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1. 发明授权

US5134995A Inspiratory airway pressure system with admittance determining apparatus and method 失效
标题翻译：具有导纳决定装置和方法的吸入气道压力系统
公开(公告)号：US5134995A
公开(公告)日：1992-08-04
申请号：US632327
申请日：1990-12-21
申请人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
发明人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
IPC分类号： A61F5/56 , A61M16/00 , A61M16/06 , A61M16/20
CPC分类号： A61M16/0051 , A61M16/00 , A61M16/0069 , A61M16/06 , A61M16/0633 , A61M16/204 , A61M16/205 , A61F5/56 , A61M16/0683 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2205/054 , A61M2205/3561 , A61M2210/0618
摘要： An apparatus and method for facilitating the respiration of a patient are disclosed which are particularly useful in treating mixed and obstructive sleep apnea and certain cardiovascular conditions, among others, by increasing nasal air pressure delivered to the patient's respiratory passages just prior to inhalation and by subsequently decreasing the pressure to ease exhalation effort. The preferred apparatus includes a patient-coupled gas delivery device for pressurizing the patient's nasal passages at a controllable pressure, and a controller coupled with the delivery device having a pressure transducer for monitoring the nasal pressure and a microcontroller for selectively controlling the nasal pressure. In operation, the controller determines a point in the patient breathing cycle just prior to inhalation and initiates an increase in nasal pressure at that point in order to stimulate normal inhalation, and subsequently lowers the nasal pressure to ease exhalation efforts.
摘要翻译：公开了一种用于促进患者呼吸的装置和方法，其特别可用于治疗混合和阻塞性睡眠呼吸暂停和某些心血管疾病，其中包括通过在吸入之前递送至患者的呼吸通道的鼻气压力和随后的降低压力以减轻呼气努力。优选的装置包括用于以可控压力加压患者鼻通道的患者联接气体输送装置，以及与输送装置相连的控制器，该输送装置具有用于监测鼻压的压力传感器和用于选择性地控制鼻压的微控制器。在操作中，控制器在吸入之前确定患者呼吸循环中的一点，并且在该点开始增加鼻压，以刺激正常吸入，随后降低鼻压以缓解呼气努力。

2. 发明授权

US5794614A Apparatus for compensating for flow and pressure variances in pneumatic circuits 失效
公开(公告)号：US5794614A
公开(公告)日：1998-08-18
申请号：US660298
申请日：1996-06-07
申请人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
发明人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
IPC分类号： A61F5/56 , A61M16/00 , A61M16/06 , A61M16/20 , A62B7/04 , F16K31/02
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/06 , A61M16/0633 , A61M16/204 , A61M16/205 , A61B5/4818 , A61F5/56 , A61M16/0683 , A61M2016/0021 , A61M2016/0039 , A61M2205/054 , A61M2205/3561 , A61M2210/0618
摘要： An apparatus and method for facilitating the respiration of a patient are disclosed which are particularly useful in treating mixed and obstructive sleep apnea and certain cardiovascular conditions, among others, by increasing nasal air pressure delivered to the patient's respiratory passages just prior to inhalation and by subsequently decreasing the pressure to ease exhalation effort. The preferred apparatus includes a patient-coupled gas delivery device for pressurizing the patient's nasal passages at a controllable pressure, and a controller coupled with the delivery device having a pressure transducer for monitoring the nasal pressure and a microcontroller for selectively controlling the nasal pressure. In operation, the controller determines a point in the patient breathing cycle just prior to inhalation and initiates an increase in nasal pressure at that point in order to stimulate normal inhalation, and subsequently lowers the nasal pressure to ease exhalation efforts. The invention further comprises an apparatus for compensating variances in a circuit used for supplying airway pressure to a patient's airway having a sensor proximal to a pneumatic circuit connection for ascertaining a circuit characteristic and producing a signal value representative thereof, as well as a memory storing a look-up table containing empirical values corresponding to known variances of pneumatic circuit connections and signal processor receiving and comparing the signal value with the empirical values to ascertain a deviation value, and a controller connected to the signal processor and source of breathing gas to control delivery of breathing gas in accordance with the deviation value an apparatus for compensating variances in a circuit used for supplying airway pressure to a patient's airway having a sensor proximal to a pneumatic circuit connection for ascertaining a circuit characteristic and producing a signal value representative thereof, as well as a memory storing a look-up table containing empirical values corresponding to known variances of pneumatic circuit connections and signal processor receiving and comparing the signal value with the empirical values to ascertain a deviation value, and a controller connected to the signal processor and source of breathing gas to control delivery of breathing gas in accordance with the deviation value.

