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1. 发明申请

US20050158769A1 Method for cloning and producing the MseI restriction endonuclease 审中-公开
标题翻译：克隆和产生MseI限制性内切核酸酶的方法
公开(公告)号：US20050158769A1
公开(公告)日：2005-07-21
申请号：US11018116
申请日：2004-12-21
申请人： Romualdas Vaisvila , Richard Morgan , Rebecca Kucera , Elisabeth Raleigh
发明人： Romualdas Vaisvila , Richard Morgan , Rebecca Kucera , Elisabeth Raleigh
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/22 , C12N15/54 , C12N15/55 , C12R1/265 , C12Q1/68 , C07H21/04 , C12N15/74
CPC分类号： C12N9/1007 , C12N9/22
摘要： A method for cloning restriction-modification system is provided whereby the target modification methylase is produced and confers full protection during all growth phases in which the cognate restriction enzyme is present. The method is employed in the cloning of the MseI restriction-modification system.
摘要翻译：提供克隆限制性修饰体系的方法，由此产生目标修饰甲基化酶，并在存在相关限制性内切酶的所有生长期赋予完全保护。该方法用于克隆MseI限制性修饰系统。

2. 发明授权

US08753203B1 Compositing device for combining visual content 有权
标题翻译：用于组合视觉内容的合成装置
公开(公告)号：US08753203B1
公开(公告)日：2014-06-17
申请号：US13366979
申请日：2012-02-06
申请人： Richard Morgan , John Paul Mendocha , Steve Gourley , Peter Simmons
发明人： Richard Morgan , John Paul Mendocha , Steve Gourley , Peter Simmons
IPC分类号： A63F13/00 , A63F9/24
CPC分类号： G07F17/3211 , A63F9/24 , A63F2009/2457 , G07F17/3202 , G07F17/3223 , G07F17/3225 , G07F17/3244
摘要： A compositing apparatus is provided that has, in certain implementations, electronic circuitry for combining visual content for an electronic game of chance. The compositing apparatus may receive wagering display information from a wagering engine that controls wagering aspects of the game and entertainment display information from an entertainment engine that controls non-wagering aspects of the game. The compositing apparatus may combine the wagering and entertainment display information for presentation to a player on a display. In certain implementations, the compositing apparatus also enables the wagering engine to control the output of display information on the display.
摘要翻译：提供了一种在某些实施方式中具有用于组合机会的电子游戏的视觉内容的电子电路的合成装置。合成装置可以从来自控制游戏的投注方面的投注引擎接收投注显示信息，以及来自控制游戏的非投注方面的娱乐引擎的娱乐显示信息。合成装置可以将投注和娱乐显示信息组合以供显示器上的玩家呈现。在某些实施方式中，合成装置还使得投注引擎能够控制显示器上的显示信息的输出。

3. 发明授权

US07247464B2 CspCI restriction endonuclease 失效
标题翻译： CspCI限制性内切核酸酶
公开(公告)号：US07247464B2
公开(公告)日：2007-07-24
申请号：US11088267
申请日：2005-03-23
申请人： Richard Morgan , Celine Nguefeu Nkenfou
发明人： Richard Morgan , Celine Nguefeu Nkenfou
IPC分类号： C12N9/22
CPC分类号： C12N9/22
摘要： A novel restriction endonuclease has been identified from Citrobacter species 2144 (NEB#1398) which can cleave at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:13) in double-stranded DNA molecules.
摘要翻译：从双链DNA分子中能够以nt序列5'-CAANNNNNGTGG-3'（SEQ ID NO：13）切割的柠檬酸杆菌物种2144（NEB＃1398）鉴定了新的限制性内切核酸酶。

