll , Maria Palasis
IPC分类号： A61N5/00
CPC分类号： A61K9/0024 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/046 , A61F2/82 , A61N5/1002
摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.
摘要翻译：本发明提供了一种系统，其包括递送治疗组合的医疗装置。这些疗法包括辐射，生物活性物质，冷冻疗法和热疗法的管理。本发明还涉及使用本发明的系统来治疗体腔表面的方法。提供了一种用于将生物活性材料递送到暴露于放射源的体腔表面的系统。一方面，该系统包括可植入医疗装置，其具有两个相对的端部，每个端部具有表面和中间部分。两个相对端包括生物活性材料，并且医疗装置的中间部分基本上不含任何生物活性物质。在另一方面，系统将遗传物质递送到暴露于放射源的体腔表面。提供了一种用于处理体腔表面的另一系统，其中该系统包括可植入医疗装置，其包括生物活性材料和用于将治疗源施加到与相对侧接触的体腔表面部分的装置医疗器械的末端。治疗源可以是冷冻治疗源或热疗源。

4. 发明授权

US06918869B2 System for administering a combination of therapies to a body lumen 有权
公开(公告)号：US06918869B2
公开(公告)日：2005-07-19
申请号：US10307917
申请日：2002-12-02
申请人： William J. Shaw , James Barry , Paul J. Goll , Maria Palasis
发明人： William J. Shaw , James Barry , Paul J. Goll , Maria Palasis
IPC分类号： A61B17/22 , A61B18/02 , A61B18/04 , A61K9/00 , A61K9/22 , A61N5/10 , A61N5/00 , A61B9/22
CPC分类号： A61K9/0024 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/046 , A61F2/82 , A61N5/1002
摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.

5. 发明申请

US20050222485A1 System for administering a combination of therapies to a body lumen 有权
标题翻译：用于将治疗组合施用于体腔的系统
公开(公告)号：US20050222485A1
公开(公告)日：2005-10-06
申请号：US11131001
申请日：2005-05-16
申请人： William Shaw , James Barry , Paul Goll , Maria Palasis
发明人： William Shaw , James Barry , Paul Goll , Maria Palasis
IPC分类号： A61B17/22 , A61B18/02 , A61B18/04 , A61K9/00 , A61K9/22 , A61N5/10 , A61N5/00
CPC分类号： A61K9/0024 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/046 , A61F2/82 , A61N5/1002
摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.
摘要翻译：本发明提供了一种系统，其包括递送治疗组合的医疗装置。这些疗法包括辐射，生物活性物质，冷冻疗法和热疗法的管理。本发明还涉及使用本发明的系统来治疗体腔表面的方法。提供了一种用于将生物活性材料递送到暴露于放射源的体腔表面的系统。一方面，该系统包括可植入医疗装置，其具有两个相对的端部，每个端部具有表面和中间部分。两个相对端包括生物活性材料，并且医疗装置的中间部分基本上不含任何生物活性物质。在另一方面，系统将遗传物质递送到暴露于放射源的体腔表面。提供了一种用于处理体腔表面的另一系统，其中该系统包括可植入医疗装置，其包括生物活性材料和用于将治疗源施加到与相对侧接触的体腔表面部分的装置医疗器械的末端。治疗源可以是冷冻治疗源或热疗源。

6. 发明授权

US08808272B2 Biocompatible medical devices 有权
标题翻译：生物相容性医疗器械
公开(公告)号：US08808272B2
公开(公告)日：2014-08-19
申请号：US11451634
申请日：2006-06-12
申请人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg
发明人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg
IPC分类号： A61M25/00
CPC分类号： A61L29/085 , A61L29/103 , A61L29/106 , A61L31/10
摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.
摘要翻译：描述了用于递送药物活性物质的改进的医疗装置。本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

7. 发明申请

US20050256450A1 Catheter for the delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂递送至组织的导管
公开(公告)号：US20050256450A1
公开(公告)日：2005-11-17
申请号：US11185801
申请日：2005-07-21
申请人： Maria Palasis , James Barry , Louis Ellis , Gary Hendrickson , Kent Harrison , Lixiao Wang
发明人： Maria Palasis , James Barry , Louis Ellis , Gary Hendrickson , Kent Harrison , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00 , A61F2/02 , A61L29/16 , A61M25/00 , A61M31/00 , A61M37/00
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.
摘要翻译：提供了用于放置原位植入物的导管。该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端设置在第二轴的远端。根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

8. 发明申请

US20060002973A1 Loading and release of water-insoluble drugs 审中-公开
公开(公告)号：US20060002973A1
公开(公告)日：2006-01-05
申请号：US11188850
申请日：2005-07-26
申请人： James Barry , Maria Palasis
发明人： James Barry , Maria Palasis
IPC分类号： A61L33/00 , A61F2/00
CPC分类号： A61L29/16 , A61F2/82 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/604 , A61L2300/606 , A61M25/10 , A61M25/1027 , A61M29/02 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/1088 , C08L75/04 , C08L67/04 , C08L33/08
摘要： A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating.

9. 发明授权

US06663606B1 Biocompatible medical devices 有权
标题翻译：生物相容性医疗器械
公开(公告)号：US06663606B1
公开(公告)日：2003-12-16
申请号：US09503586
申请日：2000-02-14
申请人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg , Justin Crank
发明人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg , Justin Crank
IPC分类号： A61M2500
CPC分类号： A61L31/10 , A61L2/18 , A61L29/08 , A61L29/085 , A61L29/103 , A61L29/106 , A61L29/14 , A61L29/16 , A61L31/16 , A61L33/0076 , A61L2300/00 , C23C22/50
摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.
摘要翻译：描述了用于递送药物活性物质的改进的医疗装置。本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

10. 发明授权

US09218742B2 System and method for airport noise monitoring 有权
标题翻译：机场噪声监测系统及方法
公开(公告)号：US09218742B2
公开(公告)日：2015-12-22
申请号：US11686172
申请日：2007-03-14
申请人： James Barry , Renee Johns Alter , Ron Dunsky
发明人： James Barry , Renee Johns Alter , Ron Dunsky
IPC分类号： G08B21/00 , G08G5/00 , G08G1/01
CPC分类号： G08G5/0095 , G08G1/0104 , G08G5/0013 , G08G5/0026 , G08G5/0082
摘要： Described are a system and a method for airport noise monitoring. The system may include (a) a data receiving arrangement receiving, from a data source, information corresponding to an airport; (b) a data comparing arrangement comparing the received information to noise rules; and (c) an alert generating arrangement generating a noise alert based on the comparison of the received information to the noise rules.
摘要翻译：描述了一种用于机场噪声监测的系统和方法。该系统可以包括（a）数据接收装置，从数据源接收对应于机场的信息; （b）将接收的信息与噪声规则进行比较的数据比较装置; 和（c）警报生成装置，其基于所接收的信息与噪声规则的比较来产生噪声警报。

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