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1. 发明申请

US20060269603A1 Controlled release tramadol formulations 审中-公开
公开(公告)号：US20060269603A1
公开(公告)日：2006-11-30
申请号：US11435015
申请日：2006-05-16
申请人： Ronald Brown Miller , Stewart Leslie , Sandra Malkowska , Kevin Smith , Walter Wimmer , Horst Winkler , Udo Hahn , Derek Prater
发明人： Ronald Brown Miller , Stewart Leslie , Sandra Malkowska , Kevin Smith , Walter Wimmer , Horst Winkler , Udo Hahn , Derek Prater
IPC分类号： A61K9/22
CPC分类号： A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/135 , A61K31/137 , A61K31/485
摘要： A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.

2. 发明申请

US20060254390A1 Stopper removing tool 有权
标题翻译：止动器去除工具
公开(公告)号：US20060254390A1
公开(公告)日：2006-11-16
申请号：US10558576
申请日：2004-08-30
申请人： Stewart Leslie
发明人： Stewart Leslie
IPC分类号： B67B7/18 , B67B7/14
CPC分类号： B67B7/066
摘要： A hand tool (1) for removing a stopper from a pressurized vessel (eg a bottle of sparkling wine) of a type where the stopper is retained by a wire cage, the wire cage including a wire band at or adjacent a neck ring on the vessel, the wire band being secured by a twisted portion terminating in a wire eye, the tool (1) including: a pair of elongate members (20a, 20b) pivotally connected together, each member having a handle portion (21) and a jaw portion (22); a stopper-gripping portion comprising a tooth (27) on an inner side of each jaw portion (22), the stopper-gripping portions (27, 27), in use, gripping the stopper therebetween and cooperating to permit relative pivoting movement between the members (20a, 20b) and the stopper substantially about a fulcrum axis defined by and extending between the two stopper-gripping portions (27,27), and a protrusion (24) at or adjacent at least one of the member (20a, 20b) and adapted to be received in the wire eye when the stopper-gripping portions (27, 27) are engaged with the stopper.
摘要翻译：一种手动工具（1），用于从塞子被线笼保持的类型的加压容器（例如，一瓶汽酒）中移除塞子，所述线框包括位于或邻近颈圈上的颈环所述工具（1）包括：一对可枢转地连接在一起的细长构件（20a，20b），每个构件具有把手部分（21）和颚部（22）; 止动器夹持部分，其包括在每个钳口部分（22）的内侧上的齿（27），所述止动器夹持部分（27,27）在使用中夹持其间的止动件，并且协作以允许在所述止动器夹持部分构件（20a，20b）和止动器基本上围绕由两个止挡器夹持部分（27,27）限定和延伸的支点轴线，以及位于或邻近构件（20）中的至少一个的突起（24） a，20b）并且当止动器抓握部分（27,27）与止动器接合时适于被接收在线眼中。

3. 发明授权

US4898729A Treatment of hypertension, compounds and compositions for antihypertension and diuresis 失效
标题翻译：治疗高血压，化合物和组合物用于抗高血压和利尿
公开(公告)号：US4898729A
公开(公告)日：1990-02-06
申请号：US559755
申请日：1983-12-09
申请人： Ronald B. Miller , Alfred Halpern , Stewart Leslie , Peter Hofer
发明人： Ronald B. Miller , Alfred Halpern , Stewart Leslie , Peter Hofer
IPC分类号： C07D279/16 , A61K31/54 , A61K31/5415 , A61K47/34 , A61K47/48 , A61P7/10 , A61P9/12 , C07D285/26 , A61K31/79
CPC分类号： A61K31/54 , A61K47/48184 , A61K47/4823 , Y10S514/869
摘要： Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve diuresis. Such administration in a non-diuretic amount is effected in 4-8 consecutive hourly doses to achieve reduction of blood pressure without high urine output. The invention further relates to complexes of thiazides with mixed cation-anion exchange resins, to insoluble basic metal hydroxy thiazide salts, the salts of thiazide with calcium disodium edetate or disodium edetate, to molecular complexes of thiazides with long chain polymers such as hydroxy alkyl cellulose polymers, carboxy methyl cellulose and polyvinylpyrrolidone, to beta-adrenergic blocking amine-thiazide salts and to amiloride thiazide salts.
摘要翻译：通过施用噻嗪类利尿剂可以实现抗高血压作用，其量足以达到抗高血压的量不足以达到利尿。这种非利尿剂量的施用是以4-8个连续的小时剂量进行的，以达到降低血压而没有高尿量。本发明还涉及噻嗪类与混合的阳离子 - 阴离子交换树脂，不溶性碱金属羟基噻嗪盐，噻嗪类与依地酸二钠盐或乙二胺四乙酸二钠盐的配合物，与噻唑烷与长链聚合物如羟烷基纤维素的分子复合物聚合物，羧甲基纤维素和聚乙烯吡咯烷酮，β-肾上腺素能阻断胺 - 噻嗪盐和阿米洛利噻嗪盐。

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