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1. 发明授权

US5847395A Adaptive baseline correction for gamma camera 失效
标题翻译：伽马相机的自适应基线校正
公开(公告)号：US5847395A
公开(公告)日：1998-12-08
申请号：US735944
申请日：1996-10-23
申请人： Ronald E. Malmin , Roger E. Arseneau
发明人： Ronald E. Malmin , Roger E. Arseneau
IPC分类号： G06T5/40 , G01D18/00
CPC分类号： H04N5/20 , G01T1/1647 , H04N5/217 , H04N5/32
摘要： Signal processing circuitry for use in medical imaging includes a flash analog-to-digital converter (FADC) for digitizing signals from a sensor; a memory for storing a plurality of digitized signals prior to a current event; and a processor for generating an adjustment signal from the plurality of digitized signals to adjust a first signal corresponding to the current event. In a fast time scale event processing, the signal processing circuitry generates an adjustment signal in near real-time corresponding to an analog error which is computed and updated from signals just prior to an event. In an alternative embodiment, the signal processing circuitry includes an FADC which generates the plurality of signals from a plurality of pseudo-event signals; and a digital-to-analog converter (DAC) is used for generating the pseudo-event signals between a previous event and the current event. A data fitting circuit is included for performing linear fitting of data corresponding to the plurality of signals to generate the adjustment signal. The baseline shifts and other effects of DC drift are corrected to improve event localization in the medical imaging system.
摘要翻译：用于医学成像的信号处理电路包括用于数字化来自传感器的信号的闪存模数转换器（FADC）; 用于在当前事件之前存储多个数字化信号的存储器; 以及处理器，用于从所述多个数字化信号产生调整信号，以调整与所述当前事件相对应的第一信号。在快速时间尺度事件处理中，信号处理电路近似实时地生成对应于刚好在事件之前的信号计算和更新的模拟错误的调整信号。在替代实施例中，信号处理电路包括从多个伪事件信号产生多个信号的FADC; 并且使用数模转换器（DAC）来产生先前事件和当前事件之间的伪事件信号。包括数据拟合电路，用于对与多个信号相对应的数据进行线性拟合以产生调整信号。纠正基线偏移和DC漂移的其他影响，以改善医学成像系统中的事件定位。

2. 发明授权

US4692890A Method and integrator circuit for integrating signals, in particular for scintillation gamma camera 失效
标题翻译：用于集成信号的方法和积分电路，特别是用于闪烁γ照相机
公开(公告)号：US4692890A
公开(公告)日：1987-09-08
申请号：US614886
申请日：1984-05-29
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G01T1/164 , G06F7/544 , G06G7/18 , G06J1/00 , G06F7/38
CPC分类号： G01T1/1642 , G06F7/544
摘要： A method and integrator circuit for digitally integrating signals wherein digital signals to be integrated are supplied to a digital adder thereby generating digital adder output signals. Each digital adder output signal is stored and the stored digital adder output signal is refed to the digital adder. Each refed stored digital adder output signal is then added by the adder to a succeeding digital signal supplied to the adder for integration. In a preferred embodiment of the invention, the digital signals are analog-to-digital converted signals produced by a radiation detector, such as a scintillation gamma camera, generated from radiation impinging on the radiation detector.
摘要翻译：一种用于数字积分信号的方法和积分器电路，其中要被积分的数字信号被提供给数字加法器，从而产生数字加法器输出信号。存储每个数字加法器输出信号，并将存储的数字加法器输出信号提供给数字加法器。每个被重新存储的数字加法器输出信号然后由加法器加到提供给加法器的后续数字信号进行积分。在本发明的一个优选实施例中，数字信号是由辐射检测器产生的模数转换信号，例如由照射在辐射检测器上的辐射产生的闪烁γ照相机。

