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1. 发明授权

US06436369B1 Anti-plaque emulsions and products containing same 有权
公开(公告)号：US06436369B1
公开(公告)日：2002-08-20
申请号：US09453383
申请日：1999-12-02
申请人： Roman M. Barabolak , Dave L. Witkewitz
发明人： Roman M. Barabolak , Dave L. Witkewitz
IPC分类号： A61K968
摘要： Anti-plaque emulsions and methods of use are provided. The emulsion comprises a surfactant, emulsifier, and triclosan.

2. 发明授权

US07022314B2 Anti-plaque emulsions and products containing same 失效
公开(公告)号：US07022314B2
公开(公告)日：2006-04-04
申请号：US10035320
申请日：2001-11-08
申请人： Roman M. Barabolak , Dave L. Witkewitz
发明人： Roman M. Barabolak , Dave L. Witkewitz
IPC分类号： A61K9/68
CPC分类号： A61Q11/00 , A61K8/06 , A61K8/347 , A61K8/4926 , A61K9/0058 , A61K9/107 , A61K31/09 , A61K31/4425 , A61K47/186 , Y10S514/835 , Y10S514/937 , A61K2300/00
摘要： Anti-plaque emulsions and methods of use are provided. The emulsion comprises a surfactant, emulsifier, and triclosan.

3. 发明授权

US4986991A Chewing gum having an extended sweetness 失效
标题翻译：口香糖具有延长的甜度
公开(公告)号：US4986991A
公开(公告)日：1991-01-22
申请号：US376037
申请日：1989-07-05
申请人： Robert Yatka , Patrick Prombo , Roman M. Barabolak , Steven Zibell , Gordon N. McGrew
发明人： Robert Yatka , Patrick Prombo , Roman M. Barabolak , Steven Zibell , Gordon N. McGrew
IPC分类号： A23G4/00 , A23G4/06 , A23G4/10 , A23G4/20
CPC分类号： A23G4/06 , A23G4/10 , A23G4/20 , Y10S426/804
摘要： A chewing gum composition having an extended sweetness and flavor comprising a chewable gum base and a sweetener comprising 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose (TGS), also known as sucralose. the gum base preferably comprises polyvinyl acetate, wax, and fats and oils. Within the initial 2 minutes of chewing, the TGS releases from said gum at a rate less than about 8 sucrose equivalents per minute, and at about 10 minutes of chewing, said TGS releases from said gum at a rate greater than about 3 sucrose equivalents per minute. To improve sweetness and flavor balance, a portion of the TGS is modified to make it fast releasing or a fast release sweetener is added to the chewing gum. The chewing gum is manufactured by mixing chewing gum ingredients including the chewable gum base and the sweetener in any conventional manner.
摘要翻译：一种口香糖组合物，其具有延长的甜度和风味，其包含可咀嚼胶基和包含也称为三氯蔗糖的4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖（TGS）的甜味剂。胶基优选包括聚乙酸乙烯酯，蜡和脂肪和油。在咀嚼的最初2分钟内，TGS以小于约8蔗糖当量/分钟的速度从所述胶中释放，并且在咀嚼约10分钟时，所述TGS以大于约3蔗糖当量的速率从所述胶中释放分钟。为了改善甜味和香味平衡，一部分TGS被改性以使其快速释放或将快速释放甜味剂加入到口香糖中。通过以任何常规方式混合口香糖成分（包括可咀嚼胶基和甜味剂）来制造口香糖。