3. 发明授权

US5259373A Inspiratory airway pressure system controlled by the detection and analysis of patient airway sounds 失效
标题翻译：通过检测和分析患者气道声音控制的吸气气道压力系统
公开(公告)号：US5259373A
公开(公告)日：1993-11-09
申请号：US846133
申请日：1992-04-09
申请人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
发明人： Roger A. Gruenke , Russell L. Trimble , Christopher D. Lasnier , Steven W. Loethen , Jiri G. Orlt , James A. Snook , Marilyn S. Wyble
IPC分类号： A61F5/56 , A61M16/00 , A61M16/06 , A61M16/20 , A62B7/00 , F16K31/02
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/06 , A61M16/0633 , A61M16/204 , A61M16/205 , A61B5/4818 , A61F5/56 , A61M16/0683 , A61M2016/0021 , A61M2016/0039 , A61M2205/054 , A61M2205/3561 , A61M2210/0618
摘要： An apparatus and method for facilitating the respiration of a patient detects patient airway sounds and resolves these sounds into audio component bands whereupon an analysis is performed to produce a trend value. In response, a pressure action is determined using the trend value for controlling the pressure delivered to a patient for preventing the onset of obstructive apnea.
摘要翻译：用于促进患者呼吸的装置和方法检测患者气道声音并将这些声音解析为音频分量频带，由此进行分析以产生趋势值。作为响应，使用用于控制输送给患者的压力的趋势值来确定压力作用，以防止发生阻塞性呼吸暂停。

4. 发明授权

US4706664A Inspiration oxygen saver 失效
标题翻译：启发氧气保护
公开(公告)号：US4706664A
公开(公告)日：1987-11-17
申请号：US851132
申请日：1986-04-11
申请人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
发明人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
IPC分类号： A61M16/00 , A61M16/06
CPC分类号： A61M16/00 , A61M16/0677 , A61M2016/0021
摘要： A reliable, pulse-flow supplemental oxygen apparatus for alleviating respiratory ailments is provided which yields substantial savings in oxygen while giving the patient the physiological equivalent of a prescribed continuous stream of oxygen. The apparatus preferably includes a demand oxygen valve operated in a pulse mode by means of electronic control circuitry which, through an appropriate sensor, monitors the patient's breathing efforts and gives a variable "custom tailored" pulse volume of oxygen to the patient during the very initial stages of each inspiration. Pulse volume variability is based upon a measured parameter characterizing at least a part of one and preferably a plurality of the patient's preceeding breaths; advantageously, the elapsed time interval of the patient's three preceding breath cycles is measured to effectively measure breath rate. These breath-characterizing parameters, together with data characterizing the prescribed continuous oxygen flow to be matched, enable the apparatus to give the desired "on the go" dose variability. The apparatus is also designed to revert to conventional, continuous-flow operation upon a power failure or circuit malfunction.
摘要翻译：提供了一种用于减轻呼吸道疾病的可靠的脉动补充氧气装置，其产生氧气的显着节省，同时给予患者生理等效的规定的连续氧气流。该装置优选地包括通过电子控制电路以脉冲模式操作的需求氧气阀，电子控制电路通过适当的传感器监测患者的呼吸努力，并且在最初的期间向患者提供可变的“定制的”脉搏体积的氧气每个灵感的阶段。脉搏体积变异性基于表征一个且优选多个患者之前呼吸的至少一部分的测量参数; 有利地，测量患者三次呼吸周期的经过时间间隔以有效地测量呼吸速率。这些呼吸特征参数与表征规定的连续氧气流的数据匹配，使得装置能够给出期望的“随时间”剂量变异性。该设备还被设计成在电源故障或电路故障时恢复到常规的连续流动操作。