3. 发明授权

US4323977A Non-uniformity energy correction method and apparatus 失效
标题翻译：不均匀性能量校正方法及装置
公开(公告)号：US4323977A
公开(公告)日：1982-04-06
申请号：US96181
申请日：1979-11-20
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1642 , A61B6/4258
摘要： A method and apparatus are disclosed for correcting energy (Z) signal non-uniformities in the response of an Anger-type scintillation camera to image events occurring at different (X, Y) positions on the camera face. Energy correction factors f(P)' corresponding to deviations of up to .+-.12.8% from a reference pixel area are determined off-line for 4,096 camera face pixel areas from a uniform flood field source Z-map. The correction factors f(P)' are stored in a 64.times.64 array of a correction factor memory, addressable by image event (X, Y) position coordinates. During on-line operation, for each image event the correction factor f(P)' corresponding to the image event (X, Y) position is retrieved, scaled in a multiplying digital to analog converter by the actual energy Z.sub.IN of the event, and added to the event Z.sub.IN signal to provide a corrected energy signal Z.sub.c =Z.sub.IN (1+f(P)') which is proportional to the incoming signal. The corrected energy signal is then applied to a fixed energy window analyzer to determine acceptance or rejection of the event. The invention is especially advantageous for correcting energy non-linearities in the detection of single source with multiple energy levels and multiple sources with different energy levels.
摘要翻译：公开了一种用于校正愤怒型闪烁照相机响应中的能量（Z）信号不均匀性以在相机面上的不同（X，Y）位置处发生的图像事件的方法和装置。对于来自均匀洪水源Z图的4,096个摄像机面像素区域离线地确定对应于参考像素区域的+/- 12.8％的偏差的能量校正因子f（P）'。校正因子f（P）'存储在校正因子存储器的64×64阵列中，可通过图像事件（X，Y）位置坐标寻址。在在线操作期间，对于每个图像事件，检索对应于图像事件（X，Y）位置的校正因子f（P）'，在乘法数模转换器中按事件的实际能量ZIN进行缩放，以及添加到事件ZIN信号以提供与输入信号成比例的校正能量信号Zc = ZIN（1 + f（P）'）。然后将校正的能量信号施加到固定能量窗口分析器以确定事件的接受或拒绝。本发明特别有利于在具有多个能量级别的单个源和具有不同能级的多个源的检测中校正能量非线性。

4. 发明授权

US09140806B2 Multiple timing measurements for positron emission tomography 有权
标题翻译：正电子发射断层扫描的多个定时测量
公开(公告)号：US09140806B2
公开(公告)日：2015-09-22
申请号：US13741830
申请日：2013-01-15
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G01T1/20 , G01T1/17 , G01T1/29 , G04F10/00
CPC分类号： G01T1/171 , G01T1/2985 , G04F10/005
摘要： Timing is determined in positron emission tomography (PET). Two or more different types of timing detection are used for each event. The difference in time from the different types of timing detection may indicate whether or not an error has occurred. An average difference or other typical offset difference may be used to correct the error. During pile up, the difference information may be used to create a missing time, such as using an average difference between second derivative and constant fraction discrimination as an offset to determine constant fraction timing from second derivative timing.
摘要翻译：正电子发射断层扫描（PET）测定时间。每个事件都使用两种或多种不同类型的定时检测。来自不同类型的定时检测的时间差可以指示是否发生错误。可以使用平均差异或其他典型偏移差来校正误差。在堆积期间，可以使用差分信息来产生缺失时间，例如使用二阶导数和常数分数鉴别之间的平均差作为偏移量来确定二阶导数定时的恒定分数时间。

5. 发明申请

US20140197320A1 Multiple Timing Measurements for Positron Emission Tomography 有权
标题翻译：正电子发射断层扫描的多重时序测量
公开(公告)号：US20140197320A1
公开(公告)日：2014-07-17
申请号：US13741830
申请日：2013-01-15
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G01T7/00
CPC分类号： G01T1/171 , G01T1/2985 , G04F10/005
摘要： Timing is determined in positron emission tomography (PET). Two or more different types of timing detection are used for each event. The difference in time from the different types of timing detection may indicate whether or not an error has occurred. An average difference or other typical offset difference may be used to correct the error. During pile up, the difference information may be used to create a missing time, such as using an average difference between second derivative and constant fraction discrimination as an offset to determine constant fraction timing from second derivative timing.
摘要翻译：正电子发射断层扫描（PET）测定时间。每个事件都使用两种或多种不同类型的定时检测。来自不同类型的定时检测的时间差可以指示是否发生错误。可以使用平均差异或其他典型偏移差来校正误差。在堆积期间，可以使用差分信息来产生缺失时间，例如使用二阶导数和常数分数鉴别之间的平均差作为偏移量来确定二阶导数定时的恒定分数时间。