4. 发明授权

US06955827B2 Method of controlling release of antimicrobial agents in chewing gum 失效
标题翻译：控制口香糖中抗微生物剂释放的方法
公开(公告)号：US06955827B2
公开(公告)日：2005-10-18
申请号：US10619849
申请日：2003-07-14
申请人： Roman M. Barabolak , Steven E. Zibell , David L. Witkewitz , Michael J. Greenberg
发明人： Roman M. Barabolak , Steven E. Zibell , David L. Witkewitz , Michael J. Greenberg
IPC分类号： A23G4/00 , A23G4/06 , A23G4/20 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/68 , A23G3/30
CPC分类号： A23G4/06 , A23G4/20 , A61K9/0058 , A61K9/143 , A61K9/1611 , A61K9/1617 , A61K9/1652 , A61K9/1658 , A61K9/2081 , A61K9/5015 , A61K9/5036
摘要： A method for producing a chewing gum with a controlled release of an antimicrobial agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the antimicrobial agent by coating and drying. The antimicrobial agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated antimicrobial agent is preferably then co-dried and particle sized to produce a release-modified antimicrobial agent for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. The preferred antimicrobial agent is chlorhexidine digluconate.
摘要翻译：通过涂布和干燥来物理改变抗微生物剂的释放性能，获得了通过控制释放抗微生物剂以及如此生产的口香糖来生产口香糖的方法。抗微生物剂通过包封进行包衣，通过附聚部分包衣，通过吸收包埋，或通过包封，附聚和吸收的多个步骤进行处理。涂覆的抗微生物剂优选然后共干燥并且粒径以产生用于口香糖的释放改性的抗微生物剂。当掺入口香糖中时，当咀嚼口香糖时，这些颗粒适于产生快速释放或延迟释放。优选的抗微生物剂是氯己定二葡糖酸盐。

5. 发明授权

US06592912B1 Method of controlling release of antimicrobial agents from chewing gum and gum produced thereby 有权
标题翻译：控制由此产生的口香糖和口香糖的抗微生物剂的释放的方法
公开(公告)号：US06592912B1
公开(公告)日：2003-07-15
申请号：US09599921
申请日：2000-06-22
申请人： Roman M. Barabolak , Steven E. Zibell , David L. Witkewitz , Michael J. Greenberg , Robert J. Yatka
发明人： Roman M. Barabolak , Steven E. Zibell , David L. Witkewitz , Michael J. Greenberg , Robert J. Yatka
IPC分类号： A23G330
CPC分类号： A23G4/06 , A23G4/20 , A61K9/0058 , A61K9/143 , A61K9/1611 , A61K9/1617 , A61K9/1652 , A61K9/1658 , A61K9/2081 , A61K9/5015 , A61K9/5036
摘要： A method for producing a chewing gum with a controlled release of an antimicrobial agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the antimicrobial agent by coating and drying. The antimicrobial agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated antimicrobial agent is preferably then co-dried and particle sized to produce a release-modified antimicrobial agent for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. The preferred antimicrobial agent is chlorhexidine digluconate.
摘要翻译：通过涂布和干燥来物理改变抗微生物剂的释放性能，获得了通过控制释放抗微生物剂以及如此生产的口香糖来生产口香糖的方法。抗微生物剂通过包封进行包衣，通过附聚部分包衣，通过吸收包埋，或通过包封，附聚和吸收的多个步骤进行处理。涂覆的抗微生物剂优选然后共干燥并且粒径以产生用于口香糖的释放改性的抗微生物剂。当掺入口香糖中时，当咀嚼口香糖时，这些颗粒适于产生快速释放或延迟释放。优选的抗微生物剂是氯己定二葡糖酸盐。

6. 发明授权

US4975287A Gum composition containing protein macrocolloids 失效
标题翻译：含有蛋白质大胶体的胶组合物
公开(公告)号：US4975287A
公开(公告)日：1990-12-04
申请号：US402210
申请日：1989-09-01
申请人： Steven E. Zibell , Lindell Richey , Michael A. Reed , Roman M. Barabolak , Steven B. Courtright
发明人： Steven E. Zibell , Lindell Richey , Michael A. Reed , Roman M. Barabolak , Steven B. Courtright
IPC分类号： A23G4/00 , A23G4/08 , A23G4/14 , A23G4/16
CPC分类号： A23G4/14 , A23G4/08 , A23G4/16 , Y10S426/804
摘要： A chewing gum that contains fro about 0.5 to about 30 percent of a proteinaceous, water-dispersible, macrocolloid comprising substantially non-aggregated particles of dairy whey protein.

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