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1. 发明授权

US08242105B2 Structural mimetics of proline-rich peptides and the pharmaceutical use thereof 有权
标题翻译：富含脯氨酸的肽的结构模拟物及其药物用途
公开(公告)号：US08242105B2
公开(公告)日：2012-08-14
申请号：US12442681
申请日：2007-09-25
申请人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz , Jan Zaminer
发明人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz , Jan Zaminer
IPC分类号： A61K31/55 , C07D223/00
CPC分类号： C07D487/14
摘要： The invention relates to compounds of general formula (I), which can be used particularly as structural mimetics of proline-rich peptides and are therefore capable of binding PRM binding domains (proline-rich motif binding domains) of proteins. The invention also relates to the use of said compounds as pharmaceutical active agents and the use of these pharmaceutical active agents for treating bacterial diseases, neurodegenerative diseases and tumors.
摘要翻译：本发明涉及通式（I）的化合物，其可特别用作富含脯氨酸的肽的结构模拟物，因此能够结合蛋白质的PRM结合结构域（富含脯氨酸的基序结合结构域）。本发明还涉及所述化合物作为药物活性剂的用途以及这些药物活性剂用于治疗细菌性疾病，神经变性疾病和肿瘤的用途。

2. 发明申请

US20110034438A1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THE PHARMACEUTICAL USE THEREOF 有权
标题翻译：富含胶原蛋白的结构化模型及其药物应用
公开(公告)号：US20110034438A1
公开(公告)日：2011-02-10
申请号：US12442681
申请日：2007-09-25
申请人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz
发明人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz
IPC分类号： A61K31/55 , C07D487/14 , A61P25/28 , A61P35/00 , A61P31/04 , A61P31/12 , A61P25/16 , A61P31/18 , A61P35/04 , A61P35/02 , G01N33/53
CPC分类号： C07D487/14
摘要： The invention relates to compounds of general formula (I), which can be used particularly as structural mimetics of proline-rich peptides and are therefore capable of binding PRM binding domains (proline-rich motif binding domains) of proteins. The invention also relates to the use of said compounds as pharmaceutical active agents and the use of these pharmaceutical active agents for treating bacterial diseases, neurodegenerative diseases and tumours.
摘要翻译：本发明涉及通式（I）的化合物，其可特别用作富含脯氨酸的肽的结构模拟物，因此能够结合蛋白质的PRM结合结构域（富含脯氨酸的基序结合结构域）。本发明还涉及所述化合物作为药物活性剂的用途以及这些药物活性剂用于治疗细菌性疾病，神经变性疾病和肿瘤的用途。

3. 发明授权

US08770674B2 Modulator 有权
标题翻译：调制器
公开(公告)号：US08770674B2
公开(公告)日：2014-07-08
申请号：US12451036
申请日：2008-04-26
申请人： Christoph Brockmann , Claudia Deike , Matthias Grimm , Hartmut Rosendahl , Ingo Torhoff , Hans-Klaus Wolff
发明人： Christoph Brockmann , Claudia Deike , Matthias Grimm , Hartmut Rosendahl , Ingo Torhoff , Hans-Klaus Wolff
IPC分类号： B60T8/32 , B60T8/36 , B60G17/052
CPC分类号： B60T8/327 , B60G17/0523 , B60T8/321 , B60T8/3605 , B60T2270/82
摘要： A modulator for a vehicle brake system connected to a central module via a data bus, includes at least one input for capturing measured values and at least one output for controlling at least one electromagnetic valve. A control circuit for actuating the valve is connected by the bus such that the measured values are transmitted to the central module. Control commands for actuating the valve are calculated from the measured values in the central module, and are transmitted via the data bus to the modulator so that the it selects the valve as a function of the commands. A vehicle system has at least two modulators and a central module integrated in a modulator. The modulator can be used as a pressure modulator in an air suspension system or in an electronic braking system or in a conventional braking system with an anti-lock braking system or an electronic stability program.
摘要翻译：一种用于经由数据总线连接到中央模块的车辆制动系统的调制器，包括用于捕获测量值的至少一个输入和用于控制至少一个电磁阀的至少一个输出。用于致动阀的控制电路通过总线连接，使得测量值被传送到中央模块。用于致动阀的控制命令根据中央模块中的测量值计算，并通过数据总线传输到调制器，以便根据命令选择阀。车辆系统具有至少两个调制器和集成在调制器中的中央模块。调制器可以用作空气悬架系统或电子制动系统中的压力调节器，或者用作具有防抱死制动系统或电子稳定程序的常规制动系统。

4. 发明授权

US09022488B2 Fault-tolerant vehicle brake system 有权
标题翻译：容错车辆制动系统
公开(公告)号：US09022488B2
公开(公告)日：2015-05-05
申请号：US12734991
申请日：2008-10-23
申请人： Peter Beier , Uwe Bensch , Christoph Brockmann , Gerhard Bruns , Henning Förster , Olaf Jantz , Hartmut Rosendahl , Wolfgang Strache , Jens Willms
发明人： Peter Beier , Uwe Bensch , Christoph Brockmann , Gerhard Bruns , Henning Förster , Olaf Jantz , Hartmut Rosendahl , Wolfgang Strache , Jens Willms
IPC分类号： B60T17/18 , B60T13/26 , B60T7/04 , B60T13/66 , B60T13/68 , B60T17/22
CPC分类号： B60T13/26 , B60T7/042 , B60T13/66 , B60T13/683 , B60T17/18 , B60T17/221 , Y10T74/2054
摘要： A braking system for a vehicle, particularly a commercial vehicle, includes an operating brake device for providing an operating brake function for braking the vehicle, and a parking brake device for providing a parking brake function independently of the operating brake system. If one of the two braking devices partially or completely fails, the vehicle can be braked automatically by means of the other braking device.
摘要翻译：用于车辆，特别是商用车辆的制动系统包括用于提供用于制动车辆的操作制动功能的操作制动装置，以及用于独立于操作制动系统提供驻车制动功能的驻车制动装置。如果两个制动装置中的一个部分或完全失效，则可以通过另一个制动装置自动制动车辆。

