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1. 发明授权

US5587292A Diagnosis of fungal infections with a chitinase 失效
标题翻译：用几丁质酶诊断真菌感染
公开(公告)号：US5587292A
公开(公告)日：1996-12-24
申请号：US402772
申请日：1995-03-09
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C12N9/24 , G01N33/569 , G01N33/53 , G01N33/532 , G01N33/536
CPC分类号： C12Y302/01014 , C12N9/2442 , G01N33/56961 , Y10S435/96 , Y10S436/80 , Y10S436/801 , Y10S436/804 , Y10S436/805
摘要： A novel method for detecting chitin, and for diagnosing fungal infections (including yeast infections), with a chitinase or other chitin-specific binding protein. This method should allow the convenient, broad spectrum diagnosis of fungal infections in tissue samples or in body fluids. Fungal infections are a particular problem in immunocompromised hosts such as AIDS patients, where they can cause opportunistic infections. This invention overcomes difficulties experienced by prior methods of diagnosing fungal infections.
摘要翻译：一种用几丁质酶或其他几丁质特异性结合蛋白检测甲壳素和诊断真菌感染（包括酵母菌感染）的新方法。该方法应允许对组织样本或体液中真菌感染的方便，广谱的诊断。真菌感染是免疫功能低下的宿主如艾滋病患者中的特殊问题，在那里它们可引起机会性感染。本发明克服了现有诊断真菌感染方法所遇到的困难。

2. 发明授权

US5935804A Method for detecting eubacteria in biological samples with catalytically inactive murein binding enzymes 失效
标题翻译：用催化无活性的murein结合酶检测生物样品中的真细菌的方法
公开(公告)号：US5935804A
公开(公告)日：1999-08-10
申请号：US823293
申请日：1997-03-21
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C07K14/00 , C12M1/00 , C12N9/24 , C12N9/36 , C12N9/96 , C12Q1/04 , C12Q1/06 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/48 , G01N33/569 , G01N33/573 , C12Q1/02
CPC分类号： C12N9/2462 , C07K14/001 , C12Q1/04 , C12Q1/18 , C12Y302/01017 , G01N33/569 , G01N33/573 , G01N2333/245 , G01N2333/40 , G01N2333/914 , G01N2333/924
摘要： A method for detecting eubacteria in biological samples with catalytically inactive murein binding enzyme is presented. The biological sample may be chemically treated with alkali to cleave peptide bonds in the sample before incubating the sample with the catalytically inactive murein binding enzyme.
摘要翻译：提出了一种利用催化无活性的murein结合酶检测生物样品中真细菌的方法。在将样品与催化无活性的murein结合酶孵育之前，生物样品可以用碱化学处理以切割样品中的肽键。

3. 发明授权

US6093552A Diagnosis of fungal infections with a chitinase 失效
标题翻译：用几丁质酶诊断真菌感染
公开(公告)号：US6093552A
公开(公告)日：2000-07-25
申请号：US770826
申请日：1996-12-20
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C12Q1/34 , G01N33/569 , G01N33/53
CPC分类号： G01N33/56961 , C12Q1/34
摘要： Chitinase fungal diagnostic reagents comprising a chitinase conjugate comprising a chitinase enzyme and a label, the label selected from among a flourescent or a radioactive compound, an enzyme and a dye, the said chitinase fungal diagnostic reagent comprises a substantially pure aqueous solution of said chitinase conjugate; kits for detecting a fungal cell wall glucosamine compound in a biological specimen comprising the chitinase fungal diagnostic reagent and a filter capable of collecting the fungal cell wall glucosamine compound; and methods for detecting a fungal cell wall glucosamine compound in a biological specimen.
摘要翻译：几丁质酶真菌诊断试剂包含几丁质酶偶联物，其包含几丁质酶和标记，选自荧光素或放射性化合物的标签，酶和染料，所述几丁质酶真菌诊断试剂包含基本上纯的所述几丁质酶缀合物的水溶液 ; 用于检测包含几丁质酶真菌诊断试剂的生物样品中的真菌细胞壁葡糖胺化合物的试剂盒和能够收集真菌细胞壁葡糖胺化合物的过滤器; 以及用于检测生物样本中的真菌细胞壁葡糖胺化合物的方法。