4. 发明申请

US20050182216A1 Directly polymerized low molecular weight granular polytetrafluoroethylene 失效
标题翻译：直接聚合低分子量粒状聚四氟乙烯
公开(公告)号：US20050182216A1
公开(公告)日：2005-08-18
申请号：US10685789
申请日：2003-10-15
申请人： Richard Morgan
发明人： Richard Morgan
IPC分类号： C08F6/24 , C08F14/18 , C08F14/26 , C08F114/26
CPC分类号： C08F6/24 , C08F14/26 , C08F114/26 , C08L27/18 , C08F2/18
摘要： A process for producing low molecular weight, granular polytetrafluoroethylene or modified polytetrafluoroethylene by suspension polymerization of pressurized tetrafluoroethylene in an agitated reaction vessel. The polymerization is conducted in aqueous medium in the presence of a free radical initiator, and a telogen. The reaction vessel is agitated during polymerization sufficiently to coagulate the polytetrafluoroethylene or modified polytetrafluoroethylene. Low molecular weight granular polytetrafluoroethylene or modified polytetrafluoroethylene having a melt viscosity of less than about 1×106 Pa.S powder is isolated directly from the reaction vessel. The low molecular weight polytetrafluoroethylene or modified polytetrafluoroethylene powder in accordance with the invention has a melt viscosity of less than about 1×106 Pa.S, a specific surface area of less than about 8 m2/g, an extractable fluoride level of about 3 ppm or less by weight, and a narrow molecular weight distribution as indicated by a polydispersity index of about 5 or less. The particles of low molecular powder have a weight average particle size of about 2 to about 40 micrometers and the powder is substantially free of particles having a particle size of less than about 1 micrometer. The low molecular weight material so produced suitable for use as additives to other materials such as inks, coatings, greases, lubricants, and plastics.
摘要翻译：通过加压四氟乙烯在搅拌反应容器中的悬浮聚合制备低分子量粒状聚四氟乙烯或改性聚四氟乙烯的方法。聚合反应在水性介质中在自由基引发剂存在下进行。反应容器在聚合过程中被充分搅拌以使聚四氟乙烯或改性聚四氟乙烯凝结。具有小于约1×10 -6 PaSS粉末的低分子量粒状聚四氟乙烯或改性聚四氟乙烯直接从反应容器中分离出来。根据本发明的低分子量聚四氟乙烯或改性聚四氟乙烯粉末的熔体粘度小于约1×10 6 Pa，比表面积小于约8μm2，大约3ppm或更少的可提取的氟化物含量，和由多分散指数为约5或更小所示的窄分子量分布。低分子粉末的颗粒具有约2至约40微米的重均粒径，粉末基本上不含粒度小于约1微米的颗粒。如此生产的低分子量材料适用于其他材料（如油墨，涂料，润滑脂，润滑剂和塑料）的添加剂。

5. 发明申请

US20140154238A1 Compositions And Methods For Treating, Diagnosing And Monitoring Disease 有权
标题翻译：治疗，诊断和监测疾病的组成和方法
公开(公告)号：US20140154238A1
公开(公告)日：2014-06-05
申请号：US14007932
申请日：2012-03-28
申请人： Richard Morgan
发明人： Richard Morgan
IPC分类号： C12N15/113 , C07K14/47 , G01N33/574 , C07K16/18
CPC分类号： C12N15/113 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/1135 , C12N15/1138 , C12N2310/14 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/57492 , G01N2800/52
摘要： Compositions and methods which inhibit the expression of the TMEM92 gene or which inhibits the function of die TMEM92 protein can be used for treating, diagnosing and monitoring disease, for example cancer.
摘要翻译：抑制TMEM92基因表达或抑制TMEM92蛋白的功能的组合物和方法可用于治疗，诊断和监测疾病，例如癌症。

6. 发明申请

US20090045944A1 Rechargeable batteries 审中-公开
标题翻译：可充电电池
公开(公告)号：US20090045944A1
公开(公告)日：2009-02-19
申请号：US12256429
申请日：2008-10-22
申请人： Richard Morgan
发明人： Richard Morgan
IPC分类号： G08C17/02 , G08B21/00
CPC分类号： H02J7/0047 , H02J7/0018
摘要： An improved rechargeable battery which comprises: a plurality of battery cells connected together to discharge in parallel, each of the cells, or each group or groups of the cells having its own respective recharging input; and an electrical switching circuit to switch a number of the battery cells or groups of cells to connect to their respective recharging input for recharging each cell or group of cells individually.
摘要翻译：一种改进的可再充电电池，包括：多个电池单元，其连接在一起以并联放电，每个电池或每个电池单元组或各组具有各自的充电输入; 以及电切换电路，用于切换多个电池单元或单元组，以连接到它们各自的充电输入，以单独地为每个单元或一组单元充电。

