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1. 发明申请

US20110260149A1 N-Phenyl carbazole-based host material for light-emitting diodes 审中-公开
标题翻译：用于发光二极管的N-苯基咔唑类主体材料
公开(公告)号：US20110260149A1
公开(公告)日：2011-10-27
申请号：US13124251
申请日：2009-10-15
申请人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur
发明人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur
IPC分类号： H01L51/54 , C07F7/10
CPC分类号： C07F7/0814 , C07D209/86 , C07F7/0816
摘要： The present invention relates to a host material comprising a compound having a carbazole moiety which is suitable for blue-emitting OLEDs. Surprisingly, it has been found that when appropriate substituents are present in the carbazole structure, the solubility of the compounds can be improved without any adverse effect on the OLED performance. The present invention further relates to the use of the host materials and to an organic light emitting device comprising the host material.
摘要翻译：本发明涉及包含具有咔唑部分的化合物的主体材料，该化合物适用于发蓝光的OLED。令人惊奇的是，已经发现，当适当的取代基存在于咔唑结构中时，可以改善化合物的溶解性，而不会对OLED性能产生任何不利影响。本发明还涉及主体材料和包含该主体材料的有机发光器件的用途。

2. 发明授权

US08586973B2 Host material for light-emitting diodes 有权
标题翻译：主机材料为发光二极管
公开(公告)号：US08586973B2
公开(公告)日：2013-11-19
申请号：US13124209
申请日：2009-10-15
申请人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur , Jonathan Maunoury
发明人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur , Jonathan Maunoury
IPC分类号： H01L51/30
CPC分类号： C07F7/0814 , C07D209/88
摘要： The present invention relates to a host material comprising a compound having two carbazole moieties which is suitable for blue-emitting OLEDs. Surprisingly, it has been found that when appropriate substituents are present in the carbazole structure, the solubility of the compounds can be improved without any adverse effect on the OLED performance. The present invention further relates to the use of the host materials and to an organic light emitting device comprising the host material.
摘要翻译：本发明涉及包含具有两个适用于发蓝光OLED的咔唑部分的化合物的主体材料。令人惊奇的是，已经发现，当适当的取代基存在于咔唑结构中时，可以改善化合物的溶解性，而不会对OLED性能产生任何不利影响。本发明还涉及主体材料和包含该主体材料的有机发光器件的用途。

3. 发明申请

US20110198579A1 Host material for light-emitting diodes 有权
标题翻译：主机材料为发光二极管
公开(公告)号：US20110198579A1
公开(公告)日：2011-08-18
申请号：US13124209
申请日：2009-10-15
申请人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur , Jonathan Maunoury
发明人： Roland Martin , Veronique Mathieu , Victor Sorokin , Praveen Bachawala , Wieslaw Adam Mazur , Jonathan Maunoury
IPC分类号： H01L51/30 , C07F7/10
CPC分类号： C07F7/0814 , C07D209/88
摘要： The present invention relates to a host material comprising a compound having two carbazole moieties which is suitable for blue-emitting OLEDs. Surprisingly, it has been found that when appropriate substituents are present in the carbazole structure, the solubility of the compounds can be improved without any adverse effect on the OLED performance. The present invention further relates to the use of the host materials and to an organic light emitting device comprising the host material.
摘要翻译：本发明涉及包含具有两个适用于发蓝光OLED的咔唑部分的化合物的主体材料。令人惊奇的是，已经发现，当适当的取代基存在于咔唑结构中时，可以改善化合物的溶解性，而不会对OLED性能产生任何不利影响。本发明还涉及主体材料和包含该主体材料的有机发光器件的用途。

