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1. 发明申请

US20060246490A1 Miniaturized genetic analysis systems and methods 审中-公开
标题翻译：小型遗传分析系统和方法
公开(公告)号：US20060246490A1
公开(公告)日：2006-11-02
申请号：US11396958
申请日：2006-04-04
申请人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
发明人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L7/52 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/0062 , B01F13/0071 , B01F13/0222 , B01F13/08 , B01F13/0809 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/525 , B01L2200/0621 , B01L2200/0673 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2300/1827 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/086
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。

2. 发明申请

US20050250199A1 Integrated nucleic acid diagnostic device 审中-公开
标题翻译：集成核酸诊断装置
公开(公告)号：US20050250199A1
公开(公告)日：2005-11-10
申请号：US11010841
申请日：2004-12-13
申请人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
发明人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

3. 发明申请

US20050202504A1 Miniaturized genetic analysis systems and methods 审中-公开
标题翻译：小型遗传分析系统和方法
公开(公告)号：US20050202504A1
公开(公告)日：2005-09-15
申请号：US11124575
申请日：2005-05-06
申请人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
发明人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor
IPC分类号： B01F11/02 , B01F13/00 , B01F13/08 , B01L3/00 , B01L7/00 , C12Q1/68 , C12M1/34 , C12N1/08
CPC分类号： B01L7/52 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/0062 , B01F13/0071 , B01F13/0222 , B01F13/08 , B01F13/0809 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/525 , B01L2200/0621 , B01L2200/0673 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2300/1827 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/086
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。

4. 发明申请

US20050100946A1 Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy 审中-公开
标题翻译：用于原位共焦显微镜的综合核酸诊断装置和方法
公开(公告)号：US20050100946A1
公开(公告)日：2005-05-12
申请号：US10997522
申请日：2004-11-24
申请人： Robert Lipshutz , Richard Rava , Rolfe Anderson
发明人： Robert Lipshutz , Richard Rava , Rolfe Anderson
IPC分类号： B01F11/02 , B01F13/00 , B01F13/08 , B01L3/00 , B01L7/00 , C12Q1/68 , C12M1/34
CPC分类号： B01L7/52 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0621 , B01L2200/10 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

5. 发明申请

US20060034902A1 Microprojection apparatus and system with low infection potential 审中-公开
标题翻译：具有低感染潜力的微型投影仪和系统
公开(公告)号：US20060034902A1
公开(公告)日：2006-02-16
申请号：US11201617
申请日：2005-08-10
申请人： Michel Cormier , Peter Daddona , Rolfe Anderson
发明人： Michel Cormier , Peter Daddona , Rolfe Anderson
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/06 , A61M2037/0023 , A61M2037/0046
摘要： A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.
摘要翻译：具有低感染潜能的透皮药物递送装置和系统包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或其阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，微突出物构件包括具有至少一种生物活性剂和设置在其中的至少一种抗微生物剂的生物相容性涂层。在另一个实施方案中，微突出物构件包括具有至少一种生物活性剂和至少一种抗微生物剂的水凝胶制剂。在另一个实施方案中，微突出物构件包括具有至少一种抗微生物剂和具有至少一种生物活性剂的固体膜的水凝胶制剂。

6. 发明申请

US20050176054A1 Single-phase amplification of nucleic acids 审中-公开
公开(公告)号：US20050176054A1
公开(公告)日：2005-08-11
申请号：US11074527
申请日：2005-03-07
申请人： Xing Su , Rolfe Anderson
发明人： Xing Su , Rolfe Anderson
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q2565/501 , C12Q2600/158 , C12Q2525/173 , C12Q2525/143
摘要： The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof. A single-phase amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.

7. 发明申请

US20080004671A1 VAGUS NERVE STIMULATION VIA ORALLY DELIVERED APPARATUS 审中-公开
标题翻译： VAGUS神经刺激通过手提电脑
公开(公告)号：US20080004671A1
公开(公告)日：2008-01-03
申请号：US11768400
申请日：2007-06-26
申请人： Rolfe Anderson , Pedro E. de la Serna , Laura Maurer
发明人： Rolfe Anderson , Pedro E. de la Serna , Laura Maurer
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/375 , A61N1/3756
摘要： Apparatus, systems and methods for stimulation of a vagus nerve of a patient are disclosed. An element that can be deployed and retained inside the patient's stomach without surgery and having a power supply and electrodes is associated with the expandable element. The electrodes are capable of stimulating the vagus nerve while the expandable element remains in the stomach for an extended period of time.
摘要翻译：公开了用于刺激患者迷走神经的装置，系统和方法。可以部署和保持在患者的胃内而不手术并且具有电源和电极的元件与可扩张元件相关联。电极能够刺激迷走神经，同时可扩张元件长时间保持在胃中。