4. 发明申请

US20080206294A1 Naphthalene Derivatives as Termite Repellents and Toxicants 审中-公开
标题翻译：萘衍生物作为白蚁驱虫剂和毒素
公开(公告)号：US20080206294A1
公开(公告)日：2008-08-28
申请号：US12024453
申请日：2008-02-01
申请人： Gregg Henderson , Sanaa A. Ibrahim , Rosemary Patton , Roger A. Laine , Betty C.R. Zhu , Feng Chen
发明人： Gregg Henderson , Sanaa A. Ibrahim , Rosemary Patton , Roger A. Laine , Betty C.R. Zhu , Feng Chen
IPC分类号： A01N31/14 , A01N25/08 , A01N31/00 , A01P17/00 , A01P7/04
CPC分类号： A01N31/04 , A01N27/00 , A01N31/14 , A01N35/04 , Y10S424/11
摘要： Several derivatives of naphthalene, including 1′-acetonaphthone, 2′-acetonaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding activity. For example, 2′-acetonaphthone was found to be an effective repellent and feeding deterrent of termites. Termites exposed to concentrations as low as 8 mg/kg sand exhibited a significant reduction in tunneling and feeding activity. Moreover, some of the dead termites had symptoms indicative of a failure to molt. At concentrations ≧20 μg/cm2, 2′-acetonaphthone was a strong repellent. Interestingly, at 160-fold lower concentration (0.125 μg/cm2), 2′-acetonaphthone stimulated termite feeding activity. As a sand barrier, 2′-acetonaphthone significantly inhibited tunneling and feeding activity in concentrations from 8.33 to 35.0 mg/kg. Molting problems were also identified in termites exposed to 2′-acetonaphthone.
摘要翻译：发现了萘的几种衍生物，包括1'-乙酰萘酮，2'-乙酰萘酮，1-甲氧基萘和2-甲氧基萘，是白蚁的有效毒素和驱避剂，导致白蚁进食活性显着降低。例如，发现2'-乙酰萘酮是有效的驱避剂和抑制白蚁的抑制作用。暴露于浓度低至8 mg / kg沙粒的白蚁显示隧道和进食活动的显着减少。此外，一些死亡的白蚁有表现为蜕皮失败的症状。在浓度≥20mug/ cm 2的情况下，2'-乙酰萘酮是强驱虫剂。有趣的是，在浓度为160倍（0.125mug / cm 2））的情况下，2'-乙酰萘酮刺激白蚁进食活性。作为沙屏障，2'-乙酰萘酮显着抑制了浓度为8.33〜35.0mg / kg的隧道和摄食活性。在暴露于2'-乙酰四氢萘酮的白蚁中也发现了溶解问题。

5. 发明授权

US6159719A Pan-bacterial and pan-fungal identification reagents and methods of use thereof 失效
标题翻译：泛菌和泛霉菌鉴定试剂及其使用方法
公开(公告)号：US6159719A
公开(公告)日：2000-12-12
申请号：US261665
申请日：1999-03-03
申请人： Roger A. Laine , Wai Chun Jennifer Lo
发明人： Roger A. Laine , Wai Chun Jennifer Lo
IPC分类号： C07K14/00 , C12M1/00 , C12N9/24 , C12N9/36 , C12N9/96 , C12Q1/04 , C12Q1/06 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/48 , G01N33/569 , G01N33/573 , C12N9/34 , G01N33/53
CPC分类号： C12N9/2462 , C07K14/001 , C12Q1/04 , C12Q1/18 , C12Y302/01017 , G01N33/569 , G01N33/573 , G01N2333/245 , G01N2333/40 , G01N2333/914 , G01N2333/924
摘要： Murein binding polypeptide and antibiotic diagnostic reagents, methods and kits for detecting eubacteria and fungus in biological samples.
摘要翻译： Murein结合多肽和抗生素诊断试剂，用于检测生物样品中真细菌和真菌的方法和试剂盒。

6. 发明授权

US6121420A Diagnosis of fungal infections, and a chitin-binding lectin useful in such diagnoses 失效
标题翻译：真菌感染的诊断和可用于这种诊断的几丁质结合凝集素
公开(公告)号：US6121420A
公开(公告)日：2000-09-19
申请号：US290836
申请日：1999-04-13
申请人： Roger A. Laine
发明人： Roger A. Laine
IPC分类号： C07K14/28 , G01N33/569
CPC分类号： C07K14/28 , G01N33/56961 , G01N2333/4724
摘要： A 134 kDa, calcium-independent, chitin-binding lectin called chitovibrin is secreted by marine bacteria of the genus Vibnio. The secretion of chitovibrin is inducible by chitin or chitin-oligomers. Chitovibrin shows no apparent enzymatic activity, but has a strong affinity for chitin and for chito-oligomers dp9 and larger. The protein has an isoelectric pH of 3.6, shows thermal tolerance, binds chitin with an optimum at pH 6 and is active in 0-4 M NaCl. Chitovibrin is useful as a stain for fungi and other chitin-containing organisms. Chitovibrin may be used to detect the presence of chitin, particularly in diagnosing fungal infections in humans, animals, and plant materials. Fungal infections are a particular problem in immunocompromised hosts such as AIDS patients and bone marrow transplant patients, because they can cause opportunistic infections. The chitovibrin diagnostic method allows the convenient, broad spectrum diagnosis of fungal infections in tissue samples or in body fluids. Other, smaller polypeptide fragments of chitovibrin will exhibit similar chitin-binding properties, and could be used in coupling to detection systems.
摘要翻译：称为chitovibrin的134 kDa，不依赖钙的几丁质结合凝集素由Vibnio属的海洋细菌分泌。壳多糖蛋白的分泌可由几丁质或几丁质寡聚体诱导。 Chitovibrin没有显示出明显的酶活性，但对几丁质和chito-oligomers dp9及更大的亲和力。蛋白质具有3.6的等电点pH，显示耐热性，在pH 6下结合几丁质，最适pH为0-4M NaCl。 Chitovibrin可用作真菌和其他含几丁质的生物体的污渍。 Chitovibrin可用于检测几丁质的存在，特别是在诊断人类，动物和植物材料中的真菌感染时。免疫功能低下的宿主如艾滋病患者和骨髓移植患者，真菌感染是一个特别的问题，因为它们可能引起机会性感染。 chitovibrin诊断方法可以方便，广谱地诊断组织样本或体液中的真菌感染。其他较小的chitovibrin多肽片段将显示相似的几丁质结合性质，并可用于与检测系统的偶联。