7. 发明申请

US20070172565A1 Method and system for molding chocolate utilizing an air knife and products made 有权
标题翻译：使用气刀成型巧克力的方法和系统
公开(公告)号：US20070172565A1
公开(公告)日：2007-07-26
申请号：US11410207
申请日：2006-04-25
申请人： John Kaiser , Dale Slesser , Dominic Diperna , Richard Morgan , Rick Floyd , Robert Parker , Robert Harvey
发明人： John Kaiser , Dale Slesser , Dominic Diperna , Richard Morgan , Rick Floyd , Robert Parker , Robert Harvey
IPC分类号： A23G3/02
CPC分类号： A23G3/007 , A23G3/0072 , A23G7/0093
摘要： Prior to cooling, an air knife is used to remove bubbles from confectionery-filled chocolates, preferably center-filled chocolates, deposited in a mold tray, preferably using a one-shot depositor. Using the method and apparatus, it is possible to manufacture novel confectionery products, including one-shot deposited caramel-filled dark chocolates.
摘要翻译：在冷却之前，使用气刀来从放置在模托盘中的糖果装满的巧克力，优选中心填充的巧克力中，优选地使用一次存放器去除气泡。使用该方法和装置，可以制造新的糖果产品，包括一次沉淀的焦糖填充的暗巧克力。

8. 发明申请

US20070166719A1 Novel modular type II restriction endonuclease, cspci, and the use of modular endonucleases for generating endonucleases with new specificities 审中-公开
标题翻译：新型模块化II型限制性内切核酸酶，cspci以及使用模块化内切核酸酶产生具有新特异性的核酸内切酶
公开(公告)号：US20070166719A1
公开(公告)日：2007-07-19
申请号：US10593790
申请日：2005-03-23
申请人： Richard Morgan , Geoffrey Wilson , Keith Lunnen , Daniel Heiter , Jack Benner , Celine Nkenfou , Stephen Picone
发明人： Richard Morgan , Geoffrey Wilson , Keith Lunnen , Daniel Heiter , Jack Benner , Celine Nkenfou , Stephen Picone
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/22 , C12N15/74 , C12N1/21
CPC分类号： C12N9/22
摘要： A novel restriction endonuclease and methods of making the same are obtainable from either Citrobacter species 2144 (NEB#1398) or the recombinant stain Escherichia coli (NEB#1554) which cleaves at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:14) in double-stranded DNA molecules. The novel restriction endonuclease is a modular protein in which the specificity moiety is an independent module from the restriction-modification module.
摘要翻译：新型限制性内切核酸酶及其制备方法可从柠檬酸杆菌物种2144（NEB＃1398）或以nt序列5'-CAANNNNNGTGG-3'（SEQ ID NO：1）切割的重组染色体大肠杆菌（NEB＃1554） 14）在双链DNA分子中。新型限制性内切核酸酶是一种模块蛋白，其中特异性部分是来自限制性修饰模块的独立模块。

9. 发明申请

US20120263654A1 MELANOMA SPECIFIC BIOMARKER 审中-公开
标题翻译： MELANOMA特殊生物标记
公开(公告)号：US20120263654A1
公开(公告)日：2012-10-18
申请号：US13513345
申请日：2010-07-13
申请人： Richard Morgan , Hardev S. Pandha
发明人： Richard Morgan , Hardev S. Pandha
IPC分类号： A61K39/395 , G01N33/574 , G01N21/64 , G01N21/78 , C07H21/04 , C07K14/47 , C07K5/103 , C07K7/06 , C07K7/08 , A61K31/7088 , A61K38/17 , A61K49/00 , C07K16/18 , A61K39/00 , A61P37/04 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Described are melanoma specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of melanoma.
摘要翻译：描述了包含Engrailed-2（EN2）基因的核酸序列或编码的EN2蛋白的氨基酸序列的黑素瘤特异性生物标志物。还描述了生物标志物在黑素瘤的治疗，诊断，监测和成像中的用途。

10. 发明申请

US20120183554A1 Biomarker 审中-公开
标题翻译：生物标志物
公开(公告)号：US20120183554A1
公开(公告)日：2012-07-19
申请号：US13383399
申请日：2010-07-13
申请人： Richard Morgan , Hardev S. Pandha
发明人： Richard Morgan , Hardev S. Pandha
IPC分类号： A61K39/395 , C07K5/10 , C07K7/06 , A61K31/7088 , C07K16/18 , G01N33/566 , A61K38/17 , C07K14/47 , A61P35/00 , A61P37/04 , G01N21/64 , C07H21/04 , A61K39/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Described are gastrointestinal cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of gastrointestinal cancer.
摘要翻译：描述了包含Engrailed-2（EN2）基因的核酸序列或编码的EN2蛋白的氨基酸序列的胃肠癌特异性生物标志物。还描述了生物标志物在胃肠癌的治疗，诊断，监测和成像中的用途。

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