4. 发明申请

US20130096291A1 New Method of Using N-Thio Compounds for Oligonucleotide Synthesis 失效
标题翻译：使用N-硫代化合物进行寡核苷酸合成的新方法
公开(公告)号：US20130096291A1
公开(公告)日：2013-04-18
申请号：US13805614
申请日：2011-06-30
申请人： Yigang He , Victor Sorokin , Wieslaw Adam Mazur
发明人： Yigang He , Victor Sorokin , Wieslaw Adam Mazur
IPC分类号： C07H19/10 , C07C303/40
CPC分类号： C07H19/10 , C07C303/40 , C07H1/00 , C07H21/00
摘要： A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R1 and R2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.
摘要翻译：一种合成寡核苷酸的方法，其包括使用通式（I）的硫化剂来硫化寡核苷酸前体的至少一个磷核苷酸间键，其中R是与S结合的芳基或杂芳基原子通过环状碳原子; 并且R 1和R 2分别是有机残基，优选C 1 -C 20烃残基。该方法还可以包括纯化寡核苷酸。还包括合成硫化剂的方法。

5. 发明申请

US20140179875A1 SULFURIZATION REAGENTS ON SOLID SUPPORTS 审中-公开
标题翻译：硫化试剂固体支持
公开(公告)号：US20140179875A1
公开(公告)日：2014-06-26
申请号：US14235852
申请日：2012-07-24
申请人： Wieslaw Adam Mazur , Victor Sorokin , Steven Karl Laughlin
发明人： Wieslaw Adam Mazur , Victor Sorokin , Steven Karl Laughlin
IPC分类号： C08F112/08 , C07H21/04
CPC分类号： C08F112/08 , C07B2200/11 , C07C381/00 , C07H21/04 , C12N15/111 , C12N2310/315 , C12N2330/30
摘要： Described herein are novel solid-supported sulfurization reagents having the general structure: (I) wherein (P) is a polymer; X is a linker; R1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and R2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —CH2—O—C(O)—R7, a methylene carbonate group having the formula —CH2—O—C(O)—OR8, or a methylene carbamate group having the formula —CH2—O—C(O)—NR9R10, wherein R7 is a C1 to C20 hydrocarbon residue, R8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and R9 and R10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of Formula I, wherein (P) is a polystyrene-based solid support and X is an aromatic linker. Also described herein are methods for synthesizing the solid-supported sulfurization reagents and their use during the synthesis of oligonucleotides.
摘要翻译：本文描述了具有以下一般结构的新型固体负载型硫化剂：（I）其中（P）是聚合物; X是一个连接子; R1是烷基，环烷基，芳基或杂环; R2为烷基，芳基，具有式-CH2-O-C（O）-R7的亚甲基酰氧基，具有式-CH2-O-C（O）-OR8的亚甲基碳酸酯基，或具有式-CH 2 -O-C（O）-NR 9 R 10的亚甲基氨基甲酸酯基，其中R 7为C 1至C 20烃残基，R 8为任何烷基，环烷基，芳基或杂芳基，R 9和R 10独立地为氢，烷基，环烷基，芳基或杂芳基。其它实施方案包括具有式I结构的固体支持的硫化试剂，其中（P）是基于聚苯乙烯的固体支持物，X是芳族连接体。本文还描述了合成固体负载型硫化试剂的方法及其在寡核苷酸合成过程中的用途。

6. 发明授权

US08710210B2 Method of using N-thio compounds for oligonucleotide synthesis 失效
标题翻译：使用N-硫代化合物进行寡核苷酸合成的方法
公开(公告)号：US08710210B2
公开(公告)日：2014-04-29
申请号：US13805614
申请日：2011-06-30
申请人： Yigang He , Victor Sorokin , Wieslaw Adam Mazur
发明人： Yigang He , Victor Sorokin , Wieslaw Adam Mazur
IPC分类号： C07H21/00
CPC分类号： C07H19/10 , C07C303/40 , C07H1/00 , C07H21/00
摘要： A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R1 and R2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.
摘要翻译：一种合成寡核苷酸的方法，其包括使用通式（I）的硫化剂来硫化寡核苷酸前体的至少一个磷核苷酸间键，其中R是与S结合的芳基或杂芳基原子通过环状碳原子; 并且R 1和R 2分别是有机残基，优选C 1 -C 20烃残基。该方法还可以包括纯化寡核苷酸。还包括合成硫化剂的方法。