5. 发明申请

US20110005874A1 BRAKE SYSTEM FOR A VEHICLE AND BRAKE PEDAL DEVICE FOR SUCH A BRAKE SYSTEM 有权
标题翻译：用于这种制动系统的车辆和制动踏板装置的制动系统
公开(公告)号：US20110005874A1
公开(公告)日：2011-01-13
申请号：US12734991
申请日：2008-10-23
申请人： Peter Beier , Uwe Bensch , Christoph Brockmann , Gerhard Bruns , Henning Förster , Olaf Jantz , Hartmut Rosendahl , Wolfgang Strache , Jens Willms
发明人： Peter Beier , Uwe Bensch , Christoph Brockmann , Gerhard Bruns , Henning Förster , Olaf Jantz , Hartmut Rosendahl , Wolfgang Strache , Jens Willms
IPC分类号： F16D65/28 , B60T7/00 , B60T7/12 , B60T11/00 , B60T11/04 , B60T11/10 , B60T13/66 , B60T7/04
CPC分类号： B60T13/26 , B60T7/042 , B60T13/66 , B60T13/683 , B60T17/18 , B60T17/221 , Y10T74/2054
摘要： The invention relates to a braking system (16) for a vehicle (10), particularly a commercial vehicle, having an operating brake device for providing an operating brake function for braking the vehicle, and a parking brake device (92) for providing a parking brake function independently of the operating brake system. In order to improve the functionality of the braking system in case of a fault, the vehicle can be braked automatically by means of the other braking device if one of the two braking devices partially or completely fails. The invention further relates to a brake pedal device for such a braking system.
摘要翻译：本发明涉及一种用于车辆（10）的制动系统（16），特别是商业车辆，其具有用于提供用于制动车辆的操作制动功能的操作制动装置，以及用于提供停车位置的驻车制动装置（92）制动功能独立于操作制动系统。为了在发生故障的情况下改善制动系统的功能，如果两个制动装置中的一个部分地或完全失效，则可以借助另一个制动装置自动制动车辆。本发明还涉及一种用于这种制动系统的制动踏板装置。

6. 发明申请

US20100141025A1 MODULATOR 有权
标题翻译：调制器
公开(公告)号：US20100141025A1
公开(公告)日：2010-06-10
申请号：US12451036
申请日：2008-04-26
申请人： Christoph Brockmann , Claudia Deike , Matthias Grimm , Hartmut Rosendahl , Ingo Torhoff , Hans-Klaus Wolff
发明人： Christoph Brockmann , Claudia Deike , Matthias Grimm , Hartmut Rosendahl , Ingo Torhoff , Hans-Klaus Wolff
IPC分类号： B60T13/68
CPC分类号： B60T8/327 , B60G17/0523 , B60T8/321 , B60T8/3605 , B60T2270/82
摘要： The invention rotates to a modulator (1), particularly for a brake system in a motor vehicle, connected to a central module (15) via a data bus (20), the modulator (1) having at least one input (6) for capturing measured values and at least one output (8) for controlling at least one electromagnetic valve, a control circuit for actuating the at least one electromagnetic valve being connected by the data bus (20) such that the measured values captured by the modulator (1) are transmitted to the central module (15), control commands for actuating the at least one electromagnetic valve being first calculated from said measured values in the central module (15), said control commands being transmitted via the data bus (20) to the modulator (1) in order that the modulator (1) selects the at least-one electromagnetic valve as a function of the control commands transmitted via the data bus (20). The invention further relates to a vehicle system having at least two such modulators (1) and a central module (15), the central module (15) being integrated in a modulator (1). The invention further relates to the use of such a modulator (1) as a pressure modulator in an air suspension system or in an electronic braking system (EBS) or in a conventional braking system, the braking system being equipped with an anti-lock braking system (ABS) or an electronic stability program (ESP).
摘要翻译：本发明旋转到调制器（1），特别是用于经由数据总线（20）连接到中央模块（15）的机动车辆中的制动系统，调制器（1）具有至少一个输入（6），用于捕获测量值和用于控制至少一个电磁阀的至少一个输出（8），用于致动所述至少一个电磁阀的控制电路，所述电磁阀由数据总线（20）连接，使得由调制器（1）捕获的测量值）传送到中央模块（15），用于致动至少一个电磁阀的控制命令首先由中央模块（15）中的所述测量值计算，所述控制命令经由数据总线（20）传送到调制器（1），以便调制器（1）根据经由数据总线（20）发送的控制命令来选择至少一个电磁阀。本发明还涉及具有至少两个这样的调制器（1）和中央模块（15）的车辆系统，所述中央模块（15）集成在调制器（1）中。本发明还涉及在空气悬架系统或电子制动系统（EBS）或常规制动系统中使用这种调制器（1）作为压力调制器，该制动系统配备有防抱死制动系统（ABS）或电子稳定程序（ESP）。

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