专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06551773B1 Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor 有权
标题翻译：与核激素受体相互作用的转录共同抑制因子及其用途
公开(公告)号：US06551773B1
公开(公告)日：2003-04-22
申请号：US09337384
申请日：1999-06-21
申请人： Ronald M. Evans , J. Don Chen
发明人： Ronald M. Evans , J. Don Chen
IPC分类号： C12Q100
CPC分类号： C07K14/4703 , G01N33/74 , G01N2500/00
摘要： In accordance with the present invention, there are provided novel receptor interacting factors, referred to herein as “SMRT”, i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
摘要翻译：根据本发明，提供了新颖的受体相互作用因子，本文称为“SMRT”，即视黄酸受体（RAR）和甲状腺激素受体（TR）的沉默介质（共抑制因子）。 SMRT是一种新的蛋白质，其与溶液中的RAR和TR在DNA响应元件上的配体不稳定。 SMRT与突变体受体的相互作用与受体的转录沉默活性相关。在体内，SMRT作为一种有效的共抑制剂。 SMRT的GAL4 DNA结合结构域（DBD）融合作为GAL4依赖性记录的坦率阻遏物。在一起，这些数据确定了一类新的辅因子，被认为代表激素作用的重要介质。

2. 发明授权

US07314747B1 SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors 失效
标题翻译： SMRT共同抑制因子，与核激素受体相互作用的转录共抑制因子
公开(公告)号：US07314747B1
公开(公告)日：2008-01-01
申请号：US09522753
申请日：2000-03-10
申请人： Ronald M. Evans , J. Don Chen , Peter Ordentlich , Michael R. Downes
发明人： Ronald M. Evans , J. Don Chen , Peter Ordentlich , Michael R. Downes
IPC分类号： C12N1/15 , C12N5/10 , C12N15/00 , C07H21/04
CPC分类号： C07K14/4703 , G01N33/74 , G01N2500/00
摘要： The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and invertebrate isoforms thereof. The invention also relates to polypeptide SMRT co-repressors encoded by invention SMRT polynucleotides, and to peptide portions thereof that can modulate transcriptional potential of a nuclear receptor. In addition, the invention relates to chimeric molecules and to complexes containing a SMRT co-repressor or peptide portion thereof, to antibodies that specifically bind such compositions, and to methods for identifying an agent that modulates the repressor potential of a SMRT co-repressor. The invention also provides methods for identifying an agent that modulates a function of a SMRT co-repressor; for modulating the transcriptional potential of a nuclear receptor in a cell using the compositions of the invention; and for identifying a molecule that interacts specifically with a SMRT co-repressor.
摘要翻译：本发明涉及编码维甲酸和甲状腺激素受体（SMRT）同种型的沉默介导家族的分离多核苷酸，包括脊椎动物和无脊椎动物同种型。本发明还涉及由本发明的SMRT多核苷酸编码的多肽SMRT共抑制子及其可调节核受体的转录潜力的肽部分。此外，本发明涉及嵌合分子和含有SMRT共抑制子或其肽部分的复合物与特异性结合该组合物的抗体以及用于鉴定调节SMRT共抑制因子的阻遏物潜力的试剂的方法。本发明还提供了用于鉴定调节SMRT共抑制子功能的试剂的方法; 用于使用本发明的组合物调节细胞中核受体的转录电位; 并用于鉴定与SMRT共抑制子特异性相互作用的分子。

3. 发明授权

US07270955B2 Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor 有权
标题翻译：与核激素受体相互作用的转录共同抑制因子及其用途
公开(公告)号：US07270955B2
公开(公告)日：2007-09-18
申请号：US10351750
申请日：2003-01-23
申请人： Ronald M. Evans , J. Don Chen
发明人： Ronald M. Evans , J. Don Chen
IPC分类号： C12Q1/68 , G01N33/567 , C12N15/36
CPC分类号： C07K14/4703 , G01N33/74 , G01N2500/00
摘要： In accordance with the present invention, there are provide novel receptor interacting factors, referred to herein as “SMRT”, i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
摘要翻译：根据本发明，提供了新的受体相互作用因子，本文称为“SMRT”，即视黄酸受体（RAR）和甲状腺激素受体（TR）的沉默介质（共抑制因子）。 SMRT是一种新的蛋白质，其与溶液中的RAR和TR在DNA响应元件上的配体不稳定。 SMRT与突变体受体的相互作用与受体的转录沉默活性相关。在体内，SMRT作为一种有效的共抑制剂。 SMRT的GAL4 DNA结合结构域（DBD）融合作为GAL4依赖性记录的坦率阻遏物。在一起，这些数据确定了一类新的辅因子，被认为代表激素作用的重要介质。

4. 发明授权

US06489441B1 Transcriptional co-repressor that interacts with nuclear hormone receptors 失效
标题翻译：与核激素受体相互作用的转录共同抑制因子
公开(公告)号：US06489441B1
公开(公告)日：2002-12-03
申请号：US08522726
申请日：1995-09-01
申请人： Ronald M. Evans , J. Don Chen
发明人： Ronald M. Evans , J. Don Chen
IPC分类号： C07K14435
CPC分类号： C07K14/4703 , G01N33/74 , G01N2500/00
摘要： In accordance with the present invention, there are provided novel receptor interacting factors, referred to herein as “SMRT”, i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
摘要翻译：根据本发明，提供了新颖的受体相互作用因子，本文称为“SMRT”，即视黄酸受体（RAR）和甲状腺激素受体（TR）的沉默介质（共抑制因子）。 SMRT是一种新的蛋白质，其与溶液中的RAR和TR在DNA响应元件上的配体不稳定。 SMRT与突变体受体的相互作用与受体的转录沉默活性相关。在体内，SMRT作为一种有效的共抑制剂。 SMRT的GAL4 DNA结合结构域（DBD）融合作为GAL4依赖性记录的坦率阻遏物。在一起，这些数据确定了一类新的辅因子，被认为代表激素作用的重要介质。

5. 发明授权

US07132258B1 Nucleic acid encoding vitamin D receptor related polypeptide 失效
标题翻译：编码维生素D受体相关多肽的核酸
公开(公告)号：US07132258B1
公开(公告)日：2006-11-07
申请号：US09041994
申请日：1998-03-13
申请人： J. Don Chen , Hui Li
发明人： J. Don Chen , Hui Li
IPC分类号： C12N15/11 , C12N5/10 , C12N15/63
CPC分类号： C07K14/4702
摘要： A new transcriptional co-activator that interacts with steroid/nuclear receptors has been identified. The peptide and its nucleic acid sequences are useful for modulating the activity of steroid/nuclear receptors and biochemical processes in which steroid/nuclear receptors play a role.
摘要翻译：已经鉴定出与类固醇/核受体相互作用的新的转录协同激活物。肽及其核酸序列可用于调节类固醇/核受体的活性和其中类固醇/核受体起作用的生物化学过程。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式