8. 发明申请

US20070119451A1 Nasal device for delivery to the olfactory region 审中-公开
标题翻译：用于输送到嗅觉区域的鼻装置
公开(公告)号：US20070119451A1
公开(公告)日：2007-05-31
申请号：US11606244
申请日：2006-11-29
申请人： Jingli Wang , Johanna Bentz , Rolfe Anderson
发明人： Jingli Wang , Johanna Bentz , Rolfe Anderson
IPC分类号： A61M5/178 , A61M15/00 , A61M16/00
CPC分类号： A61M15/08 , A61M11/008 , A61M15/0028 , A61M15/0033 , A61M2016/0024 , A61M2205/073 , A61M2205/075 , A61M2210/0618
摘要： A device for delivery of a substance to the olfactory region is described. The device includes a nosepiece and an elongate tubular member slidably disposed within the nosepiece for movement between a retracted position and an extended position. The tubular member is in flow communication with a reservoir containing the substance to be delivered. During use, the tubular member extends from the device, to direct the substance toward the olfactory region.
摘要翻译：描述了将物质输送到嗅觉区域的装置。该装置包括鼻梁和可滑动地设置在鼻梁内的细长管状构件，用于在缩回位置和延伸位置之间移动。管状构件与容纳待输送物质的容器流动连通。在使用期间，管状构件从装置延伸，以将物质引向嗅觉区域。

9. 发明申请

US20070005043A1 Osmotic Intraosseous Drug Delivery System 审中-公开
标题翻译：渗透性骨内给药系统
公开(公告)号：US20070005043A1
公开(公告)日：2007-01-04
申请号：US11428232
申请日：2006-06-30
申请人： Rolfe Anderson
发明人： Rolfe Anderson
IPC分类号： A61K9/22 , A61C5/00
CPC分类号： A61J7/0092 , A61C19/063 , A61K9/0004 , A61K9/0024 , A61K9/0063 , A61K9/0097
摘要： An osmotic intraosseous drug delivery device includes an artificial crown having a cavity defined therein and at least one inlet port in communication with the cavity. The device also includes an osmotic module including an osmotic agent and a drug formulation. The osmotic module is adapted to be inserted in the cavity in order to allow fluid received in the cavity through the inlet port to activate the osmotic module. The osmotic module has an outlet port through which the drug formulation can be dispensed.
摘要翻译：渗透性骨内药物输送装置包括具有限定在其中的空腔的人造冠和与空腔连通的至少一个入口。该装置还包括渗透模块，其包括渗透剂和药物制剂。渗透模块适于插入空腔中，以便允许通过入口端口容纳在空腔中的流体来激活渗透模块。渗透模块具有可以分配药物制剂的出口。

10. 发明申请

US20070005042A1 Programmable Intraosseous Drug Delivery System 审中-公开
标题翻译：可编程骨内给药系统
公开(公告)号：US20070005042A1
公开(公告)日：2007-01-04
申请号：US11427716
申请日：2006-06-29
申请人： Rolfe Anderson
发明人： Rolfe Anderson
IPC分类号： A61K9/22 , A61C5/00
CPC分类号： A61C8/00 , A61C19/063 , A61K9/0024 , A61K9/0063 , A61K9/0097
摘要： A device for intraosseous drug delivery includes a first implant body having a delivery orifice at a distal end thereof. The first implant body is adapted for mounting in a jawbone such that the delivery orifice communicates with the jawbone. The device further includes a drug cartridge including a reservoir for a drug disposed in the first implant body. The device further includes a pump disposed in the first implant body for pumping the drug from the reservoir to the delivery orifice.
摘要翻译：用于骨内药物递送的装置包括在其远端具有输送孔的第一植入体。第一植入体适于安装在颚骨中，使得输送孔与颚骨连通。该装置还包括药物盒，其包括用于设置在第一植入体中的药物的储存器。该装置还包括设置在第一植入体中的泵，用于将药物从储存器泵送到输送孔。

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