7. 发明授权

US06911447B2 Melanocortin receptor ligands 失效
标题翻译：黑皮质素受体配体
公开(公告)号：US06911447B2
公开(公告)日：2005-06-28
申请号：US10121874
申请日：2002-04-12
申请人： Wieslaw Adam Mazur , Xinrong Tian , Xiufeng Eric Hu , Frank Hallock Ebetino
发明人： Wieslaw Adam Mazur , Xinrong Tian , Xiufeng Eric Hu , Frank Hallock Ebetino
IPC分类号： C07D241/04 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/496 , A61P3/06 , A61P3/10 , A61P5/00 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P15/08 , A61P15/10 , A61P21/04 , A61P29/00 , A61P31/04 , A61P35/00 , C07D207/12 , C07D211/46 , C07D241/06 , C07D241/08 , C07D401/12 , C07D403/06 , A01N25/00 , A61K9/14 , A61K47/00 , A61K47/30 , A61K47/34
CPC分类号： C07D241/08 , C07D207/12 , C07D211/46 , C07D241/06 , C07D401/12 , C07D403/06 , C07K5/06078 , C07K5/06191 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic rings; b) aromatic carbocyclic rings; c) non-aromatic heterocyclic rings; d) aromatic heterocyclic rings; wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.
摘要翻译：公开了MC-3 / MC-4受体配体，所述配体具有下式：其中A是选自以下的构象限制性环系：a）非芳族碳环; b）芳族碳环; c）非芳族杂环; d）芳族杂环; 其中所述环包含5至8个原子; W是优选包含D-1-氟苯丙氨酸的单元，Y包含杂原子，Z包括芳族碳环。还公开了包含本发明配体的药物组合物以及治疗通过MC-3 / MC-4受体介导的疾病的方法。

8. 发明授权

US07608701B2 Corticotropin releasing factor 2 receptor agonists 失效
公开(公告)号：US07608701B2
公开(公告)日：2009-10-27
申请号：US11701576
申请日：2007-02-02
申请人： Robert Joseph Isfort , Wieslaw Adam Mazur
发明人： Robert Joseph Isfort , Wieslaw Adam Mazur
IPC分类号： C07H17/00
CPC分类号： C07K14/57509 , A61K38/00
摘要： Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.

9. 发明授权

US07087759B2 Melanocortin receptor ligands 失效
公开(公告)号：US07087759B2
公开(公告)日：2006-08-08
申请号：US10856983
申请日：2004-05-28
申请人： Wieslaw Adam Mazur , Xinrong Tian , Xiufeng Eric Hu , Frank Hallock Ebetino
发明人： Wieslaw Adam Mazur , Xinrong Tian , Xiufeng Eric Hu , Frank Hallock Ebetino
IPC分类号： C07D261/20 , C07D211/36 , C07D207/48 , A61K31/445
CPC分类号： C07D241/08 , C07D207/12 , C07D211/46 , C07D241/06 , C07D401/12 , C07D403/06 , C07K5/06078 , C07K5/06191 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic rings; b) aromatic carbocyclic rings; c) non-aromatic heterocyclic rings; d) aromatic heterocyclic rings; wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.

10. 发明授权

US07192923B2 Corticotropin releasing factor 2 receptor agonists 有权
公开(公告)号：US07192923B2
公开(公告)日：2007-03-20
申请号：US10315964
申请日：2002-12-11
申请人： Robert Joseph Isfort , Wieslaw Adam Mazur
发明人： Robert Joseph Isfort , Wieslaw Adam Mazur
IPC分类号： A61K38/16 , A61K38/22 , C07K14/435 , C07K14/575
CPC分类号： C07K14/57509 , A61K38/00
摘要： Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.

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