6. 发明授权

US08369928B2 Data processing system for multi-modality imaging 有权
标题翻译：多模态成像数据处理系统
公开(公告)号：US08369928B2
公开(公告)日：2013-02-05
申请号：US12564635
申请日：2009-09-22
申请人： Roger E. Arseneau , James Frank Caruba , Michael E. Casey , Mark Musrock , Nan Zhang
发明人： Roger E. Arseneau , James Frank Caruba , Michael E. Casey , Mark Musrock , Nan Zhang
IPC分类号： A61B5/05
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/5247
摘要： A data processing process and embodiment for optimizing the signal path for multi-modality imaging is described. The embodiment and process optimizes the signal to noise ratio in a positron emission tomography (PET) signal path utilizing scintillation crystals, avalanche photo diodes, and charge sensitive preamplifiers in a dual modality MRI/PET scanner. The dual use of both and analog pole zero circuit and a digital filter enables higher signal levels or a fixed ADC input range and thus a higher possible signal to noise ratio in the presence of significant pileup caused by high positron activity. The higher signal to noise ratio is needed in the PET signal architecture, because of the presence of non-modal time varying electromagnetic fields from the MR, which are a significant source of noise for the wideband PET signal modality.
摘要翻译：描述了用于优化用于多模态成像的信号路径的数据处理过程和实施例。实施例和过程利用双重模式MRI / PET扫描器中的闪烁晶体，雪崩光电二极管和电荷敏感前置放大器在正电子发射断层摄影（PET）信号路径中优化信噪比。双重使用模拟极零电路和数字滤波器可实现更高的信号电平或固定的ADC输入范围，从而在存在由高正电子活动引起的重大堆积的情况下，可能的信噪比更高。在PET信号架构中需要更高的信噪比，因为存在来自MR的非模态时变电磁场，这是对于宽带PET信号模态的噪声的重要来源。

7. 发明授权

US07247862B2 Afterglow detection and count rate generation in a nuclear imaging system 有权
标题翻译：核成像系统中的余辉检测和计数率产生
公开(公告)号：US07247862B2
公开(公告)日：2007-07-24
申请号：US11165983
申请日：2005-06-24
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G01J1/42
CPC分类号： G01T1/171 , G01T1/2985
摘要： The afterglow and count rate/dead time of a nuclear imaging detector are calculated for use in correcting event detection and energy integration circuits. Energy value signals and event triggering signals are respectively integrated as a function of the decay setting of the detector, until they reach stable values, which are respectively used as afterglow and count rate/dead time signals used by a data processor of the detector.
摘要翻译：计算核成像检测器的余辉和计数率/死区时间，用于校正事件检测和能量积分电路。能量值信号和事件触发信号分别作为检测器的衰减设置积分，直到其达到稳定值，分别用作检测器的数据处理器使用的余辉和计数率/死区时间信号。

8. 发明授权

US4316257A Dynamic modification of spatial distortion correction capabilities of scintillation camera 失效
公开(公告)号：US4316257A
公开(公告)日：1982-02-16
申请号：US96182
申请日：1979-11-20
申请人： Anthony P. Del Medico , Roger E. Arseneau
发明人： Anthony P. Del Medico , Roger E. Arseneau
IPC分类号： G01T1/164 , G06F15/42 , G06K9/00
CPC分类号： G01T1/1642
摘要： A method and apparatus for the dynamic modification of the spatial distortion correction capabilities of a scintillation camera having spatial distortion correction apparatus. The spatial distortion correction apparatus includes a memory having stored therein spatial distortion correction factors in a predetermined addressable format. During the on-line use of the scintillation camera, the spatial distortion correction apparatus transforms the image event coordinate position data from the scintillation camera in accordance with the stored distortion correction factors to provide corrected image event coordinate repositioning data. The spatial distortion correction modification apparatus and method provides modification of the corrected image event coordinate data in accordance with the respective energy levels of the image events to provide accurate spatial distortion correction characteristics for the actual energy levels of the image events. The scintillation camera is thus automatically and dynamically capable of correcting for spatial distortion effects for image events of different energy levels. Different energy levels of image events occur when the scintillation camera is utilized with energy sources having multiple energy levels or a different energy level than the energy level at which the stored spatial distortion correction factors were calculated. The spatial distortion correction modification apparatus provides operation without the alteration of the scintillation camera apparatus and without any change in the stored correction factors. In a preferred embodiment, a coordinate correction factor of the spatial distortion correction apparatus is modified in accordance with the energy level of each image event, the coordinate correction factor of the spatial distortion correction apparatus being combined with the image event coordinate position data to provide corrected image event coordinate data.

