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1. 发明申请

US20090062254A1 Acute Treatment of Headache with Phenothiazine Antipsychotics 审中-公开
标题翻译：苯并噻嗪类抗精神病药物头痛急性治疗
公开(公告)号：US20090062254A1
公开(公告)日：2009-03-05
申请号：US12245184
申请日：2008-10-03
申请人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
发明人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
IPC分类号： A61K31/5415 , A61K31/451 , A61K31/553 , A61K31/454 , A61P25/06 , A61K31/5377 , A61K31/4439
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/382 , A61K31/4439 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

2. 发明申请

US20100055048A1 ACUTE TREATMENT OF HEADACHE WITH PHENOTHIAZINE ANTIPSYCHOTICS 审中-公开
标题翻译：用苯并噻唑类抗生素治疗头痛
公开(公告)号：US20100055048A1
公开(公告)日：2010-03-04
申请号：US12615185
申请日：2009-11-09
申请人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
发明人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
IPC分类号： A61K9/12 , A61K31/445 , A61K31/4439 , A61K31/382 , A61K31/496 , A61K31/553 , A61K31/5377 , A61K31/454 , A61K31/5415 , A61P29/00
CPC分类号： A61K31/553 , A61K9/007 , A61K9/0073 , A61K31/382 , A61K31/4439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

3. 发明授权

US08506935B2 Respiratory drug condensation aerosols and methods of making and using them 有权
公开(公告)号：US08506935B2
公开(公告)日：2013-08-13
申请号：US12490102
申请日：2009-06-23
申请人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Joshua D. Rabinowitz , Martin J. Wensley
发明人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Joshua D. Rabinowitz , Martin J. Wensley
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00 , H05B3/00
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/522 , A61K31/573 , Y10S514/958
摘要： Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described. The methods comprise the steps of vaporizing and condensing a respiratory drug composition.

4. 发明授权

US07550133B2 Respiratory drug condensation aerosols and methods of making and using them 有权
标题翻译：呼吸药冷凝气溶胶及其制作和使用方法
公开(公告)号：US07550133B2
公开(公告)日：2009-06-23
申请号：US10719899
申请日：2003-11-20
申请人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Joshua D. Rabinowitz , Martin J. Wensley
发明人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Joshua D. Rabinowitz , Martin J. Wensley
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/522 , A61K31/573 , Y10S514/958
摘要： Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described. The methods comprise the steps of vaporizing and condensing a respiratory drug composition.
摘要翻译：本文描述的是呼吸药物冷凝气溶胶及其制备和使用方法。还描述了用于输送冷凝气溶胶的试剂盒。呼吸药物气溶胶通常包括呼吸药物凝结气溶胶颗粒。在一些变化中，呼吸药物化合物选自β-肾上腺素能药，甲基黄嘌呤，抗胆碱能药，皮质类固醇，介质释放抑制剂，抗白三烯药物，哮喘抑制剂，哮喘拮抗剂，抗内皮素药物，前列环素药物，离子通道或泵抑制剂，增强剂或调节剂及其药学上可接受的类似物，衍生物及其混合物。还描述了使用所述气溶胶治疗呼吸道疾病的方法。通常，所述方法通常包括向具有呼吸道疾病的人施用治疗有效量的呼吸药物冷凝气雾剂的步骤。还描述了形成呼吸药物冷凝气溶胶的方法。该方法包括蒸发和冷凝呼吸药物组合物的步骤。

5. 发明申请

US20130032139A1 Drug Condensation Aerosols And Kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US20130032139A1
公开(公告)日：2013-02-07
申请号：US13569006
申请日：2012-08-07
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61M11/04
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒，其中所述装置具有用于加热药物的元件，所述元件作为膜涂覆在基底上并且当施用药物时含有治疗有效剂量的药物气溶胶形式，以及允许蒸汽冷却以形成气溶胶的元素。还公开了使用方法。

6. 发明授权

US07090830B2 Drug condensation aerosols and kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US07090830B2
公开(公告)日：2006-08-15
申请号：US10718982
申请日：2003-11-20
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/1694 , A61M11/001 , A61M11/002 , A61M11/005 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/002 , Y10S514/958
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

7. 发明授权

US09211382B2 Drug condensation aerosols and kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US09211382B2
公开(公告)日：2015-12-15
申请号：US13569006
申请日：2012-08-07
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00 , H05B3/00 , A61M11/04 , A61K9/00 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒，其中所述装置具有用于加热药物的元件，所述元件作为膜涂覆在基底上并且当施用药物时含有治疗有效剂量的药物气溶胶形式，以及允许蒸汽冷却以形成气溶胶的元素。还公开了使用方法。

8. 发明申请

US20080311176A1 Drug Condensation Aerosols And Kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US20080311176A1
公开(公告)日：2008-12-18
申请号：US12117737
申请日：2008-05-08
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61K9/70 , A61K31/519 , A61K31/553 , A61K31/5513 , A61K31/445 , A61K31/5415
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

9. 发明授权

US08235037B2 Drug condensation aerosols and kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US08235037B2
公开(公告)日：2012-08-07
申请号：US12117737
申请日：2008-05-08
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61M15/00 , A61K9/12 , A61K9/14 , H05B3/00
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

10. 发明申请

US20110244020A1 DRUG CONDENSATION AEROSOLS AND KITS 审中-公开
标题翻译：药物浓缩气溶胶和药液
公开(公告)号：US20110244020A1
公开(公告)日：2011-10-06
申请号：US13078516
申请日：2011-04-01
申请人： Ron L. HALE , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. HALE , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61K9/70 , A61K31/551 , A61K31/445 , A61K31/554 , A61K31/5415 , A61K31/519 , A61P25/04 , A61P25/00 , A61P25/18
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

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