5. 发明授权

US4932402A Inspiration oxygen saver 失效
标题翻译：启发氧气保护
公开(公告)号：US4932402A
公开(公告)日：1990-06-12
申请号：US108948
申请日：1987-10-16
申请人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
发明人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
IPC分类号： A61M16/00 , A61M16/06
CPC分类号： A61M16/00 , A61M16/0677 , A61M2016/0021 , A61M2016/0039
摘要： A reliable, pulse-flow supplemental oxygen apparatus for alleviating respiratory ailments is provided which yields substantial savings in oxygen while giving the patient the physiological equivalent of a prescribed continuous stream of oxygen. The apparatus preferably includes a demand oxygen valve operated in a pulse mode by means of electronic control circuitry which, through an appropriate sensor, monitors the patient's breathing efforts and gives a variable "custom tailored" pulse volume of oxygen to the patient during the very initial stages of each inspiration. Pulse volume variability is based upon a measured parameter characterizing at least a part of one and preferably a plurality of the patient's preceding breaths; advantageously, the elapsed time interval of the patient's three preceding breath cycles is measured to effectively measure breath rate. These breath-characterizing parameters, together with data characterizing the prescribed continuous oxygen flow to be matched, enable the apparatus to give the desired "on the go" dose variability. The apparatus is also designed to revert to conventional, continuous-flow operation upon a power failure or circuit malfunction, and for this purpose a specialized dual flow control restrictor valve is provided in the form of the invention designed for hospital use. In the event of abnormally low or high breath rates on the part of the patient, the device automatically delivers a relatively long continuous pulse, then stops to again sample the breath rate. If the rate is normal, the usual pulse flow operation is resumed; if the rate remains abnormal, the long pulse volume-rate sampling is repeated. Actual tests with the apparatus hereof demonstrate an oxygen saving of over 50% as compared with continuous flow regimens.
摘要翻译：提供了一种用于减轻呼吸道疾病的可靠的脉动补充氧气装置，其产生氧气的显着节省，同时给予患者生理等效的规定的连续氧气流。该装置优选地包括通过电子控制电路以脉冲模式操作的需求氧气阀，电子控制电路通过适当的传感器监测患者的呼吸努力，并且在最初的期间向患者提供可变的“定制的”脉搏体积的氧气每个灵感的阶段。脉搏体积变异性是基于表征至少一部分一个，优选多个患者之前呼吸的测量参数; 有利地，测量患者三次呼吸周期的经过时间间隔以有效地测量呼吸速率。这些呼吸特征参数与表征规定的连续氧气流的数据匹配，使得装置能够给出期望的“随时间”剂量变异性。该设备还被设计成在电源故障或电路故障时恢复到常规的连续流动操作，为此目的，为了医院使用而设计了专门的双流量控制限制阀。在病人出现异常低或高呼吸频率的情况下，设备会自动传送相对较长的连续脉冲，然后停止再次抽取呼吸速率。如果速率正常，则恢复通常的脉冲流动操作; 如果速率保持不正常，则重复长脉冲体积率采样。与本装置的实际测试相比，连续流量方案的氧气节省量超过50％。

6. 发明授权

US4938212A Inspiration oxygen saver 失效
标题翻译：启发氧气保护
公开(公告)号：US4938212A
公开(公告)日：1990-07-03
申请号：US108947
申请日：1987-10-16
申请人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
发明人： James A. Snook , Thomas W. Nelson , Marilyn S. Wyble , Russell L. Trimble
IPC分类号： A61M16/00 , A61M16/06 , A61M16/20
CPC分类号： A61M16/00 , A61M16/0677 , A61M16/20 , A61M2016/0021 , A61M2016/0039 , Y10T137/87249
摘要： A reliable, pulse-flow supplemental oxygen apparatus for alleviating respiratory ailments is provided which yields substantial savings in oxygen while giving the patient the physiological equivalent of a prescribed continuous stream of oxygen. The apparatus preferably includes a demand oxygen valve operated in a pulse mode by means of electronic control circuitry which, through an appropriate sensor, monitors the patient's breathing efforts and gives a variable "custom tailored" pulse volume of oxygen to the patient during the very initial stages of each inspiration.
摘要翻译：提供了一种用于减轻呼吸道疾病的可靠的脉动补充氧气装置，其产生氧气的显着节省，同时给予患者生理等效的规定的连续氧气流。该装置优选地包括通过电子控制电路以脉冲模式操作的需求氧气阀，电子控制电路通过适当的传感器监测患者的呼吸努力，并且在最初的期间向患者提供可变的“定制的”脉搏体积的氧气每个灵感的阶段。

