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1. 发明授权

US5994087A Mammalian melanocortin receptors and uses 失效
标题翻译：哺乳动物黑皮质素受体和用途
公开(公告)号：US5994087A
公开(公告)日：1999-11-30
申请号：US475637
申请日：1995-06-07
申请人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
发明人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
IPC分类号： C07K14/72 , C12N15/12 , G01N33/74 , G01N33/567 , G01N33/48 , G01N33/53 , G01N33/574
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译：本发明涉及哺乳动物黑皮质素受体。本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。

2. 发明授权

US06261838B1 Rat melanocortin receptor MC3-R 失效
标题翻译：大鼠黑皮质素受体MC3-R
公开(公告)号：US06261838B1
公开(公告)日：2001-07-17
申请号：US09191359
申请日：1998-11-13
申请人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
发明人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
IPC分类号： C07K14705
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译：本发明涉及哺乳动物黑皮质素受体。本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。

3. 发明授权

US5837521A Nucleic acids encoding the .gamma.-MSH receptor MC3-R 失效
标题翻译：编码γ-MSH受体MC3-R的核酸
公开(公告)号：US5837521A
公开(公告)日：1998-11-17
申请号：US44812
申请日：1993-04-08
申请人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
发明人： Roger D. Cone , Linda Roselli-Rehfuss , Kathleen G. Mountjoy , Linda S. Robbins
IPC分类号： C07K14/72 , C12N15/12 , G01N33/74 , C07H21/04
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译：本发明涉及哺乳动物黑皮质素受体。本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。

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