7. 发明授权

US5618705A Synthesis of anti-inflammatory compounds and novel trisaccharides useful in the synthesis of anti-inflammatory compounds 失效
标题翻译：抗炎化合物的合成和用于合成抗炎化合物的新型三糖
公开(公告)号：US5618705A
公开(公告)日：1997-04-08
申请号：US454740
申请日：1995-05-31
申请人： Roger A. Laine , Eunsun Yoon
发明人： Roger A. Laine , Eunsun Yoon
IPC分类号： C07H3/06 , C12P19/18 , C12P19/04 , C08B37/00 , C12P19/00
CPC分类号： C12P19/18 , C07H3/06
摘要： Anti-inflammatory compounds are useful, for example, in treating arthritis and heart attack patients. Novel oligosaccharides useful in the rapid synthesis of certain anti-inflammatory compounds are disclosed, as is a rapid method of synthesizing the oligosaccharides. Low pH can loosen the acceptor specificity of galactosyltransferase (lactose synthase: EC 2.4.1.22), allowing the rapid synthesis of novel oligosaccharides. The disaccharides cellobiose (.beta.1.fwdarw.4), laminaribiose (.beta.1.fwdarw.3), gentiobiose (.beta.1.fwdarw.6) and maltose (.alpha.1.fwdarw.4) acted as acceptors for lactose synthase under low pH conditions. From these four acceptors, the following four novel trisaccharides were synthesized: Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.3)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.4)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.6)-Glc and Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.alpha.1.fwdarw.4) Glc. These trisaccharides, and other oligosaccharides, may be synthesized in a few days with the disclosed technique, as opposed to the several months which would likely have been required with more traditional organic synthetic methods. These trisaccharides may be used as intermediates in the rapid synthesis of anti-inflammatory compounds.
摘要翻译：抗炎化合物可用于例如治疗关节炎和心脏病发作患者。公开了用于快速合成某些抗炎化合物的新型寡糖，以及合成低聚糖的快速方法。低pH可以松散半乳糖转移酶（乳糖合成酶：EC 2.4.1.22）的受体特异性，可以快速合成新的低聚糖。在低pH条件下，二糖纤维二糖（β1-> 4），层状二糖（β1-> 3），龙胆二糖（β1-> 6）和麦芽糖（α1-> 4）作为乳糖合成酶的受体。从这四个受体合成了以下四种新型三糖：Galp（β1-> 4）Glcp（β1-> 3）-Glc，Galp（β1-> 4）Glcp（β1-> 4）-Glc ，Glp1（β1-> 4）Glc1（β1-> 6）-Glc和Galp（β1-> 4）Glcp（α1-4）Glc。这些三糖和其他寡糖可以在几天内用所公开的技术合成，而不是可能用更传统的有机合成方法需要的几个月。这些三糖可以用作快速合成抗炎化合物的中间体。