9. 发明授权

US08969816B2 Board-level partitioning in MR-PET imaging system integration 有权
标题翻译： MR-PET成像系统集成中的板级划分
公开(公告)号：US08969816B2
公开(公告)日：2015-03-03
申请号：US13186891
申请日：2011-07-20
申请人： James Frank Caruba , Patanit Sanpitak , Grant Arthur Albert , Darryl Hrdina , Roger E. Arseneau , John P. Valenta
发明人： James Frank Caruba , Patanit Sanpitak , Grant Arthur Albert , Darryl Hrdina , Roger E. Arseneau , John P. Valenta
IPC分类号： G01T1/164 , G01T1/24 , A61B5/05 , G01R33/28 , G01R33/48 , A61B6/00 , A61B5/055 , A61B6/03
CPC分类号： G01R33/28 , A61B5/055 , A61B6/037 , A61B6/5235 , G01R33/481 , Y10T307/305
摘要： A printed circuit board (PCB) assembly of a data processing unit for an integrated magnetic resonance (MR) and positron emission tomography (PET) system, the PCB assembly includes a plurality of PCB layers disposed in a stacked arrangement, first and second PET signal processing circuits carried by a first layer of the plurality of PCB layers, first and second ground plane structures carried by a second layer of the plurality of PCB layers and configured relative to the first and second PET signal processing circuits, respectively, and a ground partition that separates the first PET signal processing circuit from the second PET signal processing circuit on the first layer. The ground partition extends through the first layer to provide electromagnetic interference (EMI) shielding between the first and second PET signal processing circuits.
摘要翻译：一种用于集成磁共振（MR）和正电子发射断层摄影（PET）系统的数据处理单元的印刷电路板（PCB）组件，PCB组件包括以堆叠布置设置的多个PCB层，第一和第二PET信号由多个PCB层的第一层承载的处理电路，由多个PCB层的第二层承载并分别相对于第一和第二PET信号处理电路配置的第一和第二接地平面结构以及接地分区其将第一PET信号处理电路与第一PET信号处理电路分离在第一层上。接地分隔件延伸穿过第一层，以在第一和第二PET信号处理电路之间提供电磁干扰（EMI）屏蔽。

10. 发明授权

US08473253B2 Digital event timing 有权
标题翻译：数字事件定时
公开(公告)号：US08473253B2
公开(公告)日：2013-06-25
申请号：US12908907
申请日：2010-10-21
申请人： Roger E. Arseneau
发明人： Roger E. Arseneau
IPC分类号： G06F17/10 , G06F17/40 , G06F19/00
CPC分类号： G01T1/1644 , G01T1/2985
摘要： Methods, computer-readable mediums, and a circuit are provided. In one embodiment, a method is provided which obtains a digital sample. The method calculates a second derivative of the digital sample and thereafter determines when the second derivative passed through a zero crossing point. A master clock value and the second derivative value before and after the second derivate passes through zero are used to calculate a clock fraction and add the clock fraction to the master clock value. Thereafter, an event start signal is triggered to initiates signal processing.
摘要翻译：提供了方法，计算机可读介质和电路。在一个实施例中，提供了一种获得数字样本的方法。该方法计算数字样本的二阶导数，此后确定二阶导数何时通过过零点。使用主时钟值和第二导出之前和之后通过零的二阶导数值来计算时钟分数，并将时钟分数加到主时钟值。此后，触发事件开始信号以启动信号处理。

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