7. 发明申请

US20110302120A1 ADDRESSING SCHEME FOR NEURAL MODELING AND BRAIN-BASED DEVICES USING SPECIAL PURPOSE PROCESSOR 有权
标题翻译：使用特殊用途处理器进行神经建模和基于脑的设备的寻址方案
公开(公告)号：US20110302120A1
公开(公告)日：2011-12-08
申请号：US13047434
申请日：2011-03-14
申请人： James A. Snook , Richard W. Schermerhorn
发明人： James A. Snook , Richard W. Schermerhorn
IPC分类号： G06N3/02
CPC分类号： G06F15/7867 , G06N3/063 , G06N3/10
摘要： A special purpose processor (SPP) can use a Field Programmable Gate Array (FPGA) to model a large number of neural elements. The FPGAs or similar programmable device can have multiple cores doing presynaptic, postsynaptic, and plasticity calculations in parallel. Each core can implement multiple neural elements of the neural model.
摘要翻译：专用处理器（SPP）可以使用现场可编程门阵列（FPGA）对大量神经元进行建模。 FPGA或类似的可编程器件可以具有并行执行突触前，突触后和可塑性计算的多个核心。每个核心可以实现神经模型的多个神经元素。

8. 发明申请

US20090240642A1 NEURAL MODELING AND BRAIN-BASED DEVICES USING SPECIAL PURPOSE PROCESSOR 有权
标题翻译：使用特殊用途处理器的神经建模和基于脑的设备
公开(公告)号：US20090240642A1
公开(公告)日：2009-09-24
申请号：US12421503
申请日：2009-04-09
申请人： James A. Snook , Donald B. Hutson , Jeffrey L. Krichmar
发明人： James A. Snook , Donald B. Hutson , Jeffrey L. Krichmar
IPC分类号： G06N3/04
CPC分类号： G06N3/063 , G06N3/10
摘要： A special purpose processor (SPP) can use a Field Programmable Gate Array (FPGA) or similar programmable device to model a large number of neural elements. The FPGAs can have multiple cores doing presynaptic, postsynaptic, and plasticity calculations in parallel. Each core can implement multiple neural elements of the neural model.
摘要翻译：专用处理器（SPP）可以使用现场可编程门阵列（FPGA）或类似的可编程器件对大量的神经元进行建模。 FPGA可以具有多个并行执行突触前，突触后和可塑性计算的核心。每个核心可以实现神经模型的多个神经元素。

9. 发明授权

US08126828B2 Special purpose processor implementing a synthetic neural model of the human brain 有权
标题翻译：实现人脑合成神经模型的专用处理器
公开(公告)号：US08126828B2
公开(公告)日：2012-02-28
申请号：US12421503
申请日：2009-04-09
申请人： James A. Snook , Donald B. Hutson , Jeffrey L. Krichmar
发明人： James A. Snook , Donald B. Hutson , Jeffrey L. Krichmar
IPC分类号： G06F15/18 , G06G7/00 , G06N3/04 , G05B13/02
CPC分类号： G06N3/063 , G06N3/10
摘要： A special purpose processor (SPP) for implementing a synthetic neural model of the biological anatomy of the human brain to control a brain-based device (BBD) that is movable in a real-world environment, including neural processing units (NPUs), each having a programmed processor and a local memory that stores data records of neural elements, a system memory for storing data about all the NPUs, and a finite state machine and a system bus for transferring data between the NPUs and system memory.
摘要翻译：一种专用处理器（SPP），用于实现人脑生物解剖学的合成神经模型，以控制在包括神经处理单元（NPU）在内的真实环境中可移动的基于脑的装置（BBD），每个具有编程处理器和存储神经元件的数据记录的本地存储器，用于存储关于所有NPU的数据的系统存储器，以及用于在NPU和系统存储器之间传送数据的有限状态机和系统总线。

10. 发明授权

US07627540B2 Addressing scheme for neural modeling and brain-based devices using special purpose processor 有权
标题翻译：使用专用处理器的神经建模和基于脑的设备的寻址方案
公开(公告)号：US07627540B2
公开(公告)日：2009-12-01
申请号：US11426896
申请日：2006-06-27
申请人： James A. Snook , Richard W. Schermerhorn
发明人： James A. Snook , Richard W. Schermerhorn
IPC分类号： G06N5/00
CPC分类号： G06F15/7867 , G06N3/063 , G06N3/10
摘要： A special purpose processor (SPP) can use a Field Programmable Gate Array (FPGA) to model a large number of neural elements. The FPGAs or similar programmable device can have multiple cores doing presynaptic, postsynaptic, and plasticity calculations in parallel. Each core can implement multiple neural elements of the neural model.
摘要翻译：专用处理器（SPP）可以使用现场可编程门阵列（FPGA）对大量神经元进行建模。 FPGA或类似的可编程器件可以具有并行执行突触前，突触后和可塑性计算的多个核心。每个核心可以实现神经模型的多个神经元素。

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