8. 发明授权

US5032679A Heparin fragments as inhibitors of smooth muscle cell proliferation 失效
标题翻译：肝素片段作为平滑肌细胞增殖抑制剂
公开(公告)号：US5032679A
公开(公告)日：1991-07-16
申请号：US400661
申请日：1989-08-31
申请人： Brian K. Brandley , Lun H. Lam , Roger A. Laine
发明人： Brian K. Brandley , Lun H. Lam , Roger A. Laine
IPC分类号： G01N33/53 , A61K31/70 , A61K31/7012 , A61K49/00 , A61P43/00 , B01D15/00 , B01D15/04 , B01D61/24 , C07H3/06 , C07H7/027 , C07H11/00 , C07H13/04
CPC分类号： A61K31/715 , A61K31/70 , C07H11/00 , C07H13/04 , C07H3/06
摘要： A glycosaminoglycoside (GAG) composition predominantly of tetrasacchardie units derived from heparin/heparan sulfate has enchanced activity in preventing the proliferation of smooth muscle cells. This GAG preparation is useful in the treatment of diseases characterized by unwanted smooth muscle cell proliferation and activity.
摘要翻译：主要来自肝素/硫酸乙酰肝素的四糖单元的糖胺聚糖（GAG）组合物具有增强平滑肌细胞增殖的作用。该GAG制剂可用于治疗以不需要的平滑肌细胞增殖和活性为特征的疾病。

9. 发明授权

US06906108B2 Extracts of vetiver oil as repellent and toxicant to ants, ticks, and cockroaches 有权
标题翻译：香根草油的提取物作为驱避剂，对蚂蚁，蜱和蟑螂有毒
公开(公告)号：US06906108B2
公开(公告)日：2005-06-14
申请号：US09932555
申请日：2001-08-17
申请人： Gregg Henderson , Donald O. Heumann , Roger A. Laine , Lara Maistrello , Betty C. R. Zhu , Feng Chen
发明人： Gregg Henderson , Donald O. Heumann , Roger A. Laine , Lara Maistrello , Betty C. R. Zhu , Feng Chen
IPC分类号： A01N31/04 , A01N35/06 , A01N45/02 , A01N65/00 , A61K31/12 , A61K31/045 , A61K31/015 , A01N27/00
CPC分类号： A01N31/04 , A01N35/06 , A01N45/02 , A01N65/06 , A01N65/44 , Y02A50/322
摘要： Extracts of vetiver oil were found to be significant repellents and toxicants of ants, ticks, and cockroaches. Nootkatone was shown to significantly decrease ant invasion and increase mortality in fire ants. Nootkatone is an effective repellent and toxicant of ants either by itself or as an addition to other substrates, including mulches made from vetiver grass roots, diatomaceous earth, alumina, silica, clays; building materials made from either aluminum or wood; and other suitable solid substances. Nootkatone was also a repellent and toxicant to ticks; and a repellent to cockroaches. Nootkatone is non-toxic to humans and other mammals and is environmentally safe. In addition, it is believed that other extracts of vetiver oil, specifically α-cedrene, zizanol and bicyclovetivenol, will be effective against ants, ticks, and cockroaches.
摘要翻译：发现香根草油的提取物是蚂蚁，蜱和蟑螂的驱虫剂和有毒物质。 Nootkatone被证明可以显着降低蚂蚁入侵并增加蚂蚁的死亡率。 Nootkatone是本身或作为其他底物的补充剂，包括由香根草草根，硅藻土，氧化铝，二氧化硅，粘土制成的覆盖物的有效驱避剂和毒物; 铝或木制建筑材料; 和其他合适的固体物质。 Nootkatone也是蜱虫的驱避剂和毒物; 和驱虫剂蟑螂。 Nootkatone对人类和其他哺乳动物无毒，对环境无害。此外，据信香根草油的其他提取物，特别是α-雪松烯，齐赞醇和双环己酮醇，对蚂蚁，蜱和蟑螂有效。

10. 发明授权

US06897244B2 Dihydronootkatone and tetrahydronootkatone as repellents to arthropods 有权
公开(公告)号：US06897244B2
公开(公告)日：2005-05-24
申请号：US10189631
申请日：2002-07-03
申请人： Betty C. R. Zhu , Gregg Henderson , Roger A. Laine
发明人： Betty C. R. Zhu , Gregg Henderson , Roger A. Laine
IPC分类号： A01N35/06 , A01N35/04
CPC分类号： A01N35/06 , Y10S424/10 , Y10S514/919
摘要： Two derivatives of nootkatone, tetrahydronootkatone and 1,10-dihydronootkatone, are surprisingly effective as repellents of termites and mosquitos. Tetrahydronootkatone and 1,10-dihydronootkatone were shown to effectively repel termites at concentrations as low as 2 μg/ml and 12.5 μg/ml, respectively. Tetrahydronootkatone was shown to repel mosquitos at a concentration of 5%. Tetrahydronootkatone is an effective repellent of termites either by itself or as an addition to other substrates, including mulches made from wood products or other cellulose-containing material. Tetrahydronootkatone or 1,10-dihydronootkatone can be used to protect construction wood from attack by Formosan subterranean termites, either alone or used in combination with other compounds known to repel termites. It is also believed that these compounds will prove effective in repelling ants, ticks, and cockroaches. These derivatives of nootkatone are non-toxic to humans and other mammals and environmentally safe.

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